Lack of association between the rs2294008 polymorphism in the prostate stem cell antigen gene and colorectal neoplasia : a case-control and immunohistochemical study

PMID: 22824379 [PubMed - indexed for MEDLINE] PMCID: PMC3500224 Free PMC ArticlePeer reviewedPublisher PD

On Relapsing Fever

SUMMARY It may now be held to be definitely established that Relapsing Fever is due to one or other of the various varieties of the Spirochaeta Reccurentis, all of which are closely allied to the original organism described by Obermeier. Two definitely different types of the disease occur, viz. European Relapsing Fever and African Tick Fever, the spriochaete being transmitted in the former principally by means of the body louse and in the latter by ticks. The main difference between the two varieties of the disease is in the type of the fever evoked. In European Relapsing Fever the fever is of a regular type and duration, terminating by crisis, whereas in African Tick Fever the fever follows an irregular course, is often intermittent in type, and tends to be considerably prolonged. There is nothing very characteristic about the symptoms of this disease and a definite diagnosis can only be made by demonstrating the causal organism in blood films. This is particularly so in the earlier stages of the disease. The principle complications met with are nephritis, neuritis, paralysis, dysenteric symptoms, and iritis, the last two being for the most part associated with the African type of the disease

First Detection of Mycobacterium ulcerans DNA in Environmental Samples from South America

The occurrences of many environmentally-persistent and zoonotic infections are driven by ecosystem changes, which in turn are underpinned by land-use modifications that alter the governance of pathogen, biodiversity and human interactions. Our current understanding of these ecological changes on disease emergence however remains limited. Buruli ulcer is an emerging human skin disease caused by the mycobacterium, Mycobacterium ulcerans, for which the exact route of infection remains unclear. It can have a devastating impact on its human host, causing extensive necrosis of the skin and underlying tissue, often leading to permanent disability. The mycobacterium is associated with tropical aquatic environments and incidences of the disease are significantly higher on floodplains and where there is an increase of human aquatic activities. Although the disease has been previously diagnosed in South America, until now the presence of M. ulcerans DNA in the wild has only been identified in Australia where there have been significant outbreaks and in western and central regions of Africa where the disease is persistent. Here for the first time, we have identified the presence of the aetiological agent's DNA in environmental samples from South America. The DNA was positively identified using Real-time Polymerase Chain Reaction (PCR) on 163 environmental samples, taken from 23 freshwater bodies in French Guiana (Southern America), using primers for both IS2404 and for the ketoreductase-B domain of the M. ulcerans mycolactone polyketide synthase genes (KR). Five samples out of 163 were positive for both primers from three different water bodies. A further nine sites had low levels of IS2404 close to a standard CT of 35 and could potentially harbour M. ulcerans. The majority of our positive samples (8/14) came from filtered water. These results also reveal the Sinnamary River as a potential source of infection to humans. © 2014 Morris et al

Plural policing in Europe:relationships and governance in contemporary security system

References to ‘plural policing’, ‘policing beyond the police’ and the ‘extended policing family’ are now commonplace in many discussions of policing in late modern societies. There is a danger that claims about the dynamic and changing nature of plural policing themselves become a new orthodoxy and begin to lose a sense of local nuance and recognition of the importance of place-based specificity and context in understanding the particularities of policing. It is this need to unpack the complex ways in which contemporary plural policing is now configured at a local level within different national political environments that provides the underpinning rationale for this Special Issue. Focussing on aspects of relationships and governance in six jurisdictions across northern and western Europe, it provides important insights into how the policies, practices and narratives around plural policing reflect the influence of particular histories and geographies. The first three articles are focused primarily on the relationships which have emerged in the public sector through its own processes of pluralisation, in particular, through the introduction of policing auxiliaries or municipal policing in Scotland, England and The Netherlands. The fourth article considers both relationships and governance in pluralised policing in Paris, France. A detailed analysis of the governance of safety and security is taken up in the final two articles, examining the cases of Austria and Belgium. These articles clearly demonstrate that experiences of pluralised policing vary widely within Europe and call into question the assumed dominance of neo-liberal forces in this area

MyCourseMap: an interactive visual map to increase curriculum transparency for university students and staff

MyCourseMap is an interactive curriculum map created to increase curriculum transparency for both students and staff. It provides access to the entire curriculum at a glance, displays alignment of unit learning outcomes, assessments, course learning outcomes, and graduate attributes and links video from employers, graduates and students to help students reflect on the curriculum and its relevance. A prototype developed for the Bachelor of Pharmacy course at Curtin University as a proof-of-concept was tested and evaluated in 2014 and 2015. This evaluation utilised a mixed-methods approach using a blend of quantitative and qualitative data through online survey and structured focus group discussions. From the evaluation, the perceived benefits of the MyCourseMap include students’ increased understanding of their degree structure and its relevance to their chosen profession. From a staff perspective, the MyCourseMap helps with review and development of curriculum and professional accreditation. Barriers and challenges have led to prototype refinements

Mycobacterium ulcerans DNA Not Detected in Faecal Samples from Buruli Ulcer Patients: Results of a Pilot Study

It has recently been shown that in a Buruli ulcer (BU) endemic region of southeastern Australia, significant numbers of possums (native tree-dwelling marsupials) have clinical BU disease. Furthermore, based on quantitative PCR (qPCR) analysis, animals with BU lesions (and some without) shed M. ulcerans DNA in their faeces, indicative of bacterial loads of up to 108 organisms/gram. These findings led us to propose that humans might also harbour M. ulcerans in their gastrointestinal tract and shed the bacterium in their faeces. We conducted a pilot study and collected faecal swabs from 26 patients with confirmed BU and 31 healthy household controls. Faecal samples were also collected from 10 healthy controls from non-endemic regions in Ghana. All 67 specimens were negative when tested by IS2404 PCR. The detection sensitivity of this method was ≥104 bacteria per gram (wet-weight) of human faecal material. We conclude that the human gastrointestinal tract is unlikely to be a significant reservoir of M. ulcerans

Effect of High-Protein Breakfast Meals on Within-Day Appetite and Food Intake in Healthy Men and Women

The Rowett Institute and Biomathematics and Statistics Scotland are grateful to the Scottish Government for funding this work. We thank the Rowett Human Nutrition Unit staff for their technical help with the interventions. Staff members who helped include Jean Bryce, Nina Lamza and Karen Taylor. The Rowett Institute and Biomathematics and Statistics Scotland are grateful to the Scottish Government for funding this work.Peer reviewedPublisher PD

Data Submission Standards and Evidence Requirements

Presented are recommendations of the Data Submission Standards and Evidence Requirements panel from the Conference on Clinical Cancer Research along with the U.S. Food and Drug Administration's response to these recommendations

Self-Reported Purchasing Behaviour, Sociodemographic Predictors of Plant-Based Protein Purchasing and Knowledge about Protein in Scotland and England

Acknowledgments: Support for initial data analysis was given by Mary Kynn. Funding: The authors gratefully acknowledge funding from the Scottish Government from project B7-01 (2022–2027), supporting this work.Peer reviewedPublisher PD