Improving distributed video coding side information by intelligently combining macro-blocks from multiple algorithms

The performance of distributed video coding (DVC) greatly relies on the quality of Side information (SI). This paper investigates a novel way of producing SI by intelligently combining macroblocks (MB) produced by two SI generation algorithms, namely higher-order piecewise temporal trajectory interpolation (HOPTTI) and adaptive overlapped block motion compensation (AOBMC). The two algorithms address the problem differently. HOPTTI attempts to improve the motion estimation using higher order trajectory interpolation while AOMBC addresses the blocking and overlapping problem caused by inaccurate block matching. By judiciously selecting when to incorporate AOBMC with HOPTTI, it would give a peak signal-to-noise ratio (PSNR) improvement in SI quality. Two switching mechanisms, which exploit the spatial-temporal correlation at the macro-block level, have been investigated and the RST-based intelligent mode switching (IMS) algorithm is found to produce enhanced SI quality. Experimental results show that the basic mode switching algorithm gives a PSNR improvement of up to 1.8dB in SI quality compared to using only HOPTTI. The more intelligent RST-based switching provides a further PSNR enhancement of up to 1.1dB for certain test sequences

Mineralogy, Physicochemical Characteristics and Industrial Potential of Some Residual Clay Deposits within Ekiti State, Southwestern Nigeria

Residual clay deposits overlying Precambrian Basement Complex situated at Orin, Igbara Odo, Ikere and Ado Ekiti were investigated using several analytical techniques. Field evidence supported by mineralogical and physicochemical analyses suggests that the kaolinitic clay deposits is a product of hydrothermal and in-situ weathering of aplite, and granite. Kaolinite is the predominant clay mineral of the studied clay deposits with subordinate quartz, potassium iron oxide and aluminium phosphatic minerals. There is localised occurrence of halloysite. The absence of vanadium in the EDS data of rolled into tubes kaolinite sheets of Ado Ekiti clay match up with XRF data. This result trend combined with field observation suggests that clay bodies formed from weathering of feldspar is deficient in vanadium. The study suggests that morphology of kaolinitic minerals is influenced by the kind of parent material (i.e. feldspars or micas) and degree of chemical weathering. The pH values of pore water from clay samples range from 7.14 - 9.08. The electrical conductivities (EC) of the clay/water slurries (S/L ratio) range from 0.004mS/cm – 3.02mS/cm.  The oxidation reduction potential (ORP) values range between -62.4 and – 6.8 for the solids or slurries prepared with water. The dissolved oxygen (DO) values range from 6.73ppm – 7.26ppm for solids or slurries prepared with water. The loss on ignition ranges from 2.24-13.39. The SiO2/Al2O3 molar ratio of 1.40 and 1.50 for Orin and Ikere clay bodies indicated that a 1:1 clay mineral was the dominant component. The high chemical index of alteration (CIA = 77.97~98.64) and chemical index of weathering (CIW = 97.21~99.93) values probably indicated the complete weathering of feldspars to kaolinite. The weathering index of Parker (WIP) values grouped the analysed clay samples into moderate to intense degree of weathering. This observation is confirmed by the absence of detrital feldspar in the XRD spectra peak. Factor analysis showed enrichment and depletion of major and trace elements which could be attributed to moderate to intense leaching conditions of the presumed parent material. The data shows explicit relationship between the clayeyness value (Al2O3/SiO2 ratio), the relative base loss (RBL) and the cation exchange capacity (CEC). Cluster analysis of major and trace elements showed two groups of chemical differences amongst the elements in the clays; moderate and intense degree of weathered clays. Nevertheless, the variations in the degree of weathering or leaching process have greater contribution to clay deposits differentiation. Assessment of the industrial potential of the studied clay bodies based on their physical and chemical characteristics revealed that they are suitable for the production of refractory bricks and ceramics. Suitable processing would be compulsory if they are to meet the requirements for other industrial applications, such as rubber, paper, paint, cosmetics, and fertilizer industries. Keywords: Clay; Mineralogy; Physicochemical characteristics; Weathering indices; Pore water; Multivariable analysis; Igbara Odo Ekiti; Ikere Ekiti; Ado Ekiti

