105 research outputs found

    The Potential for Canadian LNG Exports to Europe

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    Offering numerous ports with the shortest shipping distances to Europe from North America, Eastern Canada has the potential to be a player in the European liquefied natural gas (LNG) market. However, the slower-moving nature of proposed projects on Canada’s East Coast, combined with a glut of global LNG liquefaction capacity, means it will likely be difficult for Canadian projects to gain a foothold in the market in the near term. As just one player in the worldwide competitive market, Eastern Canada will face challenges keeping up with faster-moving and lower-cost entrants, particularly those on the U.S. Gulf and East Coasts. Geography, too, is a double-edged sword for proposed projects in Quebec and the Maritime provinces. While they offer the benefit of proximity to Europe, they are located significant distances from Canada’s major natural-gas-producing provinces of British Columbia and Alberta. Further, there are no direct natural gas pipelines connecting proposed projects to supply sources in either Western Canada or the Northeastern U.S. This places these projects at a significant disadvantage relative to projects on the U.S. Gulf Coast. The latter are located in a petrochemical hub, complete with major infrastructure connections to numerous sources of natural gas supply.Also working against Eastern Canadian LNG development is anti-pipeline and anti-fossil fuel sentiments across the country. These sentiments are slowing Canada’s regulatory process and have also contributed to the establishment of moratoriums on hydraulic fracturing in three Maritime provinces. This virtually rules out local supply sources of natural gas for export from Canada’s East Coast in the near term.None of this necessarily means, however, that Eastern Canada’s future in LNG exports is doomed. Reason for optimism remains and it centres on indications that European countries are looking to diversify their natural gas supply sources and are prioritizing geopolitically stable and environmentally responsible supplies.Canada is a world benchmark for that kind of stability, thus making it a dependable, reliable supplier unshaken by whichever way the geopolitical winds are blowing. The kind of stability Canada offers will be key to obtaining long-term LNG supply contracts and the financial capital accompanying them to build pipelines and LNG export facilities.In 2015 the NEB granted export licenses for six proposed LNG export facilities on Canada’s East Coast. Since then, one project was cancelled and the remaining five have repeatedly pushed back their timelines. This has left Canada in a limbo of sorts, but it can extricate itself. Market entry in the 2020s is within reach and aligns with a current opening in the European LNG contract market. Canada must move faster, however, if it is going to compete with the U.S., which currently has two operating LNG export facilities and an additional four under construction. The longer Canada’s process, the more likely that, for example, countries in Europe wanting to wean themselves off unstable Russia as a supplier, will turn to the U.S. rather than Canada.Windows of opportunity continually open and close for entrance to any LNG market. For Eastern Canada to compete in the European market it will need secure supplies of natural gas, and investment and long-term contracts to shore up the financing for building the necessary export infrastructure. For all those things to work in harmony, Canada must pick up the pace and deviate from the status quo or risk losing out entirely

    An Overview of Global Liquefied Natural Gas Markets and Implications for Canada

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    Liquefied natural gas (LNG) is a small but growing share of the global natural gas market. Global consumption of natural gas rose by 2.4 per cent between 2005 and 2015. The majority (70 per cent) of consumption relies on indigenous production. Most of the rest comes from pipelines, with LNGsourced natural gas growing from seven to nine per cent of consumption between 2005 and 2015.Global LNG imports increased rapidly between 2005 and 2011, rising from 193 to 334 billion cubic metres annually. They have stayed relatively constant since, averaging 324 billion cubic metres annually. Europe and Asia and Oceania are the primary recipients of LNG imports, accounting for 90 per cent of global imports from 2005 to 2015.An increase in global LNG liquefaction terminals accompanied the rise in imports. From 2005 to 2015, the number of liquefaction terminals increased from 20 terminals in 13 countries to 38 terminals in 20 countries. Total global liquefaction capacity rose by almost 90 per cent, mostly in the Middle East.The growth in LNG is largely attributable to an increasing mismatch between areas of natural gas supply and demand. As of 2016, the world’s natural gas reserves were estimated at 194,782 billion cubic metres, with the Middle East and Russia and Eurasia having the largest shares, respectively.Despite having smaller reserves, the largest gas-producing region is North America, which accounted for 26 per cent of global production from 2005 to 2015. Production in North America – and specifically the United States – steadily increased over this period as a result of advances in horizontal drilling and hydraulic fracturing and a corresponding surge in shale gas.More so than other energy sources, the gaseous nature of natural gas has historically made it difficult to trade. This contributed to a rise in regional markets, with corresponding variation in prices. From 2010 to 2015 the LNG price in Asia was significantly higher than natural gas prices in Europe, which were in turn higher than prices in North America. These price differentials incited what was frequently referred to as the “LNG race,” with project proponents seeking to lock-in supply contracts and secure final investment decisions for new LNG liquefaction terminals.Although price differentials still remain, they have narrowed considerably since the start of the oil price crash in 2014. Lower prices, combined with a growing surplus of LNG liquefaction capacity, has led to a significant slowdown in the approval of new LNG liquefaction terminals in recent years.Looking ahead, however, another opportunity for LNG development lies on the horizon. Even if governments enact stringent measures to curb greenhouse gas emissions, natural gas production and consumption is expected to keep growing – the only fossil fuel to do so. Forecasts also suggest that the mismatch between areas of supply and demand will continue to become more pronounced.Production growth in the Middle East, Russia and Eurasia, North America and Africa is forecast to exceed growth in demand. Correspondingly, all three regions are anticipated to have a growing natural gas surplus through to 2040. In contrast, Europe and Asia and Oceania both currently have natural gas deficits that are also forecast to grow.New infrastructure will be critical to getting natural gas to consumers. While pipelines remain the cheaper option for transporting natural gas, Russia and Eurasia is the only major producing region with significant or planned pipeline access to external demand markets. As a result, it is expected that a second wave of new LNG capacity will be required by the mid-2020s.Having missed out on the first LNG race, this second development window offers the most promising opportunity for proposed Canadian export facilities to enter the global LNG market. With numerous proposals for new liquefaction terminals on standby around the globe, however, this next wave of LNG development will again be highly competitive. It is therefore important that Canadian firms and investors act now to manage investment risks and position themselves to proceed with proposed projects as soon as the next window opens. Moreover, Canadian governments have an important role in ensuring the stability of policy and regulatory environments underpinning Canada’s attractiveness as an investment destination

