Relevance of lactate level detection in migrane and fibromyalgia

The aim of this study was to determine the blood lactate levels in healthy and pathological subjects, particularly with migraine and fibromyalgia. Moreover we investigated the possible correlation between lactate concentration, postural stability and balance disorders; the composition of the groups were: migraine (n = 25; age 49.7 +/- 12.5), fibromyalgia (n = 10; age 43.7 +/- 21.2), control group (n = 16 age 28.52 +/- 2.4). The results showed that patients with fibromyalgia (FG) had higher lactate levels compared to migraine (MG) and control group (CG) (mean +/- sd: FG = 1.78 +/- 0.9 mmol/L; MG = 1.45 +/- 1 mmol/L; CG = 0,85 +/- 0,07 mmol/L). The same situation was highlighted about the sway path length with eyes closed (FG = 518 +/- 195 mm; MG = 465 +/- 165 mm; CG = 405 +/- 94,72 mm) and with eyes open (FG = 430 +/- 220 mm; MG = 411 +/- 143 mm; CG = 389 +/- 107 mm). This can be explained by the fact that energy-intensive postural strategies must be used to optimize both static and dynamic coordination, in particular with repeated contractions of tonic oxidative muscle cells responsible for postural control

Daily variability of Ceres' Albedo detected by means of radial velocities changes of the reflected sunlight

Bright features have been recently discovered by Dawn on Ceres, which extend previous photometric and Space Telescope observations. These features should produce distortions of the line profiles of the reflected solar spectrum and therefore an apparent radial velocity variation modulated by the rotation of the dwarf planet. Here we report on two sequences of observations of Ceres performed in the nights of 31 July, 26-27 August 2015 by means of the high-precision HARPS spectrograph at the 3.6-m La Silla ESO telescope. The observations revealed a quite complex behaviour which likely combines a radial velocity modulation due to the rotation with an amplitude of approx +/- 6 m/s and an unexpected diurnal effect. The latter changes imply changes in the albedo of Occator's bright features due to the blaze produced by the exposure to solar radiation. The short-term variability of Ceres' albedo is on timescales ranging from hours to months and can both be confirmed and followed by means of dedicated radial velocity observations.Comment: 5 pag, 1fig, two tables, MNRAS Letters 201

Comment on "Influence of HLA-C Expression Level on HIV Control"

Apps et al. found that high human HLA-C expression favors HIV-1 control. HLA-C was assessed with a monoclonal antibody that cross-reacts with HLA-E

Curiouser and curiouser: The peculiar chemical composition of the Li: The Na-rich star in ω Centauri

We present a multi-instrument spectroscopic analysis of the unique Li- and Na-rich giant star #25664 in ω Centauri, using spectra acquired with FLAMES-GIRAFFE, X-shooter, UVES, and HARPS. Li and Na abundances have been derived from the UVES spectrum using transitions weakly sensitive to non-local thermodynamic equilibrium and assumed isotopic ratios. This new analysis confirms the surprising Li and Na abundances of this star (A(Li)NLTE = +2.71 ± 0.07 dex, [Na/Fe]NLTE = +1.00 ± 0.05 dex). Additionally, we provide new pieces of evidence for its chemical characterisation. The 12C13C isotopic ratio (15 ± 2) shows that this star has not yet undergone the extra-mixing episode usually associated with the red giant branch bump. Therefore, we can rule out the scenario of efficient deep extra mixing during the red giant branch phase envisaged to explain the high Li and Na abundances. Also, the star exhibits high abundances of both C and N ([C/Fe] = +0.45 ± 0.16 dex and [N/Fe] = +0.99 ± 0.20 dex), which is not compatible with the typical C-N anti-correlation observed in globular cluster stars. We found evidence of a radial velocity variability in #25664, suggesting that the star could be part of a binary system, likely having accreted material from a more massive companion when the latter was evolving in the asymptotic giant branch (AGB) phase. Viable candidates for the donor star are AGB stars with 3-4 M⊙ and super-AGB stars (~7-8 M⊙), both of which are able to produce Li- and Na-rich material. Alternatively, the star could have formed from the pure ejecta of a super-AGB star before the dilution with primordial gas occurred

Impact of Diabetes Mellitus and Its Comorbidities on Elderly Patients Hospitalized in Internal Medicine Wards: Data from the RePoSi Registry

Background: Currently, diabetes represents the seventh leading cause of death worldwide, with a significant economic burden. The number and severity of comorbidities increase with age, and are identified as important determinants that influence the prognosis. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients affected by diabetes. Methods: In this observational study, we retrospectively analyzed data collected from the REgistro dei pazienti per lo studio delle POlipatologie e politerapie in reparti della rete Simi (RePoSi) reg-istry. Socio-demographic, clinical characteristics, and laboratory findings were considered. The association between variables and in-hospital and 1-year follow-up were analyzed. Results: Among 4708 in-patients, 1378 (29.3%) had a diagnosis of diabetes. Patients with diabetes had more previous hospitalization, a clinically significant disability, and more need for a urinary catheter in comparison with subjects without diabetes. Patients affected by diabetes took more drugs, both at admission, at in-hospital stay, at discharge, and at 1-year follow-up. Thirty-five comorbidities were more frequent in patients with diabetes, and the first five were hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and chronic obstructive pulmonary disease (22.7%). Heart rate was an independent predictor of in-hospital mortality. At 1-year follow-up, cancer and male sex were strongly independently associated with mortality. Conclusions: Our findings showed the severity of the impact of diabetes and its comorbidities in the real life of internal medicine and geriatric wards, and provide data to be used for a better tailored management of elderly in-patients with diabetes

Role of the mucins in pathogenesis of COPD: implications for therapy.

Introduction: Evidence accumulated in the last decade has started to reveal the enormous complexity in the expression, interactions and functions of the large number of different mucins present in the different compartments of the human lower airways. This occurs both in normal subjects and in COPD patients in different clinical phases and stages of severity.Areas covered: We review the known physiological mechanisms that regulate mucin production in human lower airways of normal subjects, the changes in mucin synthesis/secretion in COPD patients and the clinical efficacy of drugs that modulate mucin synthesis/secretion.Expert opinion: It is evident that the old simplistic concept that mucus hypersecretion in COPD patients is associated with negative clinical outcomes is not valid and that the therapeutic potential of 'mucolytic drugs' is under-appreciated due to the complexity of the associated molecular network(s). Likewise, our current knowledge of the effects of the drugs already available on the market that target mucin synthesis/secretion/structure in the lower airways is extremely limited and often indirect and more well-controlled clinical trials are needed in this area

3D Patient-Specific Virtual Models for Presurgical Planning in Patients with Recto-Sigmoid Endometriosis Nodules: A Pilot Study

Background and Objective: In recent years, 3D printing has been used to support surgical planning or to guide intraoperative procedures in various surgical specialties. An improvement in surgical planning for recto-sigmoid endometriosis (RSE) excision might reduce the high complication rate related to this challenging surgery. The aim of this study was to build novel presurgical 3D models of RSE nodules from magnetic resonance imaging (MRI) and compare them with intraoperative findings. Materials and Methods: A single-center, observational, prospective, cohort, pilot study was performed by enrolling consecutive symptomatic women scheduled for minimally invasive surgery for RSE between November 2019 and June 2020 at our institution. Preoperative MRI were used for building 3D models of RSE nodules and surrounding pelvic organs. 3D models were examined during multi-disciplinary preoperative planning, focusing especially on three domains: degree of bowel stenosis, nodule's circumferential extension, and bowel angulation induced by the RSE nodule. After surgery, the surgeon was asked to subjectively evaluate the correlation of the 3D model with the intra-operative findings and to express his evaluation as "no correlation", "low correlation", or "high correlation" referring to the three described domains. Results: seven women were enrolled and 3D anatomical virtual models of RSE nodules and surrounding pelvic organs were generated. In all cases, surgeons reported a subjective "high correlation" with the surgical findings. Conclusion: Presurgical 3D models could be a feasible and useful tool to support surgical planning in women with recto-sigmoidal endometriotic involvement, appearing closely related to intraoperative findings

Curiouser and curiouser: The peculiar chemical composition of the Li: The Na-rich star in ω Centauri

We present a multi-instrument spectroscopic analysis of the unique Li- and Na-rich giant star #25664 in ω Centauri, using spectra acquired with FLAMES-GIRAFFE, X-shooter, UVES, and HARPS. Li and Na abundances have been derived from the UVES spectrum using transitions weakly sensitive to non-local thermodynamic equilibrium and assumed isotopic ratios. This new analysis confirms the surprising Li and Na abundances of this star (A(Li)NLTE = +2.71 ± 0.07 dex, [Na/Fe]NLTE = +1.00 ± 0.05 dex). Additionally, we provide new pieces of evidence for its chemical characterisation. The 12C13C isotopic ratio (15 ± 2) shows that this star has not yet undergone the extra-mixing episode usually associated with the red giant branch bump. Therefore, we can rule out the scenario of efficient deep extra mixing during the red giant branch phase envisaged to explain the high Li and Na abundances. Also, the star exhibits high abundances of both C and N ([C/Fe] = +0.45 ± 0.16 dex and [N/Fe] = +0.99 ± 0.20 dex), which is not compatible with the typical C-N anti-correlation observed in globular cluster stars. We found evidence of a radial velocity variability in #25664, suggesting that the star could be part of a binary system, likely having accreted material from a more massive companion when the latter was evolving in the asymptotic giant branch (AGB) phase. Viable candidates for the donor star are AGB stars with 3-4 M⊙ and super-AGB stars (~7-8 M⊙), both of which are able to produce Li- and Na-rich material. Alternatively, the star could have formed from the pure ejecta of a super-AGB star before the dilution with primordial gas occurred