Novel <i>IRF6 </i>mutations in families with Van Der Woude syndrome and popliteal pterygium syndrome from sub-Saharan Africa

Orofacial clefts (OFC) are complex genetic traits that are often classified as syndromic or nonsyndromic clefts. Currently, there are over 500 types of syndromic clefts in the Online Mendelian Inheritance in Man (OMIM) database, of which Van der Woude syndrome (VWS) is one of the most common (accounting for 2% of all OFC). Popliteal pterygium syndrome (PPS) is considered to be a more severe form of VWS. Mutations in the IRF6 gene have been reported worldwide to cause VWS and PPS. Here, we report studies of families with VWS and PPS in sub-Saharan Africa. We screened the DNA of eight families with VWS and one family with PPS from Nigeria and Ethiopia by Sanger sequencing of the most commonly affected exons in IRF6 (exons 3, 4, 7, and 9). For the VWS families, we found a novel nonsense variant in exon 4 (p.Lys66X), a novel splice-site variant in exon 4 (p.Pro126Pro), a novel missense variant in exon 4 (p.Phe230Leu), a previously reported splice-site variant in exon 7 that changes the acceptor splice site, and a known missense variant in exon 7 (p.Leu251Pro). A previously known missense variant was found in exon 4 (p.Arg84His) in the PPS family. All the mutations segregate in the families. Our data confirm the presence of IRF6-related VWS and PPS in sub-Saharan Africa and highlights the importance of screening for novel mutations in known genes when studying diverse global populations. This is important for counseling and prenatal diagnosis for high-risk families

Epigenetics and the power of art

This review presents an epigenetic view on complex factors leading to development and perception of “genius.” There is increasing evidence which indicates that artistic creativity is influenced by epigenetic processes that act both as targets and mediators of neurotransmitters as well as steroid hormones. Thus, perception and production of art appear to be closely associated with epigenetic contributions to physical and mental health

Diabetes mellitus, maternal adiposity, and insulin-dependent gestational diabetes are associated with COVID-19 in pregnancy: the INTERCOVID study

BACKGROUND: Among nonpregnant individuals, diabetes mellitus and high body mass index increase the risk of COVID-19 and its severity.OBJECTIVE: This study aimed to determine whether diabetes mellitus and high body mass index are risk factors for COVID-19 in pregnancy and whether gestational diabetes mellitus is associated with COVID-19 diagnosis.STUDY DESIGN: INTERCOVID was a multinational study conducted between March 2020 and February 2021 in 43 institutions from 18 countries, enrolling 2184 pregnant women aged >= 18 years; a total of 2071 women were included in the analyses. For each woman diagnosed with COVID-19, 2 nondiagnosed women delivering or initiating antenatal care at the same institution were also enrolled. The main exposures were preexisting diabetes mellitus, high body mass index (overweight or obesity was defined as a body mass index >= 25 kg/m(2)), and gestational diabetes mellitus in pregnancy. The main outcome was a confirmed diagnosis of COVID-19 based on a real-time polymerase chain reaction test, antigen test, antibody test, radiological pulmonary findings, or >= 2 predefined COVID-19 symptoms at any time during pregnancy or delivery. Relationships of exposures and COVID-19 diagnosis were assessed using generalized linear models with a Poisson distribution and log link function, with robust standard errors to account for model misspecification. Furthermore, we conducted sensitivity analyses: (1) restricted to those with a real-time polymerase chain reaction test or an antigen test in the last week of pregnancy, (2) restricted to those with a real-time polymerase chain reaction test or an antigen test during the entire pregnancy, (3) generating values for missing data using multiple imputation, and (4) analyses controlling for month of enrollment. In addition, among women who were diagnosed with COVID-19, we examined whether having gestational diabetes mellitus, diabetes mellitus, or high body mass index increased the risk of having symptomatic vs asymptomatic COVID-19.RESULTS: COVID-19 was associated with preexisting diabetes mellitus (risk ratio, 1.94; 95% confidence interval, 1.55-2.42), overweight or obesity (risk ratio, 1.20; 95% confidence interval, 1.06-1.37), and gestational diabetes mellitus (risk ratio, 1.21; 95% confidence interval, 0.99-1.46). The gestational diabetes mellitus association was specifically among women requiring insulin, whether they were of normal weight (risk ratio, 1.79; 95% confidence interval, 1.06-3.01) or overweight or obese (risk ratio, 1.77; 95% confidence interval, 1.28-2.45). A somewhat stronger association with COVID-19 diagnosis was observed among women with preexisting diabetes mellitus, whether they were of normal weight (risk ratio, 1.93; 95% confidence interval, 1.18-3.17) or overweight or obese (risk ratio, 2.32; 95% confidence interval, 1.82-2.97). When the sample was restricted to those with a real-time polymerase chain reaction test or an antigen test in the week before delivery or during the entire pregnancy, including missing variables using imputation or controlling for month of enrollment, the observed associations were comparable.CONCLUSION: Diabetes mellitus and overweight or obesity were risk factors for COVID-19 diagnosis in pregnancy, and insulin-dependent gestational diabetes mellitus was associated with the disease. Therefore, it is essential that women with these comorbidities are vaccinated

Hormone-diversity fit: Collective testosterone moderates the effect of diversity on group performance

Prior research has found inconsistent effects of diversity on group performance. Past moderators of the diversity-performance connection have primarily focused on psychological factors and group dynamics, however hormonal moderators related to status attainment motivation have been overlooked. Integrating the diversity, status and hormone literatures, we predicted that groups collectively high in testosterone, which is associated with heightened status drive, would perform optimally when group diversity was low. In contrast, we predicted that groups collectively low in testosterone, which should be less oriented towards status competitions and more oriented toward cooperation, would take advantage of group diversity. Analysis of 74 groups engaged in a group decision-making exercise provided support for our hypotheses. The findings suggest that diversity is beneficial for performance only if group-level testosterone is low but has a negative performance effect if group-level testosterone is high. Too much collective testosterone maximizes the pains and minimizes the gains from diversity

Global energy governance : a review and research agenda

Over the past few years, global energy governance (GEG) has emerged as a major new field of enquiry in international studies. Scholars engaged in this field seek to understand how the energy sector is governed at the global level, by whom and with what consequences. By focusing on governance, they broaden and enrich the geopolitical and hard-nosed security perspectives that have long been, and still are, the dominant perspectives through which energy is analysed. Though still a nascent field, the literature on GEG is thriving and continues to attract the attention of a growing number of researchers. This article reviews the GEG literature as it has developed over the past 10 years. Our aim is to highlight both the progress and limitations of the field, and to identify some opportunities for future research. The article proceeds as follows. First, it traces the origins of the GEG literature (section “Origins and roots of GEG research”). The subsequent sections deal with the two topics that have received the most attention in the GEG literature: Why does energy need global governance (section “The goals and rationale of global energy governance”)? And, who governs energy (section “Mapping the global energy architecture”)? We then address a third question that has received far less attention: How well or poor is energy governed (section “Evaluating global energy governance”)? In our conclusions (section “Conclusions and outlook”), we reflect on the current state of GEG, review recent trends and innovations, and identify some questions that warrant future consideration by scholars. This article is published as part of a thematic collection on global governance

The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15–39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15–39 years to define adolescents and young adults. Findings: There were 1·19 million (95% UI 1·11–1·28) incident cancer cases and 396 000 (370 000–425 000) deaths due to cancer among people aged 15–39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5–65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8–57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9–15·6] per 100 000 person-years) and middle SDI (13·6 [12·6–14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9–25·2) DALYs to the global burden of disease, of which 2·7% (1·9–3·6) came from YLDs and 97·3% (96·4–98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Funding: Bill &amp; Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute