Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel’s proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters

Open Access, Research Data Management (RDM) and Open Science in Poland 2019

Data from a survey on attitudes and perceptions of librarians & researchers about Open Access, Research Data Management (RDM) and Open Science in Poland, collected in Q4 2019. Three files are provided - report on quantitative survey results, all responses in Polish, and all responses translated into English without the replies in open fields. It was collected via an online survey, targeted to approx. 7,500 Polish authors/researchers randomly selected from Scopus database and to approx. 800 librarians from Elsevier contact database. 461 responses in total representing a margin of error of ±4% at 90% confidence levels. This represent a response rate of ±6%. The data collection lasted for 1 week 29th Oct’19 to 5th Nov’ 19 with a survey reminder sent in between. Survey was designed in Polish. Notable findings: Librarians and researchers show a good understanding of Open Access. Nearly half of researchers have experienced publishing in a Gold OA journal. The publishing experience with Gold OA is positive. Value for money and reputation are the only aspects researchers rate Gold OA worse than subscription journals. Cost is the main reason for researchers not to publish in Gold OA journals. Researchers use mainly personal computers/clouds/drives to archive their research data and share it mainly within their project team. One third of libraries would benefit from obtaining more information about RDM in order to be able to support researchers. Most librarians and researchers consider their institution approach to RDM as (very) disorganised. Librarians are more knowledgeable about the concept than Researchers. Most libraries are currently supporting Open Science. Yet, the majority of researchers are not aware of the initiatives/ practices available in their institution. Librarians and researchers agree – Libraries are (very) important in the future of Open Science in Poland

Open Access, Research Data Management (RDM) and Open Science in Poland 2019

Data from a survey on attitudes and perceptions of librarians & researchers about Open Access, Research Data Management (RDM) and Open Science in Poland, collected in Q4 2019. Three files are provided - report on quantitative survey results, all responses in Polish, and all responses translated into English without the replies in open fields. It was collected via an online survey, targeted to approx. 7,500 Polish authors/researchers randomly selected from Scopus database and to approx. 800 librarians from Elsevier contact database. 461 responses in total representing a margin of error of ±4% at 90% confidence levels. This represent a response rate of ±6%. The data collection lasted for 1 week 29th Oct’19 to 5th Nov’ 19 with a survey reminder sent in between. Survey was designed in Polish. Notable findings: Librarians and researchers show a good understanding of Open Access. Nearly half of researchers have experienced publishing in a Gold OA journal. The publishing experience with Gold OA is positive. Value for money and reputation are the only aspects researchers rate Gold OA worse than subscription journals. Cost is the main reason for researchers not to publish in Gold OA journals. Researchers use mainly personal computers/clouds/drives to archive their research data and share it mainly within their project team. One third of libraries would benefit from obtaining more information about RDM in order to be able to support researchers. Most librarians and researchers consider their institution approach to RDM as (very) disorganised. Librarians are more knowledgeable about the concept than Researchers. Most libraries are currently supporting Open Science. Yet, the majority of researchers are not aware of the initiatives/ practices available in their institution. Librarians and researchers agree – Libraries are (very) important in the future of Open Science in Poland.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Progression, transformation, and unusual manifestations of myelodysplastic syndromes and myelodysplastic-myeloproliferative neoplasms: lessons learned from XIV European Bone Marrow Working Group Course 2019

Contains fulltext : 232929.pdf (Publisher’s version ) (Closed access

Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe.

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises 7-8% of B-cell lymphomas and commonly originates from a background of long-standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of MALT lymphoma. For pulmonary MALT lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S rRNA gene-based approach, we have recently identified Achromobacter (Alcaligenes) xylosoxidans in eight of nine cases of pulmonary MALT lymphoma. A. xylosoxidans is a gram-negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with A. xylosoxidans, 124 cases of pulmonary MALT lymphoma and 82 control tissues from six European countries were analysed using a specific nested PCR. Although prevalence rates for A. xylosoxidans varied significantly from country to country, they were consistently higher for MALT lymphoma as compared to controls. Overall, 57/124 (46%) pulmonary MALT lymphomas and 15/82 (18%) control tissues were positive for A. xylosoxidans (P = 0\ub7004). Whether the significant association of A. xylosoxidans with pulmonary MALT lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies

Prevalence of Achromobacter xylosoxidans in pulmonary mucosa-associated lymphoid tissue lymphoma in different regions of Europe

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) comprises 7\u20138% of B-cell lymphomas and commonly originates from a background of long-standing chronic inflammation. An association with distinct bacteria species has been confirmed for several anatomical sites of MALT lymphoma. For pulmonary MALT lymphoma, however, a clear link with an infectious agent or autoimmune disorder has not yet been reported. Using a 16S rRNA gene\u2013based approach, we have recently identified Achromobacter (Alcaligenes) xylosoxidans in eight of nine cases of pulmonary MALT lymphoma. A. xylosoxidans is a gram-negative betaproteobacterium with low virulence, but high resistance to antibiotic treatment. To further examine a potential association with A. xylosoxidans, 124 cases of pulmonary MALT lymphoma and 82 control tissues from six European countries were analysed using a specific nested PCR. Although prevalence rates for A. xylosoxidans varied significantly from country to country, they were consistently higher for MALT lymphoma as compared to controls. Overall, 57/124 (46%) pulmonary MALT lymphomas and 15/ 82 (18%) control tissues were positive for A. xylosoxidans (P = 0004). Whether the significant association of A. xylosoxidans with pulmonary MALT lymphoma demonstrated in our study points to a potential causal role in the pathogenesis of this lymphoma will require further studies