Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness.

Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS). Here, we aimed to analyze single nucleotide polymorphisms (SNPs) in the untranslated regions of the EGLN1 and HIF-1AN genes and SNPs chosen from a genome-wide adaptation study of the Han Chinese population. To assess the association between EGLN1 and HIF-1AN SNPs and AMS in a Han Chinese population, a case-control study was performed including 190 patients and 190 controls. In total, thirteen SNPs were genotyped using the MassARRAY® MALDI-TOF system. Multiple genetic models were tested; The Akaike's information criterion (AIC) and Bayesian information criterion (BIC) values indicated that the dominant model may serve as the best-fit model for rs12406290 and rs2153364 of significant difference. However, these data were not significant after Bonferroni correction. No significant association was noted between AMS and rs12757362, rs1339894, rs1361384, rs2009873, rs2739513 or rs2486729 before and after Bonferroni correction. Further haplotype analyses indicated the presence of two blocks in EGLN1; one block consists of rs12406290-rs2153364, located upstream of the EGLN1 gene. Carriers of the "GG" haplotype of rs12406290-rs2153364 exhibited an increased risk of AMS after adjustments for age and smoking status. However, no significant association was observed among HIF-1AN 3'-untranslated region (3'-UTR) polymorphisms, haplotype and AMS. Our study indicates that variants in the EGLN1 5'-UTR influence the susceptibility to AMS in a Han Chinese population

Efficient diode-pumped Er:YAP master-oscillator power-amplifier system for laser power improvement at 2920 nm

We report on the first demonstration of laser-diode-pumped master-oscillator power-amplifier (MOPA) system based on Er-doped bulk material working at 2920 nm. The relaxation oscillation at the beginning of the laser pulse from the Er:YAlO3 (YAP) oscillator was suppressed effectively when the pump frequency was increased to 140 Hz, as a result of the establishment of a three-level system. In the amplifier, the small signal gain of the Er:YAP strongly depends on pump duration and repetition frequency, and can reach the upper limit of parasitic oscillation. Further, 25.5 mJ of output pulse energy has been achieved from the amplifier at 150 Hz frequency (2.2 ms pump duration), with over 32% of optical-to-optical efficiency. Further improvement of the amplification ability of the MOPA system was discussed

The effect of base column on vortex-induced vibration of a circular cylinder with low aspect ratio

The end condition of a cylinder is known to influence its vortex-induced vibration (VIV) response. The design of a short circular cylinder with a concentric base column attached to its bottom is adopted by some floating structures for improved stability, but how the base column would affect the VIV of the cylinder has been rarely studied. In this paper, the VIV of an elastically mounted rigid cylinder with a base column and a low aspect ratio of 2 is investigated numerically by solving the Navier-Stokes equations. The numerical methods are validated against two existing VIV studies, including a 2D cylinder and a cylinder with a finite length. The impacts of the base column on the cylinder are analysed. It is found that although the free end effects associated with fluid flowing around the cylinder end are still present, attaching the base column leads to the expansion of the lock-in regime of the cylinder response. A relationship between non-dimensional response amplitude and lift coefficient is established, which takes into consideration the geometrical properties of the base column. By analysing the energy transfer from fluid to structure, the base column is also found to have significant damping effects on the cylinder response

Electro-optically Q-switched operation of a high-peak-power Tb:LiYF4 green laser

We report on an electro-optically Q-switched Tb:LiYF4 green laser pumped by a frequency-doubled optically pumped semiconductor blue laser. The electro-optically Q-switched characteristics were studied under a wide range of repetition rates from 200 Hz to 50 kHz using a KD2PO4 Q-switch. Up to 198 µJ of pulse energy was obtained with a pulse width of 248 ns at a repetition rate of 200 Hz, corresponding to a peak power of 797 W at 544 nm

The dynamic response of floating offshore wind turbine platform in wave-current condition

In this paper, the fluid–structure interaction of floating offshore wind turbine (FOWT) platforms under complex ocean conditions is investigated using OpenFOAM and in-house developed models. Two types of FOWT platform, i.e., a semi-submersible platform and a barge platform, are studied for their dynamic responses to either wave or current. The results reveal that a semi-submersible platform exhibits larger cross-flow motion and lock-in phenomenon, while a barge platform experiences smaller motion with no significant lock-in within the velocity range examined. The combined wave–current conditions are further studied for the semi-submersible platform, with different angles between wave and current, the current speeds, and wave parameters. Unlike other investigations focusing on colinear wave–current interaction, in which the waves usually mitigate vortex-induced motion (VIM); here, we find that waves might lead to an enhanced VIM with a large angle between current and wave. The evaluation on the interaction effect factor shows that the largest wave height in the lock-in region does not lead to the most dangerous scenario, herein, the largest platform motion. Instead, a smaller wave height with a large wave period can induce even larger motion

