314 research outputs found

    Foundation for Heavy Lift - Early Developments in the Ares V Launch Vehicle

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    The Ares V Cargo Launch Vehicle (CaLV) is NASA's primary vessel for safe, reliable delivery of the Lunar Surface Access Module (LSAM) and other resources into Earth orbit, as articulated in the U.S. Vision for Space Exploration. The Ares V launch concept is shown. The foundation for this heavy-lift companion to the Ares I Crew Launch Vehicle (CLV) is taking shape within NASA and with its government and industry partners. This paper will address accomplishments in the Ares V Launch Vehicle during 2006 and 2007 and offer a preview of future activities

    A prospective study comparing radiographer and clinician based localisation for patients with metastatic spinal cord compression (MSCC) to assess the feasibility of a radiographer led service.

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    OBJECTIVES: To investigate if there was parity between treatment fields localised by radiographers and clinicians, by comparing geographical variations and hence determining the feasibility of a radiographer led service. METHODS: 23 patients with metastatic spinal cord compression (MSCC) were prospectively sampled. 4 radiographers not involved in the original planning performed a localisation on each patient. The 92 localisations were compared to the clinicians approved field. Agreement was defined as ≤0.5cm between field length, width and 3 isocentre coordinates. To be feasible agreement was required in a minimum of 97% of the cases. The potential time saved with a radiographer led approach was also recorded. RESULTS: Agreement between clinicians and radiographers was 97.8%. For all field parameters, the average differences were <0.3cm and was significantly different from the 0.5cm median (p<0.0001) that would establish no agreement using wilcoxon signed rank test. The average (range) delay waiting for clinician approval was 54 minutes (4 minutes to 141 minutes). CONCLUSIONS: Strong agreement between radiographers and clinicians localisation was established. It was also highlighted that time could be saved in the patient's pathway by removing the need to wait for clinician approval. We believe this supports a radiographer led service. Advances in Knowledge: This article is novel as it is the first known comparison between clinicians and radiographers in the localisation of MSCC radiotherapy. This data shows the feasibility of introducing radiographer led practice and a methodology that could be potentially transferred to investigate the localisation parity for other treatment sites

    The Impact of Non-Equipartition on Cosmological Parameter Estimation from Sunyaev-Zel'dovich Surveys

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    The collisionless accretion shock at the outer boundary of a galaxy cluster should primarily heat the ions instead of electrons since they carry most of the kinetic energy of the infalling gas. Near the accretion shock, the density of the intracluster medium is very low and the Coulomb collisional timescale is longer than the accretion timescale. Electrons and ions may not achieve equipartition in these regions. Numerical simulations have shown that the Sunyaev-Zel'dovich observables (e.g., the integrated Comptonization parameter Y) for relaxed clusters can be biased by a few percent. The Y-mass relation can be biased if non-equipartition effects are not properly taken into account. Using a set of hydrodynamical simulations, we have calculated three potential systematic biases in the Y-mass relations introduced by non-equipartition effects during the cross-calibration or self-calibration when using the galaxy cluster abundance technique to constraint cosmological parameters. We then use a semi-analytic technique to estimate the non-equipartition effects on the distribution functions of Y (Y functions) determined from the extended Press-Schechter theory. Depending on the calibration method, we find that non-equipartition effects can induce systematic biases on the Y functions, and the values of the cosmological parameters Omega_8, sigma_8, and the dark energy equation of state parameter w can be biased by a few percent. In particular, non-equipartition effects can introduce an apparent evolution in w of a few percent in all of the systematic cases we considered. Techniques are suggested to take into account the non-equipartition effect empirically when using the cluster abundance technique to study precision cosmology. We conclude that systematic uncertainties in the Y-mass relation of even a few percent can introduce a comparable level of biases in cosmological parameter measurements.Comment: 10 pages, 3 figures, accepted for publication in the Astrophysical Journal, abstract abridged slightly. Typos corrected in version

    Exploration Launch Projects RS-68B Engine Requirements for NASA's Heavy Lift Ares V

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    NASA's Vision for Exploration requires a safe, efficient, reliable, and versatile launch vehicle capable of placing large payloads into Earth orbit for transfer to the Moon and destinations beyond. The Ares V Cargo Launch Vehicle (CaLV) will provide this heavy lift capability. The Ares V launch concept is shown in Fig. 1. When it stands on the launch pad at Kennedy Space Center late in the next decade, the Ares V stack will be almost 360 feet tall. As currently envisioned, it will lift 133,000 to 144,000 pounds to trans-lunar injection, depending on the length of loiter time on Earth orbit. This presentation will provide an overview of the Constellation architecture, the Ares launch vehicles, and, specifically, the latest developments in the RS-68B engine for the Ares V

    The Impact of Galaxy Cluster Mergers on Cosmological Parameter Estimation from Surveys of the Sunyaev-Zel'dovich Effect

