224 research outputs found
Introduction. Approches d'un genre hybride, le film sur l'art
Introduction dressant un bilan tout à la fois historique, théorique et bibliographique sur la question du film sur l'art et ses relations avec l'histoire de l'art
Iterated Moire Maps and Braiding of Chiral Polymer Crystals
In the hexagonal columnar phase of chiral polymers a bias towards cholesteric
twist competes with braiding along an average direction. When the chirality is
strong, screw dislocations proliferate, leading to either a tilt grain boundary
phase or a new "moire state" with twisted bond order. Polymer trajectories in
the plane perpendicular to their average direction are described by iterated
moire maps of remarkable complexity.Comment: 10 pages (plain tex) 3 figures uufiled and appende
Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report
<p/> <p>Background</p> <p>Hypersentivity Syndrome (HS) may be a life-threatening condition. It frequently presents with fever, rash, eosinophilia and systemic manifestations. Mortality can be as high as 10% and is primarily due to hepatic failure. We describe what we believe to be the first case of minocycline-induced HS with accompanying lymphocytic meningitis and cerebral edema reported in the literature.</p> <p>Case presentation</p> <p>A 31-year-old HIV-positive female of African origin presented with acute fever, lymphocytic meningitis, brain edema, rash, eosinophilia, and cytolytic hepatitis. She had been started on minocycline for inflammatory acne 21 days prior to the onset of symptoms. HS was diagnosed clinically and after exclusion of infectious causes. Minocycline was withdrawn and steroids were administered from the second day after presentation because of the severity of the symptoms. All signs resolved by the seventh day and steroids were tailed off over a period of 8 months.</p> <p>Conclusion</p> <p>Clinicians should maintain a high index of suspicion for serious adverse reactions to minocycline including lymphocytic meningitis and cerebral edema among HIV-positive patients, especially if they are of African origin. Safer alternatives should be considered for treatment of acne vulgaris. Early recognition of the symptoms and prompt withdrawal of the drug are important to improve the outcome.</p
Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35
The response of the immune system to probiotics remains controversial. Some strains modulate the cytokine production of dendritic cells (DCs) in vitro and induce a regulatory response, while others induce conversely a pro-inflammatory response. These strain-dependent effects are thought to be linked to specific interactions between bacteria and pattern recognition receptors. We investigated the effects of a well characterized probiotic strain, Lactobacillus rhamnosus Lcr35, on human monocyte-derived immature DCs, using a wide range of bacterial concentrations (multiplicity of infection, MOI, from 0.01 to 100). DNA microarray and qRT-PCR analysis showed that the probiotic induced a large-scale change in gene expression (nearly 1,700 modulated genes, with 3-fold changes), but only with high doses (MOI, 100). The upregulated genes were mainly involved in immune response and identified a molecular signature of inflammation according to the model of Torri. Flow cytometry analysis also revealed a dose-dependent maturation of the DC membrane phenotype, until DCs reached a semi-mature state, with an upregulation of the membrane expression of CD86, CD83, HLA-DR and TLR4, associated with a down-regulation of DC-SIGN, MR and CD14. Measurement of the DC-secreted cytokines showed that Lcr35 induced a strong dose-dependent increase of the pro-Th1/Th17 cytokine levels (TNFα, IL-1β, IL-12p70, IL-12p40 and IL-23), but only a low increase in IL-10 concentration. The probiotic L. rhamnosus Lcr35 therefore induce a dose-dependent immunomodulation of human DCs leading, at high doses, to the semi-maturation of the cells and to a strong pro-inflammatory effect. These results contribute to a fuller understanding of the mechanism of action of this probiotic, and thus of its potential clinical indications in the treatment of either infectious or IgE-dependent allergic diseases
Beta-band intermuscular coherence:A novel biomarker of upper motor neuron dysfunction in motor neuron disease
