Inteligência emocional ─ Ferramenta essencial para uma vida positiva

Este artículo presenta el papel de la inteligencia emocional y el impacto positivo que puede tener en la vida de un ser humano. A principios de la década de 1990, Salovey y Mayer (1990) publicaron un artículo que resultaría de una serie de estudios sobre la inteligencia y el papel de las emociones en el desarrollo del hombre. Sugirieron así, que había una habilidad cognitiva que hasta ahora no había sido clasificada. Esta competencia se denomina inteligencia emocional, a partir de ese momento suscita un profundo interés en muchos investigadores de todo el mundo. Goleman (1996) llama la atención al mundo para un tema ya profundizado por varios autores, haciendo hincapié en la distinta concepción de la inteligencia tradicional. Da a conocer el éxito que el papel de la inteligencia emocional y las emociones podrían tener en el desarrollo profesional, psicológico y social de cada individuo. La inteligencia emocional permite al hombre tomar conciencia de sus emociones, comprender sus sentimientos, tanto como los de los demás. Es una habilidad que poseemos para poder relacionarnos con los demás y comunicarnos de forma asertiva, que va a permitir proyectar una actitud optimista ante la vida. Relacionado con un fuerte aliado inteligencia emocional y las emociones, pueden proporcionar niveles de bienestar psicológico y físico no descubiertos hasta entonces. Participando y aplicando una psicología positiva en su vida, el hombre puede cubrir campos de estabilidad nunca antes alcanzado. La inteligencia emocional es un arte que requiere un aprendizaje simple y consciente de un valor incalculable.This paper presents the role of Emotional Intelligence and the positive impact it can have on human life. In the early 1990s, Salovey and Mayer (1990) published an article that would result from several studies on the intelligence and the role of emotions in human development. Have suggested that there was a cognitive ability that until now had not been classified. Those powers it is known as Emotional Intelligence, from that moment raises a deep interest in many researchers around the world. Goleman (1996) draws attention to the world for a theme already in detail by other authors, the distinct conception of traditional intelligence. Making known the development that the role of emotional intelligence and their emotions could have on professional success, psychological and social development of each individual. The Emotional Intelligence enables man to become aware of their emotions, understand the feelings, as much as their others. It’s a skill that we possess in order to relate to others and communicate in an assertive manner, which will allow project an optimistic attitude towards life. Linked to a strong ally emotional intelligence and emotions, can provide levels of psychological well-being and physical not covered before. Joining and applying a positive psychology in your life, man can cover fields of stability never before achieved. Emotional intelligence is an art that requires a simple learning and conscious invaluable.O presente trabalho visa apresentar o papel da Inteligência Emocional e as repercussões positivas que pode ter na vida do ser Humano. No início da década de 1990, Salovey e Mayer (1990) publicaram um artigo que resultaria de vários estudos sobre a inteligência e o papel das emoções no desenvolvimento do Homem. Sugeriram assim, que existia uma competência cognitiva que até ao momento não tinha sido classificada. Tal competência recebe a designação de Inteligência Emocional, desde esse momento suscita um profundo interesse em vários pesquisadores por todo o mundo. Goleman (1996) chama a atenção ao mundo para um tema já aprofundado por vários autores, vincando a concepção distinta da Inteligência tradicional. Dando a conhecer o sucesso que o papel da Inteligência Emocional e Emoções poderiam ter no desenvolvimento profissional, psicológico e social de cada individuo. A Inteligência Emocional permite ao ser humano tomar consciência das suas emoções, compreender os sentimentos, tanto como as dos seus demais. É a uma aptidão que possuímos, de forma a relacionar com os outros e comunicar de forma assertiva, que vai permitir projectar uma atitude optimista perante a vida. A inteligência Emocional é uma arte que pressupõe uma aprendizagem simples e consciente de valor incalculável

Combination of gemcitabine with cell-penetrating peptides: A pharmacokinetic approach using in silico tools

Gemcitabine is an anticancer drug used to treat a wide range of solid tumors and is a first line treatment for pancreatic cancer. Our group has previously developed novel conjugates of gemcitabine with cell-penetrating peptides (CPP), and here we report some preliminary data regarding the pharmacokinetics of gemcitabine, two gemcitabine-CPP conjugates and respective CPP gathered from GastroPlus™, and analyze these results considering our previous evaluation of gemcitabine release and conjugates’ bioactivity. Additionally, seeking to shed some light on the relation between the penetration ability of CPP and their physicochemical properties, chemical descriptors for the 20 natural amino acids were calculated, a new principal property scale (z-scale) was created and CPP prediction models were developed, establishing quantitative structure-activity relationships (QSAR). The z-scores of the peptides conjugated with gemcitabine are presented and analyzed with the aforementioned data.This work has been financed by Fundo Europeu de Desenvolvimento Regional (FEDER) funds through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI) and Portugal 2020, and Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT, Portugal), in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274), and through grant UID/QUI/50006/2019 (LAQV-REQUIMTE). NV also acknowledges support from FCT and FEDER (European Union), award number IF/00092/2014/CP1255/CT0004. AF thanks FCT for a doctoral fellowship (PD/BD/135120/2017)

