1,098 research outputs found
Free-Boundary Dynamics in Elasto-plastic Amorphous Solids: The Circular Hole Problem
We develop an athermal shear-transformation-zone (STZ) theory of plastic
deformation in spatially inhomogeneous, amorphous solids. Our ultimate goal is
to describe the dynamics of the boundaries of voids or cracks in such systems
when they are subjected to remote, time-dependent tractions. The theory is
illustrated here for the case of a circular hole in an infinite two-dimensional
plate, a highly symmetric situation that allows us to solve much of the problem
analytically. In spite of its special symmetry, this example contains many
general features of systems in which stress is concentrated near free
boundaries and deforms them irreversibly. We depart from conventional
treatments of such problems in two ways. First, the STZ analysis allows us to
keep track of spatially heterogeneous, internal state variables such as the
effective disorder temperature, which determines plastic response to subsequent
loading. Second, we subject the system to stress pulses of finite duration, and
therefore are able to observe elasto-plastic response during both loading and
unloading. We compute the final deformations and residual stresses produced by
these stress pulses. Looking toward more general applications of these results,
we examine the possibility of constructing a boundary-layer theory that might
be useful in less symmetric situations.Comment: 30 pages (preprint format), 9 figure
Marine alien species in Italy: A contribution to the implementation of descriptor D2 of the Marine Strategy Framework Directive
A re-examination of marine alien species or Non Indigenous Species (NIS) reported in Italian Seas, until December 2018, is provided, focusing on establishment success, year of first record, origin, potential invasiveness, and likely pathways, in particular. Furthermore, their distribution is assessed according to the marine subregions outlined by the European Union (EU) Marine Strategy Framework Directive: Adriatic Sea (ADRIA), Ionian Sea and Central Mediterranean Sea (CMED), and Western Mediterranean Sea (WMED). In Italy, 265 NIS have been detected with the highest number of species being recorded in the CMED (154 species) and the WMED (151 species) subregions, followed by the ADRIA (143) subregion. Most of these species were recorded in more than one subregion. One hundred and eighty (180 or 68%) NIS have established stable populations in Italian Seas among which 26 have exhibited invasive traits. As regards the taxa involved, Macrophyta rank first with 65 taxa. Fifty-five of them are established in at least one subregion, mostly in the ADRIA and the CMED. Crustacea rank second with 48 taxa, followed by Polychaeta with 43 taxa, Mollusca with 29 taxa, and Fishes with 28 taxa, which were mainly reported from the CMED. In the period 2012-2017, 44 new alien species were recorded, resulting in approximately one new entry every two months. Approximately half of the NIS (~52%) recorded in Italy have most likely arrived through the transport-stowaway pathway related to shipping traffic (~28% as biofoulers, ~22% in ballast waters, and ~2% as hitchhikers). The second most common pathway is the unaided movement with currents (~19%), followed by the transport-contaminant on farmed shellfishes pathway (~18%). "Unaided" is the most common pathway for alien Fishes, especially in the CMED; escapes from confinement account for ~3% and release in nature for ~2%. The present NIS distribution hotspots for new introductions were defined at the first recipient area/location in Italy. In the ADRIA, the hotspot, Venice, accounts for the highest number of alien taxa introduced in Italy, with 50 newly recorded taxa. In the CMED subregion, the hotspots of introduction are the Taranto and Catania Gulfs, hosting 21 first records each. The Strait of Sicily represents a crossroad between alien taxa from the Atlantic Ocean and the Indo-Pacific area. In the WMED, bioinvasion hotspots include the Gulfs of Naples, Genoa and Livorno. This review can serve as an updated baseline for future coordination and harmonization of monitoring initiatives under international, EU and regional policies, for the compilation of new data from established monitoring programs, and for rapid assessment surveys
Phase-field modeling of microstructural pattern formation during directional solidification of peritectic alloys without morphological instability
During the directional solidification of peritectic alloys, two stable solid
phases (parent and peritectic) grow competitively into a metastable liquid
phase of larger impurity content than either solid phase. When the parent or
both solid phases are morphologically unstable, i.e., for a small temperature
gradient/growth rate ratio (), one solid phase usually outgrows and
covers the other phase, leading to a cellular-dendritic array structure closely
analogous to the one formed during monophase solidification of a dilute binary
alloy. In contrast, when is large enough for both phases to be
morphologically stable, the formation of the microstructurebecomes controlled
by a subtle interplay between the nucleation and growth of the two solid
phases. The structures that have been observed in this regime (in small samples
where convection effect are suppressed) include alternate layers (bands) of the
parent and peritectic phases perpendicular to the growth direction, which are
formed by alternate nucleation and lateral spreading of one phase onto the
other as proposed in a recent model [R. Trivedi, Metall. Mater. Trans. A 26, 1
(1995)], as well as partially filled bands (islands), where the peritectic
phase does not fully cover the parent phase which grows continuously. We
develop a phase-field model of peritectic solidification that incorporates
nucleation processes in order to explore the formation of these structures.
