'The world is full of big bad wolves': investigating the experimental therapeutic spaces of R.D. Laing and Aaron Esterson

In conjunction with the recent critical assessments of the life and work of R.D. Laing, this paper seeks to demonstrate what is revealed when Laing’s work on families and created spaces of mental health care are examined through a geographical lens. The paper begins with an exploration of Laing’s time at the Tavistock Clinic in London during the 1960s, and of the co-authored text with Aaron Esterson entitled, Sanity, Madness and the Family (1964). The study then seeks to demonstrate the importance Laing and his colleague placed on the time-space situatedness of patients and their worlds. Finally, an account is provided of Laing’s and Esterson’s spatial thinking in relation to their creation of both real and imagined spaces of therapeutic care

The cytochrome P450 family in the parasitic nematode <i>Haemonchus contortus</i>

&lt;i&gt;Haemonchus contortus&lt;/i&gt;, a highly pathogenic and economically important parasitic nematode of sheep, is particularly adept at developing resistance to the anthelmintic drugs used in its treatment and control. The basis of anthelmintic resistance is poorly understood for many commonly used drugs with most research being focused on mechanisms involving drug targets or drug efflux. Altered or increased drug metabolism is a possible mechanism that has yet to receive much attention despite the clear role of xenobiotic metabolism in pesticide resistance in insects. The cytochrome P450s (CYPs) are a large family of drug-metabolising enzymes present in almost all living organisms, but for many years thought to be absent from parasitic nematodes. In this paper, we describe the CYP sequences encoded in the &lt;i&gt;H. Contortus&lt;/i&gt; genome and compare their expression in different parasite life-stages, sexes and tissues. We developed a novel real-time PCR approach based on partially assembled CYP sequences “tags” and confirmed findings in the subsequent draft genome with RNA-seq. Constitutive expression was highest in larval stages for the majority of CYPs, although higher expression was detected in the adult male or female for a small subset of genes. Many CYPs were expressed in the worm intestine. A number of &lt;i&gt;H. Contortus&lt;/i&gt; genes share high identity with &lt;i&gt;Caenorhabditis elegans&lt;/i&gt; CYPs and the similarity in their expression profiles supports their classification as putative orthologues. Notably, &lt;i&gt;H. Contortus&lt;/i&gt; appears to lack the dramatic CYP subfamily expansions seen in &lt;i&gt;C. elegans&lt;/i&gt; and other species, which are typical of CYPs with exogenous roles. However, a small group of &lt;i&gt;H. Contortus&lt;/i&gt; genes cluster with the &lt;i&gt;C. elegans&lt;/i&gt; CYP34 and CYP35 subfamilies and may represent candidate xenobiotic metabolising genes in the parasite

The magnetized medium around the radio galaxy B2 0755+37: an interaction with the intra-group gas

We explore the magneto-ionic environment of the isolated radio galaxy B2 0755+37 using detailed imaging of the distributions of Faraday rotation and depolarization over the radio source from Very Large Array observations at 1385,1465 and 4860 MHz and new X-ray data from XMM-Newton. The Rotation Measure (RM) distribution is complex, with evidence for anisotropic fluctuations in two regions. The approaching lobe shows low and uniform RM in an unusual `stripe' along an extension of the jet axis and a linear gradient transverse to this axis over its Northern half. The leading edge of the receding lobe shows arc-like RM structures with sign reversals. Elsewhere, the RM structures are reasonably isotropic. The RM power spectra are well described by cut-off power laws with slopes ranging from 2.1 to 3.2 in different sub-regions. The corresponding magnetic-field autocorrelation lengths, where well-determined, range from 0.25 to 1.4 kpc. It is likely that the fluctuations are mostly produced by compressed gas and field around the leading edges of the lobes. We identify areas of high depolarization around the jets and inner lobes. These could be produced by dense gas immediately surrounding the radio emission containing a magnetic field which is tangled on small scales. We also identify four ways in which the well known depolarization (Faraday depth) asymmetry between jetted and counter-jetted lobes of extended radio sources can be modified by interactions with the surrounding medium.Comment: 16 pages, 13 figures, accepted for publication in MNRAS. Full resolution paper available at: ftp://ftp.ira.inaf.it/pub/outgoing/guidetti/ Subjects: Cosmology and Extragalactic Astrophysics (astro-ph.CO

