Say What?: Demystifying Discourse Analysis for Archaeology Students

Most archaeology instructors are eager to have their students appreciate that the study of the past is relevant to the present. In fact, most current introductory textbooks include a section, however brief it may be, on the socio-politics of archaeology. These discussions are usually framed around how ideas about the past have been used to justify abuse (e.g., Nazi archaeology to support an Aryan homeland), or how the involvement of descendant communities in research is now considered best practice in the field (e.g., NAGPRA, community based archaeology). One of the most powerful tools for understanding how what we say about the past makes a difference in the present is discourse analysis. Ultimately, archaeologists communicate their findings via discourses: in reports, articles, books, museum exhibits, documentaries, podcasts, websites, and even occasionally fictional writings. Discourse analysis inspired by the work of Michel Foucault can be used to empower students to analyze and draw their own conclusions regarding the statements they encounter about “how the past was” and “what that means” in any context. It does not pre-determine or preclude any particular interpretation of the past-present relationship, or theoretical orientation, but instead supports the development of critical thinking with an eye to the power ramifications of “who says what.

What does it mean to find the Face of the Franchise? Physical Attractiveness and the Evaluation of Athletic Performance

Previous research has shown how more attractive people reap more rewards in a variety of settings. We show that attractiveness as measured by facial symmetry leads to greater rewards in professional sports. National Football League quarterbacks who are more attractive are paid greater salaries and this premium persists after controlling for player performance.

Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival

LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology. How these receptors affect cancer progression in humans remains largely unknown. Herein, we mined provisional data-bases in The Cancer Genome Atlas (TCGA) to compare expression of thirteen LRPs in ten common solid malignancies in patients. Our first goal was to determine the abundance of LRP mRNAs in each type of cancer. Our second goal was to determine whether expression of LRPs is associated with improved or worsened patient survival. In total, data from 4,629 patients were mined. In nine of ten cancers studied, the most abundantly expressed LRP was LRP1; however, a correlation between LRP1 mRNA expression and patient survival was observed only in bladder urothelial carcinoma. In this malignancy, high levels of LRP1 mRNA were associated with worsened patient survival. High levels of LDL receptor (LDLR) mRNA were associated with decreased patient survival in pancreatic adenocarcinoma. High levels of LRP10 mRNA were associated with decreased patient survival in hepatocellular carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. LRP2 was the only LRP for which high levels of mRNA expression correlated with improved patient survival. This correlation was observed in renal clear cell carcinoma. Insights into LRP gene expression in human cancers and their effects on patient survival should guide future research

LDL receptor-related protein-1 regulates NFκB and microRNA-155 in macrophages to control the inflammatory response

LDL receptor-related protein-1 (LRP1) is an endocytic and cell-signaling receptor. In mice in which LRP1 is deleted in myeloid cells, the response to lipopolysaccharide (LPS) was greatly exacerbated. LRP1 deletion in macrophages in vitro, under the control of tamoxifen-activated Cre-ER(T) fusion protein, robustly increased expression of proinflammatory cytokines and chemokines. In LRP1-expressing macrophages, proinflammatory mediator expression was regulated by LRP1 ligands in a ligand-specific manner. The LRP1 agonists, α2-macroglobulin and tissue-type plasminogen activator, attenuated expression of inflammatory mediators, even in the presence of LPS. The antagonists, receptor-associated protein (RAP) and lactoferrin (LF), and LRP1-specific antibody had the entirely opposite effect, promoting inflammatory mediator expression and mimicking LRP1 deletion. NFκB was rapidly activated in response to RAP and LF and responsible for the initial increase in expression of proinflammatory mediators. RAP and LF also significantly increased expression of microRNA-155 (miR-155) after a lag phase of about 4 h. miR-155 expression reflected, at least in part, activation of secondary cell-signaling pathways downstream of TNFα. Although miR-155 was not involved in the initial induction of cytokine expression in response to LRP1 antagonists, miR-155 was essential for sustaining the proinflammatory response. We conclude that LRP1, NFκB, and miR-155 function as members of a previously unidentified system that has the potential to inhibit or sustain inflammation, depending on the continuum of LRP1 ligands present in the macrophage microenvironment

PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology

The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling. Plasminogen activator inhibitor-1 (PAI1, also known as SERPINE1) is a rapidly acting inhibitor of tPA enzyme activity. Although tPA-initiated cell signaling is not dependent on its enzyme active site, we show that tPA signaling is neutralized by PAI1. In PC12 cells, PAI1 blocked the ERK1/2 activation mediated by tPA as well as neurite outgrowth. In Schwann cells, PAI1 blocked tPA-mediated ERK1/2 activation and cell migration. In macrophages, PAI1 blocked the ability of tPA to inhibit IκBα phosphorylation and cytokine expression. The cell signaling activity of tPA-PAI1 complex was rescued when the complex was formed with PAI1R76E, which binds to LRP1 with decreased affinity, by pre-treating cells with the LRP1 antagonist receptor-associated protein and upon LRP1 gene silencing. The inhibitory role of LRP1 in tPA-PAI1 complex-initiated cell signaling was unanticipated given the reported role of LRP1 as an NMDA-R co-receptor in signaling responses elicited by free tPA or α2-macroglobulin. We conclude that PAI1 functions as an in-hibitor not only of the enzyme activity of tPA but also of tPA receptor-mediated activities

How much measurement independence is needed in order to demonstrate nonlocality?

If nonlocality is to be inferred from a violation of Bell's inequality, an important assumption is that the measurement settings are freely chosen by the observers, or alternatively, that they are random and uncorrelated with the hypothetical local variables. We study the case where this assumption is weakened, so that measurement settings and local variables are at least partially correlated. As we show, there is a connection between this type of model and models which reproduce nonlocal correlations by allowing classical communication between the distant parties, and a connection with models that exploit the detection loophole. We show that even if Bob's choices are completely independent, all correlations obtained from projective measurements on a singlet can be reproduced, with the correlation (measured by mutual information) between Alice's choice and local variables less than or equal to a single bit.Comment: 5 pages, 1 figure. v2 Various improvements in presentation. Results unchange

Monitoring Mechanisms, Managerial Incentives, Investment Distortion Costs, and Derivatives Usage

We relate derivatives usage to the level of corporate governance/monitoring mechanisms, managerial incentives and investment decisions of UK firms. We find evidence to suggest that the monitoring environment, e.g., board size, influences the use of both currency and interest rate derivatives usage. Managerial compensation also influences derivatives usage. Investment decisions are affected by the governance and managerial compensation of firms, which in turn impact on derivatives usage. We find a strong tendency for UK firms to reduce derivatives usage in situations where derivatives usage should be increased. There is limited evidence that firms use hedging substitutes to avoid monitoring from external capital markets

The manganese ore body at the Three Kids Mine, Clark County, Nevada

Online access for this thesis was created in part with support from the Institute of Museum and Library Services (IMLS) administered by the Nevada State Library, Archives and Public Records through the Library Services and Technology Act (LSTA). To obtain a high quality image or document please contact the DeLaMare Library at https://unr.libanswers.com/ or call: 775-784-6945.The Three Kids manganese deposit lies within the lake and playa sediments belonging to the Muddy Creek formation of Pliocene (?) age. The manganiferous zone can be divided into three distinct sections: the lowermost is a series of thin manganese oxide beds separated by layers of tuff; the middle section is a thick massive manganese oxide bed; the upper section is composed of manganese oxide fragments in a tuffaceous sediment. The main manganese mineral is pyrolusite with smaller amounts of hollandite and cryptome- lane. The mineral celadonite occurs extensively throughout the mining area; its origin is problematical. The origin of the manganese is difficult to ascertain as the deposit exhibits both hydrothermal and sedimentary characteristics

Preservation, Regulations, and Policy to Protect and Grow Baltimore’s Forests

Organizations and city agencies in Baltimore, MD are working together to better protect forests and trees through a combination of preservation efforts, policies, and regulations. Non-profit Baltimore Green Space (BGS), Baltimore’s Department of Recreation and Parks (BCRP), and Baltimore’s Office of Sustainability (BOS) have played major roles in this work. To further advance these efforts, a process is underway to propose new regulations that would better protect and mitigate impacts of development on trees and forested natural areas

Non-realism : deep thought or a soft option ?

The claim that the observation of a violation of a Bell inequality leads to an alleged alternative between nonlocality and non-realism is annoying because of the vagueness of the second term.Comment: 5 page