Simulations of this model shed light on the morphology transition from islands
to bands, the dynamics of spreading of the peritectic phase on the parent phase
following nucleation, which turns out to be characterized by a remarkably
constant acceleration, and the types of growth morphology that one might expect
to observe in large samples under purely diffusive growth conditions.Comment: Final version, minor revisions, 16 pages, 14 EPS figures, RevTe
Atlanto-axial rotatory fixation in a girl with Spondylocarpotarsal synostosis syndrome
We report a 15-year-old girl who presented with spinal malsegmentation, associated with other skeletal anomalies. The spinal malsegmentation was subsequently discovered to be part of the spondylocarpotarsal synostosis syndrome. In addition, a distinctive craniocervical malformation was identified, which included atlanto-axial rotatory fixation. The clinical and the radiographic findings are described, and we emphasise the importance of computerised tomography to characterize the craniocervical malformation complex. To the best of our knowledge, this is the first clinical report of a child with spondylocarpotarsal synostosis associated with atlanto-axial rotatory fixation
Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma.
Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures and cell lines. This adaptive transcriptional upregulation is blocked by neoplasia-specific CpG island methylation in either gene, causing arginine auxotrophy and cell death. In cells with methylated ASS1 or ASL CpG islands, ADI-PEG20 initially induces a protective autophagic response, but abrogation of this by chloroquine accelerates and potentiates cytotoxicity. Concomitant methylation in the CpG islands of both ASS1 and ASL, observed in a subset of cases, confers hypersensitivity to ADI-PEG20. Cancer stem cells positive for CD133 and methylation in the ASL CpG island retain sensitivity to ADI-PEG20. Our results show for the first time that epigenetic changes occur in both of the two key genes of arginine biosynthesis in human cancer and confer sensitivity to therapeutic arginine deprivation. We demonstrate that methylation status of the CpG islands, rather than expression levels per se of the genes, predicts sensitivity to arginine deprivation. Our results suggest a novel therapeutic strategy for this invariably fatal central nervous system neoplasm for which we have identified robust biomarkers and which overcomes the limitations to conventional chemotherapy imposed by the blood/brain barrier
Eutectic colony formation: A phase field study
Eutectic two-phase cells, also known as eutectic colonies, are commonly
observed during the solidification of ternary alloys when the composition is
close to a binary eutectic valley. In analogy with the solidification cells
formed in dilute binary alloys, colony formation is triggered by a
morphological instability of a macroscopically planar eutectic solidification
front due to the rejection by both solid phases of a ternary impurity that
diffuses in the liquid. Here we develop a phase-field model of a binary
eutectic with a dilute ternary impurity and we investigate by dynamical
simulations both the initial linear regime of this instability, and the
subsequent highly nonlinear evolution of the interface that leads to fully
developed two-phase cells with a spacing much larger than the lamellar spacing.
We find a good overall agreement with our recent linear stability analysis [M.
Plapp and A. Karma, Phys. Rev. E 60, 6865 (1999)], which predicts a
destabilization of the front by long-wavelength modes that may be stationary or
oscillatory. A fine comparison, however, reveals that the assumption commonly
attributed to Cahn that lamella grow perpendicular to the envelope of the
solidification front is weakly violated in the phase-field simulations. We show
that, even though weak, this violation has an important quantitative effect on
the stability properties of the eutectic front. We also investigate the
dynamics of fully developed colonies and find that the large-scale envelope of
the composite eutectic front does not converge to a steady state, but exhibits
cell elimination and tip-splitting events up to the largest times simulated.Comment: 18 pages, 18 EPS figures, RevTeX twocolumn, submitted to Phys. Rev.
