La guerra de la Independencia en Vélez-Málaga y en la Axarquía: guerrillas y contraguerrillas

The announcement of the uprising in Madrid, on the 2nd of May, 1808, unleashed a popularresponse in Malaga, which had tragic consequences. In Vélez-Málaga, the sympathetic attitude oftheir magistrate to the French cause provoked so much tension among the neighbourhood that theLocal Cabinet Meeting cautiously considered to arrange him a police protection and subsequenttransfer to Granada. After the advance of the French army through Andalucía, José Napoleón Ibegin a royal visit to the Andalusian cities. From Málaga he moves to Vélez, in order to know abouttheir peculiar sugar cane cultivation; there, he is welcomed with all the honours. Public outcrymoves then to the Axarquía region, where many groups of patriots, leaded by rebels coming fromdifferent social classes, arise with a same objective: to expel the French occupation army fromAndalucía and restore the throne to their legitimate Sovereign, Fernando VII.La noticia del alzamiento madrileño del 2 de mayo de 1808 en Málaga desencadenó unareacción popular con trágicas consecuencias. En Vélez-Málaga la actitud afecta a la causafrancesa de su corregidor creó tal tensión entre los vecinos que la Junta Local Gubernativaconsideró prudente su protección policial y posterior traslado a Granada. Tras el avance delos ejércitos franceses por Andalucía, José Napoleón I inicia una visita real a las ciudadesandaluzas. Desde Málaga se traslada a Vélez para conocer su singular cultivo de la caña deazúcar y es recibido con todos los honores. El descontento popular se traslada a la comarcade la Axarquía, en la que surgen numerosas partidas de patriotas encabezados por rebeldes dediferente procedencia social pero con el mismo objetivo: arrojar de Andalucía al ejército deocupación francés y restablecer en el trono a su legítimo Soberano Fernando VII

Mercy in the Maltese educational system : education practices to foster respect for diversity towards the migrant population

The growing diversity of learners in Maltese schools presents new challenges to policy-makers and practitioners. Schools and teachers often find themselves at odds when trying to respond to the increasingly diverse needs of the student population within schools. Over the past decade Malta made the shift from a country of emigration to a country of immigration. This trend is represented in Maltese schools, as the student population becomes increasingly heterogeneous. While this new reality is more pronounced in certain areas, all colleges have a representation of non-Maltese students, with Maria Regina College having the highest representation with a total of 1,134 students (819 at primary level, 95 in middle school and 220 in secondary school) and Saint Nicholas College having the lowest number, with a total population of eighty one migrant students (fifty-nine in the primary, eleven in middle school and eleven in the secondary school).peer-reviewe

Assessing variations of extreme indices inducing weather-hazards on critical infrastructures over Europe?the INTACT framework

Extreme weather events are projected to be more frequent and severe across the globe because of global warming. This poses challenging problems for critical infrastructures, which could be dramatically affected (or disrupted), and may require adaptation plans to the changing climate conditions. The INTACT FP7-European project evaluated the resilience and vulnerability of critical infrastructures to extreme weather events in a climate change scenario. To identify changes in the hazard induced by climate change, appropriate extreme weather indicators (EWIs), as proxies of the main atmospheric features triggering events with high impact on the infrastructures, were defined for a number of case studies and different approaches were analyzed to obtain local climate projections. We considered the influence of weighting and bias correction schemes on the delta approach followed to obtain the resulting projections, considering data from the Euro-CORDEX ensemble of regional future climate scenarios over Europe. The aim is to provide practitioners, decision-makers, and administrators with appropriate methods to obtain actionable and plausible results on local/regional future climate scenarios. Our results show a small sensitivity to the weighting approach and a large sensitivity to bias correcting the future projections.This work has been carried out within the activities of INTACT project, receiving funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° FP7-SEC-2013-1-606799. The information and views set out in this paper are those of the authors and do not necessarily reflect the opinion of the European Union. We acknowledge the World Climate Research Programme's Working Group on Regional Climate, and the Working Group on Coupled Modelling, former coordinating body of CORDEX and responsible panel for CMIP5

Brief International Cognitive Assessment for MS (BICAMS): International Standards for Validation

An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment for MS (BICAMS) battery includes tests of mental processing speed and memory. Recognizing that resources for validation will vary internationally, the committee identified validation priorities, to facilitate international acceptance of BICAMS. Practical matters pertaining to implementation across different languages and countries were discussed. Five steps to achieve optimal psychometric validation were proposed. In Step 1, test stimuli should be standardized for the target culture or language under consideration. In Step 2, examiner instructions must be standardized and translated, including all information from manuals necessary for administration and interpretation. In Step 3, samples of at least 65 healthy persons should be studied for normalization, matched to patients on demographics such as age, gender and education. The objective of Step 4 is test-retest reliability, which can be investigated in a small sample of MS and/or healthy volunteers over 1–3 weeks. Finally, in Step 5, criterion validity should be established by comparing MS and healthy controls. At this time, preliminary studies are underway in a number of countries as we move forward with this international assessment tool for cognition in MS

The dusty AGB star RS CrB: first mid-infrared interferometric observations with the Keck Telescopes

We report interferometric observations of the semi-regular variable star RS CrB, a red giant with strong silicate emission features. The data were among the first long baseline mid-infrared stellar fringes obtained between the Keck telescopes, using parts of the new nulling beam combiner. The light was dispersed by a low-resolution spectrometer, allowing simultaneous measurement of the source visibility and intensity spectra from 8 to 12 microns. The interferometric observations allow a non-ambiguous determination of the dust shell spatial scale and relative flux contribution. Using a simple spherically-symmetric model, in which a geometrically thin shell surrounds the stellar photosphere, we find that ~30% to ~70% of the overall mid-infrared flux - depending on the wavelength - originates from 7-8 stellar radii. The derived shell opacity profile shows a broad peak around 11 microns (tau ~ 0.06), characteristic of Mg-rich silicate dust particles.Comment: Accepted for publication in ApJ Letter

Bringing metabolic networks to life: convenience rate law and thermodynamic constraints

BACKGROUND: Translating a known metabolic network into a dynamic model requires rate laws for all chemical reactions. The mathematical expressions depend on the underlying enzymatic mechanism; they can become quite involved and may contain a large number of parameters. Rate laws and enzyme parameters are still unknown for most enzymes. RESULTS: We introduce a simple and general rate law called "convenience kinetics". It can be derived from a simple random-order enzyme mechanism. Thermodynamic laws can impose dependencies on the kinetic parameters. Hence, to facilitate model fitting and parameter optimisation for large networks, we introduce thermodynamically independent system parameters: their values can be varied independently, without violating thermodynamical constraints. We achieve this by expressing the equilibrium constants either by Gibbs free energies of formation or by a set of independent equilibrium constants. The remaining system parameters are mean turnover rates, generalised Michaelis-Menten constants, and constants for inhibition and activation. All parameters correspond to molecular energies, for instance, binding energies between reactants and enzyme. CONCLUSION: Convenience kinetics can be used to translate a biochemical network – manually or automatically - into a dynamical model with plausible biological properties. It implements enzyme saturation and regulation by activators and inhibitors, covers all possible reaction stoichiometries, and can be specified by a small number of parameters. Its mathematical form makes it especially suitable for parameter estimation and optimisation. Parameter estimates can be easily computed from a least-squares fit to Michaelis-Menten values, turnover rates, equilibrium constants, and other quantities that are routinely measured in enzyme assays and stored in kinetic databases