High-efficiency, continuous-wave Fe:ZnSe mid-IR laser end pumped by an Er:YAP laser

Fe:ZnSe lasers operating in the mid-IR spectral region have gained widespread attention due to their numerous potential applications. This study presents a high-efficiency, continuous-wave Fe:ZnSe laser end pumped by an Er:YAP laser at 2920 nm. The Er:YAP laser was home-constructed and generated an output power of 3.6 W and an average slope efficiency of 36.6% with a good beam quality (M2 ≤ 2). The Fe:ZnSe laser produced a maximum output power of 1 W at 4.06 µm for 2.1 W of absorbed pump power, corresponding to an average slope efficiency of 48%. Theoretical modeling of the continuous-wave Fe:ZnSe laser is presented to determine the prospects for further power scaling

Methods for conducting international Delphi surveys to optimise global participation in core outcome set development: a case study in gastric cancer informed by a comprehensive literature review

Copyright © 2021, The Author(s) Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Background: Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly used to facilitate global participation; however, this has limitations. It is common for these surveys to be conducted in a single language potentially excluding those not fluent in that tongue. The aim of this study is to summarise current approaches for optimising international participation in Delphi studies and make recommendations for future practice. Methods: A comprehensive literature review of current approaches to translating Delphi surveys for COS development was undertaken. A standardised methodology adapted from international guidance derived from 12 major sets of translation guidelines in the field of outcome reporting was developed. As a case study, this was applied to a COS project for surgical trials in gastric cancer to translate a Delphi survey into 7 target languages from regions active in gastric cancer research. Results: Three hundred thirty-two abstracts were screened and four studies addressing COS development in rheumatoid and osteoarthritis, vascular malformations and polypharmacy were eligible for inclusion. There was wide variation in methodological approaches to translation, including the number of forward translations, the inclusion of back translation, the employment of cognitive debriefing and how discrepancies and disagreements were handled. Important considerations were identified during the development of the gastric cancer survey including establishing translation groups, timelines, understanding financial implications, strategies to maximise recruitment and regulatory approvals. The methodological approach to translating the Delphi surveys was easily reproducible by local collaborators and resulted in an additional 637 participants to the 315 recruited to complete the source language survey. Ninety-nine per cent of patients and 97% of healthcare professionals from non-English-speaking regions used translated surveys. Conclusion: Consideration of the issues described will improve planning by other COS developers and can be used to widen international participation from both patients and healthcare professionals.This study is funded by the National Institute for Health Research (NIHR) Doctoral Research Fellowship Grant (DRF-2015-08-023). JMB is partially funded by the NIHR Bristol Biomedical Research Centre and the MRC ConDUCT-II Hub for Trials Methodology Research. PRW was funded by the MRC North West Hub for Trials Methodology Research (Grant ref: MR/K025635/01).info:eu-repo/semantics/publishedVersio

Rapid biotic rebound during the late Griesbachian indicates heterogeneous recovery patterns after the Permian-Triassic mass extinction

New fossil data from two Early Triassic (Griesbachian to Dienerian) sections from South China show unusually high levels of both benthic and nektonic taxonomic richness occurring in the late Griesbachian. In total, 68 species (including 26 newly originated species) representing mollusks, brachiopods, foraminifers, conodonts, ostracods, and echinoderms occur in the late Griesbachian, indicating well-established and relatively complex marine communities. Furthermore, the nekton shows higher origination rates than the benthos. Analyses of the sedimentary facies and size distribution of pyrite framboids show that this high-diversity interval is associated with well-oxygenated environments. In contrast to the previously suggested scenario, which inferred that persistently harsh environmental conditions impeded the biotic recovery during the Early Triassic, our new findings, combined with recent work, indicate a fitful regional recovery pattern after the Permian-Triassic crisis, resulting in three main diversity highs: late Griesbachian–early Dienerian, early–middle Smithian, and Spathian. The transient rebound episodes were therefore influenced by both extrinsic local (e.g., redox condition, temperature) and intrinsic (e.g., biological tolerances, origination rates) parameters

Cryogenically cooled 2.8 μm Er:YAP laser with watt-level output power

We report the first watt-level, cryogenically cooled Er:YAP laser operating in the 3 μm spectral region. The spectroscopic properties of a 5 at% Er:YAP crystal were studied at cooling temperatures ranging from 77–290 K. The fluorescence lifetime of the 4I11/2 level associated with the 3 μm laser transition decreased with an increase in temperature; whereas, the lifetime of the 4I13/2 level increased with an increase in temperature. Moreover, over 1 W of output power at 2798 nm was achieved from the liquid-nitrogen-cooled Er:YAP laser with a slope efficiency of 20%, and the limitations to higher output power were discussed