Een archeologische evaluatie en waardering van het slagveld van Oudenaarde 1708 (Oudenaarde, provincie Oost-Vlaanderen)

Het Ename Expertisecentrum voor Erfgoedontsluiting (EEC) heeft in 2011 en 2012 in opdracht van het agentschap Onroerend Erfgoed en in functie van de mogelijke opmaak van een beschermingsdossier een archeologische evaluatie en waardering uitgevoerd van het slagveld van Oudenaarde 1708. Een eerdere survey uit 2007 onder leiding van de Britse Battlefields Trust had via metaaldetectie het archeologisch potentieel van dit slagveld aangetoond en een doorgedreven onderzoek van het slagveld mogelijk en wenselijk gemaakt. Het veldwerk werd uitgevoerd van 12 september tot 31 oktober 2011. De studie maakte een aanzienlijke vooruitgang in het begrijpen van de veldslag en in het plaatsen van de actie op het terrein, en liet toe om de aard, de toestand en de verspreiding van de archeologische zone te bepalen en de problemen die dit oplevert. Terzelfdertijd heeft dit werk inzicht gegeven in de praktische problemen op het veld, en een strategie opgeleverd voor verder onderzoek. De belangrijkste primaire bronnen van de veldslag werden samengebracht en vertaald en de grafische en geschreven bronnen werden in een redelijk accurate weergave van het landschap geplaatst zoals het er ten tijde van de veldslag moet hebben uitgezien. Oudenaarde bleek een ongewoon complexe veldslag met een opmerkelijke wisselwerking tussen het terrein en de acties. Door de goede staat van bewaring van het merendeel van het slagveld kan Oudenaarde van aanzienlijk belang zijn bij de verdere ontwikkeling van slagveldarcheologie. De kogels zijn weliswaar relatief slecht bewaard, maar toch nog voldoende goed om een adequate analyse van de inslagschade te bekomen. Het gebruik als akkerland sinds de late 18e eeuw had een ernstige destructief effect op slagveldartefacten. Het losmaken van de grond en diep ploegen is wellicht ook zeer destructief voor eventuele massagraven. Het permanent grasland op een beperkt deel van het terrein tempert wel de snelheid van verval van de artefacten, aangezien zowel verluchting van de grond als mechanische schade hierdoor vermeden wordt. De studie eindigt met aanbevelingen over de mogelijke begrenzing van de archeologische zone en stelt ook maatregelen voor naar beheer en behoud van de site

Estrategia de la empresa Chester en el simulador de negocios Capstone

La primera parte de este reporte expone el marco teórico en el que se presentan los conceptos de estrategia y modelos de negocio desde el punto de vista de diferentes autores, así como la diferencia entre ellos. También se explica el Balanced Scorecard como un método de evaluación para medir la correcta implementación de la estrategia. Se continúa con el análisis de las condiciones competitivas de la industria de fabricación de sensores, los segmentos de mercado existentes y sus preferencias. Después se define la política básica de la empresa de sensores Chester, se establecen los objetivos y la estrategia que eligió su equipo directivo para alcanzarlos. Posteriormente, se analizan los resultados que obtiene la empresa en ocho años de operaciones, de 2017 a 2024, desde el punto de vista de los cuatro departamentos que contempla el Balanced Scorecard: finanzas, cliente, procesos internos y aprendizaje. Para cada ciclo de dos años se menciona cuál es el posicionamiento de la empresa con respecto a los competidores, se analizan las estrategias que siguen las demás compañías de la industria y se evalúa la necesidad de implementar cambios con respecto al planteamiento estratégico inicial para superar sus objetivos en los siguientes años. Se concluye con reflexiones acerca de la competencia, del curso, de la maestría y de la institución

