1,367 research outputs found
Fast minimum variance wavefront reconstruction for extremely large telescopes
We present a new algorithm, FRiM (FRactal Iterative Method), aiming at the
reconstruction of the optical wavefront from measurements provided by a
wavefront sensor. As our application is adaptive optics on extremely large
telescopes, our algorithm was designed with speed and best quality in mind. The
latter is achieved thanks to a regularization which enforces prior statistics.
To solve the regularized problem, we use the conjugate gradient method which
takes advantage of the sparsity of the wavefront sensor model matrix and avoids
the storage and inversion of a huge matrix. The prior covariance matrix is
however non-sparse and we derive a fractal approximation to the Karhunen-Loeve
basis thanks to which the regularization by Kolmogorov statistics can be
computed in O(N) operations, N being the number of phase samples to estimate.
Finally, we propose an effective preconditioning which also scales as O(N) and
yields the solution in 5-10 conjugate gradient iterations for any N. The
resulting algorithm is therefore O(N). As an example, for a 128 x 128
Shack-Hartmann wavefront sensor, FRiM appears to be more than 100 times faster
than the classical vector-matrix multiplication method.Comment: to appear in the Journal of the Optical Society of America
A self-calibration approach for optical long baseline interferometry imaging
Current optical interferometers are affected by unknown turbulent phases on
each telescope. In the field of radio-interferometry, the self-calibration
technique is a powerful tool to process interferometric data with missing phase
information. This paper intends to revisit the application of self-calibration
to Optical Long Baseline Interferometry (OLBI). We cast rigorously the OLBI
data processing problem into the self-calibration framework and demonstrate the
efficiency of the method on real astronomical OLBI dataset
Cardiovascular risk profile and frailty in a population-based study of older British men.
BACKGROUND: Frailty in older age is known to be associated with cardiovascular disease (CVD) risk. However, the extent to which frailty is associated with the CVD risk profile has been little studied. Our aim was to examine the associations of a range of cardiovascular risk factors with frailty and to assess whether these are independent of established CVD.
METHODS: Cross-sectional study of a socially representative sample of 1622 surviving men aged 71-92 examined in 2010-2012 across 24 British towns, from a prospective study initiated in 1978-1980. Frailty was defined using the Fried phenotype, including weight loss, grip strength, exhaustion, slowness and low physical activity.
RESULTS: Among 1622 men, 303 (19%) were frail and 876 (54%) were pre-frail. Compared with non-frail, those with frailty had a higher odds of obesity (OR 2.03, 95% CI 1.38 to 2.99), high waist circumference (OR 2.30, 95% CI 1.67 to 3.17), low high-density lipoprotein-cholesterol (HDL-C) (OR 2.28, 95% CI 1.47 to 3.54) and hypertension (OR 1.79, 95% CI 1.27 to 2.54). Prevalence of these factors was also higher in those with frailty (prevalence in frail vs non-frail groups was 46% vs 31% for high waist circumference, 20% vs 11% for low HDL and 78% vs 65% for hypertension). Frail individuals had a worse cardiovascular risk profile with an increased risk of high heart rate, poor lung function (forced expiratory volume in 1 s (FEV1)), raised white cell count (WCC), poor renal function (low estimated glomerular filtration rate), low alanine transaminase and low serum sodium. Some risk factors (HDL-C, hypertension, WCC, FEV1, renal function and albumin) were also associated with being pre-frail. These associations remained when men with prevalent CVD were excluded.
