7 research outputs found
Intraperitoneal drain placement and outcomes after elective colorectal surgery: international matched, prospective, cohort study
- Author
- Aba M
- Abdellatif M
- Abdelmahmoud S
- Abu Hassan F
- Acil C
- Adarkwah P
- Adarraga J
- Adderley O
- Adefolaju A
- Afzal A
- Afzal Z
- Agarwal H
- Agnes A
- Agostinelli L
- Ahari D
- Ahmad H
- Ahmad R
- Ahmad S
- Ahmed N
- Ahmed N
- Ahmed WUR
- Ahmed WUR
- Akhbari M
- Akintunde A
- Akkaya YM
- Akram J
- Aktas MK
- Aktas MK
- Aktas MK
- Aktaş A
- Akula Y
- Al Nassrallah M
- Al-Habsi R
- Alam F
- Albino V
- Alfadhel S
- Ali T
- Alicata F
- Aljić A
- Allison W
- Almeida T
- Alonso Batanero E
- Alonso Batanero E
- Alsaif A
- Alsusa H
- Altaf R
- Altay L
- Altinel Y
- Altiner S
- Altomare DF
- Altomare DF
- Altunsu S
- Alvarez-Gallego M
- Amendola A
- Amjad T
- Amjad T
- Anabitarte Bautista O
- Anastasi A
- Anderson K
- Andolfi E
- Andolfi E
- Andrejevic P
- Andrejevic P
- Angarano E
- Angelini E
- Angelini M
- Angrisani M
- Anoldo P
- Anthony A
- Antropoli C
- Antypas A
- Antypas A
- Appleton B
- Argyriou A
- Arnold A
- Arnold A
- Arslan ER
- Asero S
- Ashaye A
- Ashdown T
- Asim K
- Aslam A
- Atar C
- Ates J
- Atıcı N
- Atiyah Z
- Attaallah W
- Atzeni J
- Augestad KM
- Aulicino M
- Aung MT
- Auterson L
- Aversano A
- Axmarker T
- Aydin R
- Azizan N
- Azmi A
- Badessi G
- Bagaglini G
- Bagaglini G
- Bagheri K
- Bailey E
- Bailey S
- Baili E
- Bakar B
- Baker D
- Baker E
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- Baki BE
- Balak B
- Balalis D
- Balalis D
- Balasubramanya S
- Balasubramanya S
- Baldemor S
- Banaz T
- Banerjee D
- Banerjee I
- Banerjee M
- Banji-Kelan A
- Bao QR
- Bapty J
- Bardon A
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- Barton H
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- Bastiaenen V
- Bawa JH
- Beckett RG
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- Belev N
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- Bellato V
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- Beltrán de Heredia J
- Ben Sassi A
- Benuzzi L
- Berry A
- Beuca A
- Beuca A
- Beuca A
- Bezede C
- Bhatia S
- Bhojwani D
- Bhojwani D
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- Biancafarina A
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- Bickley-Morris E
- Bilbao J
- Bini S
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- Bintintan V
- Biondi A
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- Bissett IP
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- Botelho P
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- Bozbiyik O
- Bozhkova L
- Bozonelou I
- Boğa A
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- Bradbury M
- Bradbury M
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- Braniste A
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- Bray J
- Brazkiewicz M
- Brazukas A
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- Burdekin E
- Burgher T
- Bylapudi SK
- Bylapudi SK
- Calikoglu F
- Calikoglu F
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- Camassa M
- Cambridge W
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- Cammarata F
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- Caneparo A
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- Detering R
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- Georgiou T
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- Soldevila Verdeguer C
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- Spagni G
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- Stanley A
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- Steinholt I
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- Tailor B
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- Talal El-Abur I
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- Tamini N
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- van Dalen AS
- van de Ven A
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- Yasin I
- Yates C
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- Yick C
- Yıldırım A
- Yogarajah T
- Yoldas T
- Yotsov T
- Yousaf H
