Avaliação da motivação para o tratamento de dependência química em adolescentes : comparação de dois instrumentos

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High prevalence of bronchiectasis is linked to HTLV-1-associated inflammatory disease.

BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1), a retrovirus, is the causative agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukaemia/lymphoma (ATLL). The reported association with pulmonary disease such as bronchiectasis is less certain. METHODS: A retrospective case review of a HTLV-1 seropositive cohort attending a national referral centre. The cohort was categorised into HTLV-1 symptomatic patients (SPs) (ATLL, HAM/TSP, Strongyloidiasis and HTLV associated inflammatory disease (HAID)) and HTLV-1 asymptomatic carriers (ACs). The cohort was reviewed for diagnosis of bronchiectasis. RESULT: 34/246 ACs and 30/167 SPs had been investigated for respiratory symptoms by computer tomography (CT) with productive cough +/- recurrent chest infections the predominant indications. Bronchiectasis was diagnosed in one AC (1/246) and 13 SPs (2 HAID, 1 ATLL, 10 HAM/TSP) (13/167, RR 19.2 95 % CI 2.5-14.5, p = 0.004) with high resolution CT. In the multivariate analysis ethnicity (p = 0.02) and disease state (p < 0.001) were independent predictors for bronchiectasis. The relative risk of bronchiectasis in SPs was 19.2 (95 % CI 2.5-14.5, p = 0.004) and in HAM/TSP patients compared with all other categories 8.4 (95 % CI 2.7-26.1, p = 0.0002). Subjects not of African/Afro-Caribbean ethnicity had an increased prevalence of bronchiectasis (RR 3.45 95 % 1.2-9.7, p = 0.02). CONCLUSIONS: Bronchiectasis was common in the cohort (3.4 %). Risk factors were a prior diagnosis of HAM/TSP and ethnicity but not HTLV-1 viral load, age and gender. The spectrum of HTLV-associated disease should now include bronchiectasis and HTLV serology should be considered in patients with unexplained bronchiectasis

Respiratory and Urinary Tract Infections, Arthritis, and Asthma Associated with HTLV-I and HTLV-II Infection

Human T-lymphotropic virus types I and II (HTLV-I and -II) cause myelopathy; HTLV-I, but not HTLV-II, causes adult T-cell leukemia. Whether HTLV-II is associated with other diseases is unknown. Using survival analysis, we studied medical history data from a prospective cohort of HTLV-I– and HTLV-II–infected and –uninfected blood donors, all HIV seronegative. A total of 152 HTLV-I, 387 HTLV-II, and 799 uninfected donors were enrolled and followed for a median of 4.4, 4.3, and 4.4 years, respectively. HTLV-II participants had significantly increased incidences of acute bronchitis (incidence ratio [IR] = 1.68), bladder or kidney infection (IR = 1.55), arthritis (IR = 2.66), and asthma (IR = 3.28), and a borderline increase in pneumonia (IR = 1.82, 95% confidence interval [CI] 0.98 to 3.38). HTLV-I participants had significantly increased incidences of bladder or kidney infection (IR = 1.82), and arthritis (IR = 2.84). We conclude that HTLV-II infection may inhibit immunologic responses to respiratory infections and that both HTLV-I and -II may induce inflammatory or autoimmune reactions

DC-SIGN (CD209) gene promoter polymorphisms in a Brazilian population and their association with human T-cell lymphotropic virus type 1 infection