CONCLUSIONS: Frailty was associated with increased risk of a range of cardiovascular factors (including obesity, HDL-C, hypertension, heart rate, lung function, renal function) in older people; these associations were independent of established CVD
Off the Beaten Path: Let's Replace Term-Based Retrieval with k-NN Search
Retrieval pipelines commonly rely on a term-based search to obtain candidate
records, which are subsequently re-ranked. Some candidates are missed by this
approach, e.g., due to a vocabulary mismatch. We address this issue by
replacing the term-based search with a generic k-NN retrieval algorithm, where
a similarity function can take into account subtle term associations. While an
exact brute-force k-NN search using this similarity function is slow, we
demonstrate that an approximate algorithm can be nearly two orders of magnitude
faster at the expense of only a small loss in accuracy. A retrieval pipeline
using an approximate k-NN search can be more effective and efficient than the
term-based pipeline. This opens up new possibilities for designing effective
retrieval pipelines. Our software (including data-generating code) and
derivative data based on the Stack Overflow collection is available online
Parallelized Hybrid Monte Carlo Simulation of Stress-Induced Texture Evolution
A parallelized hybrid Monte Carlo (HMC) methodology is devised to quantify
the microstructural evolution of polycrystalline material under elastic
loading. The approach combines a time explicit material point method (MPM) for
the mechanical stresses with a calibrated Monte Carlo (cMC) model for grain
boundary kinetics. The computed elastic stress generates an additional driving
force for grain boundary migration. The paradigm is developed, tested, and
subsequently used to quantify the effect of elastic stress on the evolution of
texture in nickel polycrystals. As expected, elastic loading favors grains
which appear softer with respect to the loading direction. The rate of texture
evolution is also quantified, and an internal variable rate equation is
constructed which predicts the time evolution of the distribution of
orientations.Comment: 20 pages, 8 figure
Modeling of pulsed laser guide stars for the Thirty Meter Telescope project
The Thirty Meter Telescope (TMT) has been designed to include an adaptive
optics system and associated laser guide star (LGS) facility to correct for the
image distortion due to Earth's atmospheric turbulence and achieve
diffraction-limited imaging. We have calculated the response of mesospheric
sodium atoms to a pulsed laser that has been proposed for use in the LGS
facility, including modeling of the atomic physics, the light-atom
interactions, and the effect of the geomagnetic field and atomic collisions.
This particular pulsed laser format is shown to provide comparable photon
return to a continuous-wave (cw) laser of the same average power; both the cw
and pulsed lasers have the potential to satisfy the TMT design requirements for
photon return flux.Comment: 16 pages, 20 figure
Maternal Malaria and Gravidity Interact to Modify Infant Susceptibility to Malaria
BACKGROUND: In endemic areas, placental malaria due to Plasmodium falciparum is most frequent and severe in first-time mothers, and increases the risk of infant mortality in their offspring. Placental malaria may increase the susceptibility of infants to malaria parasitemia, but evidence for this effect is inconclusive. METHODS AND FINDINGS: During 2002–2004, we monitored parasitemia in 453 infants, including 69 who were born to mothers with placental malaria, in a region of northeastern Tanzania where malaria transmission is intense. We used a Cox proportional hazards model to evaluate the time from birth to first parasitemia, and a generalized estimating equations logistic regression model to evaluate risk of any parasitemia throughout the first year of life. Compared with infants whose mothers did not have placental malaria at delivery (“PM-negative”), offspring of mothers with placental malaria at delivery (“PM-positive”) were 41% more likely to experience their first parasitemia at a younger age (adjusted hazard ratio [AHR] = 1.41, 95% confidence interval [CI] 1.01–1.99). The odds of parasitemia throughout infancy were strongly modified by the interaction between placental malaria and gravidity (p for interaction = 0.008, Type 3 likelihood ratio test). Offspring of PM-negative primigravidae had lower odds of parasitemia during infancy (adjusted odds ratio [AOR] = 0.67, 95% CI 0.50–0.91) than offspring of PM-negative multigravidae, and offspring of PM-positive primigravidae had the lowest odds (AOR = 0.21, 95% CI 0.09–0.47). In contrast, offspring of PM-positive multigravidae had significantly higher odds of parasitemia (AOR = 1.59, 95% CI 1.16–2.17). CONCLUSION: Although parasitemia is more frequent in primigravid than multigravid women, the converse is true in their offspring, especially in offspring of PM-positive women. While placental malaria is known to increase mortality risk for first-born infants, it surprisingly reduced their risk of parasitemia in this study. Placental malaria of multigravidae, on the other hand, is a strong risk factor for parasitemia during infancy, and therefore preventive antimalarial chemotherapy administered to multigravid women close to term may reduce the frequency of parasitemia in their offspring
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