The impact of Internet on the artist reputation

[EN] This work analyzes the relationship between the digital information provided by the search engine Google on the Internet and the volume of sales or revenues in the art market in order to quantify the variable artist's reputation. In particular, the usefulness of digital media information is analyzed to interpret past sales in the art market or, conversely, to estimate future sales in the short term. Finally, we study the ability of digital information to explain the volume of activity (number of lots sold) or what is the same the degree of liquidity of the secondary market of artworks.Castelló Fos, D.; De La Poza, E.; Guadalajara, N. (2016). The impact of Internet on the artist reputation. En CARMA 2016: 1st International Conference on Advanced Research Methods in Analytics. Editorial Universitat Politècnica de València. 92-99. https://doi.org/10.4995/CARMA2016.2016.3643OCS929

Aportaciones corológicas al catálogo valenciano de especies de flora amenazada

Se aportan nuevas citas o precisiones sobre otras prece- dentes, para 24 especies vegetales incluidas en el Catálogo Valenciano de Especies de Flora Amenazada (Decreto 70/2009, DOCV de 22.05.2009), tanto para la categoría legal autonómica ¿En Peligro de Extinción¿ (EP) co- mo ¿Vulnerable¿ (VU). Los datos aportados se refieren a Achillea santoli- noides (EP), Antirrhinum valentinum (VU), Biarum dispar (VU), Campa- nula mollis (VU), Carex elata (VU), Cheirolophus lagunae (VU), Coelo- glossum viride (VU), Euphorbia nevadensis subsp. nevadensis (VU), Kos- teletzkya pentacarpa (VU), Limonium mansanetianum (VU), Lupinus ma- riae-josephae (VU), Odontites valentinus (EP), Ophioglossum lusitanicum (VU), Orchis conica (VU), O. papilionacea (EP), O. purpurea (VU), Pa- rentucellia viscosa (EP), Pinguicula vallisnerifolia (VU), Serapias lingua (VU), Silene diclinis (VU), Sternbergia colchiciflora (VU), Teucrium le- picephalum (VU), Thymus lacaitae (VU) y Utricularia australis (EP). La mayoría de nuevas citas derivan del rastreo técnico intensivo y de la cola- boración de agentes medioambientales de la Generalitat Valenciana e in- formadores voluntarios.New records of 24 plant species included in the Va- lencian Catalogue of Threatened Plant Species (Decree 70/2009, DOCV 22.05.2009), both for regional categories 'Threatened to Extinction (EP)' and 'Vulnerable (VU)' are presented. Data refer to Achillea santolinoides (EP), Antirrhinum valentinum (VU), Biarum dispar (VU), Campanula mo- llis (VU), Carex elata (VU), Cheirolophus lagunae (VU), Coeloglossum viride (VU), Euphorbia nevadensis subsp. nevadensis (VU), Kosteletzkya pentacarpa (VU), Limonium mansanetianum (VU), Lupinus mariae-jose- phae (VU), Odontites valentinus (EP), Ophioglossum lusitanicum (VU), Orchis conica (VU), O. papilionacea (EP), O. purpurea (VU), Parentu- cellia viscosa (EP), Pinguicula vallisnerifolia (VU), Serapias lingua (VU), Silene diclinis (VU), Sternbergia colchiciflora (VU), Teucrium lepice- phalum (VU), Thymus lacaitae (VU) and Utricularia australis (EP). Most of the new records come from the intensive field survey carried out by technicians and forest rangers from Generalitat Valenciana as well as vo- lunteers

A transcriptomic analysis of gene expression in the venom gland of the snake Bothrops alternatus (urutu)

<p>Abstract</p> <p>Background</p> <p>The genus <it>Bothrops </it>is widespread throughout Central and South America and is the principal cause of snakebite in these regions. Transcriptomic and proteomic studies have examined the venom composition of several species in this genus, but many others remain to be studied. In this work, we used a transcriptomic approach to examine the venom gland genes of <it>Bothrops alternatus</it>, a clinically important species found in southeastern and southern Brazil, Uruguay, northern Argentina and eastern Paraguay.</p> <p>Results</p> <p>A cDNA library of 5,350 expressed sequence tags (ESTs) was produced and assembled into 838 contigs and 4512 singletons. BLAST searches of relevant databases showed 30% hits and 70% no-hits, with toxin-related transcripts accounting for 23% and 78% of the total transcripts and hits, respectively. Gene ontology analysis identified non-toxin genes related to general metabolism, transcription and translation, processing and sorting, (polypeptide) degradation, structural functions and cell regulation. The major groups of toxin transcripts identified were metalloproteinases (81%), bradykinin-potentiating peptides/C-type natriuretic peptides (8.8%), phospholipases A₂(5.6%), serine proteinases (1.9%) and C-type lectins (1.5%). Metalloproteinases were almost exclusively type PIII proteins, with few type PII and no type PI proteins. Phospholipases A₂were essentially acidic; no basic PLA₂were detected. Minor toxin transcripts were related to L-amino acid oxidase, cysteine-rich secretory proteins, dipeptidylpeptidase IV, hyaluronidase, three-finger toxins and ohanin. Two non-toxic proteins, thioredoxin and double-specificity phosphatase Dusp6, showed high sequence identity to similar proteins from other snakes. In addition to the above features, single-nucleotide polymorphisms, microsatellites, transposable elements and inverted repeats that could contribute to toxin diversity were observed.</p> <p>Conclusions</p> <p><it>Bothrops alternatus </it>venom gland contains the major toxin classes described for other <it>Bothrops </it>venoms based on trancriptomic and proteomic studies. The predominance of type PIII metalloproteinases agrees with the well-known hemorrhagic activity of this venom, whereas the lower content of serine proteases and C-type lectins could contribute to less marked coagulopathy following envenoming by this species. The lack of basic PLA₂agrees with the lower myotoxicity of this venom compared to other <it>Bothrops </it>species with these toxins. Together, these results contribute to our understanding of the physiopathology of envenoming by this species.</p