This study evaluated four polymorphisms located in the DC-SIGN (CD209) gene promoter region (positions −336, −332 −201 and −139) in DNA samples from four Brazilian ethnic groups (Caucasians, Afro-Brazilian, Asians and Amerindians) to establish the population distribution of these single-nucleotide polymorphisms (SNPs) and correlated DC-SIGN polymorphisms and infection in samples from human T-cell lymphotropic virus type 1 (HTLV-1)-infected individuals. To identify CD209 SNPs, 452 bp of the CD209 promoter region were sequenced and the genotype and allelic frequencies were evaluated. This is the first study to show genetic polymorphism in the CD209 gene in distinct Brazilian ethnic groups with the distribution of allelic and genotypic frequency. The results showed that −336A and −139A SNPs were quite common in Asians and that the −201T allele was not observed in Caucasians, Asians or Amerindians. No significant differences were observed between individuals with HTLV-1 disease and asymptomatic patients. However, the −336A variant was more frequent in HTLV-1-infected patients [HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), 80 %; healthy asymptomatic HTLV-1 carriers, 90 %] than in the control group (70 %) [P=0.0197, odds ratio (OR)=2.511, 95 % confidence interval (CI)=1.218–5.179). In addition, the −139A allele was found to be associated with protection against HTLV-1 infection (P=0.0037, OR=0.3758, 95 % CI=0.1954–0.7229) when the HTLV-1-infected patients as a whole were compared with the healthy-control group. These observations suggest that the −139A allele may be associated with HTLV-1 infection, although no significant association was observed among asymptomatic and HAM/TSP patients. In conclusion, the variation observed in SNPs −336 and −139 indicates that this lectin may be of crucial importance in the susceptibility/transmission of HTLV-1 infections

Basque Language, identities and territory. Logic of social action and collective mobilization about school in Basque.

Au Pays Basque de France, le nombre de bascophones ne cesse de diminuer. Pour autant, les dernières enquêtes sociolinguistiques présentent, chez les plus jeunes générations, une progression du nombre de locuteurs. Ce phénomène est en grande partie lié à la scolarisation en basque qui ne cesse de se développer. Entre les rentrées scolaires de 2004 et de 2016, les trois filières principales de l'enseignement en basque (bilingue publique, bilingue privée et immersion en ikastola) ont connu une augmentation de leurs effectifs de 68% tandis que le nombre d'enfants scolarisés au Pays Basque de France n'augmentait que de 6%. À l'heure où les échanges mondiaux favorisent l'acquisition de langues internationales, le succès de l'apprentissage d'une langue régionale interroge. Dans le cadre d'une intervention sociologique (qui a consisté à réunir 5 fois, durant près de deux heures, 5 groupes d’une dizaine de participants), nous avons, avec des parents ayant scolarisé leurs enfants en basque, analysé leurs pratiques. Nous avons ainsi pu définir le sens social de ce choix qui leur semblait a priori évident et personnel. En plus d’une volonté de s'inscrire dans la transmission de cette langue identitaire ou du fait de bénéficier des avantages liés au bilinguisme précoce, les parents rencontrés donnent une dimension plus militante à leur choix, dimension sous-tendue notamment par des principes universels (égalité des langues, respect des cultures, préservation du patrimoine mondial, etc.). Mais cet engouement pour la scolarisation en basque peut aussi se comprendre comme la volonté d'être acteur d'un nouveau projet social. Il apparaît que le choix de la scolarisation en basque n’est pas porté par une seule motivation mais relève d'une expérience sociale qui combine ces différentes logiques d'action. Nous cherchons dans cette thèse à identifier et analyser la pluralité des motivations évoquées par les parents, et à comprendre les liens qui les unissent dans une même expérience sociale.In French Basque Country, the number of Basque speakers keeps decreasing. Yet, the last socio-linguistic surveys show that the number of speakers increases among the youngest generations. Such a growth is partly related to the growing enrolment of children in schools in Basque. Between the school years 2004 and 2016, the three main branches of schooling in Basque (the public one, the private one, and the immersive one in ikastola) show a dramatic increase of 68% of the number of pupils in French Basque Country, whereas the total number of pupils increases by 6% only. While globalisation strengthens international languages, the growing popularity for placing young children in schools in Basque in order to acquire a regional language is challenging.Thanks to a sociological intervention (which consisted in bringing together 5 groups of about 10 parents, and meeting them 5 times each, for 2 hours) we co-analysed the practices of parents who decided to place their children in schools in Basque. This way, we defined the social meaning of their choice, which, at first, could appear obvious and personal to them.The parents involved in the sociological intervention want to take part in the transmission of an identity-sensitive language. They want to take advantage of an exposure to a bilingual learning from an early age. But they also show a sort of activism by assuming universal principals (such as equality between languages, respect for cultures, preservation of the world’s heritage, etc.). Finally, the will to take an active part in a new social project can also be considered as a driver of the desire to place their children in schools in Basque.It appears that the choice to place children in schools in Basque is never driven by a single reason only. The motivation stems from a sociological experience that articulates the different logics previously mentioned. Here, we look for identifying and analysing the diversity of the reasons the parents give, and understanding the system that relates those reasons in a same social experience

