When are apps worth paying for? An analysis of the market performance of mobile apps

Through the use of established marketing laws such as the brand usage and image relationship and the Double Jeopardy effect, this research shows how to analyze the market performance of different types of mobile apps. The key empirical findings are as follows: apps linked to an offline/online brand attract more users and obtain stronger brand image if made available to consumers at no cost; apps branded independently attract more users and obtain stronger brand image if offered at a price. These outcomes significantly add to existing knowledge about branded apps, and demonstrate that longstanding marketing laws support the understanding and evaluation of market trends in the mobile digital context. These findings also translate into practical guidelines relevant to managers of existing brands wanting to launch an app, as well as managers wanting to market apps as stand-alone digital products

Age-related changes of the ocular surface : a hospital setting-based retrospective study

Purpose. To investigate the effects of age on the prevalence of ocular surface diseases (OSD), adherence to treatment, and recovery rates. Patients and Methods. Retrospective analysis of 3000 clinical records from a first-level general ophthalmology clinic. Patients with OSD were prospectively submitted a questionnaire to assess compliance and recovery rates. Results. OSD prevalence was 10.3%. Patients with OSD were significantly older than patients without it: 67.5 \ub1 20.3 versus 57.0 \ub1 22.0 years (P = 0.036). No significant difference in season distribution was shown. Dry eye disease (DED) represented 58% of OSD; its prevalence increased with age until 80 years old and suddenly decreased thereafter. Asymptomatic DED was 37%. Adherence to treatment in OSD was very high (94%); recovery rates were lower in patients aged 21-40 and 61-80 (resp., 65.5% and 77.8%) and this was associated with higher OSDI scores. Tear substitutes represented 50% of all prescribed medications; their use increased with age. Discussion. In a "reallife"low-tech setting, OSD showed a prevalence of 10.3%. DED was the most prevalent disease, and it was asymptomatic in more than 1/3 of cases

Lee-Yang Zeros of the antiferromagnetic Ising Model

We investigate the location of zeros for the partition function of the anti-ferromagnetic Ising Model, focusing on the zeros lying on the unit circle. We give a precise characterization for the class of rooted Cayley trees, showing that the zeros are nowhere dense on the most interesting circular arcs. In contrast, we prove that when considering all graphs with a given degree bound, the zeros are dense in a circular sub-arc, implying that Cayley trees are in this sense not extremal. The proofs rely on describing the rational dynamical systems arising when considering ratios of partition functions on recursively defined trees

Revisión de resultados experimentales en técnicas de prueba y de educción de conocimientos

La cantidad de experimentos realizados en el ámbito de la ingeniería del software ha ido aumentando considerablemente en los últimos años. Estos experimentos cubren un amplio rango de temas, como por ejemplo, técnicas de pruebas en software, técnicas de educción de conocimientos, lenguajes de programación, etc. Sin embargo, si los experimentos no son tratados como investigaciones controladas, formales y rigurosas, existe un riesgo de obtener conclusiones que carezcan de validez. En este reporte, se analizan 32 experimentos sobre técnicas de prueba y de educción de conocimientos para verificar la correctitud de los mismos. En la sección 2, se describe el estado de la cuestión, donde se exponen nociones de experimentación y técnicas estadísticas. La sección 3, describe el problema a tratar; y la sección 4, la solución propuesta. Los resultados se exponen en la sección 5. En la sección 6, se presentan las conclusiones, seguidas por las futuras líneas de investigación y la bibliografía en las secciones 7 y 8 respectivamente.Eje: Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Revisión de resultados experimentales en técnicas de prueba y de educción de conocimientos

La cantidad de experimentos realizados en el ámbito de la ingeniería del software ha ido aumentando considerablemente en los últimos años. Estos experimentos cubren un amplio rango de temas, como por ejemplo, técnicas de pruebas en software, técnicas de educción de conocimientos, lenguajes de programación, etc. Sin embargo, si los experimentos no son tratados como investigaciones controladas, formales y rigurosas, existe un riesgo de obtener conclusiones que carezcan de validez. En este reporte, se analizan 32 experimentos sobre técnicas de prueba y de educción de conocimientos para verificar la correctitud de los mismos. En la sección 2, se describe el estado de la cuestión, donde se exponen nociones de experimentación y técnicas estadísticas. La sección 3, describe el problema a tratar; y la sección 4, la solución propuesta. Los resultados se exponen en la sección 5. En la sección 6, se presentan las conclusiones, seguidas por las futuras líneas de investigación y la bibliografía en las secciones 7 y 8 respectivamente.Eje: Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Tumor BRCA Test for Patients with Epithelial Ovarian Cancer: The Role of Molecular Pathology in the Era of PARP Inhibitor Therapy

The PARP inhibitor olaparib has been approved in the maintenance setting of platinum-sensitive epithelial ovarian cancer patients with germline or somatic BRCA1/2 mutation. Therefore, the availability of a tumor BRCA test has become a clinical need. We report the results of the clinical implementation of a tumor BRCA test within the frame of an institutional workflow for the management of patients with nonmucinous and nonborderline epithelial ovarian cancer. In total, 223 patients with epithelial ovarian cancer were prospectively analyzed. BRCA1/2 status was evaluated on formalin-fixed, paraffin-embedded tumor specimens using next-generation sequencing technology. The tumor BRCA test had a success rate of 99.1% (221 of 223 successfully analyzed cases) and a median turnaround time of 17 calendar days. Among the 221 cases, BRCA1 or BRCA2 pathogenic/likely pathogenic mutations were found in 62 (28.1%) cases and variants of uncertain significance in 25 (11.3%) cases. The concordance rate between tumor BRCA test results and germline BRCA1/2 status was 87%, with five cases harboring pathogenic/likely pathogenic somatic-only mutations. The next-generation, sequencing-based tumor BRCA test showed a high success rate and a turnaround time compatible with clinical purposes. The tumor BRCA test could be implemented in a molecular diagnostic setting and it may guide the clinical management of patients with epithelial ovarian cancer

Assessment of respiratory function and exercise tolerance at 4-6 months after COVID-19 infection in patients with pneumonia of different severity

The evaluation of COVID-19 systemic consequences is a wide research field in which respiratory function assessment has a pivotal role. However, the available data in the literature are still sparse and need further strengthening

Differential Diagnosis and Clinical Management of a Case of COVID-19 in a Patient With Stage III Lung Cancer Treated With Radio-chemotherapy and Durvalumab

none14nononeGuerini A.E.; Borghetti P.; Filippi A.R.; Bonu M.L.; Tomasini D.; Greco D.; Imbrescia J.; Volpi G.; Triggiani L.; Borghesi A.; Maroldi R.; Pasinetti N.; Buglione M.; Magrini S.M.Guerini, A. E.; Borghetti, P.; Filippi, A. R.; Bonu, M. L.; Tomasini, D.; Greco, D.; Imbrescia, J.; Volpi, G.; Triggiani, L.; Borghesi, A.; Maroldi, R.; Pasinetti, N.; Buglione, M.; Magrini, S. M