349 research outputs found
CPA\u27s guide to sophisticated estate planning techniques
https://egrove.olemiss.edu/aicpa_guides/1300/thumbnail.jp
CPA\u27s basic guide to proven estate planning strategies to protect client wealth
https://egrove.olemiss.edu/aicpa_guides/1445/thumbnail.jp
An Open Source Software Culture in the Undergraduate Computer Science Curriculum
Open source software has made inroads into mainstream computing where it was once the territory of software altruists, and the open source culture of technological collegiality and accountability may benefit education as well as industry. This paper describes the Recourse project, which seeks to transform the computer science undergraduate curriculum through teaching methods based on open source principles, values, ethics, and tools. Recourse differs from similar projects by bringing the open source culture into the curriculum comprehensively, systematically, and institutionally. The current state of the project is described, and initial results from a pilot exercise are presented
Extramedullary disease in multiple myeloma: a systematic literature review
Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM), characterized by the ability of a clone and/or subclone to thrive and grow independent of the bone marrow microenvironment. Several different definitions of EMD have been used in the published literature. We advocate that true EMD is restricted to soft-tissue plasmacytomas that arise due to hematogenous spread and have no contact with bony structures. Typical sites of EMD vary according to the phase of MM. At diagnosis, EMD is typically found in skin and soft tissues; at relapse, typical sites involved include liver, kidneys, lymph nodes, central nervous system (CNS), breast, pleura, and pericardium. The reported incidence of EMD varies considerably, and differences in diagnostic approach between studies are likely to contribute to this variability. In patients with newly diagnosed MM, the reported incidence ranges from 0.5% to 4.8%, while in relapsed/refractory MM the reported incidence is 3.4 to 14%. Available data demonstrate that the prognosis is poor, and considerably worse than for MM without soft-tissue plasmacytomas. Among patients with plasmacytomas, those with EMD have poorer outcomes than those with paraskeletal involvement. CNS involvement is rare, but prognosis is even more dismal than for EMD in other locations, particularly if there is leptomeningeal involvement. Available data on treatment outcomes for EMD are derived almost entirely from retrospective studies. Some agents and combinations have shown a degree of efficacy but, as would be expected, this is less than in MM patients with no extramedullary involvement. The paucity of prospective studies makes it difficult to justify strong recommendations for any treatment approach. Prospective data from patients with clearly defined EMD are important for the optimal evaluation of treatment outcomes
Extramedullary disease in multiple myeloma: a systematic literature review
Extramedullary involvement (or extramedullary disease, EMD) represents an aggressive form of multiple myeloma (MM), characterized by the ability of a clone and/or subclone to thrive and grow independent of the bone marrow microenvironment. Several different definitions of EMD have been used in the published literature. We advocate that true EMD is restricted to soft-tissue plasmacytomas that arise due to hematogenous spread and have no contact with bony structures. Typical sites of EMD vary according to the phase of MM. At diagnosis, EMD is typically found in skin and soft tissues; at relapse, typical sites involved include liver, kidneys, lymph nodes, central nervous system (CNS), breast, pleura, and pericardium. The reported incidence of EMD varies considerably, and differences in diagnostic approach between studies are likely to contribute to this variability. In patients with newly diagnosed MM, the reported incidence ranges from 0.5% to 4.8%, while in relapsed/refractory MM the reported incidence is 3.4 to 14%. Available data demonstrate that the prognosis is poor, and considerably worse than for MM without soft-tissue plasmacytomas. Among patients with plasmacytomas, those with EMD have poorer outcomes than those with paraskeletal involvement. CNS involvement is rare, but prognosis is even more dismal than for EMD in other locations, particularly if there is leptomeningeal involvement. Available data on treatment outcomes for EMD are derived almost entirely from retrospective studies. Some agents and combinations have shown a degree of efficacy but, as would be expected, this is less than in MM patients with no extramedullary involvement. The paucity of prospective studies makes it difficult to justify strong recommendations for any treatment approach. Prospective data from patients with clearly defined EMD are important for the optimal evaluation of treatment outcomes
Foreign policy and political possibility
