Variation in Epidermal Morphology in Human Skin at Different Body Sites as Measured by Reflectance Confocal Microscopy

Two methods of estimating stratum corneum thickness using reflectance confocal microscopy were examined, and epidermal thickness measurements at multiple body sites were compared. Measurements of stratum corneum thickness were made using the derivative method, which is based on the rate of change of image intensity as a proxy for keratin concentration, and simple visual analysis of confocal images. To compare epidermal thickness we collected 1491 z-axis stacks of confocal images from 10 body sites in 39 subjects. An artefact associated with the imaging process interfered with the derivative method for stratum corneum thickness, and simple visual analysis is to be preferred. Although some epidermal properties varied by site, the most striking finding was the degree of within-site variation, which accounted for between 50% and 74% of the total variation observed. The majority of this variation was not due to measurement error, and represents genuine topographical irregularity. This fine-scale variation limits the ease of use of reflectance confocal microscopy for quantitative studies of the epidermis and stratum corneum.</p

Internal Migration and Regional Population Dynamics in Europe: Norway Case Study

This paper reports on internal migration and regional population dynamics in Norway. It examines internal migration patterns and trends in two years, 1984 and 1994, and compares them. Norway's population maintains relatively high population growth by European standards, fuelled by continuing natural increase and net migration from outside the country. About half of Norway's municipalities lost population in aggregate over the 1984 to 1994. These municipalities are concentrated in the Centre-North and interior of southern Norway. There is evidence that communities with the lowest densities and least centrality are losing population through internal migration. Although the direction of migration is towards denser and more central places, this is a product mainly of the migration of young people when the migration streams are broken down by age, the resulting tales show that the largest urban areas are experiencing net losses from middle age and upwards. There is little direct evidence of net positive migration flows to rural remote areas for the population as a whole. Migration flows out of the Oslo region are to other municipalities within commuting range. This deconcentration should therefore be identified as extended suburanisation rather than counter-urbanisation. Throughout the current report the role of life course stage in influencing the direction of migration has been stressed. Most often the overall pattern of population shifts conceal very different flow structures for family migrants, young adults, older workers, retirees and the elderly. In this respect internal migration dynamics in Norway strongly resemble those in other West European countries. Economic factors have an important influence on migration patterns. Municipalities with an economic concentration in service industries attract internal migrants while those specialised in primary industry suffer migration outflows consequent on the decline of or productivity improvements in their economic activities. There is a strong gradient of increasing net outflows with increasing levels of unemployment

Analysis of pressure distortion testing

The development of a distortion methodology, method D, was documented, and its application to steady state and unsteady data was demonstrated. Three methodologies based upon DIDENT, a NASA-LeRC distortion methodology based upon the parallel compressor model, were investigated by applying them to a set of steady state data. The best formulation was then applied to an independent data set. The good correlation achieved with this data set showed that method E, one of the above methodologies, is a viable concept. Unsteady data were analyzed by using the method E methodology. This analysis pointed out that the method E sensitivities are functions of pressure defect level as well as corrected speed and pattern

Renal replacement therapies in neonates: Issues and ethics.

Chronic irreversible kidney disease requiring dialysis is rare in the neonate. Many such neonates are diagnosed following antenatal ultrasound with congenital abnormalities of the kidneys and urinary tract. There is an increased incidence of prematurity and infants that are small for gestational age. Given the natural improvement in renal function that occurs in the neonatal period, some with extremely poor renal function may, with careful management of fluid and electrolytes, be kept off dialysis until the creatinine reaches a nadir when a definitive plan can be made. There is a very high incidence of comorbidity and this affects survival, which for those on dialysis is about 80% at five years. The multiple and complex ethical issues surrounding the management of these very young children are discussed

Developing a national dental education research strategy:priorities, barriers and enablers

Objectives: This study aimed to identify national dental education research (DER) priorities for the next 3-5 years and to identify barriers and enablers to DER. Setting: Scotland Participants: In this two-stage online questionnaire study we collected data with multiple dental professions (e.g. dentistry, dental nursing, dental hygiene) and stakeholder groups (e.g. learners, clinicians, educators, managers, researchers, academics). Eighty-five participants completed the Stage 1 qualitative questionnaire and 649 participants the Stage 2 quantitative questionnaire. Results: Eight themes were identified at Stage 1. Of the 24 DER priorities identified, the top three were: role of assessments in identifying competence; undergraduate curriculum prepares for practice; and promoting teamwork. Following exploratory factor analysis, the 24 items loaded onto four factors: teamwork and professionalism, measuring and enhancing performance, dental workforce issues, and curriculum integration and innovation. Barriers and enablers existed at multiple levels: individual, interpersonal, institutional structures and cultures, and technology. Conclusion: This priority setting exercise provides a necessary first step to developing a national DER strategy capturing multiple perspectives. Promoting DER requires improved resourcing alongside efforts to overcome peer stigma and lack of valuing and motivation

Ionized Gas in Damped Lyman Alpha Protogalaxies: II. Comparison Between Models and the Kinematic Data