The Use of Both Therapeutic and Prophylactic Vaccines in the Therapy of Papillomavirus Disease

Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk HPV types (i.e., HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the main etiological agents of genital tract cancers, such as cervical, vulvar, vaginal, penile, and anal cancers, and of a subset of head and neck cancers. Three prophylactic HPV vaccines are available that are bivalent (vs. HPV16, 18), tetravalent (vs. HPV6, 11, 16, 18), and non-avalent (vs. HPV6, 11, 16, 18, 31, 33,45, 52, 58). All of these vaccines are based on recombinant DNA technology, and they are prepared from the purified L1 protein that self-assembles to form the HPV type-specific empty shells (i.e., virus-like particles). These vaccines are highly immunogenic and induce specific antibodies. Therapeutic vaccines differ from prophylactic vaccines, as they are designed to generate cell-mediated immunity against transformed cells, rather than neutralizing antibodies. Among the HPV proteins, the E6 and E7 oncoproteins are considered almost ideal as targets for immunotherapy of cervical cancer, as they are essential for the onset and evolution of malignancy and are constitutively expressed in both premalignant and invasive lesions. Several strategies have been investigated for HPV therapeutic vaccines designed to enhance CD4+ and CD8+ T-cell responses, including genetic vaccines (i.e., DNA/ RNA/virus/ bacterial), and protein-based, peptide-based or dendritic-cell-based vaccines. However, no vaccine has yet been licensed for therapeutic use. Several studies have suggested that administration of prophylactic vaccines immediately after surgical treatment of CIN2 cervical lesions can be considered as an adjuvant to prevent reactivation or reinfection, and other studies have described the relevance of prophylactic vaccines in the management of genital warts. This review summarizes the leading features of therapeutic vaccines, which mainly target the early oncoproteins E6 and E7, and prophylactic vaccines, which are based on the L1 capsid protein. Through an analysis of the specific immunogenic properties of these two types of vaccines, we discuss why and how prophylactic vaccines can be effective in the treatment of HPV-related lesions and relapse

Atividade antimicrobiana de subfrações padronizadas da planta Arrabidaea chica Verl.

Este estudo analisou o potencial terapêutico de extratos e subfrações padronizadas da planta amazônica Arrabidaea chica, visando seu uso tópico como medicamento e eficácia comprovada em doenças cutâneas

Covid 19_ Pandemia sob o olhar e intervenção positiva da psicologia

The Covid19 pandemic is an unexpected reality. If, for many difficult to understand, accept and comply with the guidelines recommended by the general direction of health; for others, a monstrous reality that we could experience, and all care is little. And in this panoply of feelings, confusion and difficulty in similar to how much is said/heard; the urgency of psychology arises both clinical and social and even educational, having a look and a proposal of intervention, which is as simple as possible, lucid and with a good dose of optimism; to be able to reach everyone as soon as possible. Thus, thinking about how we behave, think and communicate, is extremely urgent to avoid, to point the finger by pointing, to say bad ly by saying; that we can realize and accept that we are ALL INTERCONNECTED. A word, a gesture, a behavior can have both assertive and positive, as negative and catastrophic (cavernously speaking can be “something beasty”, such as being an attitude, word or behavior of “beast”); the wonderful thing is that we can all DECIDE how we want to be, how we want to act, how we want to communicate! Here is our look and possible interventions as Psychologists, with whom you can ALWAYS COUNT!A pandemia Covid-19 é uma realidade inesperada. Se, para muitos difícil de compreender, aceitar e acatar as diretrizes preconizadas pela direção geral da saúde; para outros, uma realidade monstruosa que poderíamos vivenciar, e todo o cuidado é pouco. E nesta panóplia de sentimentos, confusão e dificuldade em similar o tanto que se diz/ouve; surge a urgência da psicologia quer clinica como social e até mesmo educacional, ter um olhar e uma proposta de intervenção, que se quer do mais simples possível, lucido e com uma boa dose de otimismo; para poder chegar a todos na maior brevidade possível. Assim, pensar como nos comportamos, pensamos e comunicamos, é de extrema urgência para que se evite, o apontar o dedo por apontar, o dizer mal por dizer; que possamos perceber e aceitar que estamos TODOS INTERLIGADOS. Uma palavra, um gesto, um comportamento que pode ter tanto de assertivo e positivo, como de negativo e catastrófico (cavernosamente falando pode ser “algo bestial” , como ser uma atitude, palavra ou comportamento de “besta”); o maravilhoso é que todos nós podemos DECIDIR como queremos ser, como queremos agir, como queremos comunicar! Aqui fica o nosso olhar e possíveis intervenções enquanto Psicólogos, com quem pode SEMPRE CONTAR

