The Building of Astronomical Observatories on Native American Sacred Sites

In the past few years, there has been controversy about the use of the Hawaiian mountain Mauna Kea as a location for observatories. Astronomers are planning for a new telescope to be built while some native Hawaiian people are protesting it. This is one of the examples that will be used in discussing the general conflict between astronomy projects and Native Americans. Astronomers see mountains as prime locations for observing the sky; Native people can see them as extremely sacred places that, in some cases, are central to their traditional religion. Their differing worldviews are at the core of disputes over the use of these sites. This paper investigates the process of site selection for observatories (specifically if cultural significance is considered); tries to understand why astronomers and indigenous people hold the views they do about building observatories; and puts forth a way to lessen future conflicts

Alien Registration- Lacomb, Fred W. (Medway, Penobscot County)

https://digitalmaine.com/alien_docs/8258/thumbnail.jp

Load Slammer Design for DC-DC Converter Testing

In this work, we dive into the detailed design of a test load or load slammer circuit for DC/DC converters to ensure their correct functioning. This is accomplished through quick variations in frequency, amplitude, and duty cycle of the current being drawn by the converter into the load. Computer simulations of the design were performed using LTSpice and the results show that the load current could be varied per design objectives. Hardware implementation of the design was also conducted and then tested. Results were then compared with the design requirements at lower currents to evaluate the validity of the design. Although good results were obtained from the current design, further improvements would still be needed to improve the overall performance and design of the load slammer circuit

Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression

Platelet Derived Growth Factor (PDGF) is a family of mesenchymal growth factors that regulate cell proliferation, migration, and differentiation. Unlike the classic PDGF ligands A and B, which are secreted as active dimers, PDGF D must undergo extracellular proteolytic processing to remove its N-terminal CUB domain from the C-terminal PDGF growth domain before the ligand is able to stimulate its receptor, PDGF receptor beta (?-PDGFR). Importantly, recent clinical studies have shown that ?-PDGFR is upregulated in primary prostate cancer and bone metastases. However, PDGF B, formerly thought to be the sole ligand for ?-PDGFR, is not expressed in clinical prostate cancer samples. In a study of human primary prostate carcinoma and bone metastases, we found that PDGF D and matriptase are associated with prostate cancer progression. Additionally, in a clinically relevant prostate-specific PTEN (phosphatase and tensin homolog) knockout mouse model, we found an increase in PDGF D expression and ?-PDGFR phosphorylation upon loss of PTEN. Upon inhibition of the PI3K pathway, PDGF D/ ?-PDGFR induction was abolished in PTEN-/- cells. Among Akt isoforms, downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF D/?-PDGFR signaling driven by the loss of PTEN, a frequent occurrence in human prostate cancer. Similarly, PTEN/Akt3 expression correlates with PDGF expression in human PCa cell lines, DU145 and PC3. Taken together, these results suggest that loss of PTEN in prostate cancer results in upregulation of PDGF D, which can then be activated by increased levels of serine proteases. The active growth domain is then able to activate ?-PDGFR, thus causing subsequent downstream signaling

Assessment Technologies Institute Test Results and Blended Experiences for Senior Community Health Nursing Students

The purpose of the study was to examine the relationship between senior community health nursing students’ ATI test scores and their clinical community health nursing experiences, either in-country or out-of-country. The ATI test results are a reliable predictor of whether the student will pass their nursing board exams (NCLEX-RN). The study also examined whether the two groups of students reported any similarities and differences in their sense of confidence or transcultural self-efficacy and conceptual knowledge and their clinical experiences. ATI test scores were reviewed for the two groups. Focus groups were held to discuss any similarities or differences in the students’ community health nursing experiences. Cultural competency was evaluated using Jeffreys’ (2016) Transcultural Self- Efficacy Tool

Globalización y Política Económica

La globalización, entendida con integración económica internacional, ha aumentado en las últimas décadas impulsada, entre otros factores, por la reducción de los costes de los transportes y de las comunicaciones. En este contexto, se ha reavivado el debate sobre la pertinencia de la coordinación internacional de las políticas económicas que, más allá de discusiones teóricas, obliga a dar una respuesta a la aparición de los bienes públicos globales o los efectos desbordamiento.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Structural changes in mixed Col I/Col V collagen gels probed by SHG microscopy: implications for probing stromal alterations in human breast cancer

Second Harmonic Generation (SHG) microscopy has been previously used to describe the morphology of collagen in the extracellular matrix (ECM) in different stages of invasion in breast cancer. Here this concept is extended by using SHG to provide quantitative discrimination of self-assembled collagen gels, consisting of mixtures of type I (Col I) and type V (Col V) isoforms which serve as models of changes in the ECM during invasion in vivo. To investigate if SHG is sensitive to changes due to Col V incorporation into Col I fibrils, gels were prepared with 0-20% Col V with the balance consisting of Col I. Using the metrics of SHG intensity, fiber length, emission directionality, and depth-dependent intensities, we found similar responses for gels comprised of 100% Col I, and 95% Col I/5% Col V, where these metrics were all significantly different from those of the 80% Col I/20% Col V gels. Specifically, the gels of lower Col V content produce brighter SHG, are characterized by longer fibers, and have a higher forward/backward emission ratio. These attributes are all consistent with more highly organized collagen fibrils/fibers and are in agreement with previous TEM characterization as well as predictions based on phase matching considerations. These results suggest that SHG can be developed to discriminate Col I/Col V composition in tissues to characterize and follow breast cancer invasion

Oral vs. Nasal Breathing during Submaximal Aerobic Exercise

When comparing oral breathing versus nasal breathing more volume of air can be transported through the oral passageway, but nasal breathing can lead to slower respiration rates and cleaner inspired air. The purpose of this study is to find the most efficient mode of breathing during different intensities of submaximal aerobic exercise. There were 9 males and 10 females that completed this study. First test was a VO2 Max test, 3.0 mph for 3 minutes, with increases in 1.0 mph every minute after that. Using a regression equation running speeds were determined for each individual’s submaximal intensities. The desire was to have each individual complete 4 minutes on the treadmill at 50%, 65%, and 80% of VO2 max. One trial was completed by nasally and other orally. Oral breathing was significantly greater (p\u3c.05) in all three intensities (50%, 65%, and 80%) in RR, VE, VO2/kg, VO2, and VCO2. Oral breathing creates greater respiratory rates and allows for greater volumes of air to be transferred to the lungs; combined with greater O2 consumption and CO2 expiration this breathing mode met the exercise demands more proficiently. With greater respiratory and metabolic demands met in oral breathing it provided the more suitable breathing mode for intensities greater than 50% VO2 max. Steady state did not seem to be reached in nasal breathing during the short 4 minute stages. There were beliefs that anaerobic contributions during the nasal breathing mode allowed for measures to create similar responses

EXAMINING TRADER BEHAVIOR IN IDEA MARKETS: AN IMPLEMENTATION OF GE'S IMAGINATION MARKETS

We present the outcome of an idea market run for one of GE Energy's sub-businesses in July and August of 2006.  GE Energy used this market to elicit and rank-order technology and product ideas from across the sub-business. In this experiment, we examine the behavior of traders that have submitted the ideas on the market and their influence on the market's outcome. An idea’s submitter is clearly motivated to have his idea valued highly by the market, both by the funding given to the top idea as well as smaller prizes given to the top three ideas. In general, founders tended to buy their suggested ideas at prices above the volume-weighted-average-price (VWAP) in significant volumes. We discuss the implications and mitigation strategies. A survey of market participants yielded mixed results regarding the market's effectiveness at ranking ideas but very positive results regarding the quality of ideas proposed