‘Sono cittadino del Mediterraneo’ Erri De Luca il poeta e il mare

Il saggio apre una finestra sulle numerose pagine che lo scrittore e poeta Erri De Luca ha dedicato al Mediterraneo. De Luca più di molti altri è impregnato di mediterraneità dandone continuamente testimonianza nei suoi numerosi scritti e nelle sue vibranti interviste. Partendo da queste considerazioni si traccia una linea immaginaria che partendo da uno dei suoi ultimi lavori Il più e il meno del 2015 arriva a ritroso fino alla raccolta poetica Solo Andata del 2005, recentemente transcodificata in cortometraggio per la regia di Alessandro Gassman, per mostrare come l’Europa debba al Mediterraneo quasi tutto, dal suo nome antico a una miriade di voci dei suoi vocabolari, dall’architettura al vino, dalla filosofia ai numeri, al teatro, all’olio, fino alla sua divinità monoteista. La civiltà d’Europa nasce dall’immaginazione meridionale e più in generale dalla mediterraneità di cui è intrisa. Attraverso De Luca il Mediterraneo torna a essere protagonista di un mondo di carta in cui finalmente si vede un orizzonte di luce. Lo scrittore sembra quindi volerci lasciare in eredità un prezioso tesoro: per imparare a navigare nuovamente come i nostri antenati nel Mediterraneo dobbiamo superare i confini esterni e interni della nostra memoria e lasciarci guidare dal mondo di carta della poesia.peer-reviewe

Microstructural characterization of a 3D-printed soil

Transversal applications of 3D-printing (or Additive Manufacturing) have been recently implemented in the field of Geomechanics. In a 3D-printing process, the printed volume is obtained from successive layering of adjacent soil filaments. In this work, the fabric of an as-printed soil has been carried out by combining Mercury Intrusion Porosimetry (MIP) tests and Scanning Electron Microscope (SEM) observations, with the aim to highlight how the particle arrangements and the orientation and shape of pores are linked to the printing operation. The microstructural analyses showed that macropores are the result of the relative position of the filaments and their initial distortion in quasi-undrained conditions. Particle arrangement within the soil filament is strongly anisotropic, due to the rotative movement of the soil in the extruder

Nonlinear Models for Silicon Semiconductors

In this paper we present exact closures of the 8-moment and the 9-moment models for the charge transport in silicon semiconductors based on the maximum entropy principle. The validity of these models is assessed by numerical simulations of an n-n-n device. The results are compared with those obtained from the numerical solution of the Boltzmann Transport Equation both by Monte Carlo method and directly by a finite difference scheme

High prevalence of anti-hepatitis e virus antibodies among blood donors in central Italy, february to march 2014

Prevalence of anti-hepatitis E virus (HEV) antibodies is highly variable in developed countries, which seems partly due to differences in assay sensitivity. Using validated sensitive assays, we tested 313 blood donors attending a hospital transfusion unit in central Italy in January and February 2014 for anti-HEV IgG and IgM and HEV RNA. Data on HEV exposure were collected from all donors. Overall anti-HEV IgG prevalence was 49% (153/313). Eating raw dried pig-liver sausage was the only independent predictor of HEV infection (adjusted prevalence rate ratio = 2.14; 95% confidence interval: 1.23–3.74). Three donors were positive for either anti-HEV IgM (n = 2; 0.6%) or HEV RNA (n = 2; 0.6%); they were completely asymptomatic, without alanine aminotransferase (ALT) abnormalities. Of the two HEV RNA-positive donors (both harbouring genotype 3), one was anti-HEV IgG- and IgM-positive, the other was anti-HEV IgG- and IgM-negative. The third donor was positive for anti-HEV IgG and IgM but HEV RNA-negative. HEV infection is therefore hyperendemic among blood donors (80% men 18–64 years-old) from central Italy and associated with local dietary habits. Nearly 1% of donors have acute or recent infection, implying potential transmission to blood recipients. Neither ALT nor anti-HEV IgM testing seems useful to prevent transfusion-transmitted HEV infection. © 2016, European Centre for Disease Prevention and Control

Type III pleuropulmonary blastoma in a 7-month-old female baby with impending respiratory failure: a case report

INTRODUCTION: Pleuropulmonary blastoma is a very rare, aggressive, embryonal pulmonary neoplasm which mostly affects children under the age of 5. According to the histopathological features, three subtypes of pleuropulmonary blastoma have been recognized: type I (purely cystic), type II (grossly visible cystic and solid elements) and type III (purely solid). Characteristics of type I and type II blastoma allow an earlier diagnosis compared with type III. Here we present a case report of an unusual presentation of type III pleuropulmonary blastoma. CASE PRESENTATION: We describe the case of a 7-month-old female baby of Italian mother and Kurdish father who was diagnosed with type III pleuropulmonary blastoma, which entirely occupied her right hemithorax. CONCLUSIONS: The reported case is an unusual presentation because type III pleuropulmonary blastoma typically occurs in older children. The complete re-expansion of her residual, previously totally compressed, right lung observed immediately after the resection of the lesion suggests an atypical rapid growth of this embryonal tumor in the late phase of gestation or after delivery. This case report suggests that, in addition to other childhood tumors, type III pleuropulmonary blastoma should be included in the differential diagnosis of solid nonhomogeneous thoracic large masses, compressing the mediastinal and chest wall structures in infants. This is an original case report of interest for several specialities such us pediatrics, radiology, surgery and oncology

Autologous Haematopoietic Stem Cell Transplantation and Systemic Sclerosis: Focus on Interstitial Lung Disease

Autologous hematopoietic stem cells transplantation (AHSCT) has been employed as treatment for severe systemic sclerosis (SSc) with high risk of organ failure. In the last 25 years overall survival and treatment-related mortality have improved, in accordance with a better patient selection and mobilization and conditioning protocols. This review analyzes the evidence from the last 5 years for AHSCT-treated SSc patients, considering in particular the outcomes related to interstitial lung disease. There are increasing data supporting the use of AHSCT in selected patients with rapidly progressive SSc. However, some unmet needs remain, such as an accurate patient selection, pre-transplantation analysis to identify subclinical conditions precluding the transplantation, and the alternatives for post-transplant ILD recurrence

Synthesis, biophysical characterization and anti-HIV activity of d(TG3AG) Quadruplexes bearing hydrophobic tails at the 5'-end

Novel conjugated G-quadruplex-forming d(TG3AG) oligonucleotides, linked to hydrophobic groups through phosphodiester bonds at 50-end, have been synthesized as potential anti-HIV aptamers, via a fully automated, online phosphoramidite-based solid-phase strategy. Conjugated quadruplexes showed pronounced anti-HIV activity with some preference for HIV-1, with inhibitory activity invariably in the low micromolar range. The CD and DSC monitored thermal denaturation studies on the resulting quadruplexes, indicated the insertion of lipophilic residue at the 50-end, conferring always improved stability to the quadruplex complex (20 < DTm < 40 C). The data suggest no direct functional relationship between the thermal stability and anti-HIV activity of the folded conjugated G-quartets. It would appear that the nature of the residue at 50 end of the d(TG3AG) quadruplexes plays an important role in the thermodynamic stabilization but a minor influence on the anti-HIV activity. Moreover, a detailed CD and DSC analyses indicate a monophasic behaviour for sequences I and V, while for ODNs (II–IV) clearly show that these quadruplex structures deviate from simple two-state melting, supporting the hypothesis that intermediate states along the dissociation pathway may exis