- Yousuff M
- Yánez C
- Yüksel E
- Zabiyaka M
- Zafer F
- Zafer F
- Zaffaroni G
- Zagibová D
- Zagorac Z
- Zaheer M
- Zahid A
- Zahid M
- Zaidi M
- Zambon M
- Zammit-Maempel M
- Zanframundo C
- Zanni M
- Zayed M
- Zazza S
- Zeidan Z
- Zhang Y
- Zhu L
- Zhu X
- Ziolkowska K
- Ziolkowska K
- Zografos G
- Zonta S
- Çetin B
- Ölmez M
- Özbalcı GS
- Özen D
- Özen D
- Öztürk OU
- Čustović S
- Štefanová H
- Ευσταθίου Η
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Despite current guidelines, intraperitoneal drain placement after elective colorectal surgery remains widespread. Drains were not associated with earlier detection of intraperitoneal collections, but were associated with prolonged hospital stay and increased risk of surgical-site infections.Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and time to diagnosis of postoperative intraperitoneal collections; rate of surgical site infections (SSIs); time to discharge; and 30-day major postoperative complications (Clavien-Dindo grade at least III). After propensity score matching, multivariable logistic regression and Cox proportional hazards regression were used to estimate the independent association of the secondary outcomes with drain placement. Results Overall, 1805 patients from 22 countries were included (798 women, 44.2 per cent; median age 67.0 years). The drain insertion rate was 51.9 per cent (937 patients). After matching, drains were not associated with reduced rates (odds ratio (OR) 1.33, 95 per cent c.i. 0.79 to 2.23; P = 0.287) or earlier detection (hazard ratio (HR) 0.87, 0.33 to 2.31; P = 0.780) of collections. Although not associated with worse major postoperative complications (OR 1.09, 0.68 to 1.75; P = 0.709), drains were associated with delayed hospital discharge (HR 0.58, 0.52 to 0.66; P < 0.001) and an increased risk of SSIs (OR 2.47, 1.50 to 4.05; P < 0.001). Conclusion Intraperitoneal drain placement after elective colorectal surgery is not associated with earlier detection of postoperative collections, but prolongs hospital stay and increases SSI risk
The Effect of Short-Term Physical Activity on the Oxidative Stress in Rats with Different Stress Resistance Profiles in Cerebral Hypoperfusion
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- A Wislowska-Stanek
- AC Venezia
- AH Arisha
- AT Dao
- B Lima Giacobbo
- C Benatti
- C Cheignon
- CB Quines
- CD Bushnell
- DH Choi
- DM Kent
- EE Martinez Leo
- EF Shevtsova
- ER Milaeva
- EV Koplik
- GL Perlovich
- GS Griesbach
- H Akimoto
- H Shen
- IL Uijen
- J Horecky
- JA Morgan
- JA Zoladz
- JC Shenk
- JE Ahlskog
- JH Park
- JM Robbins
- KM Moench
- L Gliemann
- L Jianguo
- L Rossi Dare
- M Banqueri
- M Fayyaz
- ME Neganova
- MK Tanner
- MP Mota
- N Issam
- N Jamshed
- NAM Ghonimi
- O Ozcelik
- PI Moreira
- PM Balaban
- RM Anderson
- RX Jia
- S Finkbeiner
- S Vaynman
- SA Savel'ev
- SO Bachurin
- T Abel
- T Yamamoto
- TY Pang
- V Bragin
- V Bragin
- W Xiao-Li
- X Xie
- Y Kong
- Y Liu
- Z Radak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Review of shadow detection and de-shadowing methods in remote sensing
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- A A Apan
- A Eiumnoh
- A Fahsi
- A I T Sotomayor
- A Massalabi
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A Review on Various Shadow Detection and Compensation Techniques in Remote Sensing Images
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2022
- Field of study
Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice
Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery. An international, prospective cohort study
- Author
- A Adefolaju
- A Afzal
- A Agnes
- A Akintunde
- A Aktaş
- A Aljić
- A Alsaif
- A Amendola
- A Anastasi
- A Anthony
- A Antypas
- A Antypas
- A Argyriou
- A Arnold
- A Arnold
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- R Mercer
- R Morgan
- R Motiwale
- R Nzewi
- R O Hare
- R Ooi
- R Orman
- R Osborne
- R Pancharatnam
- R Pancharatnam
- R Patel
- R Patrone
- R Pawar
- R Pedroso de Lima
- R Ponniah
- R R Gujjuri
- R Risquet
- R Risquet
- R Rocks
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- R Sethi
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- R Trapani
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- R Troller
- R Troller
- R Troller
- R Tutino
- R Tutino
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- S A Güler
- S A Güler
- S A Vigna
- S Abdelmahmoud
- S Ahmad
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- S Altiner
- S Altunsu
- S Asero
- S Bailey
- S Balasubramanya
- S Balasubramanya
- S Baldemor
- S Begum
- S Bhatia
- S Bini
- S Bini
- S Bini
- S Brown
- S Brozzetti
- S C Reiser
- S Capuzzolo
- S Chan
- S Choi
- S D Sa
- S D'Amico
- S D'Amico
- S Davakis
- S Delibegovic
- S Dhillon
- S Douglas
- S Duff
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- S Elias
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- S Iliev
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- S Jamal
- S Jamieson
- S Jassim
- S Jauhari
- S Jeffery
- S Jeri
- S K Bylapudi
- S K Bylapudi
- S K Kamarajah
- S Kural
- S Kural
- S Latif
- S Latif
- S Leelamanthep
- S Leventoğlu
- S Loganathan
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- S Mankal
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- S McDonnell
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- S O'Brien
- S O'Hara
- S Palagi
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- S Pérez-Ajates
- S Pérez-Ajates
- S Rahmat
- S Rao
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- S Rossi
- S Rossi
- S Rossi Del Monte
- S Roy Bentley
- S S Sundaralingam
- S Salih
- S Sethi
- S Shafi
- S Shah
- S Sheefat
- S Smolarek
- S Smyth
- S Sreenivasan
- S Takar
- S Toh
- S Valiyeva
- S Van Straten
- S Vertaldi
- S Y Choo
- S Y Kwak
- S Z Gan
- S Z Kuiper
- S Zazza
- S Zonta
- S Čustović
- Shk Yap
- T Ali
- T Almeida
- T Amjad
- T Amjad
- T Ashdown
- T Axmarker
- T Banaz
- T Bargellini
- T Brankin-Frisby
- T Burchi-Khairy
- T Burgher
- T Campagnaro
- T Cavus
- T Choudhary
- T Dušek
- T Dušek
- T Gala
- T Gala
- T Georgiou
- T Gimenez Maurel
- T Glynn
- T Gómez Sanz
- T Ivanov
- T Jamadar
- T K Uprak
- T Kouli
- T Liassides
- T Morey
- T Nelli
- T Noton
- T Noton
- T Palyvou
- T Perra
- T Perra
- T Poskus
- T Rafe
- T Richards
- T Sammour
- T Sidiropoulos
- T Thomas
- T Triantafyllou
- T Triantafyllou
- T V Pham
- T V Vadiveloo
- T Yogarajah
- T Yoldas
- T Yotsov
- U G Vo
- U Grossi
- U Janković
- U Okwu
- U Pace
- U Shafiq
- V Albino
- V Bastiaenen
- V Bellato
- V Bellato
- V Bintintan
- V Chan
- V Cuk
- V De Peppo
- V Fagarasan
- V Ford
- V Grillo
- V Ivanov
- V Kaminskaite
- V Kaminskaite
- V Mario
- V Murray
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- V Ntomi
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- V Ozben
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- V Tanna
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- V Tsimplis
- V Verlingieri
- Vwy Soh
- W Allison
- W Attaallah
- W Cambridge
- W Chung
- W H Toh
- W Hurst
- W L Chia
- W Ravindran
- W Roberts
- W Seow
- W X Neo
- W Xu
- W Y Yek
- Wur Ahmed
- Wur Ahmed
- X Hysejni
- X Zhu
- Y Akula
- Y Altinel
- Y Kasmy El Kasmy
- Y Kaya
- Y Kaya
- Y Lim
- Y M Akkaya
- Y Ma
- Y Salama
- Y Shafiq
- Y Zhang
- Yhl Lau
- Z Afzal
- Z Atiyah
- Z Garoufalia
- Z H Sam
- Z Halford
- Z Hussain
- Z Karim
- Z Karmally
- Z Nowinka
- Z Nowinka
- Z S Sabrina
- Z Seymour
- Z Zagorac
- Z Zeidan
- Η Ευσταθίου
- Publication venue
- place:Oxford
- Publication date
- 01/01/2023
- Field of study
Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method: COMPlicAted intra-abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time-to-diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30-day major postoperative complications (Clavien-Dindo III-V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results: Some 725 patients (median age 68.0 years; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] = 1.56, 95% CI: 0.48-5.02, p = 0.457) or earlier detection (hazard ratio [HR] = 1.07, 95% CI: 0.61-1.90, p = 0.805) of collections. Drains were not significantly associated with worse major postoperative complications (OR = 1.26, 95% CI: 0.67-2.36, p = 0.478), delayed hospital discharge (HR = 1.11, 95% CI: 0.91-1.36, p = 0.303) or increased risk of SSIs (OR = 1.61, 95% CI: 0.87-2.99, p = 0.128). Conclusion: This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery
Second asymptomatic carotid surgery trial (ACST-2) : a randomised comparison of carotid artery stenting versus carotid endarterectomy
- Author
- \u160ercl Miroslav
- \u160koloud\uedk David
- \u160tekl\ue1cov\ue1 Anna
- Abd-Allah Foad
- Abdul-Hamiq Ahmed
- Abdulamit Timur
- Accrocca Federico
- Acosta Stefan
- Ahlhelm Frank J
- Aidashova Balzhan
- Akyea-Mensah Joyce
- Albuquerque e Castro Jo\ue3o
- Aleksic Nikola
- Allaire Eric
- Almekhlafi Mohammed A
- Alonso Angelika
- Alves Gon\ue7alo
- Alwis Lanka
- Amatucci Giovanni
- Ambrogi Cesare
- Amis Deborah
- Anderson Dawn
- Andonova Silva
- Andziak Piotr
- Angiletta Domenico
- Angus Jane
- Antonopoulos Constantine N
- Aparici Robles Fernando
- Argentieri Angelo
- Arnold Sebastian
- Ashleigh Ray
- Ashley Simon
- Asokanathan Asaipillai
- Astarci Parla
- Babic Srdan
- Bachvarov Chavdar
- Baht Hardeep
- Bajardi Guido
- Bajoriene Milda
- Baker Lucy
- Bakke S\uf8ren
- Bal Simerpreet
- Ball Stephen
- Balogun Ibrahim
- Barbazza Renzo
- Barber Phillip A
- Barer David
- Bari Vasha
- Barlinn Jessica
- Bartko Daniel
- Barwell James
- Barz\uf3 P\ue1l
- Bastos Gon\ue7alves Frederico
- Bausback Yvonne
- Beard Jonathan
- Becquemin Jean-Pierre
- Belcastro Fernando
- Bellenis Ion
- Belli Anna
- Bellini Dalio Marcelo
- Belyasnik Andrey
- Bene\u161 III Vladim\uedr
- Benevento Domenico
- Beno Peter
- Berekoven B\ue4rbel
- Berg Bengt
- Berger Hermann
- Bergeron Patrice
- Bernardini Giulia
- Berry Clive
- Beyar Rafi
- Bialek Pawel
- Bianchi Paolo
- Bicknell Colin
- Biejat Zbigniew
- Biermaier Bernhard
- Bir\uf3 G\ue1bor
- Birt Angela
- Bj\uf6rses Katarina
- Blackham Kristine
- Blanco Ca\uf1ibano Estrella
- Blanes Orti Paula
- Bodosi Mihaly
- Bombic Martin
- Bonati Leo H
- Bonati Leo H
- Borger Franka
- Bosiers Marc
- Botsios Spiridon
- Br\ue4unlich Sven
- Bradshaw S
- Brandt Kerstin
- Branzan Daniela
- Briley Dennis
- Brountzos Elias
- Brown Andrew
- Brown Ellen
- Brown Ellen
- Brown James
- Brown Pauline
- Brudlo Wojciech
- Bryce Jenny
- Buchvald Pavel
- Bulbulia Richard
- Bulbulia Richard
- Burger Ilse
- Burzotta Francesco
- Butterfield Stephen
- C\uf6ster Andreas
- Callaert Joren
- Campbell Erik
- Campos Jr Walter
- Cannizzaro Alfredo
- Cao Piergiorgio
- Capoccia Laura
- Cappelli Alessandro
- Cardon Jean-Marie
- Carimati Federico
- Casana Renato
- Casella Ivan B
- Caso Valeria
- Catterson Martin
- Cernetti Carlo
- Chamorro \uc1ngel
- Chataway Jeremy
- Chatzinikou Eleni
- Chechulov Pavel
- Chernyavsky Mikhail A
- Cheshire Nicholas
- Chester Johanna
- Chester Johanna
- Chetter Ian
- Chiarandini Stefano
- Chisci Emiliano
- Chlouba Vladim\uedr
- Chrisopoulou Angela
- Cieri Enrico
- Cirelli Silvana
- Cireni Lea
- Civilini Efrem
- Clarke Alison
- Clarke Mike
- Clarke Sandra
- Cleveland Trevor
- Clifton Andrew
- Clifton Andrew
- Cochennec-Paliwoda Fr\ue9d\ue9ric
- Codispoti Francesco Alberto
- Colgan Mary P
- Colic Momcilo
- Colston Amanda
- Coppi Elisabetta
- Coppi Gioacchino
- Corbetta Riccardo
- Cosier Tracy
- Coutts Shelagh B
- Cowie Linda
- Cox Robin
- Cradduck-Bamford Andrea
- Cradduck-Bamford Andrea
- Cras Patrick
- Crawford Susan
- Crinnion Jamie
- Csobay-Nov\ue1k Csaba
- Cuenoud Larissa
- Cura Fernando
- Cvetic Vladimir
- Cvjetko Ivan
- Czepel Wojciech
- Czlonkowska Anna
- D'Angelo Costantino L
- D'Oria Mario
- D'Souza Stephen
- D\uf3sa Edit
- da Silva Erasmo S
- Dabek Pawel
- Darby Chris
- Davey Philip
- Davidovic Lazar
- Davies Paul
- Davis Michelle
- de Arag\ue3o Morais Jos\ue9
- de Borst Gert J
- De Donato Gianmarco
- De Koster Guy
- de Luccia Nelson
- Debus Eike S
- Dei Negri Massimo
- Delle Martin
- Delodovici Maria Luisa
- Deloose Koen
- DeMarco Ester
- Demchuk Andrew M
- DeRango Paola
- Desantis Claudio
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- Dowzenko Anatol
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- Drelichowski Stanislaw
- Dunlop Paul
