Southern extensions for Holocene records of Australian pelican (Pelecanus conspicillatus) and New Zealand musk duck (Biziura delautouri) in New Zealand

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Substance deposition assessment in obstructed pulmonary system through numerical characterization of airflow and inhaled particles attributes

Background Chronic obstructive pulmonary disease (COPD) and asthma are considered as the two most widespread obstructive lung diseases, whereas they affect more than 500 million people worldwide. Unfortunately, the requirement for detailed geometric models of the lungs in combination with the increased computational resources needed for the simulation of the breathing did not allow great progress to be made in the past for the better understanding of inflammatory diseases of the airways through detailed modelling approaches. In this context, computational fluid dynamics (CFD) simulations accompanied by fluid particle tracing (FPT) analysis of the inhaled ambient particles are deemed critical for lung function assessment. Also they enable the understanding of particle depositions on the airways of patients, since these accumulations may affect or lead to inflammations. In this direction, the current study conducts an initial investigation for the better comprehension of particle deposition within the lungs. More specifically, accurate models of the airways obstructions that relate to pulmonary disease are developed and a thorough assessment of the airflow behavior together with identification of the effects of inhaled particle properties, such as size and density, is conducted. Our approach presents a first step towards an effective personalization of pulmonary treatment in regards to the geometric characteristics of the lungs and the in depth understanding of airflows within the airways. Methods A geometry processing technique involving contraction algorithms is established and used to employ the different respiratory arrangements associated with lung related diseases that exhibit airways obstructions. Apart from the normal lung case, two categories of obstructed cases are examined, i.e. models with obstructions in both lungs and models with narrowings in the right lung only. Precise assumptions regarding airflow and deposition fraction (DF) over various sections of the lungs are drawn by simulating these distinct incidents through the finite volume method (FVM) and particularly the CFD and FPT algorithms. Moreover, a detailed parametric analysis clarifies the effects of the particles size and density in terms of regional deposition upon several parts of the pulmonary system. In this manner, the deposition pattern of various substances can be assessed. Results For the specific case of the unobstructed lung model most particles are detected on the right lung (48.56% of total, when the air flowrate is 12.6 L/min), a fact that is also true when obstructions arise symmetrically in both lungs (51.45% of total, when the air flowrate is 6.06 L/min and obstructions occur after the second generation). In contrast, when narrowings are developed on the right lung only, most particles are pushed on the left section (68.22% of total, when the air flowrate is 11.2 L/min) indicating that inhaled medication is generally deposited away from the areas of inflammation. This observation is useful when designing medical treatment of lung diseases. Furthermore, particles with diameters from 1 μm to 10 μm are shown to be mainly deposited on the lower airways, whereas particles with diameters of 20 μm and 30 μm are mostly accumulated in the upper airways. As a result, the current analysis indicates increased DF levels in the upper airways when the particle diameter is enlarged. Additionally, when the particles density increases from 1000 Kg/m3 to 2000 Kg/m3, the DF is enhanced on every generation and for all cases investigated herein. The results obtained by our simulations provide an accurate and quantitative estimation of all important parameters involved in lung modeling. Conclusions The treatment of respiratory diseases with inhaled medical substances can be advanced by the clinical use of accurate CFD and FPT simulations and specifically by evaluating the deposition of inhaled particles in a regional oriented perspective in regards to different particle sizes and particle densities. Since a drug with specific characteristics (i.e. particle size and density) exhibits maximum deposition on particular lung areas, the current study provides initial indications to a qualified physician for proper selection of medication

Wavelet analysis of stratosphere gravity wave packets over Macquarie Island 1. Wave parameters

We describe a technique to detect gravity wave packets in high-resolution radiosonde soundings of horizontal wind and temperature. The vertical profiles of meridional and zonal wind speeds are transformed using the Morlet wavelet, and regions of high wind variance in height-wavenumber space are identified as gravity wave packets. Application of the Stokes parameter analysis to horizontal wind and temperature profiles of the reconstructed wave packets yields the wave parameters. The technique was applied to twice-daily radiosonde launches at Macquarie Island (55°S, 159°E) between 1993 and 1995. A strong seasonal cycle in the total wave variance was found, with a maximum in winter. The amount of wave energy propagating downward from the upper stratosphere also maximized in winter. Waves propagated predominately toward the southwest in winter, but in summer propagation directions were approximately isotropic. The intrinsic frequencies were close to the inertial frequency, and the waves had inferred horizontal wavelengths of several hundred kilometers.Florian Zink and Robert A. Vincen