    Osteoarthritis: quality of life, comorbidities, medication and health service utilization assessed in a large sample of primary care patients

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    <p>Abstract</p> <p>Objective</p> <p>To assess the gender related impact of osteoarthritis (OA) on quality of life (QoL) and health service utilization (HSU) of primary care patients in Germany.</p> <p>Methods</p> <p>Cross sectional study with 1250 OA patients attending 75 primary care practices from March to May 2005. QoL was assessed using the GERMAN-AIMS2-SF. Data about comorbidities, prescriptions, health service utilization, and physical activity were obtained by questioning patients or from the patients' medical files. Depression was assessed by means of the Patient Health Questionnaire (PHQ-9).</p> <p>Results</p> <p>1021 (81.7%) questionnaires were returned. 347 (34%) patients were male. Impact of OA on QoL was different between gender: women achieved significantly higher scores in the AIMS 2-SF dimensions lower body (p < 0.01), symptom (p < 0.01), affect (p < 0.01) and work (p < 0.05). Main predictors of pain and disability were a high score in the "upper body "scale of the AIMS2-SF (beta = 0.280; p < 0.001), a high score in the PHQ-9 (beta = 0.214; p < 0.001), duration of OA (beta = 0.097; p = 0.004), age (beta = 0.090; p = 0.023) and the BMI (beta = 0.069; p = 0.034). Predictors of pain and disability did not differ between gender. 18.8 % of men and 19.7% of women had a concomitant depression. However, no gender differences occurred. Women visited their GP (mean 5.61 contacts in 6 months) more often than men (mean 4.08; p < 0.01); visits to orthopedics did not differ between gender.</p> <p>Conclusion</p> <p>The extent to which OA impacts men and women differs in primary care patients. This might have resulted in the revealed differences in the pharmacological treatment and the HSU. Further research is needed to confirm our findings and to assess causality.</p

    Somatic mutations in solid tumors: a spectrum at the service of diagnostic armamentarium or an indecipherable puzzle? The morphological eyes looking for BRAF and somatic molecular detections on cyto-histological samples

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    This review article deals with the analysis and the detection of the morphological features associated with somatic mutations, mostly BRAF(V600E) mutation, on both cytological and histological samples of carcinomas. Few authors demonstrated that some architectural and specific cellular findings (i.e. polygonal eosinophilic cells defined as "plump cells" and sickle-shaped nuclei) are able to predict BRAF (V600E) mutation in both cytological and histological samples of papillary thyroid carcinoma (PTC) as well as in other carcinomas. In the current review article we evaluated the first comprehensive analysis of the morphological prediction of BRAFV600E and other somatic mutations in different malignant lesions with the description of the possible mechanisms beneath these morphologic features. The detection of predictive morphological features, mostly on FNAC, may add helpful information to the stratification of the malignant risk and personalized management of cancers. Additionally, the knowledge of the molecular mechanism of different oncogenic drivers can lead to the organ-specific triaging selection of cases and can provide significant insight for targeted therapies in different malignant lesions.info:eu-repo/semantics/publishedVersio

    Ultrasonic intensification as a tool for enhanced microbial biofuel yields

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    peer-reviewedUltrasonication has recently received attention as a novel bioprocessing tool for process intensification in many areas of downstream processing. Ultrasonic intensification (periodic ultrasonic treatment during the fermentation process) can result in a more effective homogenization of biomass and faster energy and mass transfer to biomass over short time periods which can result in enhanced microbial growth. Ultrasonic intensification can allow the rapid selective extraction of specific biomass components and can enhance product yields which can be of economic benefit. This review focuses on the role of ultrasonication in the extraction and yield enhancement of compounds from various microbial sources, specifically algal and cyanobacterial biomass with a focus on the production of biofuels. The operating principles associated with the process of ultrasonication and the influence of various operating conditions including ultrasonic frequency, power intensity, ultrasonic duration, reactor designs and kinetics applied for ultrasonic intensification are also described
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