9,420 research outputs found
Self-organization and Mechanical Properties of Active Filament Bundles
A phenomenological description for active bundles of polar filaments is
presented. The activity of the bundle results from crosslinks, that induce
relative displacements between the aligned filaments. Our generic description
is based on momentum conservation within the bundle. By specifying the internal
forces, a simple minimal model for the bundle dynamics is obtained, capturing
generic dynamic behaviors. In particular, contracted states as well as solitary
and oscillatory waves appear through dynamic instabilities. The introduction of
filament adhesion leads to self-organized persistent filament transport.
Furthermore, calculating the tension, homogeneous bundles are shown to be able
to actively contract and to perform work against external forces. Our
description is motivated by dynamic phenomena in the cytoskeleton and could
apply to stress-fibers and self-organization phenomena during cell-locomotion.Comment: 19 pages, 10 figure
District-level mineral survey using airborne hyperspectral data, Los Menucos, Argentina
The Los Menucos District, Rio Negro, Argentina, provides an excellent case history of a complex epithermal
gold system mapped and explored using a combination of field mapping and multispectral/hyperspectral remote
sensing. The district offers a host of argillic and advanced argillic alteration minerals at the surface, many of
which are difficult to identify visually. A strategy utilizing regional targeting with Landsat TM to optimize field
mapping followed by district-level survey with hyperspectral imaging (HSI) data demonstrates the value added
by high-spectral resolution aircraft data. Standardized analysis methods consisting of spatial and spectral data
reduction to a few key endmember spectra provides a consistent way to map spectrally active minerals. Minerals
identified in the Los Menucos district using the JPL Airborne Visible/Infrared Imaging Spectrometer
(AVIRIS) include hematite, goethite, kaolinite, dickite, alunite, pyrophyllite, muscovite/sericite, montmorillonite,
calcite, and zeolites. Hyperspectral maps show good correspondence with the results of field reconnaissance
verification and spectral measurements acquired using an ASD field spectrometer. Further analysis of Hyperion
(satellite-based) hyperspectral data indicates that similar mapping results can be achieved from satellite
altitudes. These examples illustrate the high potential of hyperspectral remote sensing for geologic mapping and
mineral exploration
Conceptualizing community resilience to natural hazards - the emBRACE framework
Abstract. The level of community is considered to be vital for building disaster resilience. Yet, community resilience as a scientific concept often remains vaguely defined and lacks the guiding characteristics necessary for analysing and enhancing resilience on the ground. The emBRACE framework of community resilience presented in this paper provides a heuristic analytical tool for understanding, explaining and measuring community resilience to natural hazards. It was developed in an iterative process building on existing scholarly debates, on empirical case study work in five countries and on participatory consultation with community stakeholders, where the framework was applied and ground-tested in different contexts and for different hazard types. The framework conceptualizes resilience across three core domains: resources and capacities; actions; and learning. These three domains are conceptualized as intrinsically conjoined within a whole. Community resilience is influenced by these integral elements as well as by extra-community forces, comprising disaster risk governance and thus laws, policies and responsibilities on the one hand and on the other, the general societal context, natural and human-made disturbances and system change over time. The framework is a graphically rendered heuristic, which through application can assist in guiding the assessment of community resilience in a systematic way and identifying key drivers and barriers of resilience that affect any particular hazard-exposed community
Coarse-grained model of entropic allostery
Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins
Data perspective in process choreographies : modeling and execution
Process choreographies - communication between different organizations to exchange information - is part of daily business. While the correct ordering of exchanged messages can be modeled and enacted with current choreography techniques, no approach exists to describe the data perspective for a successful process choreography. In this paper, we describe an entirely model-driven approach for BPMN, the industry standard, to include the data perspective while maintaining control flow aspects by utilizing a recent concept to enact data dependencies in internal processes. This work provides a modeling guideline with the require artifacts and their operational semantics to allow automatic choreography enactment covering data retrieval, transformation, and correlation. We show applicability of our approach by an implementation for the Camunda BPM platform, a java-based process engine, and validate it with the service interaction patterns. Keywords: Process Modeling, Data Modeling, Process Choreographies, Process Enactment, BPMN, SQ