Caracterización fisicoquímica de mieles monoflorales de Euphorbia resinifera

The physicochemical characteristics of Euphorbia resinifera honey were studied. Considering the low water content, the majority of the honeys presented a proper maturity. The values of acidity revealed the absence of inappropriate fermentation, while the low values of hydroxymethylfurfural (0.4–16.48 mg/kg) were suitable for of unprocessed honeys. The average values for electrical conductivity and ashes were 451 µS/cm and 1.6 g/kg, respectively. As for the mineral content, the K was the most abundant element; Ca, Na, Mg, P, S, and Si are all present in differing quantities in the honeys. On the other hand, Principal Components Analysis (PCA) and Stepwise Discriminant Analysis (SDA) were applied to distinguish between three related Euphorbia honey types. PCA showed that the cumulative variance of the two first factors explained approximately 53%. The results of SDA showed that variables with a higher discriminant power were K, C*ab and a*, and 100% of the samples were properly classified in their corresponding class.Los parámetros fisicoquímicos de 29 de mieles monoflorales de Euphorbia resinifera fueron estudiadas. 24 parámetros, incluyendo humedad, pH, acidez (libre, lactónica y total), HMF, cenizas, conductividad eléctrica, monosacáridos (glucosa y fructosa), contenido mineral y parámetros cromáticos fueron analizados. Desde el punto de vista de su calidad las mieles fueron acordes con la legislación Europea en cuanto a contenido en agua, acidez y HMF. Los valores de cenizas y conductividad eléctrica fueron 1,6 g/kg y 451 μS/cm, respectivamente. El contenido en minerales mostró que el K es el elemento más abundante; mientras que Ca, Na, Mg, P, S y Si se presentaron en contenidos intermedios. En cuanto a los valores de los parámetros del color fueron típicos de mieles ámbar claras. Se ha realizado un análisis estadístico multivariante a los datos obtenidos para diferenciar tres especies de mieles de Euphorbia. El análisis discriminante permite diferencia las mieles por su origen botánico siendo el contenido en K, C*ab y la variable cromática a* las variables con mayor poder discriminate, siendo el 100% de las muestras clasificadas correctamente en su grupo

Autologous whole ram seminal plasma and its vesicle-free fraction improve motility characteristics and membrane status but not in vivo fertility of frozen-thawed ram spermatozoa

Motility characteristics (assessed subjectively and with computer-assisted semen analysis) and membrane status (after staining with chlortetracycline) of washed and non-washed frozen-thawed ram spermatozoa were evaluated after incubation in buffer and buffer containing autologous whole seminal plasma or one of its two fractions: the pellet of membrane vesicles obtained by ultracentrifugation (and used at three times normal protein concentration) or the vesicle-free supernatant fraction. Whole seminal plasma and supernatant, but not membrane vesicles, improved the motility characteristics of spermatozoa after 3 and 6 h of post-thaw incubation compared with the control buffer. Resuspension and incubation with whole seminal plasma, supernatant or membrane vesicles lowered the proportion of acrosome-reacted frozen-thawed spermatozoa compared with the control buffer. Unwashed frozen-thawed semen from three rams, incubated with autologous whole seminal plasma or its fractions and inseminated using cervical or intrauterine artificial insemination, had no effect on pregnancy rates of ewes in synchronized oestrus. However, fertility was higher after laparoscopic than cervical insemination (44.9 vs 12.3%, p < 0.001). In conclusion, resuspension and incubation of frozen-thawed ram spermatozoa in autologous whole seminal plasma or its vesicle-free supernatant fraction improved their motility characteristics and, with membrane vesicles, membrane status, but these benefits were not reflected in improved fertility after cervical or intrauterine insemination. © 2007 The Authors

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG. At genome-wide significance level, only ABCA1 harbors associations to both diseases. Here, we investigated the genetic architecture of POAG and AMD using genome-wide array data. We estimated the heritability for POAG (h2 g = 0.42 ± 0.09) and AMD (h2 g = 0.71 ± 0.08). Removing known loci for POAG and AMD decreased the h2 g estimates to 0.36 and 0.24, respectively. There was evidence for a positive genetic correlation between POAG and AMD (rg = 0.47 ± 0.25) which remained after removing known loci (rg = 0.64 ± 0.31). We also found that the genetic correlation between sexes for POAG was likely to be less than 1 (rg = 0.33 ± 0.24), suggesting that differences of prevalence among genders may be partly due to heritable factors

Comunidades de Aprendizaje: una apuesta educativa ante el fracaso escolar de alumnos con necesidades educativas especiales

El propósito general de esta investigación fue conocer y comprender la propia práctica educativa, detectar los problemas inmediatos y solucionarlos mediante la elaboración de un proyecto de intervención que lograra la transformación de la misma. El proyecto de intervención consistió en transformar un salón de clases en una comunidad de aprendizaje, donde se pretendió fomentar el trabajo colaborativo y la conversación entre iguales. Para este proyecto, se tomó como base principal el paradigma sociocultural ya que resulta esclarecedor y explicativo de los fenómenos educativos; como modelo de investigación, se utilizó la investigación-acción práctica, ya que permite entrar en la realidad, analizarla y volver a ella mediante la construcción de espirales auto-reflexivos

By-Products of Prosperity: Transborder Hazardous Waste Issues Confronting the Maquiladora Industry