La topología molecular en el descubrimiento de nuevas terapias

En este artículo pretendemos ofrecer una vista panorámica de la topología molecular, que es una aplicación de la teoría de grafos muy utilizada en la industria química y, sobre todo, en la farmacéutica. El objetivo de la topología molecular es la caracterización estructural de moléculas mediante unos invariantes sencillos, llamados índices topológicos. Estos índices, una vez procesados estadísticamente, tienen un papel fundamental en el descubrimiento de nuevas aplicaciones de moléculas conocidas y en el diseño de moléculas con propiedades químicas y farmacológicas específicas.Medicin

Comparative evaluation of adverse effects in the use of powder trivalent antivenom and liquid antivenoms in Bothrops snake bites

INTRODUCTION: Snake bite, a problem in public health, generally occurs where there is no electric power. METHODS: A comparative clinical study was conducted with 102 victims of Bothrops snake bite, from the state of Amazonas, Brazil; 58 victims were treated with liofilizated trivalent antivenom serum (SATL) and 44 victims treated with liquid bivalent and monovalent antivenom serum (SAMBL). RESULTS: 17% (10/58) of patients presented adverse effects with the SATL and 25% (11/44) with the SAMBL. CONCLUSIONS: There was no statistic difference in number of adverse effects between the two types of snake bite antivenom

Comparison of Bothropoides jararaca bites with and without envenoming treated at the Vital Brazil Hospital of the Butantan Institute, State of São Paulo, Brazil Comparação dos acidentes causados por Bothropoides jararaca com e sem envenenamento atendidos no Hospital Vital Brazil do Instituto Butantan, Estado de São Paulo

INTRODUCTION: This study analyses the cases of all bites (including dry bites) caused by Bothropoides jararaca attended at the Vital Brazil Hospital of the Butantan Institute, State of São Paulo, Brazil. METHODS: A retrospective study was conducted of patients bitten by Bothropoides jararaca (n=792) from January 1990 to December 2004. The characteristics of the snake specimen, data related to the accident and clinical manifestations on admission were obtained from patient medical records. RESULTS: The majority of the cases in this study were caused by female and juvenile snakes. No stomach contents were found in 93.4% of the snake specimens after dissection. No statistical difference was observed between the occurrence of dry bites and the maturity or sex of the snake. The median SVL of snakes in mild and moderate cases was 40.5cm and in severe cases, SVL increased to 99cm. Necrosis was more common in the digits of the feet and hands (4.8%) compared to the other body regions (1.8%). A significant difference was verified between severity and a time interval greater than six hours from the bite to hospital admission. A significant association was verified between gingival bleeding and abnormal blood coagulability. In accidents caused by adult snakes, necrosis was more frequent (7.2%) compared to accidents caused by juvenile snakes (1%). CONCLUSIONS: In this work, the association between certain epidemiological data and the evolution of biological parameters in the clinical course of Bothrops sensu latu accidents were highlighted, contributing to the improvement of snake bite assistance.<br>INTRODUÇÃO: Neste estudo, analisou-se todos os casos de picadas (incluindo picadas secas) causadas por Bothropoides jararaca atendidos no Hospital Vital Brazil do Instituto Butantan, São Paulo, Brasil. MÉTODOS: Estudo retrospectivo em que foram incluídos pacientes atendidos no Hospital Vital Brazil do Instituto Butantan, picados por serpentes da espécie Bothropoides jararaca (nº=792) entre 1990 a 2004. Os dados foram obtidos através de prontuários médicos. RESULTADOS: No presente estudo, a maioria dos acidentes foi causada por serpentes fêmeas e filhotes. Não havia presença de conteúdo estomacal em 93,4% das serpentes dissecadas. Não houve diferença estatística entre a ocorrência de picada seca e o sexo da serpente. O comprimento rostro cloacal das serpentes nos casos leves e moderados foram 40,5cm e nos casos severos 99cm. Necrose foi mais comum nos dedos dos pés e das mãos (4,8%) em comparação com outras regiões do corpo (1,8%). Houve diferença estatística entre a gravidade e o intervalo de tempo entre a picada e a admissão hospitalar superior a seis horas. Encontramos uma associação significativa entre gengivorragia e incoagulabilidade sanguínea. Nos acidentes causados por serpentes adultas, a necrose foi mais frequente (7,2%) quando comparado aos acidentes causados por serpentes filhotes (1%). CONCLUSÕES: Neste estudo, destaca-se a associação entre os dados epidemiológicos e biológicos em relação à evolução do quadro clínico nos acidentes botrópicos, contribuindo para a melhoria da assistência nos acidentes ofídicos