“Learning on a chip:” Microfluidics for formal and informal science education
© 2019 Author(s). Microfluidics is a technique for the handling of small volumes of liquids on the order of picoliters to nanoliters and has impact for miniaturized biomedical science and fundamental research. Because of its multi- and interdisciplinary nature (i.e., combining the fields of biology, chemistry, physics, and engineering), microfluidics offers much potential for educational applications, both at the university level as well as primary and secondary education. Microfluidics is also an ideal "tool" to enthuse and educate members of the general public about the interdisciplinary aspects of modern sciences, including concepts of science, technology, engineering, and mathematics subjects such as (bio)engineering, chemistry, and biomedical sciences. Here, we provide an overview of approaches that have been taken to make microfluidics accessible for formal and informal learning. We also point out future avenues and desired developments. At the extreme ends, we can distinguish between projects that teach how to build microfluidic devices vs projects that make various microscopic phenomena (e.g., low Reynolds number hydrodynamics, microbiology) accessible to learners and the general public. Microfluidics also enables educators to make experiments low-cost and scalable, and thereby widely accessible. Our goal for this review is to assist academic researchers working in the field of microfluidics and lab-on-a-chip technologies as well as educators with translating research from the laboratory into the lecture hall, teaching laboratory, or public sphere
A simple self-organized swimmer driven by molecular motors
We investigate a self-organized swimmer at low Reynolds numbers. The
microscopic swimmer is composed of three spheres that are connected by two
identical active linker arms. Each linker arm contains molecular motors and
elastic elements and can oscillate spontaneously. We find that such a system
immersed in a viscous fluid can self-organize into a state of directed
swimming. The swimmer provides a simple system to study important aspects of
the swimming of micro-organisms.Comment: 6 pages, 4 figure
Fluctuation theorem and large deviation function for a solvable model of a molecular motor
We study a discrete stochastic model of a molecular motor. This discrete
model can be viewed as a \emph{minimal} ratchet model. We extend our previous
work on this model, by further investigating the constraints imposed by the
Fluctuation Theorem on the operation of a molecular motor far from equilibrium.
In this work, we show the connections between different formulations of the
Fluctuation Theorem. One formulation concerns the generating function of the
currents while another one concerns the corresponding large deviation function,
which we have calculated exactly for this model. A third formulation of FT
concerns the ratio of the probability of making one forward step to the
probability of making one backward step. The predictions of this last
formulation of the Fluctuation Theorem adapted to our model are in very good
agreement with the data of Carter and Cross [Nature, {\bf 435}, 308 (2005)] on
single molecule measurements with kinesin. Finally, we show that all the
formulations of FT can be understood from the notion of entropy production.Comment: 15 pages, 9 figure
On the monotone stability approach to BSDEs with jumps: Extensions, concrete criteria and examples
We show a concise extension of the monotone stability approach to backward
stochastic differential equations (BSDEs) that are jointly driven by a Brownian
motion and a random measure for jumps, which could be of infinite activity with
a non-deterministic and time inhomogeneous compensator. The BSDE generator
function can be non convex and needs not to satisfy global Lipschitz conditions
in the jump integrand. We contribute concrete criteria, that are easy to
verify, for results on existence and uniqueness of bounded solutions to BSDEs
with jumps, and on comparison and a-priori -bounds. Several
examples and counter examples are discussed to shed light on the scope and
applicability of different assumptions, and we provide an overview of major
applications in finance and optimal control.Comment: 28 pages. Added DOI
https://link.springer.com/chapter/10.1007%2F978-3-030-22285-7_1 for final
publication, corrected typo (missing gamma) in example 4.1
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