Remote ischemic preconditioning in patients with intermittent claudication

OBJECTIVE: Remote ischemic preconditioning (RIPC) is a phenomenon in which a short period of sub-lethal ischemia in one organ protects against subsequent bouts of ischemia in another organ. We hypothesized that RIPC in patients with intermittent claudication would increase muscle tissue resistance to ischemia, thereby resulting in an increased ability to walk. METHODS: In a claudication clinic, 52 ambulatory patients who presented with complaints of intermittent claudication in the lower limbs associated with an absent or reduced arterial pulse in the symptomatic limb and/or an ankle-brachial index <0.90 were recruited for this study. The patients were randomly divided into three groups (A, B and C). All of the patients underwent two tests on a treadmill according to the Gardener protocol. Group A was tested first without RIPC. Group A was subjected to RIPC prior to the second treadmill test. Group B was subjected to RIPC prior to the first treadmill test and then was subjected to a treadmill test without RIPC. In Group C (control group), both treadmill tests were performed without RIPC. The first and second tests were conducted seven days apart. Brazilian Clinical Trials: RBR-7TF6TM. RESULTS: Group A showed a significant increase in the initial claudication distance in the second test compared to the first test. CONCLUSION: RIPC increased the initial claudication distance in patients with intermittent claudication; however, RIPC did not affect the total walking distance of the patients

Air quality during uncontrolled fires: a multi-years case of study

Exposure to high level of pollutant as a consequence of uncontrolled fire is a issue that must be managed in the right way in order to protect environment and ensure a safe habitat for humans, flora and fauna, because is well know that emissions occurred during those events could serious contaminate air soil and water, and some pollutant could be hazardous for the human health (Lemieux, 2002). During uncontrolled fires a lot of contaminants may be emitted, but in high concern for the human health are persistent organic pollutants (POPs) and PAHs (Coudon et al., 2019, Zhang et al., 2008). Moreover uncontrolled burning could release polychlorinated biphenyls dioxin-like (PCB dl), that are generated as by-product during industrial combustions. Those pollutants are all of high concern for human health because they have well-known carcinogenic and mutagenic properties, e.g. is well known that PAHs is the main carcinogenic constituent of ambient aerosol (Zhang et al., 2008, Fent et al., 2018; Ravindra et al., 2008). Moreover, PCDD/PCDF, frequently referred as dioxin, are recognized as toxic chemical pollutant, with endocrine proprieties and toxic dioxin congener is classified as group1 carcinogen by the international agency for research in cancer (IARC). The aim of this study is evaluate how uncontrolled fires can affect air quality by characterizing persistent organic pollutant emitted from some events occurred from 2015 to 2018 in Veneto region (northern Italy). This area is one of the most polluted and urbanized areas in Europe (Larsen et al., 2012)and uncontrolled fire can further enhance this severe situation, leading air pollution to critical level. During those accidental events the Environmental Protection Agency of Veneto (ARPAV), in order to monitoring the effect of fires, and ensure public health, collected some air samples using Hi-vol samplers equipped with quartz fiber filter (QFF) for collecting “particulate” phase compounds and a polyurethane foam plug (PUF) for retaining “gas-phase” compounds. Subsequently, polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/PCDF), polychlorinated biphenyls dioxin-like (PCB dl) and Polycyclic aromatic hydrocarbons (PAHs), were analysed using a High Resolution Gas Chromatography (HRGC), coupled with High Resolution Mass Spectrometry (HRMS). As expected results show large increase of PCDD/PCDF, PCB dl and PAHs during and immediately after incidental fires, with differences in pollutant composition. It’s noticeable how, in a few time (hours to days) pollutant concentration presented a clear and strong drop, leading air quality to better conditions. This drop is probably due to meteorological factors, that will be investigated

Separatrix splitting at a Hamiltonian 02iω0^2 i\omega bifurcation

We discuss the splitting of a separatrix in a generic unfolding of a degenerate equilibrium in a Hamiltonian system with two degrees of freedom. We assume that the unperturbed fixed point has two purely imaginary eigenvalues and a double zero one. It is well known that an one-parametric unfolding of the corresponding Hamiltonian can be described by an integrable normal form. The normal form has a normally elliptic invariant manifold of dimension two. On this manifold, the truncated normal form has a separatrix loop. This loop shrinks to a point when the unfolding parameter vanishes. Unlike the normal form, in the original system the stable and unstable trajectories of the equilibrium do not coincide in general. The splitting of this loop is exponentially small compared to the small parameter. This phenomenon implies non-existence of single-round homoclinic orbits and divergence of series in the normal form theory. We derive an asymptotic expression for the separatrix splitting. We also discuss relations with behaviour of analytic continuation of the system in a complex neighbourhood of the equilibrium