From Ideal to Practice and Back Again: Beginning Teachers Teaching for Social Justice

The five authors of this article designed a multicase study to follow recent graduates of an elementary preservice teacher education program into their beginning teaching placements and explore the ways in which they enacted social justice curricula. The authors highlight the stories of three beginning teachers, honoring the plurality of their conceptions of social justice teaching and the resiliency they exhibited in translating social justice ideals into viable pedagogy. They also discuss the struggles the teachers faced when enacting social justice curricula and the tenuous connection they perceived between their conceptions and their practices. The authors emphasize that such struggles are inevitable and end the article with recommendations for ways in which teacher educators can prepare beginning teachers for the uncertain journey of teaching for social justice

Effectiveness of myAirCoach: a mHealth self-management system in asthma

BACKGROUND: Self-management programs have beneficial effects on asthma control, but their implementation in clinical practice is poor. Mobile health (mHealth) could play an important role in enhancing self-management.OBJECTIVE: To assess the clinical effectiveness and technology acceptance of myAirCoach-supported self-management on top of usual care in patients with asthma using inhalation medication.METHODS: Patients were recruited in 2 separate studies. The myAirCoach system consisted of an inhaler adapter, an indoor air-quality monitor, a physical activity tracker, a portable spirometer, a fraction exhaled nitric oxide device, and an app. The primary outcome was asthma control; secondary outcomes were exacerbations, quality of life, and technology acceptance. In study 1, 30 participants were randomized to either usual care or myAirCoach support for 3 to 6 months; in study 2, 12 participants were provided with the myAirCoach system in a 3-month before-after study.RESULTS: In study 1, asthma control improved in the intervention group compared with controls (Asthma Control Questionnaire difference, 0.70; P = .006). A total of 6 exacerbations occurred in the intervention group compared with 12 in the control group (hazard ratio, 0.31; P = .06). Asthma-related quality of life improved (mini Asthma-related Quality of Life Questionnaire difference, 0.53; P = .04), but forced expiratory volume in 1 second was unchanged. In study 2, asthma control improved by 0.86 compared with baseline (P = .007) and quality of life by 0.16 (P=.64). Participants reported positive attitudes toward the system.DISCUSSION: Using the myAirCoach support system improves asthma control and quality of life, with a reduction in severe asthma exacerbations. Well-validated mHealth technologies should therefore be further studied. (C) 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/).Pathogenesis and treatment of chronic pulmonary disease

Development of a low-temperature and high-performance green extraction process for the recovery of polyphenolic phytochemicals fromwaste potato peels using hydroxypropyl β-cyclodextrin

Potato peels (PP) are a major agri-food side-stream originating from potato processing, but to date, their green valorization as a bioresource of antioxidant polyphenols is limited to extraction processes involving mainly water/ethanol-based solvents, whereas other eco-friendly methodologies are scarce. This study aimed at developing a simple, straight-forward and green extraction methodology to effectively recover PP polyphenols, using hydroxypropyl β-cyclodextrin (HP-β-CD). After an initial assay to identify the optimal HP-β-CD concentration that would provide increased extraction yield, optimization based on response surface methodology enabled maximization of the extraction performance, providing a total polyphenol yield of 17.27 0.93 mg chlorogenic acid equivalent g-1 dry mass, at 30 °C. Testing of temperatures higher than 30 °C and up to 80 °C did not favor higher yields. The extracts obtained with HP-β-CD were slightly richer in polyphenols than extracts prepared with conventional solvents, such as aqueous ethanol and methanol, displaying similar antioxidant characteristics. The major polyphenols that could be identified in the extracts were neochlorogenic, chlorogenic, caffeic and ferulic acids. The outcome of this study demonstrated that HP-β-CD may be used as a highly effective green means of recovering PP polyphenols, at near-ambient temperature. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Tunable terahertz metamaterials by means of piezoelectric MEMS actuators

A programmable THz metamaterial, derived from the utilisation of a piezoelectric controlled microgripper as a split-ring resonator (SRR), is introduced in this paper. By applying the appropriate actuation voltage on the piezoelectric microelectromechanical systems (MEMS), a reconfigurable complex medium, offering enhanced bandwidth tunability, is attained. Several polarisation topologies are examined in order to clarify the interesting attributes of the metamaterial. Finally, thorough numerical investigations, via a robust finite element method (FEM), support the efficiency and reveal the advantages and applicability of the proposed device