In motor neuron disease, the focus of therapy is to prevent or slow neuronal degeneration with neuroprotective pharmacological agents; early diagnosis and treatment are thus essential. Incorporation of needle electromyographic evidence of lower motor neuron degeneration into diagnostic criteria has undoubtedly advanced diagnosis, but even earlier diagnosis might be possible by including tests of subclinical upper motor neuron disease. We hypothesized that beta-band (15-30Hz) intermuscular coherence could be used as an electrophysiological marker of upper motor neuron integrity in such patients. We measured intermuscular coherence in eight patients who conformed to established diagnostic criteria for primary lateral sclerosis and six patients with progressive muscular atrophy, together with 16 age-matched controls. In the primary lateral sclerosis variant of motor neuron disease, there is selective destruction of motor cortical layer V pyramidal neurons and degeneration of the corticospinal tract, without involvement of anterior horn cells. In progressive muscular atrophy, there is selective degeneration of anterior horn cells but a normal corticospinal tract. All patients with primary lateral sclerosis had abnormal motor-evoked potentials as assessed using transcranial magnetic stimulation, whereas these were similar to controls in progressive muscular atrophy. Upper and lower limb intermuscular coherence was measured during a precision grip and an ankle dorsiflexion task, respectively. Significant beta-band coherence was observed in all control subjects and all patients with progressive muscular atrophy tested, but not in the patients with primary lateral sclerosis. We conclude that intermuscular coherence in the 15-30Hz range is dependent on an intact corticospinal tract but persists in the face of selective anterior horn cell destruction. Based on the distributions of coherence values measured from patients with primary lateral sclerosis and control subjects, we estimated the likelihood that a given measurement reflects corticospinal tract degeneration. Therefore, intermuscular coherence has potential as a quantitative test of subclinical upper motor neuron involvement in motor neuron disease
High-pT pi^zero Production with Respect to the Reaction Plane in Au + Au Collisions at sqrt(s_NN) = 200 GeV
Measurements of the azimuthal anisotropy of high-\pT neutral pion neutral
pion production in Au+Au collisions at sqrt(s_NN) = 200 GeV by the PHENIX
experiment are presented. The data included in this paper were collected during
the 2004 RHIC running period and represent approximately an order of magnitude
increase in the number of analyzed events relative to previously published
results. Azimuthal angle distributions of pi^0s detected in the PHENIX
electromagnetic calorimeters are measured relative to the reaction plane
determined event-by-event using the forward and backward beam-beam counters.
Amplitudes of the second Fourier component (v_2) of the angular distributions
are presented as a function of pi^0 transverse momentum p_T for different bins
in collision centrality. Measured reaction plane dependent pi^0 yields are used
to determine the azimuthal dependence of the pi^0 suppression as a function of
p_T, R_AA (Delta phi,p_T). A jet-quenching motivated geometric analysis is
presented that attempts to simultaneously describe the centrality dependence
and reaction plane angle dependence of the pi^0 suppression in terms of the
path lengths of hypothetical parent partons in the medium. This set of results
allows for a detailed examination of the influence of geometry in the collision
region, and of the interplay between collective flow and jet-quenching effects
along the azimuthal axis.Comment: 344 authors, 35 pages text, RevTeX-4, 24 figures, 8 tables. Submitted
to Physical Review
Transverse momentum and centrality dependence of dihadron correlations in Au+Au collisions at sqrt(s_NN)=200 GeV: Jet-quenching and the response of partonic matter
Azimuthal angle \Delta\phi correlations are presented for charged hadrons
from dijets for 0.4 < p_T < 10 GeV/c in Au+Au collisions at sqrt(s_NN) = 200
GeV. With increasing p_T, the away-side distribution evolves from a broad to a
concave shape, then to a convex shape. Comparisons to p+p data suggest that the
away-side can be divided into a partially suppressed "head" region centered at
Delta\phi ~ \pi, and an enhanced "shoulder" region centered at Delta\phi ~ \pi
+/- 1.1. The p_T spectrum for the "head" region softens toward central
collisions, consistent with the onset of jet quenching. The spectral slope for
the "shoulder" region is independent of centrality and trigger p_T, which
offers constraints on energy transport mechanisms and suggests that the
"shoulder" region contains the medium response to energetic jets.Comment: 420 authors from 58 institutions, 6 pages, 4 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Quantitative Constraints on the Transport Properties of Hot Partonic Matter from Semi-Inclusive Single High Transverse Momentum Pion Suppression in Au+Au collisions at sqrt(s_NN) = 200 GeV
The PHENIX experiment has measured the suppression of semi-inclusive single
high transverse momentum pi^0's in Au+Au collisions at sqrt(s_NN) = 200 GeV.