The maquiladora program allows Mexican laborers to work in American factories operating in Mexico. This program was specifically designed to generate employment and stimulate industry in Mexico. After a brief discussion of the current status and significance of the maquiladora industry, this Article explains the procedures for the transborder shipment of hazardous waste from Mexico to the United States, a hallmark of the maquiladora program. The authors analyze these procedures in light of anticipated regulatory and economic trends in the region. The analysis includes a discussion of the issue of commingled waste, as well as how NAFTA (North American Free Trade Agreement) will impact Mexico\u27s environmental policies. The authors conclude that the maquiladora program has a prosperous future, despite the hazardous waste issues that threaten the health of the industry

ESTRUCTURA ESPACIO‐TEMPORAL DE LA DIVERSIDAD TAXONÓMICA Y FUNCIONAL DE COLIBRÍES EN LA RESERVA DE LA BIOSFERA EL TRIUNFO, CHIAPAS, MÉXICO

RESUMEN ∙ La diversidad taxonómica y funcional de las comunidades de aves está determinada por la distribución espacio‐temporal y la densidad de las poblaciones de las especies que las integran. La diversidad puede variar según el gradiente de elevación, en general al aumentar la elevación se reduce la riqueza de especies, como es el caso en algunas comunidades de colibríes (Trochilidae). En este estudio se evaluó la distribución, la densidad, la diversidad taxonómica y funcional de tres comunidades de colibríes en diferentes elevaciones y temporadas en la Reserva de la Biosfera El Triunfo, Chiapas, México. Establecimos transectos en tres elevaciones (300 a 2500 m s.n.m.), los cuales se recorrieron durante tres temporadas (secas, lluvias y post‐lluvias) de 2015 a 2016. Asimismo, obtuvimos datos morfométricos de las especies para analizar rasgos funcionales (i.e., masa corporal, longitud y curvatura del pico) y evaluar la diversidad funcional de las comunidades. Los resultados indican que la mayor diversidad de colibríes ocurrió en la elevación media, y no hubo variación significativa de la diversidad entre temporadas. De acuerdo a los rasgos funcionales medidos, solo la masa corporal mostró diferencias con la altura, siendo mayor en elevaciones altas. Los valores de la diversidad funcional obtenidos fueron similares entre elevaciones, pero la divergencia fue mayor en la elevación baja, y la especialización fue mayor en elevaciones media y baja. Esto indica una diferenciación de nichos en la elevación baja y un efecto ambiental en la elevación alta, lo que estructuraría las comunidades de colibríes en nuestro sitio de estudio.Abstract ∙ Spatio‐temporal structure of the taxonomic and functional diversity of hummingbirds at the biosphere reserve El Triunfo, Chiapas, Mexico The taxonomic and functional diversity of bird communities is determined by the spatio‐temporal distribution and population density of their constitutive species. Diversity can change along environmental gradients and one of these patterns shows that as the elevation increases bird richness is reduced, as has been observed in some communities of hummingbirds. We evaluated the distribution, taxonomic and functional structure of three hummingbird (Trochilidae) communities at El Triunfo Biosphere Reserve, Chiapas, Mexico. We established transects where we performed counts at three elevations (300 to 2500 m a.s.l.) and during three seasons (dry, rainy, and post‐rainy) from 2015 to 2016. We also obtained morphometric data from the species to analyze functional traits (i.e., body mass, length, and curvature of the bill) and functional diversity. The results indicate that the highest species diversity of hummingbirds occurred at intermediate elevation, and that there was no significant variation in diversity among seasons. Out of the functional traits measured only body mass showed differences, being higher at high elevations. Functional diversity values were similar across elevations, but the divergence was higher at low elevations, and the degree of specialization was higher at medium and low elevations. This suggests a differentiation of niches at low elevations and an environmental filtering effect at high elevation, which structure hummingbird communities at our study site

Assessing the genetic architecture of epithelial ovarian cancer histological subtypes.

