1,568 research outputs found
Agent-oriented Modeling for Collaborative Learning Environments: A Peer-to-Peer Helpdesk Case Study
In this paper, we present the analysis and modelling of Help&Learn, an agent-based peer-to-peer helpdesk system to support extra-class interactions among students and teachers. Help&Learn expands the student’s possibility of solving problems, getting involved in a cooperative learning experience that transcends the limits of classrooms. To model Help&Learn, we have used Agent-Object-Relationship Modeling Language (AORML), an UML extension for agent-oriented information systems modeling. The aim of this research is two-fold. On one hand, we aim at modeling the variety of roles and the complexity of their interactions and activities within the Help&Learn system. On the other hand, we aim at showing the expressive power and the modeling strengths of AORML
Electronic dynamic Hubbard model: exact diagonalization study
A model to describe electronic correlations in energy bands is considered.
The model is a generalization of the conventional Hubbard model that allows for
the fact that the wavefunction for two electrons occupying the same Wannier
orbital is different from the product of single electron wavefunctions. We
diagonalize the Hamiltonian exactly on a four-site cluster and study its
properties as function of band filling. The quasiparticle weight is found to
decrease and the quasiparticle effective mass to increase as the electronic
band filling increases, and spectral weight in one- and two-particle spectral
functions is transfered from low to high frequencies as the band filling
increases. Quasiparticles at the Fermi energy are found to be more 'dressed'
when the Fermi level is in the upper half of the band (hole carriers) than when
it is in the lower half of the band (electron carriers). The effective
interaction between carriers is found to be strongly dependent on band filling
becoming less repulsive as the band filling increases, and attractive near the
top of the band in certain parameter ranges. The effective interaction is most
attractive when the single hole carriers are most heavily dressed, and in the
parameter regime where the effective interaction is attractive, hole carriers
are found to 'undress', hence become more like electrons, when they pair. It is
proposed that these are generic properties of electronic energy bands in solids
that reflect a fundamental electron-hole asymmetry of condensed matter. The
relation of these results to the understanding of superconductivity in solids
is discussed.Comment: Small changes following referee's comment
Semigroup Closures of Finite Rank Symmetric Inverse Semigroups
We introduce the notion of semigroup with a tight ideal series and
investigate their closures in semitopological semigroups, particularly inverse
semigroups with continuous inversion. As a corollary we show that the symmetric
inverse semigroup of finite transformations of the rank
is algebraically closed in the class of (semi)topological inverse
semigroups with continuous inversion. We also derive related results about the
nonexistence of (partial) compactifications of classes of semigroups that we
consider.Comment: With the participation of the new coauthor - Jimmie Lawson - the
manuscript has been substantially revised and expanded. Accordingly, we have
also changed the manuscript titl
Shapes, contact angles, and line tensions of droplets on cylinders
Using an interface displacement model we calculate the shapes of
nanometer-size liquid droplets on homogeneous cylindrical surfaces. We
determine effective contact angles and line tensions, the latter defined as
excess free energies per unit length associated with the two contact lines at
the ends of the droplet. The dependences of these quantities on the cylinder
radius and on the volume of the droplets are analyzed.Comment: 26 pages, RevTeX, 10 Figure
Low-intensity resistance exercise does not affect cardiac autonomic modulation in patients with peripheral artery disease
OBJECTIVE: To analyze the effect of a single bout of resistance exercise on cardiac autonomic modulation in patients with peripheral artery disease. METHODS: Fifteen patients with peripheral artery disease (age: 58.3±4.0 years) underwent the following sessions in a random order: resistance exercise (three sets of 10 repetitions of the six resistance exercises with a workload of 5-7 in the OMNI-RES scale) and control (similar to the resistance session; however, the resistance exercises were performed with no load). The frequency domain (low frequency, high frequency and sympathovagal balance) and symbolic analysis (0V, 1V and 2V patterns) of heart rate variability were obtained before and until one hour after the interventions. RESULTS: After the resistance exercise and control sessions, similar increases were observed in the consecutive heartbeat intervals (control: 720.8±28.6 vs. 790.9±34.4 ms; resistance exercise: 712.9±30.1 vs. 756.8±37.9 ms;
Intersubband spin-density excitations in quantum wells with Rashba spin splitting
In inversion-asymmetric semiconductors, spin-orbit coupling induces a
k-dependent spin splitting of valence and conduction bands, which is a
well-known cause for spin decoherence in bulk and heterostructures.
Manipulating nonequilibrium spin coherence in device applications thus requires
understanding how valence and conduction band spin splitting affects carrier
spin dynamics. This paper studies the relevance of this decoherence mechanism
for collective intersubband spin-density excitations (SDEs) in quantum wells. A
density-functional formalism for the linear spin-density matrix response is
presented that describes SDEs in the conduction band of quantum wells with
subbands that may be non-parabolic and spin-split due to bulk or structural
inversion asymmetry (Rashba effect). As an example, we consider a 40 nm
GaAs/AlGaAs quantum well, including Rashba spin splitting of the conduction
subbands. We find a coupling and wavevector-dependent splitting of the
longitudinal and transverse SDEs. However, decoherence of the SDEs is not
determined by subband spin splitting, due to collective effects arising from
dynamical exchange and correlation.Comment: 10 pages, 4 figure
Neutrino Interferometry In Curved Spacetime
Gravitational lensing introduces the possibility of multiple (macroscopic)
paths from an astrophysical neutrino source to a detector. Such a multiplicity
of paths can allow for quantum mechanical interference to take place that is
qualitatively different to neutrino oscillations in flat space. After an
illustrative example clarifying some under-appreciated subtleties of the phase
calculation, we derive the form of the quantum mechanical phase for a neutrino
mass eigenstate propagating non-radially through a Schwarzschild metric. We
subsequently determine the form of the interference pattern seen at a detector.