This article explores the relationship between foreign policy and political possibility in two parts. First, the relationship between foreign policy and political possibility is theorized around three analytical moments: political possibility is linked to the framing of conceivable, communicable and coercive foreign policy. Second, this framework is developed and demonstrated through a brief analysis of Coalition foreign policy in the War on Terror, considering American, British and Australian foreign policy between 2001 and 2003. This analysis dissects distinct and divergent Coalition foreign policies through a linked three-part conceptualization of political possibility. It enables an understanding of how the War on Terror was rendered possible through the construction of foreign policy in thinkable, resonant and ultimately dominant terms. The article concludes by looking to the wider analytical applicability of this particular theorization of the relationship between foreign policy and political possibility
The Nearby Evolved Stars Survey I. JCMT/SCUBA-2 Submillimeter Detection of the Detached Shell of U Antliae
We present the highest resolution single-dish submillimetre observations of the detached shell source U Antliae to date. The observations were obtained at 450 and 850m with SCUBA-2 instrument on the James Clerk Maxwell Telescope as part of the Nearby Evolved Stars Survey. The emission at 850m peaks at 40 arcsec with hints of a second peak seen at 20 arcsec. The emission can be traced out to a radius of 56 arcsec at a 3 level. The outer peak observed at 850m aligns well with the peak observed at Herschel/PACS wavelengths. With the help of spectral energy distribution fitting and radiative transfer calculations of multiple-shell models for the circumstellar envelope, we explore the various shell structures and the variation of grain sizes along the in the circumstellar envelope. We determine a total shell dust mass of (2.0 0.3) 105 M and established that the thermal pulse that gave rise to the detached shell occurred 3500 500 yr ago
Geographically touring the eastern bloc: British geography, travel cultures and the Cold War
This paper considers the role of travel in the generation of geographical knowledge of the eastern bloc by British geographers. Based on oral history and surveys of published work, the paper examines the roles of three kinds of travel experience: individual private travels, tours via state tourist agencies, and tours by academic delegations. Examples are drawn from across the eastern bloc, including the USSR, Poland, Romania, East Germany and Albania. The relationship between travel and publication is addressed, notably within textbooks, and in the Geographical Magazine. The study argues for the extension of accounts of cultures of geographical travel, and seeks to supplement the existing historiography of Cold War geography
Howard's War on Terror: A Conceivable, Communicable and Coercive Foreign Policy Discourse
This article explores the relationship between language and political possibility. It is argued that John Howard’s language from 11 September 2001 to mid 2003 helped to enable the ‘War on Terror’ in an Australian context in three principal ways. Firstly, through contingent and contestable constructions of Australia, the world and their relationship, Howard’s language made interventionism conceivable. Secondly, emphasising shared values, mateship and mutual sacrifice in war, Howard embedded his foreign policy discourse in the cultural terrain of ‘mainstream Australia’, specifically framing a foreign policy discourse that was communicable to ‘battlers’ and disillusioned ‘Hansonites’. Thirdly, positioning alternatives as ‘un-Australian’, Howard’s language was particularly coercive, silencing potential oppositional voices
The Hybrid Legal Geographies of a War Crimes Court
This paper explores the implications of understanding war crime trials as hybrid legal spaces. Drawing on twelve months of residential fieldwork in the Court of Bosnia and Herzegovina, Sarajevo, it examines the circulation of evidence, the choreography of the court room and the nature and possibilities for legal observation. Analyzing hybrid legal geographies foregrounds the material and embodied nature of trials, illuminating the forms of comportment, categorization and exclusion through which law establishes its legitimacy. Rather than emphasizing separation and distance, the lens of hybridity illuminates the multiple ways in which war crimes trials are grounded in the social and political context of present day Bosnia and Herzegovina. Consequently this analysis traces the disjuncture between the imagined geographies of legal jurisdiction and the material and embodied spaces of trial practices. In conclusion we argue that the establishment of the Court of Bosnia and Herzegovina illustrates the tensions that emerge when an institution of trial justice is used to strengthen the coherence of a post-conflict state.This paper is based on research funded by the Economic and Social Research Council (RES-061-25-0479).This is the accepted manuscript. The final version is available from http://www.tandfonline.com/doi/abs/10.1080/00045608.2014.892365
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