Ewald Sums for One Dimension

We derive analytic solutions for the potential and field in a one-dimensional system of masses or charges with periodic boundary conditions, in other words Ewald sums for one dimension. We also provide a set of tools for exploring the system evolution and show that it's possible to construct an efficient algorithm for carrying out simulations. In the cosmological setting we show that two approaches for satisfying periodic boundary conditions, one overly specified and the other completely general, provide a nearly identical clustering evolution until the number of clusters becomes small, at which time the influence of any size-dependent boundary cannot be ignored. Finally we compare the results with other recent work with the hope of providing clarification over differences these issues have induced. We explain that modern formulations of physics require a well defined potential which is not available if the forces are screened directly.Comment: 2 figures added references expanded discussion of algorithm corrected figures added discussion of screened forc

On the morphology of the electron-positron annihilation emission as seen by SPI/INTEGRAL

The 511 keV positron annihilation emission remains a mysterious component of the high energy emission of our Galaxy. Its study was one of the key scientific objective of the SPI spectrometer on-board the INTEGRAL satellite. In fact, a lot of observing time has been dedicated to the Galactic disk with a particular emphasis on the central region. A crucial issue in such an analysis concerns the reduction technique used to treat this huge quantity of data, and more particularly the background modeling. Our method, after validation through a variety of tests, is based on detector pattern determination per ~6 month periods, together with a normalisation variable on a few hour timescale. The Galactic bulge is detected at a level of ~70 sigma allowing more detailed investigations. The main result is that the bulge morphology can be modelled with two axisymmetric Gaussians of 3.2 deg. and 11.8 deg. FWHM and respective fluxes of 2.5 and 5.4 x 10^-4 photons/(cm^2.s^1). We found a possible shift of the bulge centre towards negative longitude at l=-0.6 +/- 0.2 degrees. In addition to the bulge, a more extended structure is detected significantly with flux ranging from 1.7 to 2.9 x10^-3 photons/(cm^2.s^1) depending on its assumed geometry (pure disk or disk plus halo). The disk emission is also found to be symmetric within the limits of the statistical errors.Comment: This paper has 12 pages and 14 figures. Accepted for publication by the Astrophysical Journa

Rapid and MR-Independent IK1 activation by aldosterone during ischemia-reperfusion

In ST elevation myocardial infarction (STEMI) context, clinical studies have shown the deleterious effect of high aldosterone levels on ventricular arrhythmia occurrence and cardiac mortality. Previous in vitro reports showed that during ischemia-reperfusion, aldosterone modulates K+ currents involved in the holding of the resting membrane potential (RMP). The aim of this study was to assess the electrophysiological impact of aldosterone on IK1 current during myocardial ischemia-reperfusion. We used an in vitro model of “border zone” using right rabbit ventricle and standard microelectrode technique followed by cell-attached recordings from freshly isolated rabbit ventricular cardiomyocytes. In microelectrode experiments, aldosterone (10 and 100 nmol/L, n=7 respectively) increased the action potential duration (APD) dispersion at 90% between ischemic and normoxic zones (from 95±4ms to 116±6 ms and 127±5 ms respectively, P<0.05) and reperfusion-induced sustained premature ventricular contractions occurrence (from 2/12 to 5/7 preparations, P<0.05). Conversely, potassium canrenoate 100 nmol/L and RU 28318 1 μmol/l alone did not affect AP parameters and premature ventricular contractions occurrence (except Vmax which was decreased by potassium canrenoate during simulated-ischemia). Furthermore, aldosterone induced a RMP hyperpolarization, evoking an implication of a K+ current involved in the holding of the RMP. Cell-attached recordings showed that aldosterone 10 nmol/L quickly activated (within 6.2±0.4 min) a 30 pS K+-selective current, inward rectifier, with pharmacological and biophysical properties consistent with the IK1 current (NPo =1.9±0.4 in control vs NPo=3.0±0.4, n=10, P<0.05). These deleterious effects persisted in presence of RU 28318, a specific MR antagonist, and were successfully prevented by potassium canrenoate, a non specific MR antagonist, in both microelectrode and patch-clamp recordings, thus indicating a MR-independent IK1 activation. In this ischemia-reperfusion context, aldosterone induced rapid and MR-independent deleterious effects including an arrhythmia substrate (increased APD90 dispersion) and triggered activities (increased premature ventricular contractions occurrence on reperfusion) possibly related to direct IK1 activation

Formation of fractal structure in many-body systems with attractive power-law potentials

We study the formation of fractal structure in one-dimensional many-body systems with attractive power-law potentials. Numerical analysis shows that the range of the index of the power for which fractal structure emerges is limited. Dependence of the growth rate on wavenumber and power-index is obtained by linear analysis of the collisionless Boltzmann equation, which supports the numerical results.Comment: accepted by PR

A continuous non-linear shadowing model of columnar growth

We propose the first continuous model with long range screening (shadowing) that described columnar growth in one space dimension, as observed in plasma sputter deposition. It is based on a new continuous partial derivative equation with non-linear diffusion and where the shadowing effects apply on all the different processes.Comment: Fast Track Communicatio

An integrating factor matrix method to find first integrals

In this paper we developed an integrating factor matrix method to derive conditions for the existence of first integrals. We use this novel method to obtain first integrals, along with the conditions for their existence, for two and three dimensional Lotka-Volterra systems with constant terms. The results are compared to previous results obtained by other methods

Characteristics of the summit lakes of Ambae volcano and their potential for generating lahars

Volcanic eruptions through crater lakes often generate lahars, causing loss of life and property. On Ambae volcano, recent eruptive activities have rather tended to reduce the water volume in the crater lake (Lake Voui), in turn, reducing the chances for outburst floods. Lake Voui occupies a central position in the summit caldera and is well enclosed by the caldera relief. Eruptions with significantly higher magnitude than that of 1995 and 2005 are required for an outburst. A more probable scenario for lahar events is the overflow from Lake Manaro Lakua bounded on the eastern side by the caldera wall. Morphology and bathymetry analysis have been used to identify the weakest point of the caldera rim from which water from Lake Manaro Lakua may overflow to initiate lahars. The 1916 disaster described on south-east Ambae was possibly triggered by such an outburst from Lake Manaro Lakua. Taking into account the current level of Lake Manaro Lakua well below a critical overflow point, and the apparently low potential of Lake Voui eruptions to trigger lahars, the Ambae summit lakes may not be directly responsible for numerous lahar deposits identified around the Island

Possible common central pathway for resistin and insulin in regulating food intake.

Aim: Adipose tissue has been the object of intense research in the field of obesity and diabetes diseases in the last decade. Examination of adipocyte-secreted peptides led to the identification of a unique polypeptide, resistin (RSTN), which has been suggested as a link between obesity and diabetes. RSTN plays a clearly documented role in blocking insulin (INS)-induced hypoglycaemia. As brain injection of INS affects feeding behaviour, we studied the possible interaction between INS and RSTN in food-deprived rats, measuring effects on food intake. In addition, we examined how RSTN might affect neuropeptide Y (NPY)-induced feeding, as studies have shown that rat RSTN can interfere with the NPY system. Methods: Overnight food-deprived rats were injected into the third brain ventricle (3V) with either INS (10 or 20 mUI), RSTN (0.1–0.4 nmol/rat), or saline before access to food. Another group of rats was injected into the 3V with RSTN alone, NPY alone or RSTN plus NPY. Their food intake and body weight were measured. Results: Our results confirm the hypophagic effect of RSTN on food deprivation-induced food intake, and more importantly, show that RSTN neither potentiates nor blocks the effects of INS on food intake, but does reduce the hyperphagic effect of NPY. Conclusion:  The observation that RSTN does not modify feeding INS-induced hypophagia, but does influence NPY-induced feeding, points to the possibility that RSTN may be involved in control of food intake through an NPY-ergic mechanism as INS

Primary HIV-1 Infection Among Infants in sub-Saharan Africa: HPTN 024.

Our objectives were to assess clinical signs and diagnoses associated with primary HIV-1 infection among infants. We analyzed data from a clinical trial (HIV Prevention Trials Network Protocol 024) in sub-Saharan Africa. Study visits were conducted at birth, at 4-6 weeks, and at 3, 6, 9, and 12 months. The study population comprised live born, singleton, first-born infants of HIV-1-infected women with negative HIV-1 RNA assays who were still breastfeeding at 4-6 weeks. Of 1317 HIV-1-exposed infants, 84 became HIV-1 infected after 4-6 weeks and 1233 remained uninfected. There were 102 primary and 5650 nonprimary infection visits. The most common signs were cough and diarrhea, and the most common diagnoses were malaria and pneumonia. Primary infection was associated with significantly increased odds of diarrhea [odds ratio (OR) = 2.4], pneumonia (OR = 3.5), otitis media (OR = 3.1), and oral thrush (OR = 2.9). For the clinical signs and diagnoses evaluated, sensitivity was low (1%-16.7%) and specificity was high (88.2%-99%). Positive predictive values ranged from 0.1%-1.4%. Negative predictive values ranged from 28.0%-51.1%. Certain clinical signs and diagnoses, although more common during primary HIV-1 infection, had low sensitivity and high specificity. Efforts to expand access to laboratory assays for the diagnosis of primary HIV-1 infection among infants of HIV-1-infected women should be emphasized