Isolation and X-ray crystal structure of tetrahydroisoquinoline alkaloids from Calycotome villosa Subsp. intermedias

Two tetrahydroisoquinoline alkaloids were extracted from the alkaloid fraction of a methanol extract of the seeds of Calycotome Villosa Subsp. intermedia. Their structures were established as (R)-1-hydroxymethyl-7-8-dimethoxy-1,2,3,4-tetrahydro- isoquinoline (1) and (S)-7-hydroxymethyl-2-3-dimethoxy-7,8,9,10-tetrahydroisoquinoline chloride (2) by spectroscopic techniques and X-ray diffraction analysis

In vitro study of the antimitotic power and in vivo acute toxicity of aqueous and organic extracts of the aerial part of Haloxylon scoparium Pomel. and evaluation of the correlation between the chemical profile and their biological activities

The present study was conducted on the extracts from the aerial part of Haloxylon scoparium Pomel. The current research has focused on the evaluation of the antimitotic activity with the Lepidium sativum phytotest on aqueous (decocted, infused, macerated) and organic extracts (methanolic extract, methanolic macerated, ethyl acetate extract, chloroform extract and petroleum ether extract) extracts of the aerial portion of Haloxylon scoparium. In order to visualise the correlation between the content of chemical compounds in the aqueous and organic extracts with the results of the Lepidium sativum phytotest, we have used the principal component analysis (PCA). Then, we were interested in studying the acute in vivo toxicity of the methanolic extract and the decocted of Haloxylon scoparium. Antimitotic activity has shown that the methanolic extract exhibited high inhibition of Lepidium sativum germination (IC50=128.16±3.89 µg/mL) than colchicine (IC50=474.66±1.86 µg/mL). The decocted also showed high inhibition compared to the other aqueous extracts (IC50=1359.00±106.69 µg/mL). The correlation study showed that there is a strong correlation between Lepidium sativum phytotest and total polyphenol (r=0.9453) and flavonoid (r=0.9884) composition. In addition, the MLD50 of the methanolic extract and the decocted was estimated at 2000 mg/kg. The present study shows that Haloxylon scoparium could be a potential antimitotic of low toxicity

Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (H2DAB)[Co(H2PO3)4]·2H2O

A novel hybrid cobalt phosphite, (H2DAB)[Co(H2PO3 )4 ] 2H2O, was synthesized by using a slow evaporation method in the presence of cobalt nitrate, phosphorous acid, and 1,4-diaminobutane (DAB = 1,4-diaminobutane) as a structure-directing agent. Single-crystal X-ray diffraction analysis showed that the compound crystallizes in the triclinic system (space group P-1(n.2)) with the following unit cell parameters (Å, ◦ ) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5), and V = 447.33 (4) Å3 . The crystal structure is built up from corner-sharing [CoO6 ] octahedra, forming chains parallel to [001], which are interconnected by H2PO3 − pseudo-tetrahedral units. The diprotonated cations, residing between the parallel chains, interact with the inorganic moiety via hydrogen bonds, thus leading to the formation of the 3D crystal structure. The Fourier transform infrared spectrum showed characteristic bands corresponding to the phosphite group and the organic amine. The thermal behavior of the compound mainly consisted of the loss of its organic moiety and the water molecules. The biological tests exhibited significant activity against Candida albicans and Escherichia coli strains at different concentrations, while less inhibitory activity was pronounced against Staphylococcus epidermidis and Saccharomyces cerevisiae, and in the case of multi-cellular organisms, no activity against the nematode model Steinernema feltiae was detected

Synthesis, Structural Characterization, and Biological Activities of Organically Templated Cobalt Phosphite (C4N2H14)Co(H2PO3)4·2H2O

A novel hybrid phosphite [(C4N2H14)Co(H2PO3)4·2H2O] was synthesized with 1,4- diaminobutane (dabn) as a structure-directing agent using slow evaporation method. Single crystal X-ray diffraction analysis showed that it crystallizes in the triclinic system (S.G: P-1, #2) with the following unit cell parameters (Å, °) a = 5.4814 (3), b = 7.5515 (4), c = 10.8548 (6), α = 88.001 (4), β = 88.707 (5), γ = 85.126 (5). The crystal structure was built up from corner-sharing [CoO6]-octahedrons, forming chains parallel to [001], which are interconnected by H2PO3 pseudo-pyramid units. The diprotonated 1,4-diaminobutane molecules, residing between the parallel chains, interacted with the inorganic moiety via hydrogen bonds leading thus to the formation of the 3D crystal structure. The Fourier transform infrared result exhibited characteristic bands corresponding to the phosphite group and the organic molecule. The thermal decomposition of the compound consists mainly of the loss of the organic moiety and the water molecules. The biological tests exhibited significant activity against Candida albicans and Escherichia coli strains in all used concentrations, while less activity was pronounced when tested against Staphylococcus epidermidis and Saccharomyces cerevisiae, while there was no activity against the nematode model Steinernema feltiae

Le problème de l’interprétation Chez al-Ġazzālī (1058-1111)

Our presentation deals with the problem of interpretation in thethought of al-Ġazzālī. Starting from the chronology of his works, we will try to describe the contours and the nuances of his concept of interpretation, but, at thesame time, to emphasize the context and the framework of this concept both theoretically and practically. First of all, we mention that it is not possible, concerning the issue of interpretation, to set a clear distinction in the works ofal-Ġazzālī, between the purely theoretical writings and others with a purelypractical character. However, if the ideas of al-Ġazzālī are often the home of alternation between the contextual approach focusing more on the practical illustration and the abstract approach regarding the theoretical foundation, it is true that these ideas are, as a whole, governed by unifying and constant principles. For this reason, we prefer not to analyze the conception of al-Ġazzālī in the paradigm of the couple theoretical/practical, but to approach him moreover starting from the fundamental principles that create a sort of general framework for the deployment and usage of the interpretation process. There are three suchprinciples. The first concerns the unchangeable aspect of interpretation; the second,the hierarchical aspect; and the third, the undefined aspect

قراءة في كتاب "بين مثابتين: منزلة الغزالي في فلسفة ابن رشد" لمؤلفه محمد مساع د

Some years after the publication of the article by Professor Jamal Al-Din Al-Alaoui entitled (Al-Ghazali and the philosophical discourse in the Islamic West: Al-Ghazali and the formation of the philosophical discourse of Averroes), in which he expounded his point of vue on the limits and the nature of the presence of Al-Ghazali with the philosophers of the Islamic West in general and of Averroes in particular, Mohammed Mousaid (one of his students) in his new book, tried to shed more light on this issue according to his new vision.The author of this book believes that the presence of Al-Ghazali in the thought of Averroes should not be confined only from the ideological aspect, because there is a philosophical depth of the relationship between the two men. This presence is distributed over several levels as: the Usul, the psycho / ideology and the philosophy

Synthesis, Characterization and X-ray Crystal Structures of New Ethylxanthato Complexes of Zinc(II) with N-donor Ligands

Zn(II) complexes of general formula [Zn(S2COEt)2L] [L=pyrazole (Hpz) 1; 3,5-dimethylpyrazole (Hdmpz) 2; 2-pyridylamine (pyam) 3; phenyl 2-pyridylamine (phpyam) 4; 2,2'-dipyridylamine (dpyam) 5; 1,4-pyrazine (pyr) 6] have been synthesized and characterized by elemental analyses and IR and NMR spectroscopy. The crystal structures of complexes 2, 5 and 6 have been determined by X-ray diffraction, showing different geometries and modes of coordination of the xanthate ligand depending on the type of N-donor ligand.Peer reviewe

Otite externe maligne à Candida Albicans

L’otite externe maligne est une ostéomyélite de la base du crane. Le Pseudomonas aeruginosa est le germe le plus incriminé. Cependant l’origine fongique n’est pas rare. Patiente âgée de 80 ans avait présenté une otalgie gauche persistante depuis deux mois malgré un traitement bien conduit. L’examen otologique mettait en évidence des signes inflammatoires au niveau du pavillon, une sténose du conduit avec des granulomes, et otorrhée d’allure purulente. Le scanner montrait un comblement otomastoïdien, un processus inflammatoire extensif des tissus pré et rétro-auriculaire et une lyse du tympanal. Vu l’absence d’amélioration un examen mycologique a été réalisé et qui a révélé la présence de Candida Albicans. Les cas d’otite externe maligne à Candida Albicans sont rarement rapportés. L’origine fongique doit être suspecté devant la négativité des prélèvements bactériologiques et la non amélioration malgré un traitement antibiotique bien conduit, et confirmée par des prélèvements mycologiques parfois multiples. L’otite externe maligne à Candida Albicans est une infection rare potentiellement mortelle.The Pan African Medical Journal 2016;2

Dihydrocyclam dimaleate [H2(cyclam)(maleate)2]

The asymmetric unit of the title molecular salt [systematic name: 1,4,8,11-tetraazacyclotetradecane-1,8-diium bis(3-carboxyprop-2-enoate)], C10H26N4 2+·2C4H3O4 -, contains two half-cations (both completed by crystallographic inversion symmetry) and two maleate anions. The cyclam macrocycles adopt trans-III conformations, supported by two intramolecular N - H⋯O hydrogen bonds. The O-bonded H atom of each maleate ion is disordered over two positions with an occupancy ratio of 0.61 (5):0.39 (5): each one generates an intramolecular O - H⋯O hydrogen bond. In the crystal, the cations are linked to the anions by N - H⋯O hydrogen bonds, generating [001] chains.Peer Reviewe

Structural characterisation of the first mononuclear bismuth porphyrin

International audienceA single carboxylate picket bismuth porphyrin has been characterised in the solid state as the first instance of a nondimeric structure; the carboxylate picket, bent over the macrocycle, is coordinated to the bismuth, inducing a significant distortion of the porphyrin core