Approximation of proximities by aggregating T-indistinguishability operators

For a continuous Archimedean t-norm T a method to approximate a proximity relation R (i.e. a reflexive and symmetric fuzzy relation) by a T-transitive one is provided. It consists of aggregating the transitive closure R of R with a (maximal) T-transitive relation B contained in R using a suitable weighted quasi-arithmetic mean to maximize the similarity or minimize the distance to R.Peer Reviewe

Combining Fine- and Coarse-Grained Classifiers for Diabetic Retinopathy Detection

Visual artefacts of early diabetic retinopathy in retinal fundus images are usually small in size, inconspicuous, and scattered all over retina. Detecting diabetic retinopathy requires physicians to look at the whole image and fixate on some specific regions to locate potential biomarkers of the disease. Therefore, getting inspiration from ophthalmologist, we propose to combine coarse-grained classifiers that detect discriminating features from the whole images, with a recent breed of fine-grained classifiers that discover and pay particular attention to pathologically significant regions. To evaluate the performance of this proposed ensemble, we used publicly available EyePACS and Messidor datasets. Extensive experimentation for binary, ternary and quaternary classification shows that this ensemble largely outperforms individual image classifiers as well as most of the published works in most training setups for diabetic retinopathy detection. Furthermore, the performance of fine-grained classifiers is found notably superior than coarse-grained image classifiers encouraging the development of task-oriented fine-grained classifiers modelled after specialist ophthalmologists.Comment: Pages 12, Figures

A logical study of local and global graded similarities

In this work we study the relationship between global and local similarities in the graded framework of fuzzy class theory (FCT), in which there already exists a graded notion of similarity. In FCT we can express the fact that a fuzzy relation is reflexive, symmetric, or transitive up to a certain degree, and similarity is defined as a first-order sentence, which is the fusion of three sentences corresponding to the graded notions of reflexivity, symmetry, and transitivity. This allows us to speak in a natural way of the degree of similarity of a relation. We consider global similarities defined from local similarities using t-norms as aggregation operators, and we obtain some results in the framework of FCT that, adequately interpreted, allow us to say that when we take a t-norm as an aggregation operator, the properties of reflexivity, symmetry, and transitivity of fuzzy binary relations are inherited from the local to the global level, and that the global similarity is a congruence if some of the local similarities are congruence

II Congrés Internacional sobre Traducció : abril 1994 : actes

Machine learning-based approach unravels distinct pathological signatures induced by patient-derived α-synuclein seeds in monkeys. Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established characteristic of Parkinson's disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that α-syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here, we have used a machine learning-based approach to identify unique signatures of neurodegeneration in monkeys induced by distinct α-syn pathogenic structures derived from patients with PD. Unexpectedly, our results show that, in nonhuman primates, a small amount of singular α-syn aggregates is as toxic as larger amyloid fibrils present in the LBs, thus reinforcing the need for preclinical research in this species. Furthermore, our results provide evidence supporting the true multifactorial nature of PD, as multiple causes can induce a similar outcome regarding dopaminergic neurodegeneratio

Investigating cortico-subcortical circuits during auditory sensory attenuation: A combined magnetoencephalographic and dynamic causal modeling study

Sensory attenuation refers to the decreased intensity of a sensory percept when a sensation is self‐generated compared with when it is externally triggered. However, the underlying brain regions and network interactions that give rise to this phenomenon remain to be determined. To address this issue, we recorded magnetoencephalographic (MEG) data from 35 healthy controls during an auditory task in which pure tones were either elicited through a button press or passively presented. We analyzed the auditory M100 at sensor‐ and source‐level and identified movement‐related magnetic fields (MRMFs). Regression analyses were used to further identify brain regions that contributed significantly to sensory attenuation, followed by a dynamic causal modeling (DCM) approach to explore network interactions between generators. Attenuation of the M100 was pronounced in right Heschl's gyrus (HES), superior temporal cortex (ST), thalamus, rolandic operculum (ROL), precuneus and inferior parietal cortex (IPL). Regression analyses showed that right postcentral gyrus (PoCG) and left precentral gyrus (PreCG) predicted M100 sensory attenuation. In addition, DCM results indicated that auditory sensory attenuation involved bi‐directional information flow between thalamus, IPL, and auditory cortex. In summary, our data show that sensory attenuation is mediated by bottom‐up and top‐down information flow in a thalamocortical network, providing support for the role of predictive processing in sensory‐motor system

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), affect millions of people every year and so far, there are no therapeutic cures available. Even though animal and histological models have been of great aid in understanding disease mechanisms and identifying possible therapeutic strategies, in order to find disease-modifying solutions there is still a critical need for systems that can provide more predictive and physiologically relevant results. One possible avenue is the development of patient-derived models, e.g. by reprogramming patient somatic cells into human induced pluripotent stem cells (hiPSCs), which can then be differentiated into any cell type for modelling. These systems contain key genetic information from the donors, and therefore have enormous potential as tools in the investigation of pathological mechanisms underlying disease phenotype, and progression, as well as in drug testing platforms. hiPSCs have been widely cultured in 2D systems, but in order to mimic human brain complexity, 3D models have been proposed as a more advanced alternative. This review will focus on the use of patient-derived hiPSCs to model AD, PD, HD and ALS. In brief, we will cover the available stem cells, types of 2D and 3D culture systems, existing models for neurodegenerative diseases, obstacles to model these diseases in vitro, and current perspectives in the field

Toda la ciudad era un paisaje. Naturaleza, arquitectura y pintura en la obra de Wang Shu

Según Wang Shu, su arquitectura produce una experiencia análoga a la que ofrece la contemplación de la pintura tradicional china. Esta se diferencia del arte occidental en que no trata de expresar la sensibilidad visual de su autor a través de la descripción de la luz, el espacio y los objetos. No define los temas a través del color sino perfilándolos con líneas oscuras y unas pocas tonalidades. El pintor no trabaja del natural; normalmente es, también, filósofo y poeta, además de dominar muchas otras disciplinas técnicas y humanísticas; vive aislado en los parajes elegidos antes de pintarlos, para captar el funcionamiento estructural del mundo natural del que forma parte y compartir después, a través de su arte, ese conocimiento. Provocar ese mismo tipo de vivencias es también para Wang Shu el principal propósito de su arquitectura