- Durairajan Ragunath
- Dutta Dipankar
- Dyker Alexander
- Dzieciuchowicz Lukasz
- Eckstein Hans-Henning
- Eesa Muneer
- Egun Anselm A
- Eldessoki Mohamed H
- Eley Caroline
- Eliot-Jones Bekky
- Emerson Lorraine
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- Endrych Ladislav
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- Estenssoro Andr\ue9 E V
- Ettles Duncan
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- F\ufcl\uf6p B\ue9la
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- Fraedrich Gustav
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- Galeotti Roberto
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- Garc\ueda Fresnillo Beatriz
- Garcia Ana C
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- Gillies Michelle
- Gissler Hans Martin
- Gizewski Elke
- Golovkova Maria S
- Gordon Vera
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- Grzyska Ulrich
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- Gunathilagan Gunaratnam
- Guyler Paul
- H\uf6lzer Henryk
- Haase Kathrin
- Haider Syed N
- Halliday Alison
- Halliday Alison
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- Hamady Mohammad
- Hammer Frank
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- Hrb\ue1c Tom\ue1\u161
- Hudon Mark E
- Hughes Andrea
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- Ignatenko Pavel
- Ilijevski Nenad
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- Irsara Sandro
- Isaak Andrej
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- Iwanowski Wojciech
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- Joseph Thomas
- Jovanovic Dejana R
- Joviliano Edwaldo E
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- Justin Frances
- Juszynski Michal
- K\uf6lbel Tilo
- K\ufchme Tobias
- Kahles Timo
- Kakisis John D
- Kall Torbj\uf6rn B
- Kallmayer Michael
- Kandyba Dmitry
- Kappadath Sreevalsan
- Kappelle Jaap L
- Karathanos Christos
- Karpenko Andrey
- Karram Tony
- Karvouniari Panagiota
- Kasemi Holta
- Kazan Viviane
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- Kerner Arthur
- Keunen Rudolf W M
- Khanom Nyma
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- Kimura Naoto
- King Craig
- Kjellin Per
- Kl\uf6tzsch Christof
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- Lardenoije Jan W
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- Lazaris Andreas
- le Conte Steffi
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- Lenzer Janin
- Leopold Peter
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- Lindert Ralph
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- Lindh Mats
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- Liu Chang-Wei
- Lo Rob H
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- Loos Caroline
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- McCaslin James
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- Moore Dermot
- Morata Barrado Pilar C
- Moratto Roberto
- Morris Dylan
- Morrish William F
- Morrison Jackie
- Moulakakis Konstantinos G
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- Mujagic Edin
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- Pontes Neto Oct\ue1vio M
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- Pozzi Mucelli Fabio
- Pr\uedvara Mojm\uedr
- Prabakaran Raji O
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- Proch\ue1zka V\ue1clav
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- Ryckborst Karla J
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- Seweryniak Piotr
- Shanik Gregor
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- Zdanowski Zbigniew
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- Zherdev Nikolay N
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- Zielinski Maciej
- Zimmel L
- Zimmermann Alexander
- Zini Andrea
- Zuromskis Tadas
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence.
Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362.
Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86-1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91-1·32; p=0·21).
Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable