Redshift constraints for RGB 0136+391 and PKS 0735+178 from deep optical imaging

We present the results of deep I-band imaging of two BL Lacerate objects, RGB 0136+391 and PKS 0735+178, during an epoch when the optical nucleus was in a faint state in both targets. In PKS 0735+178 we find a significant excess over a point source, which, if fitted by the de Vaucouleurs model, corresponds to a galaxy with I = 18.64 +- 0.11 and r_eff = 1.8 +- 0.4 arcsec. Interpreting this galaxy as the host galaxy of PKS 0735+178 we derive z = 0.45 +- 0.06 using the host galaxy as a "standard candle". We also discuss the immediate optical environment of PKS 0735+178 and the identity of the MgII absorber at z = 0.424. Despite of the optimally chosen epoch and deep imaging we find the surface brightness profile of RGB 0136+391 to be consistent with a point source. By determining a lower limit for the host galaxy brightness by simulations, we derive z > 0.40 for this target.Comment: 6 pages, 5 figures, accepted for publication in Astronomy & Astrophysic

S53P4 bioactive glass scaffolds induce BMP expression and integrative bone formation in a critical-sized diaphysis defect treated with a single-staged induced membrane technique

Surgical management of critical-sized diaphyseal defects involves multiple challenges, and up to 10% result in delayed or non-union. The two-staged induced membrane technique is successfully used to treat these defects, but it is limited by the need of several procedures and bone graft. Repeated procedures increase costs and morbidity, while grafts are subject to donor-site complications and scarce availability. To transform this two-staged technique into one graft-independent procedure, we developed amorphous porous scaffolds sintered from the clinically used bioactive glass S53P4. This work constitutes the first evaluation of such scaffolds in vivo in a critical-sized diaphyseal defect in the weight-bearing rabbit femur. We provide important knowledge and prospects for future development of sintered S53P4 scaffolds as a bone substitute. Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions. The two staged induced membrane technique has been used to treat these challenging defects since the 1980 & rsquo;s. It involves temporary implantation of a membrane-inducing spacer and subsequent bone graft defect filling. A single-staged, graft-independent technique would reduce both socio-economic costs and patient morbidity. Our aim was to enable such single-staged approach through development of a strong bioactive glass scaffold that could replace both the spacer and the graft filling. We constructed amorphous porous scaffolds of the clinically used bioactive glass S53P4 and evaluated them in vivo using a critical sized defect model in the weight-bearing femur diaphysis of New Zealand White rabbits. S53P4 scaffolds and standard polymethylmethacrylate spacers were implanted for 2, 4, and 8 weeks. Induced membranes were confirmed histologically, and their osteostimulative activity was evaluated through RT-qPCR of bone morphogenic protein 2, 4, and 7 (BMPs). Bone formation and osseointegration were examined using histology, scanning electron microscopy, energy-dispersive X-ray analysis, and micro-computed tomography imaging. Scaffold integration, defect union and osteosynthesis were assessed manually and with X-ray projections. We demonstrated that S53P4 scaffolds induce osteostimulative membranes and produce osseointegrative new bone formation throughout the scaffolds. We also demonstrated successful stable scaffold integration with early defect union at 8 weeks postoperative in critical-sized segmental diaphyseal defects with implanted sintered amorphous S53P4 scaffolds. This study presents important considerations for future research and the potential of the S53P4 bioactive glass as a bone substitute in large diaphyseal defects. Statement of significance Surgical management of critical-sized diaphyseal defects involves multiple challenges, and up to 10% result in delayed or non-union. The two-staged induced membrane technique is successfully used to treat these defects, but it is limited by the need of several procedures and bone graft. Repeated procedures increase costs and morbidity, while grafts are subject to donor-site complications and scarce availability. To transform this two-staged technique into one graft-independent procedure, we developed amorphous porous scaffolds sintered from the clinically used bioactive glass S53P4. This work constitutes the first evaluation of such scaffolds in vivo in a critical-sized diaphyseal defect in the weight-bearing rabbit femur. We provide important knowledge and prospects for future development of sintered S53P4 scaffolds as a bone substitute. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )Peer reviewe

S53P4 bioactive glass scaffolds induce BMP expression and integrative bone formation in a critical-sized diaphysis defect treated with a single-stage d induce d membrane technique

Surgical management of critical-sized diaphyseal defects involves multiple challenges, and up to 10% result in delayed or non-union. The two-staged induced membrane technique is successfully used to treat these defects, but it is limited by the need of several procedures and bone graft. Repeated procedures increase costs and morbidity, while grafts are subject to donor-site complications and scarce availability. To transform this two-staged technique into one graft-independent procedure, we developed amorphous porous scaffolds sintered from the clinically used bioactive glass S53P4. This work constitutes the first evaluation of such scaffolds in vivo in a critical-sized diaphyseal defect in the weight-bearing rabbit femur. We provide important knowledge and prospects for future development of sintered S53P4 scaffolds as a bone substitute. Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions. The two staged induced membrane technique has been used to treat these challenging defects since the 1980 & rsquo;s. It involves temporary implantation of a membrane-inducing spacer and subsequent bone graft defect filling. A single-staged, graft-independent technique would reduce both socio-economic costs and patient morbidity. Our aim was to enable such single-staged approach through development of a strong bioactive glass scaffold that could replace both the spacer and the graft filling. We constructed amorphous porous scaffolds of the clinically used bioactive glass S53P4 and evaluated them in vivo using a critical sized defect model in the weight-bearing femur diaphysis of New Zealand White rabbits. S53P4 scaffolds and standard polymethylmethacrylate spacers were implanted for 2, 4, and 8 weeks. Induced membranes were confirmed histologically, and their osteostimulative activity was evaluated through RT-qPCR of bone morphogenic protein 2, 4, and 7 (BMPs). Bone formation and osseointegration were examined using histology, scanning electron microscopy, energy-dispersive X-ray analysis, and micro-computed tomography imaging. Scaffold integration, defect union and osteosynthesis were assessed manually and with X-ray projections. We demonstrated that S53P4 scaffolds induce osteostimulative membranes and produce osseointegrative new bone formation throughout the scaffolds. We also demonstrated successful stable scaffold integration with early defect union at 8 weeks postoperative in critical-sized segmental diaphyseal defects with implanted sintered amorphous S53P4 scaffolds. This study presents important considerations for future research and the potential of the S53P4 bioactive glass as a bone substitute in large diaphyseal defects. Statement of significance Surgical management of critical-sized diaphyseal defects involves multiple challenges, and up to 10% result in delayed or non-union. The two-staged induced membrane technique is successfully used to treat these defects, but it is limited by the need of several procedures and bone graft. Repeated procedures increase costs and morbidity, while grafts are subject to donor-site complications and scarce availability. To transform this two-staged technique into one graft-independent procedure, we developed amorphous porous scaffolds sintered from the clinically used bioactive glass S53P4. This work constitutes the first evaluation of such scaffolds in vivo in a critical-sized diaphyseal defect in the weight-bearing rabbit femur. We provide important knowledge and prospects for future development of sintered S53P4 scaffolds as a bone substitute. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of Acta Materialia Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )Peer reviewe

A significant hardening and rising shape detected in the MeV/GeV nuFnu spectrum from the recently-discovered very-high-energy blazar S4 0954+65 during the bright optical flare in 2015 February

We report on Fermi Large Area Telescope (LAT) and multi-wavelength results on the recently-discovered very-high-energy (VHE, $E>$ 100 GeV) blazar S4 0954+65 ($z=0.368$) during an exceptionally bright optical flare in 2015 February. During the time period (2015 February, 13/14, or MJD 57067) when the MAGIC telescope detected VHE $\gamma$-ray emission from the source, the Fermi-LAT data indicated a significant spectral hardening at GeV energies, with a power-law photon index of $1.8 \pm 0.1$---compared with the 3FGL value (averaged over four years of observation) of $2.34 \pm 0.04$. In contrast, Swift/XRT data showed a softening of the X-ray spectrum, with a photon index of $1.72 \pm 0.08$ (compared with $1.38 \pm 0.03$ averaged during the flare from MJD 57066 to 57077), possibly indicating a modest contribution of synchrotron photons by the highest-energy electrons superposed on the inverse Compton component. Fitting of the quasi-simultaneous ($<1$ day) broadband spectrum with a one-zone synchrotron plus inverse-Compton model revealed that GeV/TeV emission could be produced by inverse-Compton scattering of external photons from the dust torus. We emphasize that a flaring blazar showing high flux of $\gtrsim 1.0 \times 10^{-6}$ photons cm$^{-2}$ s$^{-1}$ ($E>$ 100 MeV) and a hard spectral index of $\Gamma_{\rm GeV} < 2.0$ detected by Fermi-LAT on daily time scales is a promising target for TeV follow-up by ground-based Cherenkov telescopes to discover high-redshift blazars, investigate their temporal variability and spectral features in the VHE band, and also constrain the intensity of the extragalactic background light.Comment: 15 pages, 3 figures, 2 tables. Accepted by PAS

Precursor flares in OJ 287

We have studied three most recent precursor flares in the light curve of the blazar OJ 287 while invoking the presence of a precessing binary black hole in the system to explain the nature of these flares. Precursor flare timings from the historical light curves are compared with theoretical predictions from our model that incorporate effects of an accretion disk and post-Newtonian description for the binary black hole orbit. We find that the precursor flares coincide with the secondary black hole descending towards the accretion disk of the primary black hole from the observed side, with a mean z-component of approximately z_c = 4000 AU. We use this model of precursor flares to predict that precursor flare of similar nature should happen around 2020.96 before the next major outburst in 2022.Comment: to appear in the Astrophysical Journa

Locating the γ-ray emission site in Fermi/LAT blazars – II. Multifrequency correlations

In an attempt to constrain and understand the emission mechanism of γ-rays, we perform a cross-correlation analysis of 15 blazars using light curves in millimetre, optical and γ-rays. We use discrete correlation function and consider only correlations significant at the 99 per cent level. A strong correlation was found between 37 and 95 GHz with a near-zero time delay in most of the sources, and ∼1 month or longer in the rest. A similar result was obtained between the optical and γ-ray bands. Of the 15 sources, less than 50 per cent showed a strong correlation between the millimetre and γ-ray or millimetre and optical bands. The primary reason for the lack of statistically significant correlation is the absence of a major outburst in the millimetre bands of most of the sources during the 2.5 yr time period investigated in our study. This may indicate that only the long-term variations or large flares are correlated between these bands. The variability of the sources at every waveband was also inspected using fractional rms variability (F_(var)). The F_(var) displays an increase with frequency reaching its maximum in the γ-rays

Rayleigh Imaging of Graphene and Graphene Layers

We investigate graphene and graphene layers on different substrates by monochromatic and white-light confocal Rayleigh scattering microscopy. The image contrast depends sensitively on the dielectric properties of the sample as well as the substrate geometry and can be described quantitatively using the complex refractive index of bulk graphite. For few layers (<6) the monochromatic contrast increases linearly with thickness: the samples behave as a superposition of single sheets which act as independent two dimensional electron gases. Thus, Rayleigh imaging is a general, simple and quick tool to identify graphene layers, that is readily combined with Raman scattering, which provides structural identification.Comment: 8 pages, 9 figure

INTEGRAL observations of the field of the BL Lacertae object S5~0716+714

We have performed observations of the blazar S5 0716+714 with INTEGRAL on 2-6 April 2004. In the first months of 2004, the source had increased steadily in optical brightness and had undergone two outbursts. During the latter, occurred in March, it reached the extreme level of R = 12.1 mag, which triggered our INTEGRAL program. The target has been detected with IBIS/ISGRI up to 60 keV, with a flux of ~3 x 10e-11 erg/s/cm2 in the 30-60 keV interval, a factor of ~2 higher than observed by the BeppoSAX PDS in October 2000. In the field of S5 0716+714 we have also detected the Flat Spectrum Radio Quasar S5 0836+710 and the two Seyfert galaxies Mkn 3 and Mkn 6. Their IBIS/ISGRI spectra are rather flat, albeit consistent with those measured by BeppoSAX. In the spectrum of Mkn 3 we find some evidence of a break between ~60 and ~100 keV, reminiscent of the high energy cut-offs observed in other Seyfert galaxies. This is the first report of INTEGRAL spectra of weak Active Galactic Nuclei.Comment: 5 pages, 5 figures, in press in A&

Radio-to-UV monitoring of AO 0235+164 by the WEBT and Swift during the 2006--2007 outburst

The blazar AO 0235+164 was claimed to show a quasi-periodic behaviour in the radio and optical bands. Moreover, an extra emission component contributing to the UV and soft X-ray flux was detected, whose nature is not yet clear. A predicted optical outburst was observed in late 2006/early 2007. We here present the radio-to-optical WEBT light curves during the outburst, together with UV data acquired by Swift in the same period. We found the optical outburst to be as strong as the big outbursts of the past: starting from late September 2006, a brightness increase of 5 mag led to the outburst peak in February 19-21, 2007. We also observed an outburst at mm and then at cm wavelengths, with an increasing time delay going toward lower frequencies during the rising phase. Cross-correlation analysis indicates that the 1 mm and 37 GHz flux variations lagged behind the R-band ones by about 3 weeks and 2 months, respectively. These short time delays suggest that the corresponding jet emitting regions are only slightly separated and/or misaligned. In contrast, during the outburst decreasing phase the flux faded contemporaneously at all cm wavelengths. This abrupt change in the emission behaviour may suggest the presence of some shutdown mechanism of intrinsic or geometric nature. The behaviour of the UV flux closely follows the optical and near-IR one. By separating the synchrotron and extra component contributions to the UV flux, we found that they correlate, which suggests that the two emissions have a common origin.Comment: 9 pages, 7 figures, in press for Astronomy and Astrophysic