Cyclotron resonant scattering feature simulations. I. Thermally averaged cyclotron scattering cross sections, mean free photon-path tables, and electron momentum sampling

Electron cyclotron resonant scattering features (CRSFs) are observed as absorption-like lines in the spectra of X-ray pulsars. A significant fraction of the computing time for Monte Carlo simulations of these quantum mechanical features is spent on the calculation of the mean free path for each individual photon before scattering, since it involves a complex numerical integration over the scattering cross section and the (thermal) velocity distribution of the scattering electrons. We aim to numerically calculate interpolation tables which can be used in CRSF simulations to sample the mean free path of the scattering photon and the momentum of the scattering electron. The tables also contain all the information required for sampling the scattering electron's final spin. The tables were calculated using an adaptive Simpson integration scheme. The energy and angle grids were refined until a prescribed accuracy is reached. The tables are used by our simulation code to produce artificial CRSF spectra. The electron momenta sampled during these simulations were analyzed and justified using theoretically determined boundaries. We present a complete set of tables suited for mean free path calculations of Monte Carlo simulations of the cyclotron scattering process for conditions expected in typical X-ray pulsar accretion columns (0.01<B/B_{crit}<=0.12, where B_{crit}=4.413x10^{13} G and 3keV<=kT<15keV). The sampling of the tables is chosen such that the results have an estimated relative error of at most 1/15 for all points in the grid. The tables are available online at http://www.sternwarte.uni-erlangen.de/research/cyclo.Comment: A&A, in pres

Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus.

We examined the effect of the immunosuppressive agent, tacrolimus (FK506), on antigen-induced bronchial hyperreactivity to acetylcholine and leukocyte infiltration into the airways of ovalbumin-challenged guinea-pigs. Subcutaneous injection of 0.5 mg/kg of FK506, 1 h before and 5 h after intra-nasal antigen challenge prevented bronchial hyperreactivity to aerosolized acetylcholine, eosinophilia in bronchoalveolar lavage (BAL) fluid and bronchial tissue and the invasion of the bronchial wall by CD4+ T-lymphocytes. FK506 also suppressed ovalbumin-induced increase in the number of leukocytes adhering to the pulmonary vascular endothelium and expressing alpha4-integrins. Inhibition by FK506 of antigen-induced bronchial hyperreactivity in sensitized guinea-pigs may thus relate to its ability to prevent the emergence of important inflammatory components of airway inflammation, such as eosinophil accumulation, as well as CD4+ T-lymphocyte infiltration into the bronchial tissue

Human Papillomavirus infections in cervical samples from HIV-positive women: evaluation of the presence of the nonavalent HPV genotypes and genetic diversity

Non-nonavalent vaccine (9v) Human papillomavirus (HPV) types have been shown to have high prevalence among HIV-positive women. Here, 1444 cervical samples were tested for HPV DNA positivity. Co-infections of the 9v HPV types with other HPV types were evaluated. The HPV81 L1 and L2 genes were used to investigate the genetic variability of antigenic epitopes. HPV-positive samples were genotyped using the HPVCLART2 assay. The L1 and L2 protein sequences were analyzed using a self-optimized prediction method to predict their secondary structure. Co-occurrence probabilities of the 9v HPV types were calculated. Non9v types represented 49% of the HPV infections; 31.2% of the non9v HPV types were among the low-grade squamous intraepithelial lesion samples, and 27.3% among the high-grade squamous intraepithelial lesion samples, and several genotypes were low risk. The co-occurrence of 9v HPV types with the other genotypes was not correlated with the filogenetic distance. HPV81 showed an amino-acid substitution within the BC loop (N75Q) and the FGb loop (T315N). In the L2 protein, all of the mutations were located outside antigenic sites. The weak cross-protection of the 9v types suggests the relevance of a sustainable and effective screening program, which should be implemented by HPV DNA testing that does not include only high-risk types