The Effect of Posture During CPR on Rescuer Muscular Fatigue Development and CPR Quality

The purpose of this study was to evaluate muscle fatigue and CPR quality over time, during four CPR positions. Twenty-one, CPR-certified participants performed six-minutes of CPR, on a training manikin, at four heights (KH, LH, FH, WH). EMG of sixteen muscles, kinematics of the manikin, and kinetic data at the hands were collected. The MPF identified that four, six, four, and nine muscles fatigued during KH, LH, FH, and WH, respectively. Furthermore, there was a linear decrease in CC force and CC depth over time, during all positions. The results indicated that rescuers should perform CPR below WH. Furthermore, as the TB produced the highest peak activation and fatigued within all CPR positions, it is recommended rescuers attempt to rest the TB during ventilations, if CPR is performed with two or more rescuers. Lastly, CPR feedback devices should be improved to detect full CC and display force vs. depth measurements

Taking action in the first five years to increase career equality: the impact of professional relationships on young women’s advancement

Purpose The purpose of this paper is to examine how young women understand and make meaning of their status as early-career women (ECW) in the creative communication industry, which is typically dominated by male leadership. It explores how professional relationships influence their transition into full-time employment and influences their career trajectories. Design/methodology/approach Interviews with 31 women in the first five years of their communication careers provided insights into how they experience professional relationships in the workplace in relation to leadership advancement. Inductive coding, a feminist organizational communication lens and literature on mentorship and role modeling was used to explore the standpoint of these young women. Findings Young women understand that professional relationships are necessary for acclimation and professional development. Our analysis revealed an intersection of three distinct ways these relationships help young women cultivate a strong career foundation, positioning themselves for leadership opportunities. Practical implications This study provides insight into the experiences of ECW, a group significantly overlooked by industry and research as a way to increase career equity. Findings from this study guide programmatic and socialization practices to help young women overcome barriers. Originality/value Developing a deeper understanding of women worker’s realities, this research encourages industries to regard the entire career path, emphasizing the importance of beginning socialization experiences in the workplace. It offers actionable managerial practices, and it drives a new scholarly focus on a demographic critical to closing the leadership gender gap

The Power of Stories: Using Fiction & Nonfiction to Develop Information Literacy Skills

In this presentation, we will outline our experiences crafting new credit-bearing courses that integrate information literacy skills using non-traditional materials. Through the use of fiction and films based on real women, science fiction, and popular nonfiction, we will share how we built courses that satisfy university information literacy curriculum requirements. One challenge of credit-bearing information literacy courses can be providing authentic context for students. Students may not understand how skills transfer outside of the artificial contexts provided. We will address ways course content can be used to provide authentic context by asking students to use non-traditional materials to consider research. We will demonstrate the way that course content has impacted our design decisions, assessment, and instructional activities while adhering to common objectives. Course A uses fictional depictions of real women in fiction and film to engage students in discussions of authority. Students research the real women whose stories are told fictionally. This research forces them to grapple with what authority means in both fictional and non-fictional contexts. Course B uses science fiction to understand complex, technical science concepts. By combining active learning with science fiction stories and films, students can identify the role of science in a story, problems and solutions in modern science, and pseudoscience. Science fiction helps students communicate scientific concepts clearly, value forms of science journalism, and explore “forbidden knowledge,” the scientific method, transparency, and peer review. Course C uses popular nonfiction to consider scholarship as a conversation. Using Modern Romance by Aziz Ansari, students are asked to consider the larger conversation that Ansari is part of. By considering the book’s research, students consider academic privilege and how we determine authority. Through stand-up comedy and Ansari’s Netflix show students evaluate how purpose impacts production and product, and how conversations are constructed as accessible or inaccessible

Roles of Candida albicans Mig1 and Mig2 in glucose repression, pathogenicity traits, and SNF1 essentiality.

Metabolic adaptation is linked to the ability of the opportunistic pathogen Candida albicans to colonize and cause infection in diverse host tissues. One way that C. albicans controls its metabolism is through the glucose repression pathway, where expression of alternative carbon source utilization genes is repressed in the presence of its preferred carbon source, glucose. Here we carry out genetic and gene expression studies that identify transcription factors Mig1 and Mig2 as mediators of glucose repression in C. albicans. The well-studied Mig1/2 orthologs ScMig1/2 mediate glucose repression in the yeast Saccharomyces cerevisiae; our data argue that C. albicans Mig1/2 function similarly as repressors of alternative carbon source utilization genes. However, Mig1/2 functions have several distinctive features in C. albicans. First, Mig1 and Mig2 have more co-equal roles in gene regulation than their S. cerevisiae orthologs. Second, Mig1 is regulated at the level of protein accumulation, more akin to ScMig2 than ScMig1. Third, Mig1 and Mig2 are together required for a unique aspect of C. albicans biology, the expression of several pathogenicity traits. Such Mig1/2-dependent traits include the abilities to form hyphae and biofilm, tolerance of cell wall inhibitors, and ability to damage macrophage-like cells and human endothelial cells. Finally, Mig1 is required for a puzzling feature of C. albicans biology that is not shared with S. cerevisiae: the essentiality of the Snf1 protein kinase, a central eukaryotic carbon metabolism regulator. Our results integrate Mig1 and Mig2 into the C. albicans glucose repression pathway and illuminate connections among carbon control, pathogenicity, and Snf1 essentiality

