24 research outputs found
Damage localization in laminated composite plates using mode shapes measured by pulsed TV holography
Three methods for the damage localization of impact damage in laminated composite plates, based on their vibrational characteristics, are presented in this paper. These methods use double pulse TV holography with acoustic excitation for mode shapes acquisition and the differences in translations, rotations and curvatures. The rotations and curvatures are obtained by numerical differentiation of mode shapes translations using a differentiation/smoothing technique. The methods are applied to a carbon fiber reinforced epoxy rectangular plate, free in space, subjected to two cases of impact damage. It is shown that the method based on curvatures allows the localization of both cases of damage, which can be undetected by visual, X-ray or C-scan inspections. The best localizations are achieved by selecting and applying the method to the most changed mode.Three methods for the damage localization of impact damage in laminated composite plates, based on their vibrational characteristics, are presented in this paper. These methods use double pulse TV holography with acoustic excitation for mode shapes acquisition and the differences in translations, rotations and curvatures. The rotations and curvatures are obtained by numerical differentiation of mode shapes translations using a differentiation/smoothing technique. The methods are applied to a carbon fiber reinforced epoxy rectangular plate, free in space, subjected to two cases of impact damage. It is shown that the method based on curvatures allows the localization of both cases of damage, which can be undetected by visual, X-ray or C-scan inspections. The best localizations are achieved by selecting and applying the method to the most changed mode
Damage localization in laminated composite plates using double pulse-electronic holographic interferometry
One method for the damage localization of impact damage in laminated composite
plates, based on their vibrational characteristics, is presented in this paper. This method uses double pulse-electronic holographic interferometry for mode shapes acquisition and the differences in curvatures. The rotations and curvatures are numerically obtained. The method is applied to a carbon fibre reinforced epoxy rectangular plate, free in space, subjected to two cases of impact damage. It is shown that the method based on curvatures allows for the localization of both cases of damage, which can be undetected by visual, X-ray or C-Scan inspections. The best localizations are achieved by selecting and applying the method to the most changed mode
Associação entre características de desempenho de tilápia-do-nilo ao longo do período de cultivo
Temporal dynamics of the shrub and herbaceous layer of an area of moist grassland in Alto Paraíso de Goiás, Brazil
Este trabalho avaliou a dinâmica estrutural e fl orística de uma comunidade de espécies herbáceo-arbustivas
de uma área de campo limpo úmido em Alto Paraíso de Goiás, o primeiro inventário realizado em 2000 (T0) e o
segundo em 2007 (T1). A diversidade de Shannon entre os períodos foi comparada pelo teste-t de Hutcheson e a
similaridade fl orística, pelo índice de similaridade de Chao-Sørensen. As relações fl orísticas e a cobertura, entre os
períodos e as linhas, foram avaliadas por meio de análises de correspondência retifi cada (DCA). Foram amostradas
98 espécies, 88 no T0 e 67 no T1, sendo 31 exclusivas do T0 e 10 do T1. A diversidade fl orística na comunidade
foi elevada nos dois períodos, porém diferente entre esses (t = 7,12; p < 0,001), devido a variação no número e
cobertura das espécies. A similaridade entre os dois inventários foi alta (Chao-Sørensen ± IC = 0,841 ± 0,074). A
ordenação por DCA indicou relações entre a composição fl orística e a cobertura com o gradiente de umidade e
de matéria orgânica no solo identifi cados em T0. Houve modifi cações nas linhas em zonas sazonais, as quais se
tornaram mais semelhantes às linhas constantemente saturadas por água. Em um intervalo de sete anos o campo
limpo úmido apresentou mudanças na composição fl orística e, principalmente na estrutura devido o aumento da
cobertura de espécies perenes, cespitosas e entouceiradas, que foram favorecidas pela maior umidade no solo em
resposta à elevação da pluviosidade da região. __________________________________________________________________________________________ ABSTRACTTh is study evaluated the fl oristic and structural dynamics of a community of herbaceous-shrub species
in an area of moist grassland in Alto Paraíso de Goiás. Th e fi rst inventory was undertaken in 2000 (T0) and the