L’école en basque : comprendre l’« évidence » d’un choix

En 1969, l’embryon de la première ikastola, école immersive en langue basque, et l’association Seaska qui la gérait, naissaient au domicile d’une famille de Bayonne. Cinquante ans plus tard, la petite association est devenue une fédération de parents et compte plus de 4 000 enfants scolarisés de la maternelle à la terminale. Le succès de l’enseignement du basque, l’un des étendards des mobilisations citoyennes au Pays Basque de France (PBF), pose aujourd’hui la question des multiples sens ass..

Basque language, identities and territory. Logics of action and collective mobilizations about schooling in Basque.

Au Pays Basque de France, le nombre de bascophones ne cesse de diminuer. Pour autant, les dernières enquêtes sociolinguistiques présentent, chez les plus jeunes générations, une progression du nombre de locuteurs. Ce phénomène est en grande partie lié à la scolarisation en basque qui ne cesse de se développer.Entre les rentrées scolaires de 2004 et de 2016, les trois filières principales de l'enseignement en basque (bilingue publique, bilingue privée et immersion en ikastola) ont connu une augmentation de leurs effectifs de 68% tandis que le nombre d'enfants scolarisés au Pays Basque de France n'augmentait que de 6%. À l'heure où les échanges mondiaux favorisent l'acquisition de langues internationales, le succès de l'apprentissage d'une langue régionale interroge.Dans le cadre d'une intervention sociologique (qui a consisté à réunir 5 fois, durant près de deux heures, 5 groupes d’une dizaine de participants), nous avons, avec des parents ayant scolarisé leurs enfants en basque, analysé leurs pratiques. Nous avons ainsi pu définir le sens social de ce choix qui leur semblait a priori évident et personnel.En plus d’une volonté de s'inscrire dans la transmission de cette langue identitaire ou du fait de bénéficier des avantages liés au bilinguisme précoce, les parents rencontrés donnent une dimension plus militante à leur choix, dimension sous-tendue notamment par des principes universels (égalité des langues, respect des cultures, préservation du patrimoine mondial, etc.). Mais cet engouement pour la scolarisation en basque peut aussi se comprendre comme la volonté d'être acteur d'un nouveau projet social.Il apparaît que le choix de la scolarisation en basque n’est pas porté par une seule motivation mais relève d'une expérience sociale qui combine ces différentes logiques d'action. Nous cherchons dans cette thèse à identifier et analyser la pluralité des motivations évoquées par les parents, et à comprendre les liens qui les unissent dans une même expérience sociale.In French Basque Country, the number of Basque speakers keeps decreasing. Yet, the last socio-linguistic surveys show that the number of speakers increases among the youngest generations. Such a growth is partly related to the growing enrolment of children in schools in Basque.Between the school years 2004 and 2016, the three main branches of schooling in Basque (the public one, the private one, and the immersive one in ikastola) show a dramatic increase of 68% of the number of pupils in French Basque Country, whereas the total number of pupils increases by 6% only. While globalisation strengthens international languages, the growing popularity for placing young children in schools in Basque in order to acquire a regional language is challenging.Thanks to a sociological intervention (which consisted in bringing together 5 groups of about 10 parents, and meeting them 5 times each, for 2 hours) we co-analysed the practices of parents who decided to place their children in schools in Basque. This way, we defined the social meaning of their choice, which, at first, could appear obvious and personal to them.The parents involved in the sociological intervention want to take part in the transmission of an identity-sensitive language. They want to take advantage of an exposure to a bilingual learning from an early age. But they also show a sort of activism by assuming universal principals (such as equality between languages, respect for cultures, preservation of the world’s heritage, etc.). Finally, the will to take an active part in a new social project can also be considered as a driver of the desire to place their children in schools in Basque.It appears that the choice to place children in schools in Basque is never driven by a single reason only. The motivation stems from a sociological experience that articulates the different logics previously mentioned. Here, we look for identifying and analysing the diversity of the reasons the parents give, and understanding the system that relates those reasons in a same social experience