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    Sensitive surveys of the Cosmic Microwave Background will detect thousands of galaxy clusters via the Sunyaev-Zel'dovich (SZ) effect. Two SZ observables, the central or maximum and integrated Comptonization parameters y_max and Y, relate in a simple way to the total cluster mass, which allow the construction of mass functions (MFs) that can be used to estimate cosmological parameters such as Omega_M, sigma_8, and the dark energy parameter w. However, clusters form from the mergers of smaller structures, events that can disrupt the equilibrium of intracluster gas upon which SZ-M relations rely. From a set of N-body/hydrodynamical simulations of binary cluster mergers, we calculate the evolution of Y and y_max over the course of merger events and find that both parameters are transiently "boosted," primarily during the first core passage. We then use a semi-analytic technique developed by Randall et al. (2002) to estimate the effect of merger boosts on the distribution functions YF and yF of Y and y_max, respectively, via cluster merger histories determined from extended Press-Schechter (PS) merger trees. We find that boosts do not induce an overall systematic effect on YFs, and the values of Omega_M, sigma_8, and w were returned to within 2% of values expected from the nonboosted YFs. The boosted yFs are significantly biased, however, causing Omega_M to be underestimated by 15-45%, sigma_8 to be overestimated by 10-25%, and w to be pushed to more negative values by 25-45%. We confirm that the integrated SZ effect, Y, is far more robust to mergers than y_max, as previously reported by Motl et al. (2005) and similarly found for the X-ray equivalent Y_X, and we conclude that Y is the superior choice for constraining cosmological parameters.Comment: 16 pages, 6 figures, Accepted for publication in the Astrophysical Journa

    Daily Dietary Intake Patterns Improve after Visiting a Food Pantry among Food-Insecure Rural Midwestern Adults.

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    Emergency food pantries provide food at no cost to low-resource populations. The purpose of this study was to evaluate single-day dietary intake patterns before and after visiting a food pantry among food-secure and food-insecure pantry clients. This observational cohort study comprised a paired, before-and-after design with a pantry visit as the intervention. Participants (n = 455) completed a demographic and food security assessment, and two 24-h dietary recalls. Adult food security was measured using the U.S. Household Food Security Survey Module. Dietary intake patterns were assessed using Automated Self-Administered 24-h Recall data and classified by Healthy Eating Index (HEI-2010) scores, dietary variety, number of eating occasions, and energy intake. Paired t-tests and Wilcoxon signed-rank tests compared outcomes before and after a pantry visit. Mean dietary variety increased after the pantry visit among both food-secure (p = 0.02) and food-insecure (p \u3c 0.0001) pantry clients. Mean energy intake (p = 0.0003), number of eating occasions (p = 0.004), and HEI-2010 component scores for total fruit (p \u3c 0.001) and whole fruit (p \u3c 0.0003) increased among food-insecure pantry clients only. A pantry visit may improve dietary intake patterns, especially among food-insecure pantry clients

    Nonthermal Emission from Accreting and Merging Clusters of Galaxies

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    We compare the nonthermal emission from clusters of galaxies undergoing minor mergers (``accreting'' clusters) and major mergers (``merging'' clusters). For accreting clusters, the radial distribution of the nonthermal emission in the clusters is also calculated. The relativistic electrons, which are the origin of the nonthermal radiation through inverse Compton (IC) and synchrotron mission, are assumed to be accelerated at shocks produced by accretion or mergers. We estimate the typical accretion rate and merger probability according to a hierarchical clustering model. We show that the total luminosity of IC emission from accreting and merging clusters are similar. On the other hand, the luminosity of synchrotron radio emission of the former is much smaller than that of the latter. We show that about 10% of clusters at z~0 should have hard X-ray and radio nonthermal emissions due to their last major merger, which are comparable to or dominate those due to ongoing accretion. Moreover, 20-40% of clusters should have significant EUV emission due to their last merger. We also investigate the case where the criterion of mergers is relaxed. If we extend the definition of a merger to an increase in the mass of the larger subcluster by at least 10% of its initial mass, about 20-30% of clusters at z~0 should have hard X-ray and radio nonthermal emissions due to the merger even in a low density universe. We compare the results with observations. We find that the observed EUV emission from clusters is not attributed to accretion. If the diffuse radio emission observed in clusters is synchrotron emission from electrons accelerated via accretion or merging, the magnetic fields of clusters are generally as small as ~0.1 mu G.Comment: 33 pages, 18 figures, accepted by Ap

    A feasibility study for a randomised controlled trial of the Positive Reappraisal Coping Intervention, a novel supportive technique for recurrent miscarriage

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    Introduction: Recurrent miscarriage (RM) is diagnosed when a woman has had three or more miscarriages. Increased levels of distress and anxiety are common during the waiting period of any subsequent pregnancies, posing a significant threat to psychological well-being. However, only limited support and therapy are available for these women, and many are left to cope alone. The Positive Reappraisal Coping Intervention (PRCI) is a novel self-administered supportive technique which has been shown to be effective in patients awaiting the outcome of in vitro fertilisation treatment. The primary objective of this study is to assess the feasibility and effectiveness of the PRCI in improving quality of life in the difficult waiting period which women with previous RM endure before an ongoing pregnancy can be confirmed. Methods and analysis: A randomised controlled trial (RCT) feasibility study will establish the viability of conducting a multicentre RCT to definitively test the effects of the PRCI on the psychological well-being of women who have experienced RM during the initial waiting period of a subsequent pregnancy. A second component consists of a qualitative process evaluation exploring the initial experience of pregnancy following repeated miscarriages. Participants (n=50) will be randomised into one of two groups. The PRCI intervention group will receive the PRCI card and weekly questionnaires to assess their psychological well-being during the waiting period of their new pregnancy. The non-intervention group will be asked to complete the same weekly questionnaires. The qualitative process analysis will employ semistructured interviews (n=20) to address relevant aspects of the study objectives. Ethics and dissemination: Ethics approval has been obtained from the National Research Ethics Service Committee South Central—Hampshire A. Participating centres have given National Health Service R&D approval. Study findings will be disseminated through peer reviewed journals, national and international conferences and lay user groups
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