Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users.

There have been several recent efforts in the UK and the Netherlands to describe the harms of psychoactive substances based on ratings of either experts or drug users. This study aimed to assess the perceived benefits as well as harms of widely used recreational drugs, both licit and illicit, in an international sample of drug users. The survey was hosted at https://www.internationaldrugsurvey.org/ and was available in three languages. Residents reported their experience of 15 commonly used drugs or drug classes; regular users then rated their harms and benefits. In all, 5791 individuals from over 40 countries completed the survey, although the majority were from English speaking countries. Rankings of drugs differed across 10 categories of perceived benefits. Skunk and herbal cannabis were ranked consistently beneficial, whilst alcohol and tobacco fell below many classified drugs. There was no correlation at all between users' harm ranking of drugs and their classification in schedules of the USA or ABC system in the UK. Prescription analgesics, alcohol and tobacco were ranked within the top 10 most harmful drugs. These findings suggest that neither the UK nor US classification systems act to inform users of the harms of psychoactive substances. It is hoped the results might inform health professionals and educators of what are considered to be both the harms and benefits of psychoactive substances to young people

The identification of markers for Geoforensic HPLC profiling at close proximity sites

Soil is a highly transferable source of trace physical material that is both persistent in the environment and varied in composition. This inherent variability can provide useful information to determine the geographical origin of a questioned sample or when comparing and excluding samples, since the composition of soil is dependent on geographical factors such as climate, bedrock geology and land use. Previous studies have limited forensic relevance due to the requirement for large sample amounts and unrealistic differences between the land use and geographical location of the sample sites. In addition the philosophical differences between the disciplines of earth sciences, for which most analytical techniques have been designed, and forensic sciences, particularly with regard to sample preparation and data interpretation have not been fully considered. This study presents an enhanced technique for the analysis of organic components of geoforensic samples by improving the sample preparation and data analysis strategies used in previous research into the analysis of soil samples by high performance liquid chromatography (HPLC). This study provides two alternative sets of marker peaks to generate HPLC profiles which allow both easy visual comparison of samples and the correct assignment of 100% of the samples to their location of origin when discriminating between locations of interest in multivariate statistical analyses. This technique thereby offers an independent form of analysis that is complementary to inorganic geoforensic techniques and offers an easily accessible method for discriminating between close proximity forensically relevant locations

The discrimination of geoforensic trace material from close proximity locations by organic profiling using HPLC and plant wax marker analysis by GC

There is a need to develop a wider empirical research base to expand the scope for utilising the organic fraction of soil in forensic geoscience, and to demonstrate the capability of the analytical techniques used in forensic geoscience to discriminate samples at close proximity locations. The determination of wax markers from soil samples by GC analysis has been used extensively in court and is known to be effective in discriminating samples from different land use types. A new HPLC method for the analysis of the organic fraction of forensic sediment samples has also been shown recently to add value in conjunction with existing inorganic techniques for the discrimination of samples derived from close proximity locations. This study compares the ability of these two organic techniques to discriminate samples derived from close proximity locations and finds the GC technique to provide good discrimination at this scale, providing quantification of known compounds, whilst the HPLC technique offered a shorter and simpler sample preparation method and provided very good discrimination between groups of samples of different provenance in most cases. The use of both data sets together gave further improved accuracy rates in some cases, suggesting that a combined organic approach can provide added benefits in certain case scenarios and crime reconstruction contexts

Die politische Bedeutung von Hausbesetzungen im ländlichen Raum und der Stadt und die politische Herausforderung an die Soziale Arbeit

Die Arbeit untersucht die Geschichte der Hausbesetzungsbewegung in Deutschland. In einem kurzen Umriss wird diese Anhand zahlreicher Beispiele dargestellt. Die Bewegung hatte zeitweise sehr ausgeprägte Phasen. Im Verlauf sollen die Motive, die Ziele und die politische Bedeutung näher erläutert werden. Besonders herauskristallisiert hat sich der Wunsch nach Selbstbestimmung weswegen ich auf die daran geknüpften Forderungen an die Soziale Arbeit eingehe

The effects of attachment style on coping with visible skin conditions and responsiveness to a compassion based self-help intervention

No abstract available

Multi-Professional Perspectives on Adolescent and Young Adult Oncology Across Europe: An e-Delphi Survey

The aims of this article are to describe the ongoing development of adolescent and young adult (AYA) cancer services within the European Union (EU), and to develop consensus on key areas within the field. This survey used an e-Delphi design. An initial survey was distributed via email to professionals working in Europe. A snowball sampling technique was used to promote distribution. Consensus was sought over three rounds from October 2012 to April 2015. Consensus was defined as >80% agreement (“agree” or “strongly agree”). Sixty professionals participated in round 1, 106 in round 2, and 61 in round 3. Twenty-six countries were represented across all rounds. Consensus was achieved for: the need for national policy guidance, the importance of patient choice, the validity of the International Charter of Rights for Young People, and some aspects of multi-disciplinary working. There was 75% agreement on a single definition of the patient age range within AYA cancer care. European professionals with expertise in AYA cancer care reached consensus on key elements of care for this group. The optimal AYA age range remained an elusive topic on which to agree. The broad engagement and interest in AYA cancer across the EU through the European Network for Cancer in Children and Adolescents (ENCCA) network was also demonstrated

An XMM-Newton view of Planetary Nebulae in the Small Magellanic Cloud. The X-ray luminous central star of SMP SMC 22

During an X-ray survey of the Small Magellanic Cloud, carried out with the XMM-Newton satellite, we detected significant soft X-ray emission from the central star of the high-excitation planetary nebula SMP SMC 22. Its very soft spectrum is well fit with a non local thermodynamical equilibrium model atmosphere composed of H, He, C, N, and O, with abundances equal to those inferred from studies of its nebular lines. The derived effective temperature of 1.5x10^5 K is in good agreement with that found from the optical/UV data. The unabsorbed flux in the 0.1-0.5 keV range is about 3x10^{-11} erg cm^-2 s^-1, corresponding to a luminosity of 1.2x10^37 erg/s at the distance of 60 kpc. We also searched for X-ray emission from a large number of SMC planetary nebulae, confirming the previous detection of SMP SMC 25 with a luminosity of (0.2-6)x10^35 erg/s (0.1-1 keV). For the remaining objects that were not detected, we derived flux upper limits corresponding to luminosity values from several tens to hundreds times smaller than that of SMP SMC 22. The exceptionally high X-ray luminosity of SMP SMC 22 is probably due to the high mass of its central star, quickly evolving toward the white dwarf's cooling branch, and to a small intrinsic absorption in the nebula itself.Comment: Accepted for publication on Astronomy and Astrophysic

Lagrange Anchor for Bargmann-Wigner equations

A Poincare invariant Lagrange anchor is found for the non-Lagrangian relativistic wave equations of Bargmann and Wigner describing free massless fields of spin s > 1/2 in four-dimensional Minkowski space. By making use of this Lagrange anchor, we assign a symmetry to each conservation law.Comment: A contribution to Proceedings of the XXXI Workshop on the Geometric Methods in Physic