900 research outputs found
Alien Registration- Lacasse, May R. (Jackman, Somerset County)
https://digitalmaine.com/alien_docs/7031/thumbnail.jp
Controversies in Psychiatry and DSM-5: The Relevance for Social Work (Occasional Essay)
This essay addresses recent controversies surrounding the forthcoming fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5âthe first major revision of the DSM since 1994), as well as questions regarding the safety and efficacy of psychotropic medications discussed in the public domain. Mental health professionals across a wide range of professions have signed a petition to the DSM-5 Task Force protesting changes in the new edition, and critiques of psychiatric medications are increasingly disseminated in the media. These issues have particular relevance for children in foster care, who receive diagnoses and medication at high rates. The general public is increasingly exposed to information on these topics through the media; as advocates and clinicians, it is important that social work practitioners be informed regarding these issues
Investigating the Structure of Potential New Drug to Treat Sickle Cell Anemia through Inhibition of the Polymerization of Hemoglobin Sâ
Sickle cell anemia is a hematologic disorder impacting over 15 million people worldwide. It is caused by a single point mutation in the gene hemoglobin-Betha, where a glu group is replaced by val (GAG --- GTG) in the seventh codon (glu7val) of chromosome 1. In this study, we are comparing the anti-sickling properties of drugs in varied conditions in order to create a drug that is effective in an O2-independent manner and with a 1:1 stoichiometry for lower dosage purposes. We used Pymol and Jmol to compare the structures of the aldehydes GBT-440 and VZHE-039, which interact on the same binding site to treat sickle cell disease. GBT-440âs bulkiness allows it to have a 1:1 stoichiometry, while VZHE-039âs solubility is due to its interaction with the hemoglobinâs alpha cleft, allowing it to be O2-independent. We identified the pyridine and pyrazole structure from GBT-440 and the methyl hydroxy moite from VZHE-039 as key structures, and created a hypothetical new drug, a hybrid of VZHE-039 and GBT-440. The pose predicted would allow the drug to interact with the sickled hemoglobin in a 1 to 1 ratio and in an O2-independent manner.https://nsuworks.nova.edu/protein_modeling_reports/1002/thumbnail.jp
Clinical Social Work and the Biomedical Industrial Complex
This article examines how the biomedical industrial complex has ensnared social work within a foreign conceptual and practice model that distracts clinical social workers from the special assistance that they can provide for people with mental distress and misbehavior. We discuss: (1) social work\u27s assimilation of psychiatric perspectives and practices during its pursuit of professional status; (2) the persistence of psychiatric hospitalization despite its coercive methods, high cost, and doubtful efficacy; (3) the increasing reliance on the Diagnostic and Statistical Manual of Mental Disorders, despite its widely acknowledged scientific frailty; and (4) the questionable contributions of psychoactive drugs to clinical mental health outcomes and their vast profits for the pharmaceutical industry, using antipsychotic drugs as a case example. We review a number of promising social work interventions overshadowed by the biomedical approach. We urge social work and other helping professions to exercise intellectual independence from the reigning paternalistic drug-centered biomedical ideology in mental health and to rededicate themselves to the supportive, educative, and problem-solving methods unique to their disciplines
Mammary cell activity and turnover in dairy cows treated with the prolactin-release inhibitor quinagolide and milked once daily
To assess the regulation of mammary cell activity, survival, and proliferation by prolactin (PRL), 5 Holstein cows in early lactation received daily i.m. injections of 1 mg of quinagolide, a suppressor of PRL release, for 9 wk, whereas 4 control cows received the vehicle (water) only. During the last week of treatment, one udder half was milked once a day (1Ă) and the other twice a day (2Ă). Mammary biopsies were harvested 1 wk before and 4 and 8 wk after the start of quinagolide treatment. The quinagolide injections reduced milk yield and resulted in lower levels of Îș-casein and α-lactalbumin mRNA in the mammary biopsies at wk 4 compared with the control cows. In the mammary tissue of the quinagolide-treated cows at wk 8 of treatment, cell proliferation (as determined by proliferating cell nuclear antigen labeling) was lower and apoptosis (as determined by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay) was higher than in the mammary tissue of the control cows. During differential milking, mammary epithelial cells (MEC) were extracted from the milk by centrifugation and purified by immunocytochemical binding to allow variations in the levels of mammary transcripts to be observed. After 9 wk of treatment, levels of α-lactalbumin and Îș-casein mRNA were lower in the MEC isolated from milk of the quinagolide-treated cows. This effect was associated with lower PRL receptor mRNA levels and a tendency toward lower viability in the milk-isolated MEC from the 2Ă-milked glands. The decrease from 2Ă milking to 1Ă milking also downregulated α-lactalbumin and Îș-casein transcripts in the milk-isolated MEC. Viability was higher for the MEC collected from the 1Ă-milked udder halves compared with the 2Ă-milked halves. In conclusion, the reduction in milk yield after chronic administration of the PRL-release inhibitor quinagolide is associated with a reduction in mammary cell activity, survival, and proliferation in lactating dairy cows. Reduced milking frequency was also associated with a decrease in MEC activity
Proton stopping in C+C, d+C, C+Ta and d+Ta collisions at 4.2A GeV/c
The shape of proton rapidity distributions is analysed in terms of their
Gaussian components, and the average rapidity loss is determined in order to
estimate the amount of stopping in C+C, d+C, C+Ta and d+Ta collisions at 4.2A
GeV/c. Three Gaussians correspond to the nuclear transparency and describe well
all peripheral and also C+C central collisions. Two-component shape is obtained
in case of d+C and C+Ta central collisions. Finally one Gaussian, found in d+Ta
central collisions, corresponds to the full stopping. The calculated values of
the average rapidity loss support the qualitative relationship between the
number of Gaussian components and the corresponding stopping power. It is also
observed, in central collisions, that the average rapidity loss increases with
the ratio of the number of target and the number of projectile participants.Comment: 9 pages REVTeX, 1 PS figure replaced, to be published in Phys.Rev.
Serotonin and Depression: A Disconnect between the Advertisements and the Scientific Literature
Many ads for SSRI antidepressants claim that the drugs boost brain serotonin levels. Lacasse and Leo argue there is little scientific evidence to support this claim
Infrared Imaging of Capella with the IOTA Closure Phase Interferometer
We present infrared aperture synthesis maps produced with the upgraded IOTA
interferometer. Michelson interferograms on the close binary system Capella
(Alpha Aur) were obtained in the H-band between 2002 November 12 and 16 using
the IONIC3 beam combiner. With baselines of 15m < B < 38m, we were able to
determine the relative position of the binary components with milliarcsecond
(mas) precision and to track their movement along the approx. 14 degree arc
covered by our observation run. We briefly describe the algorithms used for
visibility and closure phase estimation. Three different Hybrid Mapping and
Bispectrum Fitting techniques were implemented within one software framework
and used to reconstruct the source brightness distribution. By dividing our
data into subsets, the system could be mapped at three epochs, revealing the
motion of the stars. The precise position of the binary components was also
determined with model fits, which in addition revealed I_Aa/I_Ab=1.49 +/- 0.10
and apparent stellar uniform-disk (UD) diameters of Theta_Aa=8.9 +/- 0.6 mas
and Theta_Ab=5.8 +/- 0.8 mas.
To improve the u, v-plane coverage, we compensated this orbital motion by
applying a rotation-compensating coordinate transformation. The resulting
model-independent map with a beam size of 5.4 x 2.6 mas allows the resolution
of the stellar surfaces of the Capella giants themselves.Comment: Accepted by the Astronomical Journal (2005-03-21
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