The present understanding of this suppression is in terms of energy-loss of the
parent (fragmenting) parton in a dense color-charge medium. We have performed a
quantitative comparison between various parton energy-loss models and our
experimental data. The statistical point-to-point uncorrelated as well as
correlated systematic uncertainties are taken into account in the comparison.
We detail this methodology and the resulting constraint on the model
parameters, such as the initial color-charge density dN^g/dy, the medium
transport coefficient , or the initial energy-loss parameter epsilon_0.
We find that high transverse momentum pi^0 suppression in Au+Au collisions has
sufficient precision to constrain these model dependent parameters at the +/1
20%-25% (one standard deviation) level. These constraints include only the
experimental uncertainties, and further studies are needed to compute the
corresponding theoretical uncertainties.Comment: 422 authors, 13 pages text, RevTeX-4, 9 figures, 2 tables. This
version is updated with changes made during the review process and is now the
same as what was published in Physical Review C. Plain text data tables for
the points plotted in figures for this and previous PHENIX publications are
publicly available at http://www.phenix.bnl.gov/papers.htm
Charged hadron multiplicity fluctuations in Au+Au and Cu+Cu collisions from sqrt(s_NN) = 22.5 to 200 GeV
A comprehensive survey of event-by-event fluctuations of charged hadron
multiplicity in relativistic heavy ions is presented. The survey covers Au+Au
collisions at sqrt(s_NN) = 62.4 and 200 GeV, and Cu+Cu collisions sqrt(s_NN) =
22.5, 62.4, and 200 GeV. Fluctuations are measured as a function of collision
centrality, transverse momentum range, and charge sign. After correcting for
non-dynamical fluctuations due to fluctuations in the collision geometry within
a centrality bin, the remaining dynamical fluctuations expressed as the
variance normalized by the mean tend to decrease with increasing centrality.
The dynamical fluctuations are consistent with or below the expectation from a
superposition of participant nucleon-nucleon collisions based upon p+p data,
indicating that this dataset does not exhibit evidence of critical behavior in
terms of the compressibility of the system. An analysis of Negative Binomial
Distribution fits to the multiplicity distributions demonstrates that the heavy
ion data exhibit weak clustering properties.Comment: 464 authors from 60 institutions, 17 pages, 12 figures, 1 table.
Submitted to Physical Review C. Plain text data tables for the points plotted
in figures for this and previous PHENIX publications are (or will be)
publicly available at http://www.phenix.bnl.gov/papers.htm
Transverse-energy distributions at midrapidity in , Au, and AuAu collisions at --200~GeV and implications for particle-production models
Measurements of the midrapidity transverse energy distribution, d\Et/d\eta,
are presented for , Au, and AuAu collisions at
GeV and additionally for AuAu collisions at
and 130 GeV. The d\Et/d\eta distributions are first
compared with the number of nucleon participants , number of
binary collisions , and number of constituent-quark participants
calculated from a Glauber model based on the nuclear geometry. For
AuAu, \mean{d\Et/d\eta}/N_{\rm part} increases with , while
\mean{d\Et/d\eta}/N_{qp} is approximately constant for all three energies.
This indicates that the two component ansatz, , which has been used to represent
distributions, is simply a proxy for , and that the term
does not represent a hard-scattering component in distributions. The
distributions of AuAu and Au are then calculated from
the measured distribution using two models that both reproduce
the AuAu data. However, while the number-of-constituent-quark-participant
model agrees well with the Au data, the additive-quark model does not.Comment: 391 authors, 24 pages, 19 figures, and 15 Tables. Submitted to Phys.
Rev. C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/papers.htm
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