second in 2007 (T1). Shannon’s diversity between the periods was compared by Hutchesons´s t-test, and the
fl oristic similarity by the Chao-Sørensen similarity index. Floristic composition and cover, between periods and
lines, were evaluated by detrended correspondence analysis (DCA). We sampled 98 species, 88 at T0 and 67 at T1;
31 were unique to T0 and 10 to T1. Floristic diversity in the community was high in both periods, but diff erent
between them (t = 7.12, p <0.001), due to variation in species number and coverage. Similarity between the two
surveys was high (Chao-Sørensen CI = ± 0.841 ± 0.074). Th e DCA ordination indicated relationships between the
fl oristic composition and cover with a gradient of moisture and organic matter in the soil identifi ed in T0. Th ere
were changes in the lines in the seasonal zones, which became more similar in those constantly saturated with
water. During an interval of seven years the moist grassland showed changes in fl oristic composition and mainly
in structure due to increased cover of the clumped tussock perennial species, which were favored by higher soil
moisture due to high rainfall in the region
Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma
SummaryBRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs. Resistance is often mediated by pathway reactivation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which drive paradoxical reactivation of the pathway. We describe pan-RAF inhibitors (CCT196969, CCT241161) that also inhibit SFKs. These compounds do not drive paradoxical pathway activation and inhibit MEK/ERK in BRAF and NRAS mutant melanoma. They inhibit melanoma cells and patient-derived xenografts that are resistant to BRAF and BRAF/MEK inhibitors. Thus, paradox-breaking pan-RAF inhibitors that also inhibit SFKs could provide first-line treatment for BRAF and NRAS mutant melanomas and second-line treatment for patients who develop resistance
Análise de rendimento cárneo das principais espécies de peixes comercializadas no Estado do Amazonas, Brasil
Development and characterization of polymorphic microsatellite markers in taro (Colocasia esculenta)
Microsatellite-containing sequences were isolated from enriched genomic libraries of taro (Colocasia esculenta (L.) Schott). The sequencing of 269 clones yielded 77 inserts containing repeat motifs. The majority of these (81.7%) were dinucleotide or trinucleotide repeats. The GT/CA repeat motif was the most common, accounting for 42% of all repeat types. From a total of 43 primer pairs designed, 41 produced markers within the expected size range. Sixteen (39%) were polymorphic when screened against a restricted set of taro genotypes from Southeast Asia and Oceania, with an average of 3.2 alleles detected on each locus. These markers represent a useful resource for taro germplasm management, genome mapping, and marker-assisted selection
Evaluation of temporal, seasonal and geographic stability of the molluscicidal property of Euphorbia splendens latex
Avaliação funcional e histológica da tireoide de ovinos suplementados com fluoreto de sódio por um período de 150 dias
International nosocomial infection control consortium (INICC) report, data summary of 36 countries, for 2004-2009
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated health care-associated infections, we gathered prospective data from 313,008 patients hospitalized in the consortium's ICUs for an aggregate of 2,194,897 ICU bed-days. Despite the fact that the use of devices in the developing countries' ICUs was remarkably similar to that reported in US ICUs in the CDC's NHSN, rates of device-associated nosocomial infection were significantly higher in the ICUs of the INICC hospitals; the pooled rate of central line-associated bloodstream infection in the INICC ICUs of 6.8 per 1,000 central line-days was more than 3-fold higher than the 2.0 per 1,000 central line-days reported in comparable US ICUs. The overall rate of ventilator-associated pneumonia also was far higher (15.8 vs 3.3 per 1,000 ventilator-days), as was the rate of catheter-associated urinary tract infection (6.3 vs. 3.3 per 1,000 catheter-days). Notably, the frequencies of resistance of Pseudomonas aeruginosa isolates to imipenem (47.2% vs 23.0%), Klebsiella pneumoniae isolates to ceftazidime (76.3% vs 27.1%), Escherichia coli isolates to ceftazidime (66.7% vs 8.1%), Staphylococcus aureus isolates to methicillin (84.4% vs 56.8%), were also higher in the consortium's ICUs, and the crude unadjusted excess mortalities of device-related infections ranged from 7.3% (for catheter-associated urinary tract infection) to 15.2% (for ventilator-associated pneumonia). Copyright © 2012 by the Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved