Mean first passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding

We have analyzed dynamics on the complex free energy landscape of protein folding in the FOLD-X model, by calculating for each state of the system the mean first passage time to the folded state. The resulting kinetic map of the folding process shows that it proceeds in jumps between well-defined, local free energy minima. Closer analysis of the different local minima allows us to reveal secondary, parallel pathways as well as dead ends.Comment: 7 page

Binary morphological shape-based interpolation applied to 3-D tooth reconstruction

In this paper we propose an interpolation algorithm using a mathematical morphology morphing approach. The aim of this algorithm is to reconstruct the $n$-dimensional object from a group of (n-1)-dimensional sets representing sections of that object. The morphing transformation modifies pairs of consecutive sets such that they approach in shape and size. The interpolated set is achieved when the two consecutive sets are made idempotent by the morphing transformation. We prove the convergence of the morphological morphing. The entire object is modeled by successively interpolating a certain number of intermediary sets between each two consecutive given sets. We apply the interpolation algorithm for 3-D tooth reconstruction

Deriving a systematic approach to changeable manufacturing system design

It has long been argued that Factories are long life and complex products. The complexity of designing factories, and their underlying manufacturing systems, is further amplified when dealing with continuously changing customer demands. At the same time, due to research fragmentation, little if any scientific explanations are available supporting and exploiting the paradigm that "factories are products". In order to address this weakness, this paper presents research results arising from a comparative analysis of systematic "product design" and "manufacturing system design" approaches. The contribution emerging from this research is an integrated systematic design approach to changeable manufacturing systems, based on scientific concepts founded upon product design theories, and is explained through a case study in the paper. This research is part of collaboration between the CERU University of Malta and IAO Fraunhofer aimed at developing a digital decision support tool for planning changeable manufacturing systems.peer-reviewe

Compact phases of polymers with hydrogen bonding

We propose an off-lattice model for a self-avoiding homopolymer chain with two different competing attractive interactions, mimicking the hydrophobic effect and the hydrogen bond formation respectively. By means of Monte Carlo simulations, we are able to trace out the complete phase diagram for different values of the relative strength of the two competing interactions. For strong enough hydrogen bonding, the ground state is a helical conformation, whereas with decreasing hydrogen bonding strength, helices get eventually destabilized at low temperature in favor of more compact conformations resembling $\beta$-sheets appearing in native structures of proteins. For weaker hydrogen bonding helices are not thermodynamically relevant anymore.Comment: 5 pages, 3 figures; revised version published in PR

Constrained dynamic control of traffic junctions

Excessive traffic in our urban environments has detrimental effects on our health, economy and standard of living. To mitigate this problem, an adaptive traffic lights signalling scheme is developed and tested in this paper. This scheme is based on a state space representation of traffic dynamics, controlled via a dynamic programme. To minimise implementation costs, only one loop detector is assumed at each link. The comparative advantages of the proposed system over optimal fixed time control are highlighted through an example. Results will demonstrate the flexibility of the system when applied to different junctions. Monte Carlo runs of the developed scheme highlight the consistency and repeatability of these results.peer-reviewe

Community, work and family in diverse contexts and changing times

The 8th International Community, Work and Family conference took place in Malta at the Valletta campus of the University of Malta between the 23rd to the 25th May 2019. In a pre-COVID-19 world with no traveling restrictions, the conference brought together over 100 experts, academics, and students from a broad range of countries and disciplines to focus on the theme of Community, Work and Family in Diverse Contexts and Changing Times. The research presented during the conference highlights some of the challenges that communities, organizations and families are facing in the twenty-first century across diverse and rapidly changing contexts. The topics presented spanned from broad studies that analyze the work-life interface of well-studied groups such as fathers and mothers, to other clusters that are generally less well-researched such as the police and the military, migrants, solo entrepreneurs, the LGBTIQ community, and those who work with people with special needs. The recurrent theme of the gendered division of labor and work-life measures was discussed by various researchers, as were the issues of flexible work, family policy, and the impact of technology. It was refreshing to note that various researchers focused on the issue of community as a source of support, whilst others explored how peer, supervisor and management support impacts work-life issues. Overall, the conference provided a diverse and rich range of scholarly material upon which to develop this special issue for Community, Work & Family. [...

Scale Free Cluster Distributions from Conserving Merging-Fragmentation Processes

We propose a dynamical scheme for the combined processes of fragmentation and merging as a model system for cluster dynamics in nature and society displaying scale invariant properties. The clusters merge and fragment with rates proportional to their sizes, conserving the total mass. The total number of clusters grows continuously but the full time-dependent distribution can be rescaled over at least 15 decades onto a universal curve which we derive analytically. This curve includes a scale free solution with a scaling exponent of -3/2 for the cluster sizes.Comment: 4 pages, 3 figure