Stability of bedforms in laminar flows with free surface: from bars to ripples

International audienceThe present paper is devoted to the formation of sand patterns by laminar flows. It focuses on the rhomboid beach pattern, formed during the backswash. A recent bedload transport model, based on a moving-grains balance, is generalized in three dimensions for viscous flows. The water flow is modelled by the full incompressible Navier–Stokes equations with a free surface. A linear stability analysis then shows the simultaneous existence of two distinct instabilities, namely ripples and bars. The comparison of the bar instability characteristics with laboratory rhomboid patterns indicates that the latter could result from the nonlinear evolution of unstable bars. This result, together with the sensibility of the stability analysis with respect to the parameters of the transport law, suggests that the rhomboid pattern could help improving sediment transport models, so critical to geomorphologists

J Biol Chem

The GTPase-activating protein (GAP) p190RhoGAP (p190A) is encoded by ARHGAP35 which is found mutated in cancers. p190A is a negative regulator of the GTPase RhoA in cells and must be targeted to RhoA-dependent actin-based structures to fulfill its roles. We previously identified a functional region of p190A called the PLS (protrusion localization sequence) required for localization of p190A to lamellipodia but also for regulating the GAP activity of p190A. Additional effects of the PLS region on p190A localization and activity need further characterization. Here, we demonstrated that the PLS is required to target p190A to invadosomes. Cellular expression of a p190A construct devoid of the PLS (p190AΔPLS) favored RhoA inactivation in a stronger manner than WT p190A, suggesting that the PLS is an autoinhibitory domain of p190A GAP activity. To decipher this mechanism, we searched for PLS-interacting proteins using a two-hybrid screen. We found that the PLS can interact with p190A itself. Coimmunoprecipitation experiments demonstrated that the PLS interacts with a region in close proximity to the GAP domain. Furthermore, we demonstrated that this interaction is abolished if the PLS harbors cancer-associated mutations: the S866F point mutation and the Δ865-870 deletion. Our results are in favor of defining PLS as an inhibitory domain responsible for masking the p190A functional GAP domain. Thus, p190A could exist in cells under two forms: an inactive closed conformation with a masked GAP domain and an open conformation allowing p190A GAP function. Altogether, our data unveil a new mechanism of p190A regulation

Experiencia clínica en el tratamiento con aféresis terapéutica en el Hospital Militar Escuela «Dr. Alejandro Dávila Bolaños»

Doctora en Ciencias de Salud Pública, Docente Investigadora, Facultad de Ciencias Médicas «Coronel Dr. Juan Ignacio Gutiérrez Sacasa», Managua, Nicaragua. [email protected] ORCID: https://orcid.org/0000-0001-8860-2193 Doctor en Epidemiología, Profesor Investigador en el Instituto Regional de Investigación en Salud Pública, Centro Universitario de Ciencias de la Salud-Universidad de Guadalajara, México. [email protected] ORCID https://orcid.org/0000-0002-2827-8093. Internista, nefrólogo, Jefe de Unidad de hemodiálisis del HMEADB. [email protected] ORCID: https://orcid.org/0000-0003-0797-9306. Médico General. Dirección de atención primaria CMM. [email protected] ORCID: https://orcid.org/0000-0003-3001-1336. Médico General Dirección de atención primaria CMM. [email protected]. ORCID: https://orcid.org/0000-0001-6057-3984.La plasmaféresis terapéutica es un procedimiento con enormes beneficios terapéuticos cuando se utiliza en patologías con demostrada eficacia. Es una técnica de tratamiento dirigido, principalmente, a enfermedades autoinmunes. Ha cobrado gran importancia en el manejo de enfermedades renales, reumatológicas, neurológicas, infecciosas y metabólicas. Actualmente se ha posicionado como el tratamiento de primera línea. Este tipo de patologías no son tan frecuentes en nuestro medio, la incidencia en la población nicaragüense ha aumentado progresivamente. La prevalencia de la esclerosis múltiple del 2012 con respecto al año 2013 se incrementó de 1.8 a 2 por cada 100,000 habitantes en nuestro país. Se describe la experiencia clínica en el tratamiento con aféresis terapéutica en pacientes atendidos en el Servicio de Medicina Interna del Hospital Militar Escuela «Dr. Alejandro Dávila Bolaños». La metodología Se realizó estudio observacional descriptivo, retrospectivo en el Hospital Militar Escuela «Dr. Alejandro Dávila Bolaños», durante 2017-2019 con el objetivo de describir la experiencia clínica de los pacientes tratados con aféresis terapéutica. En el hospital fuerontudio. Los resultados muestran que 92 % de pacientes seleccionados tenían enfermedades neurológicas y 8 % enfermedades renales. El 80 % de los pacientes tuvieron una respuesta adecuada. La indicación más frecuente para la plasmaféresis fue el diagnóstico de miastenia gravis (32 %), seguida de síndrome de Guillain-Barré (28 %) y esclerosis múltiple (12 %). El 76 % de los pacientes no presentó complicaciones durante el procedimiento mientras que el 24 % experimentaron hipotensión arterial transitoria resuelta en los primeros 20 minutos del procedimiento