The effective elastic thickness of the India Plate from receiver function imaging, gravity anomalies and thermomechanical modelling

The range and the meaning of the effective elastic thickness (EET) in continental areas have been subject to controversy over the last two decades. Here we take advantage of the new data set from the Hi-CLIMB seismological experiment to re-estimate the EET of the India Plate along a south-north profile extending from the Ganges basin to central Tibet. Receiver functions give a high-resolution image of the base of the foreland basin at similar to 5 km depth and constrain the crustal thickness, which increases northwards from similar to 35 km beneath the indo-gangetic plain to similar to 70 km in southern Tibet. Together with available data sets including seismic profiles, seismological images from both INDEPTH and HIMNT experiments, deep well measurements and Bouguer anomaly profiles, we interpret this new image with 2-D thermomechanical modelling solutions, using different type of crustal and mantle rheologies. We find that (1) the EET of the India Plate decreases northwards from 60-80 to 20-30 km as it is flexed down beneath Himalaya and Tibet, due to thermal and flexural weakening; (2) the only resistant layer of the India Plate beneath southern Tibet is the upper mantle, which serves as a support for the topographic load and (3) the most abrupt drop in the EET, located around 200 km south of the MFT, is associated with a gradual decoupling between the crust and the mantle. We show that our geometrical constraints do not allow to determine if the upper and lower crust are coupled or not. Our results clearly reveal that a rheology with a weak mantle is unable to explain the geometry of the lithosphere in this region, and they are in favour of a rheology in which the mantle is strong

Experimental pig-to-pig transmission dynamics for African swine fever virus, Georgia 2007/1 strain

African swine fever virus (ASFV) continues to cause outbreaks in domestic pigs and wild boar in Eastern European countries. To gain insights into its transmission dynamics, we estimated the pig-to-pig basic reproduction number (R 0) for the Georgia 2007/1 ASFV strain using a stochastic susceptible-exposed-infectious-recovered (SEIR) model with parameters estimated from transmission experiments. Models showed that R 0 is 2·8 [95% confidence interval (CI) 1·3–4·8] within a pen and 1·4 (95% CI 0·6–2·4) between pens. The results furthermore suggest that ASFV genome detection in oronasal samples is an effective diagnostic tool for early detection of infection. This study provides quantitative information on transmission parameters for ASFV in domestic pigs, which are required to more effectively assess the potential impact of strategies for the control of between-farm epidemic spread in European countries.ISSN:0950-2688ISSN:1469-440

Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression

In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induction associated with cyclooxygenase-2 (COX-2) up-regulation. Celecoxib, a selective COX-2 inhibitor, provoked a large decrease in diosgenin-induced apoptosis even in the presence of exogenous prostaglandin E(2), whereas interleukin-1β, a COX-2 inducer, strongly increased diosgenin-induced apoptosis of these synoviocytes. These findings suggest that the proapoptotic effect of diosgenin is associated with overexpression of COX-2 correlated with overproduction of endogenous prostaglandin E(2). We also observed a loss of mitochondrial membrane potential, caspase-3 activation, and DNA fragmentation after diosgenin treatment

The 2015 Gorkha earthquake: A large event illuminating the Main Himalayan Thrust fault

International audienceThe 2015 Gorkha earthquake sequence provides an outstanding opportunity to better characterize the geometry of the Main Himalayan Thrust (MHT). To overcome limitations due to unaccounted lateral heterogeneities, we perform Centroid Moment Tensor inversions in a 3-D Earth model for the main shock and largest aftershocks. In parallel, we recompute S-toP and P-to-S receiver functions from the Hi-CLIMB data set. Inverted centroid locations fall within a low-velocity zone at 10–15 km depth and corresponding to the subhorizontal portion of the MHT that ruptured during the Gorkha earthquake. North of the main shock hypocenter, receiver functions indicate a north dipping feature that likely corresponds to the midcrustal ramp connecting the flat portion to the deep part of the MHT. Our analysis of the main shock indicates that long-period energy emanated updip of high-frequency radiation sources previously inferred. This frequency-dependent rupture process might be explained by different factors such as fault geometry and the presence of fluids

Preformed expression of defense is a hallmark of partial resistance to rice blast fungal pathogen Magnaporthe oryzae

Background: Partial resistance to plant pathogens is extensively used in breeding programs since it could contribute to resistance durability. Partial resistance often builds up during plant development and confers quantitative and usually broad-spectrum resistance. However, very little is known on the mechanisms underlying partial resistance. Partial resistance is often explained by poorly effective induction of plant defense systems. By exploring rice natural diversity, we asked whether expression of defense systems before infection could explain partial resistance towards the major fungal pathogen Magnaporthe oryzae. The constitutive expression of 21 defense-related genes belonging to the defense system was monitored in 23 randomly sampled rice cultivars for which partial resistance was measured. Results: We identified a strong correlation between the expression of defense-related genes before infection and partial resistance. Only a weak correlation was found between the induction of defense genes and partial resistance. Increasing constitutive expression of defense-related genes also correlated with the establishment of partial resistance during plant development. Some rice genetic sub-groups displayed a particular pattern of constitutive expression, suggesting a strong natural polymorphism for constitutive expression of defense. Constitutive levels of hormones like salicylic acid and ethylene cannot explain constitutive expression of defense. We could identify an area of the genome that contributes to explain both preformed defense and partial resistance. Conclusion: These results indicate that constitutive expression of defense-related genes is likely responsible for a large part of partial resistance in rice. The finding of this preformed defense system should help guide future breeding programs and open the possibility to identify the molecular mechanisms behind partial resistance. ( Résumé d'auteur

Invariants of solvable rigid Lie algebras up to dimension 8

The invariants of all complex solvable rigid Lie algebras up to dimension eight are computed. Moreover we show, for rank one solvable algebras, some criteria to deduce to non-existence of non-trivial invariants or the existence of fundamental sets of invariants formed by rational functions of the Casimir invariants of the associated nilradical.Comment: 16 pages, 7 table

Low field hysteresis in disordered ferromagnets

We analyze low field hysteresis close to the demagnetized state in disordered ferromagnets using the zero temperature random-field Ising model. We solve the demagnetization process exactly in one dimension and derive the Rayleigh law of hysteresis. The initial susceptibility a and the hysteretic coefficient b display a peak as a function of the disorder width. This behavior is confirmed by numerical simulations d=2,3 showing that in limit of weak disorder demagnetization is not possible and the Rayleigh law is not defined. These results are in agreement with experimental observations on nanocrystalline magnetic materials.Comment: Extended version, 18 pages, 5 figures, to appear in Phys. Rev.

On the structure of maximal solvable extensions and of Levi extensions of nilpotent algebras

We establish an improved upper estimate on dimension of any solvable algebra s with its nilradical isomorphic to a given nilpotent Lie algebra n. Next we consider Levi decomposable algebras with a given nilradical n and investigate restrictions on possible Levi factors originating from the structure of characteristic ideals of n. We present a new perspective on Turkowski's classification of Levi decomposable algebras up to dimension 9.Comment: 21 pages; major revision - one section added, another erased; author's version of the published pape