A relativistic model of the radio jets in NGC 315

We apply our intrinsically symmetrical, decelerating relativistic jet model to deep VLA imaging of the inner 140 arcsec of the giant low-luminosity radio galaxy NGC 315. An optimized model accurately fits the data in both total intensity and linear polarization. We infer that the velocity, emissivity and field structure in NGC 315 are very similar to those of the other low-luminosity sources we have modelled, but that all of the physical scales are larger by a factor of about 5. We derive an inclination to the line of sight of 38 degrees for the jets. Where they first brighten, their on-axis velocity is approximately v/c = 0.9. They decelerate to v/c = 0.4 between 8 and 18 kpc from the nucleus and the velocity thereafter remains constant. The speed at the edge of the jet is roughly 0.6 of the on-axis value where it is best constrained, but the transverse velocity profile may deviate systematically from the Gaussian form we assume. The proper emissivity profile is split into three power-law regions separated by shorter transition zones. In the first of these, at 3 kpc (the flaring point) the jets expand rapidly at constant emissivity, leading to a large increase in the observed brightness on the approaching side. At 10 kpc, the emissivity drops abruptly by a factor of 2. Where the jets are well resolved their rest-frame emission is centre-brightened. The magnetic field is modelled as random on small scales but anisotropic and we rule out a globally ordered helical configuration. To a first approximation, the field evolves from a mixture of longitudinal and toroidal components to predominantly toroidal, but it also shows variations in structure along and across the jets, with a significant radial component in places. Simple adiabatic models fail to fit the emissivity variations.Comment: 20 pages, 17 figures, MNRAS (in press

Direct dialling of Haar random unitary matrices

Random unitary matrices find a number of applications in quantum information science, and are central to the recently defined boson sampling algorithm for photons in linear optics. We describe an operationally simple method to directly implement Haar random unitary matrices in optical circuits, with no requirement for prior or explicit matrix calculations. Our physically-motivated and compact representation directly maps independent probability density functions for parameters in Haar random unitary matrices, to optical circuit components. We go on to extend the results to the case of random unitaries for qubits

Chimera states in networks of phase oscillators: the case of two small populations

Chimera states are dynamical patterns in networks of coupled oscillators in which regions of synchronous and asynchronous oscillation coexist. Although these states are typically observed in large ensembles of oscillators and analyzed in the continuum limit, chimeras may also occur in systems with finite (and small) numbers of oscillators. Focusing on networks of $2N$ phase oscillators that are organized in two groups, we find that chimera states, corresponding to attracting periodic orbits, appear with as few as two oscillators per group and demonstrate that for $N>2$ the bifurcations that create them are analogous to those observed in the continuum limit. These findings suggest that chimeras, which bear striking similarities to dynamical patterns in nature, are observable and robust in small networks that are relevant to a variety of real-world systems.Comment: 13 pages, 16 figure

Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia

Acute Myeloid Leukaemia (AML) develops when there is a block in differentiation and uncontrolled proliferation of myeloid precursors, resulting in bone marrow failure. AML is a heterogeneous disease clinically, morphologically, and genetically, and biological differences between adult and childhood AML have been identified. AML comprises 15-20% of all children less than fifteen years diagnosed with acute leukaemia. Relapse occurs in up to 40% of children with AML and is the commonest cause of death.1,2 Relapse arises from leukaemic stem cells (LSCs) that persist after conventional chemotherapy. The treatment of AML is challenging and new strategies to target LSCs are required. The cell surface marker CD33 has been identified as a therapeutic target, and novel anti-CD33 immunotherapies are promising new agents in the treatment of AML. This review will summarise recent developments emphasising the genetic differences in adult and childhood AML, while highlighting the rationale for CD33 as a target for therapy, in all age groups