The effects of deformation inertia (kinetic energy) in the orbital and spin evolution of close-in bodies

The purpose of this work is to evaluate the effect of deformation inertia on tide dynamics, particularly within the context of the tide response equations proposed independently by Boué et al. (Celest Mech Dyn Astron 126:31–60, 2016) and Ragazzo and Ruiz (Celest Mech Dyn Astron 128(1):19–59, 2017). The singular limit as the inertia tends to zero is analyzed, and equations for the small inertia regime are proposed. The analysis of Love numbers shows that, independently of the rheology, deformation inertia can be neglected if the tide-forcing frequency is much smaller than the frequency of small oscillations of an ideal body made of a perfect (inviscid) fluid with the same inertial and gravitational properties of the original body. Finally, numerical integration of the full set of equations, which couples tide, spin and orbit, is used to evaluate the effect of inertia on the overall motion. The results are consistent with those obtained from the Love number analysis. The conclusion is that, from the point of view of orbital evolution of celestial bodies, deformation inertia can be safely neglected. (Exceptions may occur when a higher-order harmonic of the tide forcing has a high amplitude.)publishe

Uncovering genetic and non-genetic biomarkers specific for exudative age-related macular degeneration : significant association of twelve variants

Age-related Macular Degeneration (AMD) represents one of the most sightthreatening diseases in developed countries that substantially impacts the patients' lifestyle by compromising everyday activities, such as reading and driving. In this context, understanding the prevalence, burden, and population-specific risk/ protective factors of AMD is essential for adequate health care planning and provision. Our work aimed to characterize exudative AMD in Italian population and to identify the susceptibility/protective factors (genetic variants, age, sex, smoking and dietary habits) which are specific for the onset of disease. Our study involved a cohort of 1976 subjects, including 976 patients affected with exudative AMD and 1000 control subjects. In particular, the sample cohort has been subjected to a large genotyping analysis of 20 genetic variants which are known to be associated with AMD among European and Asiatic populations. This analysis revealed that 8 genetic variants (CFH, ARMS2, IL-8, TIMP3, SLC16A8, RAD51B, VEGFA and COL8A1) were significantly associated with AMD susceptibility. Successively, we performed a multivariate analysis, considering both genetic and non-genetic data available for our sample cohort. The multivariate analysis showed that age, smoking, dietary habits and sex, together with the genetic variants, were significantly associated with AMD in our population. Altogether, these data represent a starting point for the set-up of adequate preventive and personalized strategies aimed to decrease the burden of disease and improve the patients' quality of life

No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age

Background : we investigated the association between 9 polymorphisms of genes encoding hemostasis factors and myocardial infarction in a large sample of young patients chosen because they have less coronary atherosclerosis than older patients, and thus their disease is more likely to be related to a genetic predisposition to a prothrombotic state Methods and Results : this nationwide case-control study involved 1210 patients who had survived a first myocardial infarction at an age of 45 years who underwent coronary arteriography in 125 coronary care units and 1210 healthy subjects matched for age, sex, and geographical origin. None of the 9 polymorphisms of genes encoding proteins involved in coagulation (G-455A -fibrinogen: OR, 1.0; CI, 0.8 to 1.2; G1691A factor V: OR, 1.1; CI, 0.6 to 2.1; G20210A factor II: OR, 1.0; CI, 0.5 to 1.9; and G10976A factor VII: OR, 1.0; CI, 0.8 to 1.3), platelet function (C807T glycoprotein Ia: OR, 1.1; CI, 0.9 to 1.3; and C1565T glycoprotein IIIa: OR, 0.9; CI, 0.8 to 1.2), fibrinolysis (G185T factor XIII: OR, 1.2; CI, 0.9 to 1.6; and 4G/5G plasminogen activator inhibitor type 1: OR, 0.9; CI, 0.7 to 1.2), or homocysteine metabolism (C677T methylenetetrahydrofolate reductase: OR, 0.9; CI, 0.8 to 1.1) were associated with an increased or decreased risk of myocardial infarction Conclusions : this study provides no evidence supporting an association between 9 polymorphisms of genes encoding proteins involved in hemostasis and the occurrence of premature myocardial infarction or protection against it

Progetti di riattivazione temporanea dello spazio pubblico: quale eredità? / Projects for the temporary reactivation of public space: what legacy?

The expressions tactical urbanism, place making, pop-up city, openstreet projects distinguish highly relational projects, which generally constitute the result of bottom-up operations, carried out with the participation of the population, with or without the support of institutions. Starting from the detection of approaches found in literature and the identification of international case studies, the essay focuses on a qualitative analysis of intervention models, proposing an evaluation matrix that identifies significant indicators to assess the effectiveness of projects over time. The evaluation matrix also takes advantage of the experience of a collective that promotes projects of public spaces through new forms of interaction between inhabitants and common goods