Why Are Deep Representations Good Perceptual Quality Features?

Recently, intermediate feature maps of pre-trained convolutional neural networks have shown significant perceptual quality improvements, when they are used in the loss function for training new networks. It is believed that these features are better at encoding the perceptual quality and provide more efficient representations of input images compared to other perceptual metrics such as SSIM and PSNR. However, there have been no systematic studies to determine the underlying reason. Due to the lack of such an analysis, it is not possible to evaluate the performance of a particular set of features or to improve the perceptual quality even more by carefully selecting a subset of features from a pre-trained CNN. This work shows that the capabilities of pre-trained deep CNN features in optimizing the perceptual quality are correlated with their success in capturing basic human visual perception characteristics. In particular, we focus our analysis on fundamental aspects of human perception, such as the contrast sensitivity and orientation selectivity. We introduce two new formulations to measure the frequency and orientation selectivity of the features learned by convolutional layers for evaluating deep features learned by widely-used deep CNNs such as VGG-16. We demonstrate that the pre-trained CNN features which receive higher scores are better at predicting human quality judgment. Furthermore, we show the possibility of using our method to select deep features to form a new loss function, which improves the image reconstruction quality for the well-known single-image super-resolution problem.Comment: To be presented at ECCV 202

Correlações entre características relacionadas ao temperamento em animais da raça Canchim.

O temperamento de um animal representa uma interação complexa entre seu genótipo e o ambiente ao qual está exposto. Medidas de temperamento diferentes e realizadas sob diferentes metodologias podem ser aplicadas aos programas de seleção. O objetivo do trabalho foi obter correlações fenotípicas e de ranking entre reatividade e escores de temperamento relacionados ao deslocamento e à tensão na balança de animais da raça Canchim pertencentes a um programa de melhoramento. Dados de 217 animais da safra 2012 foram avaliados à desmama, na balança, por meio de escores de deslocamento (DES10 e DES20) e de tensão (TEN10 e TEN20) aos 10 e aos 20 segundos e do número e intensidade de movimentos do animal (REAT) quantificados por meio de equipamento e software específicos. As correlações foram obtidas por meio do pacote estatístico SAS, tanto para os dados gerais, quanto por sexo e para os grupos de avaliação (de 1 a 4). De maneira geral, as correlações fenotípicas e de ranking entre REAT, TEN10, TEN20, DES10 e DES20 foram altas e positivas, indicando concordância entre as metodologias na avaliação de animais desmamados da raça Canchim. Outras avaliações serão realizadas em idades posteriores e até a finalização do projeto com outras safras, em 2017

Development of large radii half-wave plates for CMB satellite missions

The successful European Space Agency (ESA) Planck mission has mapped the Cosmic Microwave Background (CMB) temperature anisotropy with unprecedented accuracy. However, Planck was not designed to detect the polarised components of the CMB with comparable precision. The BICEP2 collaboration has recently reported the first detection of the B-mode polarisation. ESA is funding the development of critical enabling technologies associated with B-mode polarisation detection, one of these being large diameter half-wave plates. We compare different polarisation modulators and discuss their respective trade-offs in terms of manufacturing, RF performance and thermo-mechanical properties. We then select the most appropriate solution for future satellite missions, optimized for the detection of B-modes.Comment: 16 page

The screening for depression and neurocognitive disorders in subjects newly diagnosed with HIV

Background Inflammatory mediators may be relevant to explain the frequent comorbidity between depression, neurocognitive disorders and HIV. HIV induces activation of inflammatory mediators, mainly cytokines, that have been involved in the onset of depression and response to antidepressant treatment. Aim To identify recurring profiles of inflammatory biomarkers subtending depression, effectiveness of antidepressants and neurocognitive disorders among HIV-infected individuals. Methods All adult newly HIV-diagnosed out-patients attending HIV clinics in three towns of Northern Italy were screened, assessed for depression and studied immunologically and for neurocognitive disorders. Results Twenty-five patients have been enrolled so far: of these, 35% were positive to PHQ-9 screening, of which 6 were positive to the diagnostic assessment for depression. No neurocognitive disorders were found among the patients. As the project will develop, it is expected that frequency of depression, neurocognitive disorders and effective antidepressant treatment will be found to correlate to the profile of immune biomarkers. These findings might help to understand the etiology of depression in HIV, and specifically the role of inflammation and immunological changes

Detection of Zak phases and topological invariants in a chiral quantum walk of twisted photons

Topological insulators are fascinating states of matter exhibiting protected edge states and robust quantized features in their bulk. Here, we propose and validate experimentally a method to detect topological properties in the bulk of one-dimensional chiral systems. We first introduce the mean chiral displacement, and we show that it rapidly approaches a multiple of the Zak phase in the long time limit. Then we measure the Zak phase in a photonic quantum walk, by direct observation of the mean chiral displacement in its bulk. Next, we measure the Zak phase in an alternative, inequivalent timeframe, and combine the two windings to characterize the full phase diagram of this Floquet system. Finally, we prove the robustness of the measure by introducing dynamical disorder in the system. This detection method is extremely general, as it can be applied to all one-dimensional platforms simulating static or Floquet chiral systems.Comment: 10 pages, 7 color figures (incl. appendices) Close to the published versio

The High Frequency Instrument of Planck: Requirements and Design

The Planck satellite is a project of the European Space Agency based on a wide international collaboration, including United States and Canadian laboratories. It is dedicated to the measurement of the anisotropy of the Cosmic Microwave Background (CMB) with unprecedented sensitivity and angular resolution. The detectors of its High frequency Instrument (HFI) are bolometers cooled down to 100 mK. Their sensitivity will be limited by the photon noise of the CMB itself at low frequencies, and of the instrument background at high frequencies. The requirements on the measurement chain are directly related to the strategy of observation used for the satellite. Due to the scanning on the sky, time features of the measurement chain are directly transformed into angular features in the sky maps. This impacts the bolometer design as well as other elements: For example, the cooling system must present outstanding temperature stability, and the amplification chain must show, down to very low frequencies, a flat noise spectrum

Socio-Economic and Clinical Factors as Predictors of Disease Evolution and Acute Events in COPD Patients

BACKGROUND: Socio-economic, cultural and environmental factors are becoming increasingly important determinants of chronic obstructive pulmonary disease (COPD). We conducted a study to investigate socio-demographic, lifestyle and clinical factors, and to assess their role as predictors of acute events (mortality or hospitalization for respiratory causes) in a group of COPD patients. METHODS: Subjects were recruited among outpatients who were undertaking respiratory function tests at the Pneumology Unit of the Sant'Orsola-Malpighi Hospital, Bologna. Patients were classified according to the GOLD Guidelines. RESULTS: 229 patients with COPD were included in the study, 44 with Mild, 68 Moderate, 52 Severe and 65 Very Severe COPD (GOLD stage). Significant differences among COPD stage, in terms of smoking status and fragility index, were detected. COPD stage significantly affected the values of all clinical tests (spirometry and ABG analysis). Kaplan-Meier estimates showed a significant difference between survival curves by COPD stage with lower event-free probability in very severe COPD stage. Significant risk factors for acute events were: underweight (HR = 4.08; 95% CI 1.01-16.54), having two or more comorbidities (HR = 4.71; 95% CI 2.52-8.83), belonging to moderate (HR = 3.50; 95% CI 1.01-12.18) or very severe COPD stage (HR = 8.23; 95% CI 2.35-28.85). CONCLUSIONS: Our findings indicate that fragility is associated with COPD stage and that comorbidities and the low body mass index are predictors of mortality or hospitalization. Besides spirometric analyses, FeNO measure and comorbidities, body mass index could also be considered in the management and monitoring of COPD patients

Planck pre-launch status: HFI beam expectations from the optical optimisation of the focal plane

Planck is a European Space Agency (ESA) satellite, launched in May 2009, which will map the cosmic microwave background anisotropies in intensity and polarisation with unprecedented detail and sensitivity. It will also provide full-sky maps of astrophysical foregrounds. An accurate knowledge of the telescope beam patterns is an essential element for a correct analysis of the acquired astrophysical data. We present a detailed description of the optical design of the High Frequency Instrument (HFI) together with some of the optical performances measured during the calibration campaigns. We report on the evolution of the knowledge of the pre-launch HFI beam patterns when coupled to ideal telescope elements, and on their significance for the HFI data analysis procedure

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elusive. Neuronal circuits are shaped by experience during critical periods of heightened plasticity. The maturation of cortical GABA inhibitory circuitry, the parvalbumin+ (PV+) fast-spiking interneurons in particular, is a key component that regulates the initiation and termination of the critical period. Using MeCP2-null mice, we examined experience-dependent development of neural circuits in the primary visual cortex. The functional maturation of parvalbumin interneurons was accelerated upon vision onset, as indicated by elevated GABA synthetic enzymes, vesicular GABA transporter, perineuronal nets, and enhanced GABA transmission among PV interneurons. These changes correlated with a precocious onset and closure of critical period and deficient binocular visual function in mature animals. Reduction of GAD67 expression rescued the precocious opening of the critical period, suggesting its major role in MECP2-mediated regulation of experience-driven circuit development. Our results identify molecular changes in a defined cortical cell type and link aberrant developmental trajectory to functional deficits in a model of neuropsychiatric disorder

QUBIC: The QU Bolometric Interferometer for Cosmology

One of the major challenges of modern cosmology is the detection of B-mode polarization anisotropies in the CMB. These originate from tensor fluctuations of the metric produced during the inflationary phase. Their detection would therefore constitute a major step towards understanding the primordial Universe. The expected level of these anisotropies is however so small that it requires a new generation of instruments with high sensitivity and extremely good control of systematic effects. We propose the QUBIC instrument based on the novel concept of bolometric interferometry, bringing together the sensitivity advantages of bolometric detectors with the systematics effects advantages of interferometry. Methods: The instrument will directly observe the sky through an array of entry horns whose signals will be combined together using an optical combiner. The whole set-up is located inside a cryostat. Polarization modulation will be achieved using a rotating half-wave plate and interference fringes will be imaged on two focal planes (separated by a polarizing grid) tiled with bolometers. We show that QUBIC can be considered as a synthetic imager, exactly similar to a usual imager but with a synthesized beam formed by the array of entry horns. Scanning the sky provides an additional modulation of the signal and improve the sky coverage shape. The usual techniques of map-making and power spectrum estimation can then be applied. We show that the sensitivity of such an instrument is comparable with that of an imager with the same number of horns. We anticipate a low level of beam-related systematics thanks to the fact that the synthesized beam is determined by the location of the primary horns. Other systematics should be under good control thanks to an autocalibration technique, specific to our concept, that will permit the accurate determination of most of the systematics parameters.Comment: 12 pages, 10 figures, submitted to Astronomy and Astrophysic