4,007 research outputs found

    Radar backscattering data for surfaces of geological interest

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    Radar backscattering data for surfaces of geological interes

    The Mutual Interpretation of Active and Passive Microwave Sensor Outputs

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    Mutual interpretation of active and passive microwave sensor output

    Spin transition in Gd3_3N@C80_{80}, detected by low-temperature on-chip SQUID technique

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    We present a magnetic study of the Gd3_3N@C80_{80} molecule, consisting of a Gd-trimer via a Nitrogen atom, encapsulated in a C80_{80} cage. This molecular system can be an efficient contrast agent for Magnetic Resonance Imaging (MRI) applications. We used a low-temperature technique able to detect small magnetic signals by placing the sample in the vicinity of an on-chip SQUID. The technique implemented at NHMFL has the particularity to operate in high magnetic fields of up to 7 T. The Gd3_3N@C80_{80} shows a paramagnetic behavior and we find a spin transition of the Gd3_3N structure at 1.2 K. We perform quantum mechanical simulations, which indicate that one of the Gd ions changes from a 8S7/2^8S_{7/2} state (L=0,S=7/2L=0, S=7/2) to a 7F6^7F_{6} state (L=S=3,J=6L=S=3, J=6), likely due to a charge transfer between the C80_{80} cage and the ion

    Investigating the Magnetospheres of Rapidly Rotating B-type Stars

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    Recent spectropolarimetric surveys of bright, hot stars have found that ~10% of OB-type stars contain strong (mostly dipolar) surface magnetic fields (~kG). The prominent paradigm describing the interaction between the stellar winds and the surface magnetic field is the magnetically confined wind shock (MCWS) model. In this model, the stellar wind plasma is forced to move along the closed field loops of the magnetic field, colliding at the magnetic equator, and creating a shock. As the shocked material cools radiatively it will emit X-rays. Therefore, X-ray spectroscopy is a key tool in detecting and characterizing the hot wind material confined by the magnetic fields of these stars. Some B-type stars are found to have very short rotational periods. The effects of the rapid rotation on the X-ray production within the magnetosphere have yet to be explored in detail. The added centrifugal force due to rapid rotation is predicted to cause faster wind outflows along the field lines, leading to higher shock temperatures and harder X-rays. However, this is not observed in all rapidly rotating magnetic B-type stars. In order to address this from a theoretical point of view, we use the X-ray Analytical Dynamical Magnetosphere (XADM) model, originally developed for slow rotators, with an implementation of new rapid rotational physics. Using X-ray spectroscopy from ESA's XMM-Newton space telescope, we observed 5 rapidly rotating B-type stars to add to the previous list of observations. Comparing the observed X-ray luminosity and hardness ratio to that predicted by the XADM allows us to determine the role the added centrifugal force plays in the magnetospheric X-ray emission of these stars.Comment: IAUS Conference Proceeding

    Protein Fingerprinting: A Domain-Free Approach to Protein Analysis

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    An alternative method for analyzing proteins is proposed. Currently, protein search engines available on the internet utilize domains (predefined sequences of amino acids) to align proteins. The method presented converts a protein sequence with the use of 1200 numeric codes that represent a unique three—amino-acid protein sequence. Each numeric code starts with one of three specific amino acids, followed by any two additional amino acids. With the use of the FPC (FingerPrinted Contig) program, the total protein database (including “redundant” records) from the National Center for Biotechnology Information (NCBI) has been processed and placed into “bins/contigs” based on associations of these triplet codes. When analyzed with FPC, proteins are “contigged” together based on the number of shared fragments, regardless of order. These associations were supported by additional analysis with the standard BLASTP utility from NCBI. Within the created contig sets, there are numerous examples of proteins (allotypes and orthotypes) that have evolved into different, seemingly unrelated proteins. The power of this domain-free technique has yet to be explored; however, the ability to bin proteins together with no a priori knowledge of domains may prove a powerful tool in the characterization of the hundreds of thousands of available, yet undescribed expressed protein and open reading frame sequences

    Electrical Conductivity of Fermi Liquids. I. Many-body Effect on the Drude Weight

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    On the basis of the Fermi liquid theory, we investigate the many-body effect on the Drude weight. In a lattice system, the Drude weight DD is modified by electron-electron interaction due to Umklapp processes, while it is not renormalized in a Galilean invariant system. This is explained by showing that the effective mass mm' for Dn/mD\propto n/m' is defined through the current, not velocity, of quasiparticle. It is shown that the inequality D>0D>0 is required for the stability against the uniform shift of the Fermi surface. The result of perturbation theory applied for the Hubbard model indicates that DD as a function of the density nn is qualitatively modified around half filling n1n\sim 1 by Umklapp processes.Comment: 20 pages, 2 figures; J. Phys. Soc. Jpn. Vol.67, No.

    Fine map of the Gct1 spontaneous ovarian granulosa cell tumor locus

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    The spontaneous development of juvenile-onset, ovarian granulosa cell (GC) tumors in the SWR/Bm (SWR) inbred mouse strain is a model for juvenile-type GC tumors that appear in infants and young girls. GC tumor susceptibility is supported by multiple Granulosa cell tumor (Gct) loci, but the Gct1 locus on Chr 4 derived from SWR strain background is fundamental for GC tumor development and uniquely responsive to the androgenic precursor dehydroepiandrosterone (DHEA). To resolve the location of Gct1 independently from other susceptibility loci, Gct1 was isolated in a congenic strain that replaces the distal segment of Chr 4 in SWR mice with a 47 × 10(6)-bp genomic segment from the Castaneus/Ei (CAST) strain. SWR females homozygous for the CAST donor segment were confirmed to be resistant to DHEA- and testosterone-induced GC tumorigenesis, indicating successful exchange of CAST alleles (Gct1(CA)) for SWR alleles (Gct1(SW)) at this tumor susceptibility locus. A series of nested, overlapping, congenic sublines was created to fine-map Gct1 based on GC tumor susceptibility under the influence of pubertal DHEA treatment. Twelve informative lines have resolved the Gct1 locus to a 1.31 × 10(6)-bp interval on mouse Chr 4, a region orthologous to human Chr 1p36.22. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00335-012-9439-6) contains supplementary material, which is available to authorized users

    Lentiviral Vector Delivery of Human Interleukin-7 (hIL-7) to Human Immune System (HIS) Mice Expands T Lymphocyte Populations

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    Genetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important survival and growth signals. To circumvent this problem, we utilized a lentivirus-based delivery system to express physiologically relevant levels of human interleukin-7 (hIL-7) in Rag2-/-γc-/- mice following a single intravenous injection. hIL-7 promoted homeostatic proliferation of both adoptively transferred and endogenously generated T-cells in Rag2-/-γc-/- Human Immune System (HIS) mice. Interestingly, we found that hIL-7 increased T lymphocyte numbers in the spleens of HIV infected HIS mice without affecting viral load. Taken together, our study unveils a versatile approach to deliver human cytokines to HIS mice, to both improve engraftment and determine the impact of cytokines on human diseases
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