Gigahertz-gated InGaAs/InP single-photon detector with detection efficiency exceeding 55% at 1550 nm

We report on a gated single-photon detector based on InGaAs/InP avalanche photodiodes (APDs) with a single-photon detection efficiency exceeding 55% at 1550 nm. Our detector is gated at 1 GHz and employs the self-differencing technique for gate transient suppression. It can operate nearly dead time free, except for the one clock cycle dead time intrinsic to self-differencing, and we demonstrate a count rate of 500 Mcps. We present a careful analysis of the optimal driving conditions of the APD measured with a dead time free detector characterization setup. It is found that a shortened gate width of 360 ps together with an increased driving signal amplitude and operation at higher temperatures leads to improved performance of the detector. We achieve an afterpulse probability of 7% at 50% detection efficiency with dead time free measurement and a record efficiency for InGaAs/InP APDs of 55% at an afterpulse probability of only 10.2% with a moderate dead time of 10 ns.L. C. Comandar acknowledges personal support via the EPSRC funded CDT in Photonics System Development.This is the author accepted manuscript. The final version is available via AIP at http://scitation.aip.org/content/aip/journal/jap/117/8/10.1063/1.4913527

Quantum cryptography without detector vulnerabilities using optically-seeded lasers

© 2016 Macmillan Publishers Limited. All rights reserved. Security in quantum cryptography is continuously challenged by inventive attacks targeting the real components of a cryptographic set-up, and duly restored by new countermeasures to foil them. Owing to their high sensitivity and complex design, detectors are the most frequently attacked components. It was recently shown that two-photon interference from independent light sources can be used to remove any vulnerability from detectors. This new form of detection-safe quantum key distribution (QKD), termed measurement-device-independent (MDI), has been experimentally demonstrated but with modest key rates. Here, we introduce a new pulsed laser seeding technique to obtain high-visibility interference from gain-switched lasers and thereby perform MDI-QKD with unprecedented key rates in excess of 1 megabit per second in the finite-size regime. This represents a two to six orders of magnitude improvement over existing implementations and supports the new scheme as a practical resource for secure quantum communications.L. C. Comandar acknowledges personal support via the EPSRC funded CDT in Photonic Systems Development and Toshiba Research Europe Ltd

Experimental measurement-device-independent quantum digital signatures

The development of quantum networks will be paramount towards practical and secure telecommunications. These networks will need to sign and distribute information between many parties with information-theoretic security, requiring both quantum digital signatures (QDS) and quantum key distribution (QKD). Here, we introduce and experimentally realise a quantum network architecture, where the nodes are fully connected using a minimum amount of physical links. The central node of the network can act either as a totally untrusted relay, connecting the end users via the recently-introduced measurement-device-independent (MDI)-QKD, or as a trusted recipient directly communicating with the end users via QKD. Using this network, we perform a proof-of-principle demonstration of QDS mediated by MDI-QKD. For that, we devised an efficient protocol to distil multiple signatures from the same block of data, thus reducing the statistical fluctuations in the sample and greatly enhancing the final QDS rate in the finite-size scenario.We acknowledge Ryan Amiri and Petros Wallden for their useful discussions. G.L.R. gratefully acknowledges financial support from the EPSRC CDT in Integrated Photonic and Electronic Systems and Toshiba Research Europe Ltd. M.C. acknowledges support from the Galician Regional Government (Grant No. EM2014/033, and consolidation of Research Units: AtlantTIC), the Spanish Ministry of Economy and Competitiveness (MINECO), the Fondo Europeo de Desarrollo Regional (FEDER) through Grant No. TEC2014-54898-R, and the European Commission (Project QCALL). I.V.P. and E.A. acknowledge financial support by EPSRC Grant EP/M013472/1

Molecular basis for the folding of β-helical autotransporter passenger domains

Bacterial autotransporters comprise a C-terminal β-barrel domain, which must be correctly folded and inserted into the outer membrane to facilitate translocation of the N-terminal passenger domain to the cell exterior. Once at the surface, the passenger domains of most autotransporters are folded into an elongated β-helix. In a cellular context, key molecules catalyze the assembly of the autotransporter β-barrel domain. However, how the passenger domain folds into its functional form is poorly understood. Here we use mutational analysis on the autotransporter Pet to show that the β-hairpin structure of the fifth extracellular loop of the β-barrel domain has a crucial role for passenger domain folding into a β-helix. Bioinformatics and structural analyses, and mutagenesis of a homologous autotransporter, suggest that this function is conserved among autotransporter proteins with β-helical passenger domains. We propose that the autotransporter β-barrel domain is a folding vector that nucleates folding of the passenger domain

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans

This is the final version of the article. Available from the publisher via the DOI in this record.Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative splicing are also associated with strain longevity in old and young mice, across 6 different mouse strains with varying lifespan (A/J, NOD.B10Sn-H2(b) /J, PWD.Phj, 129S1/SvlmJ, C57BL/6J and WSB/EiJ). Splicing factor expression and changes to alternative splicing were associated with strain lifespan in spleen and to a lesser extent in muscle. These changes mainly involved hnRNP splicing inhibitor transcripts with most changes more marked in spleens of young animals from long-lived strains. Changes in spleen isoform expression were suggestive of reduced cellular senescence and retained cellular proliferative capacity in long-lived strains. Changes in muscle isoform expression were consistent with reduced pro-inflammatory signalling in longer-lived strains. Two splicing regulators, HNRNPA1 and HNRNPA2B1, were also associated with parental longevity in humans, in the InCHIANTI aging study. Splicing factors may represent a driver, mediator or early marker of lifespan in mouse, as expression differences were present in the young animals of long-lived strains. Changes to alternative splicing patterns of key senescence genes in spleen and key remodelling genes in muscle suggest that correct regulation of alternative splicing may enhance lifespan in mice. Expression of some splicing factors in humans was also associated with parental longevity, suggesting that splicing regulation may also influence lifespan in humans.The authors would like to acknowledge the Wellcome Trust (grant number WT097835MF LWH, DM), and NIH-NIA grant number AG038070 to The Jackson Laboratory for providing the funding for this study