Epithelial ovarian cancer (EOC) is one of the deadliest common cancers. The five most common types of disease are high-grade and low-grade serous, endometrioid, mucinous and clear cell carcinoma. Each of these subtypes present distinct molecular pathogeneses and sensitivities to treatments. Recent studies show that certain genetic variants confer susceptibility to all subtypes while other variants are subtype-specific. Here, we perform an extensive analysis of the genetic architecture of EOC subtypes. To this end, we used data of 10,014 invasive EOC patients and 21,233 controls from the Ovarian Cancer Association Consortium genotyped in the iCOGS array (211,155 SNPs). We estimate the array heritability (attributable to variants tagged on arrays) of each subtype and their genetic correlations. We also look for genetic overlaps with factors such as obesity, smoking behaviors, diabetes, age at menarche and height. We estimated the array heritabilities of high-grade serous disease ([Formula: see text] = 8.8 ± 1.1 %), endometrioid ([Formula: see text] = 3.2 ± 1.6 %), clear cell ([Formula: see text] = 6.7 ± 3.3 %) and all EOC ([Formula: see text] = 5.6 ± 0.6 %). Known associated loci contributed approximately 40 % of the total array heritability for each subtype. The contribution of each chromosome to the total heritability was not proportional to chromosome size. Through bivariate and cross-trait LD score regression, we found evidence of shared genetic backgrounds between the three high-grade subtypes: serous, endometrioid and undifferentiated. Finally, we found significant genetic correlations of all EOC with diabetes and obesity using a polygenic prediction approach.The Ovarian Cancer Association Consortium is supported by a grant from the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). The Nurses’ Health Studies would like to thank the participants and staff of the Nurses' Health Study and Nurses' Health Study II for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. The authors assume full responsibility for analyses and interpretation of these data. Funding of the constituent studies was provided by the California Cancer Research Program (00-01389V-20170, N01-CN25403, 2II0200); the Canadian Institutes of Health Research (MOP-86727); Cancer Australia; Cancer Council Victoria; Cancer Council Queensland; Cancer Council New South Wales; Cancer Council South Australia; Cancer Council Tasmania; Cancer Foundation of Western Australia; the Cancer Institute of New Jersey; Cancer Research UK (C490/A6187, C490/A10119, C490/A10124); the Danish Cancer Society (94-222-52); the ELAN Program of the University of Erlangen-Nuremberg; the Eve Appeal; the Helsinki University Central Hospital Research Fund; Helse Vest; the Norwegian Cancer Society; the Norwegian Research Council; the Ovarian Cancer Research Fund; Nationaal Kankerplan of Belgium; the L & S Milken Foundation; the Polish Ministry of Science and Higher Education (4 PO5C 028 14, 2 PO5A 068 27); the Roswell Park Cancer Institute Alliance Foundation; the US National Cancer Institute (K07-CA095666, K07-CA80668, K07-CA143047, K22-CA138563, N01-CN55424, N01-PC67001, N01-PC067010, N01-PC035137, P01-CA017054, P01-CA087696, P30-CA072720, P30-CA15083, P30-CA008748, P50-CA159981, P50-CA105009, P50-CA136393, R01-CA149429, R01-CA014089, R01-CA016056, R01-CA017054, R01-CA049449, R01-CA050385, R01-CA054419, R01-CA058598, R01-CA058860, R01-CA061107, R01-CA061132, R01-CA063678, R01-CA063682, R01-CA067262, R01-CA071766, R01-CA074850, R01-CA080978, R01-CA083918, R01-CA087538, R01-CA092044, R01-CA095023, R01-CA122443, R01-CA112523, R01-CA114343, R01-CA126841, R01-CA136924, R03-CA113148, R03-CA115195, U01-CA069417, U01-CA071966, UM1-CA186107, UM1-CA176726 and Intramural research funds); the NIH/National Center for Research Resources/General Clinical Research Center (MO1-RR000056); the US Army Medical Research and Material Command (DAMD17-01-1-0729, DAMD17-02-1-0666, DAMD17-02-1-0669, W81XWH-07-0449, W81XWH-10-1-02802); the US Public Health Service (PSA-042205); the National Health and Medical Research Council of Australia (199600 and 400281); the German Federal Ministry of Education and Research of Germany Programme of Clinical Biomedical Research (01GB 9401); the State of Baden-Wurttemberg through Medical Faculty of the University of Ulm (P.685); the German Cancer Research Center; the Minnesota Ovarian Cancer Alliance; the Mayo Foundation; the Fred C. and Katherine B. Andersen Foundation; the Lon V. Smith Foundation (LVS-39420); the Oak Foundation; Eve Appeal; the OHSU Foundation; the Mermaid I project; the Rudolf-Bartling Foundation; the UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge, Imperial College London, University College Hospital ‘Womens Health Theme’ and the Royal Marsden Hospital; and WorkSafeBC 14. Investigator-specific funding: G.C.P receives scholarship support from the University of Queensland and QIMR Berghofer. Y.L. was supported by the NHMRC Early Career Fellowship. G.C.T. is supported by the National Health and Medical Research Council. S.M. was supported by an ARC Future Fellowship