We test semi-analytic models for galaxy formation with accurate kinematic data of damped Lyman alpha protogalaxies (DLAs) presented in the companion paper I. The models envisage centrifugally supported exponential disks at the centers of dark matter halos which are filled with ionized gas undergoing radial infall to the disks. The halo masses are drawn from cross-section weighted mass distributions predicted by CDM cosmogonies, or by the null hypothesis (TF model) that the dark matter mass distribution has not evolved since z ~ 3. In our models, C IV absorption lines detected in DLAs arise in infalling ionized clouds while the low-ion absorption lines arise from neutral gas in the disks. Using Monte Carlo methods we find: (a) The CDM models are incompatible with the low-ion statistics at more than 99% confidence whereas some TF models cannot be excluded at more than 88% confidence. (b) Both CDM and TF models agree with the observed distribution of C IV velocity widths. (c) The CDM models generate differences between the mean velocities of C IV and low ion profiles in agreement with the data, while the TF model produces differences in the means that are too large. (d) Both CDM and TF models produce ratios of C IV to low-ion velocity widths that are too large. (e) Both CDM and TF models generate C IV versus low-ion cross-correlation functions incompatible with the data. While it is possible to select model parameters resulting in consistency with the data, the disk-halo configuration assumed in both cosmogonies still does not produce significant overlap in velocity space between C IV low-ion velocity profiles. We conjecture that including angular momentum of the infalling clouds will increase the overlap between C IV and low-ion profiles.Comment: 18 pages, 12 Figures, Accepted for publication in the Dec. 20 issue of the Astrophysical Journa

Improving supply and phosphorous use efficiency in organic farming systems

Phosphorus (P) is an essential plant nutrient that needs to be managed carefully in organic systems so that crop yield and quality remain sustainable without contributing to environmental damage, particularly that associated with eutrophication. Under organic regulations, minimally processed rock phosphate (PR) can be used to amend low P fertility soils, although the solubility is extremely low at optimum soil pH for most crop growth (pH 6.5). This paper describes a project (PLINK) which aims to develop methods of improving P efficiency on organic farms, although the same approaches may also be applicable on conventional and low-input farms. The methodologies that the project is developing include the fermentation and composting of crop waste material with PR in order to solubilise P and make it more available to the crop. Some initial results are described here. In addition, the project will investigate the alteration of the rotation to include crops or varieties with high P uptake efficiency, or roots that possess acidifying properties which improve P availability for following crops

Internal Migration and Regional Population Dynamics in Europe: Estonia Case Study

Estonia has experienced a long-lasting and strong influence of international migration on regional population growth. Post-war immigrants account for about 36 per cent of the total population, and are concentrated in larger cities of Northern Estonia. Regionally, the relative proportions of the native-born and immigrant origin sub-populations are important for the understanding of population change and internal migration flows in the 1980-1990s. In Estonia, the quality of migration data requires careful assessment. The preservation of Soviet-type record-keeping has reduced data quality in the 1990s, already low, and use of the data should keep data quality problems in mind. Otherwise, false conclusions can be reached. To describe internal migration patterns, it has proved technically feasible and very useful to disaggregate the county population into rural and urban components, and correspondingly, the migration flows into four directions (urban-urban, urban-rural, rural-urban and rural-rural). During the 1980s the pattern of population growth and internal migration has changed in Estonia. Reflecting the turnaround in long-term population processes, migration development reached the advanced stage with more or less regionally balanced in- and out-migration flows and decreasing importance of net migration. Accordingly, to understand current trends and patterns, explanations must be sought from the 1980s which has served a starting point for the present trends rather than from the period of economic transition in the 1990s. As a part of the turnaround, the century-long persistent rural depopulation has come to an end and the moderate growth has started reflecting natural population increase as well as deurbanization. In the 1980s two developments have occurred in parallel: migratory increase of rural population led by a deurbanizing native-born population, and continued urban population growth as a result of the population momentum of pre-transition immigrants. In future decades, the urban deconcentration will probably be the underlying trend in Estonia. In Estonia, noticeable proportion of territory and population is located in islands. However, the island population does not show any systematic difference in the type of internal migration. Particularly, the depopulation of island populations, observed in several comparable European cases, is not occurring. Each life-course stage was found to have its specific migration pattern, more stable than the pattern for the total population. In many cases the changes of internal migration are determined by the change in the proportion of population in different life-course stages. Additionally, the life-course approach has been useful in demonstrating the features of the present Estonian internal migration pattern which appear closer to the countries of comparable in demographic development, more or less regardless of the significant differences in the level of economic development. Among life-course groups, in Estonia the older working age population was characterized by the strongest deurbanization intensities in 1995. The same group has also undergone the largest modification of migration pattern during the economic transition (1987-1995)

An investigation of the social support experiences of high-level sports performers

publication-status: Publishedtypes: Articleas accepted for publication© 2000 Human Kinetics, IncLock of consensus regarding the nature and conceptual definition of the social support construct has led to a plethora of different forms of measurement of this psychosocial variable, many with psychometric limitations. Beyond the psychometric limitations of some measures, in sport there is also a need for measures to be relevant to the specific experiences of sports performers. In order to gain a greater understanding of the social support experiences of sports people, 10 high-level sports performers were interviewed regarding their experiences of social support. Principles of the grounded theory (Glaser & Strauss, 1967) approach were adopted for analysis of their responses and insights. Four dimensions of support were generated, within each of which were comments relating to sport-specific support and comments relating to support not directly concerning the sport itself. The dimensions were labeled emotional, esteem, informational, and tangible. Example quotes are given to highlight each dimension of support, and implications for intervention are derived