Spectral imaging of the Central Molecular Zone in multiple 3-mm molecular lines
We have mapped 20 molecular lines in the Central Molecular Zone (CMZ) around
the Galactic Centre, emitting from 85.3 to 93.3 GHz. This work used the 22-m
Mopra radio telescope in Australia, equipped with the 8-GHz bandwidth UNSW-MOPS
digital filter bank, obtaining \sim 2 km/s spectral and \sim 40 arcsec spatial
resolution. The lines measured include emission from the c-C3H2, CH3CCH, HOCO+,
SO, H13CN, H13CO+, SO, H13NC, C2H, HNCO, HCN, HCO+, HNC, HC3N, 13CS and N2H+
molecules. The area covered is Galactic longitude -0.7 to 1.8 deg. and latitude
-0.3 to 0.2 deg., including the bright dust cores around Sgr A, Sgr B2, Sgr C
and G1.6-0.025. We present images from this study and conduct a principal
component analysis on the integrated emission from the brightest 8 lines. This
is dominated by the first component, showing that the large-scale distribution
of all molecules are very similar. We examine the line ratios and optical
depths in selected apertures around the bright dust cores, as well as for the
complete mapped region of the CMZ. We highlight the behaviour of the bright
HCN, HNC and HCO+ line emission, together with that from the 13C isotopologues
of these species, and compare the behaviour with that found in extra-galactic
sources where the emission is unresolved spatially. We also find that the
isotopologue line ratios (e.g. HCO+/H13CO+) rise significantly with increasing
red-shifted velocity in some locations. Line luminosities are also calculated
and compared to that of CO, as well as to line luminosities determined for
external galaxies.Comment: 27 pages, 15 figures, 12 tables, accepted by MNRA
Spectral imaging of the central molecular zone in multiple 7-mm molecular lines
We have imaged 24 spectral lines in the central molecular zone (CMZ) around the Galactic Centre, in the range 42–50 GHz. The lines include emission from the CS, CH3OH, HC3N, SiO, HNCO, HOCO+, NH2CHO, OCS, HCS+, CCS, C34S, 13CS, 29SiO, H13CCCN, HCC13CN and HC5N molecules, and three hydrogen recombination lines. The area covered is Galactic longitude −0.7 to 1.8and latitude −0.3 to 0.2, including the bright cores around Sgr A, Sgr B2, Sgr C and G1.6-0.025. This work used the 22-m Mopra radio telescope in Australia, obtaining ~1.8 km s−1 spectral and ~ 65 arcsec spatial resolutions. We present peak images from this study and conduct a principal component analysis on the integrated emission from the brightest 10 lines, to study similarities and differences in the line distribution. We examine the integrated line intensities and line ratios in selected apertures around the bright cores, as well as for the complete mapped region of the CMZ. We compare these 7-mm lines to the corresponding lines in the 3-mm band, for five molecules, to study the excitation. There is a variation in 3 to 7-mm line ratio across the CMZ, with relatively higher ratio in the centre around Sgr B2 and Sgr A. We find that the lines are sub-thermally excited, and from modelling with RADEX find that non-Local Thermodynamic Equilibrium conditions apply, with densities of the order of 104 cm−3
Electron induced chemistry: a new frontier in astrochemistry
The commissioning of the ALMA array and the next generation of space telescopes heralds the dawn of a new age of Astronomy, in which the role of chemistry in the interstellar medium and in star and planet formation may be quantified. A vital part of these studies will be to determine the molecular complexity in these seemingly hostile regions and explore how molecules are synthesised and survive. The current hypothesis is that many of these species are formed within the ice mantles on interstellar dust grains with irradiation by UV light or cosmic rays stimulating chemical reactions. However, such irradiation releases many secondary electrons which may themselves induce chemistry. In this article we discuss the potential role of such electron induced chemistry and demonstrate, through some simple experiments, the rich molecular synthesis that this may lead to
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