From Haloes to Galaxies. II. The Fundamental Relations in Star Formation and Quenching

Star formation and quenching are two of the most important processes in galaxy formation and evolution. We explore in the local Universe the interrelationships among key integrated galaxy properties, including stellar mass $M_*$, star formation rate (SFR), specific SFR (sSFR), molecular gas mass $M_{\rm H_2}$, star formation efficiency (SFE) of the molecular gas and molecular gas to stellar mass ratio $\mu$. We aim to identify the most fundamental scaling relations among these key galaxy properties and their interrelationships. We show the integrated $M_{\rm H_2}$-SFR, SFR-$M_*$ and $M_{\rm H_2}$-$M_*$ relation can be simply transformed from the $\mu$-sSFR, SFE-$\mu$ and SFE-sSFR relation, respectively. The transformation, in principle, can increase or decrease the scatter of each relation. Interestingly, we find the latter three relations all have significantly smaller scatter than the former three corresponding relations. We show the probability to achieve the observed small scatter by accident is extremely close to zero. This suggests that the smaller scatters of the latter three relations are driven by a more fundamental physical connection among these quantities. We then show the large scatters in the former relations are due to their systematic dependence on other galaxy properties, and on star formation and quenching process. We propose the sSFR-$\mu$-SFE relation as the Fundamental Formation Relation (FFR), which governs the star formation and quenching process, and provides a simple framework to study galaxy evolution. Other scaling relations, including integrated Kennicutt-Schmidt law, star-forming main sequence and molecular gas main sequence, can all be derived from the FFR.STFC ER

Price regulation, new entry, and information shock on pharmaceutical market in Taiwan: a nationwide data-based study from 2001 to 2004

<p>Abstract</p> <p>Background</p> <p>Using non-steroidal anti-inflammatory drugs (NSAIDs) as a case, we used Taiwan's National Health Insurance (NHI) database, to empirically explore the association between policy interventions (price regulation, new drug entry, and an information shock) and drug expenditures, utilization, and market structure between 2001 and 2004.</p> <p>Methods</p> <p>All NSAIDs prescribed in ambulatory visits in the NHI system during our study period were included and aggregated quarterly. Segmented regression analysis for interrupted time series was used to examine the associations between two price regulations, two new drug entries (cyclooxygennase-2 inhibitors) and the rofecoxib safety signal and expenditures and utilization of all NSAIDs. Herfindahl index (HHI) was applied to further examine the association between these interventions and market structure of NSAIDs.</p> <p>Results</p> <p>New entry was the only variable that was significantly correlated with changes of expenditures (positive change, p = 0.02) and market structure of the NSAIDs market in the NHI system. The correlation between price regulation (first price regulation, p = 0.62; second price regulation, p = 0.26) and information shock (p = 0.31) and drug expenditure were not statistically significant. There was no significant change in the prescribing volume of NSAIDs per rheumatoid arthritis (RA) or osteoarthritis (OA) ambulatory visit during the observational period. The market share of NSAIDs had also been largely substituted by these new drugs up to 50%, in a three-year period and resulted in a more concentrated market structure (HHI 0.17).</p> <p>Conclusions</p> <p>Our empirical study found that new drug entry was the main driving force behind escalating drug spending, especially by altering the market share.</p

From Haloes to Galaxies. III. The Gas Cycle of Local Galaxy Populations

In Dou et al. (2021), we introduced the Fundamental Formation Relation (FFR), a tight relation between specific SFR (sSFR), H2 star formation efficiency (SFEH2 ), and the ratio of H2 to stellar mass. Here we show that atomic gas H i does not follow a similar FFR as H2. The relation between SFEHI and sSFR shows significant scatter and strong systematic dependence on all of the key galaxy properties that we have explored. The dramatic difference between H i and H2 indicates that different processes (e.g., quenching by different mechanisms) may have very different effects on the H i in different galaxies and hence produce different SFEHI-sSFR relations, while the SFEH2 -sSFR relation remains unaffected. The facts that SFEH2 -sSFR relation is independent of other key galaxy properties, and that sSFR is directly related to the cosmic time and acts as the cosmic clock, make it natural and very simple to study how different galaxy populations (with different properties and undergoing different processes) evolve on the same SFEH2 -sSFR ∼ t relation. In the gas regulator model (GRM), the evolution of a galaxy on the SFEH2 -sSFR(t) relation is uniquely set by a single mass-loading parameter λnet,H2 . This simplicity allows us to accurately derive the H2 supply and removal rates of the local galaxy populations with different stellar masses, from star-forming galaxies to the galaxies in the process of being quenched. This combination of FFR and GRM, together with the stellar metallicity requirement, provide a new powerful tool to study galaxy formation and evolution.ERC STF

Unparticle Physics in Single Top Signals

We study the single production of top quarks in $e^+e^-, ep$ and $pp$ collisions in the context of unparticle physics through the Flavor Violating (FV) unparticle vertices and compute the total cross sections for single top production as functions of scale dimension d_{\U}. We find that among all, LHC is the most promising facility to probe the unparticle physics via single top quark production processes.Comment: 14 pages, 10 figure