We show that the neutrino signal from a supernova could exhibit the
interference effects we discuss were it lensed by an object in a suitable mass
range. We finally conclude, however, that -- given current neutrino detector
technology -- the probability of such lensing occurring for a
(neutrino-detectable) supernova is tiny in the immediate future.Comment: 25 pages, 1 .eps figure. Updated version -- with simplified notation
-- accepted for publication in Phys.Rev.D. Extra author adde
MutSα expression predicts a lower disease-free survival in malignant salivary gland tumors: an immunohistochemical study
Background: Appropriate DNA replication is vital to maintain cell integrity at the genomic level. Malfunction on DNA repair mechanisms can have implications related to tumor behavior. Our aim was to evaluate the expression of key complexes of the DNA mismatch-repair system MutSα (hMSH2-hMSH6) and MutSβ (hMSH2-hMSH3) in a panel comprising the most common benign and malignant salivary gland tumors (SGT), and to determine their association with disease-free survival. Material and Methods: Ten cases of normal salivary gland (NSG) and 92 of SGT (54 benign and 38 malignant) were retrieved. Immunohistochemistry was performed for hMSH2, hMSH3, hMSH6. Scanned slides were digitally analyzed based on the percentage of positive cells with nuclear staining. Cases were further classified in MutSαhigh and MutSβhigh based on hMSH2-hMSH6 and hMSH3-hMSH6 expression, respectively. Results: hMSH3 expression was lower in malignant SGT compared to NSG and benign cases. Adenoid cystic carcinoma (ACC) cases with perineural invasion presented a lower percentage of hMSH3 positive cells. hMSH6 was downregulated in both benign and malignant SGT compared to NSG. Malignant SGT cases with MutSαhigh expression had lower disease-free survival compared to MutSαlow cases. A 10.26-fold increased risk of presenting local recurrence was observed. Conclusions: Our findings suggest that a lack of hMSH3 protein function is associated with a more aggressive phenotype (malignancy and perineural invasion) and that MutSα overexpression predicts a poor clinical outcome in malignant SGT
Associations of Father and Adult Male Presence with First Pregnancy and HIV Infection: Longitudinal Evidence from Adolescent Girls and Young Women in Rural South Africa (HPTN 068)
This study, a secondary analysis of the HPTN 068 randomized control trial, aimed to quantify the association of father and male presence with HIV incidence and first pregnancy among 2533 school-going adolescent girls and young women (AGYW) in rural South Africa participating in the trial between March 2011 and April 2017. Participants’ ages ranged from 13–20 years at study enrollment and 17–25 at the post-intervention visit. HIV and pregnancy incidence rates were calculated for each level of the exposure variables using Poisson regression, adjusted for age using restricted quadratic spline variables, and, in the case of pregnancy, also adjusted for whether the household received a social grant. Our study found that AGYW whose fathers were deceased and adult males were absent from the household were most at risk for incidence of first pregnancy and HIV (pregnancy: aIRR = 1.30, Wald 95% CI 1.05, 1.61, Wald chi-square p = 0.016; HIV: aIRR = 1.27, Wald 95% CI 0.84, 1.91, Wald chi-square p = 0.263) as compared to AGYW whose biological fathers resided with them. For AGYW whose fathers were deceased, having other adult males present as household members seemed to attenuate the incidence (pregnancy: aIRR = 0.92, Wald 95% CI 0.74, 1.15, Wald chi-square p = 0.462; HIV: aIRR = 0.90, Wald 95% CI 0.58, 1.39, Wald chi-square p = 0.623) such that it was similar, and therefore not statistically significantly different, to AGYW whose fathers were present in the household
Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41
Genome-wide association studies have identified multiple renal cell carcinoma (RCC) susceptibility loci. Here, we use regional imputation and bioinformatics analysis of the 12p12.1 locus to identify the single-nucleotide polymorphism (SNP) rs7132434 as a potential functional variant. Luciferase assays demonstrate allele-specific regulatory activity and, together with data from electromobility shift assays, suggest allele-specific differences at rs7132434 for AP-1 transcription factor binding. In an analysis of The Cancer Genome Atlas data, SNPs highly correlated with rs7132434 show allele-specific differences in BHLHE41 expression (trend P value=6.3 Ă— 10(-7)). Cells overexpressing BHLHE41 produce larger mouse xenograft tumours, while RNA-seq analysis reveals that constitutively increased BHLHE41 induces expression of IL-11. We conclude that the RCC risk allele at 12p12.1 maps to rs7132434, a functional variant in an enhancer that upregulates BHLHE41 expression which, in turn, induces IL-11, a member of the IL-6 cytokine famil
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