Uptake and distribution of lead in tobacco (Nicotiana tabacum L.)

Six Nicotiana tabacum varieties were in vitro cultured and experimentally exposed to lead in order to estimate lead uptake and distribution in tobacco plantlets and to observe possible differences depending on variety. Fifty-day-old plantlets were exposed to four Pb rates ranging from 0 to 200 mg dm-3. No statistically significant effect of lead on dry matter weight was observed for any variety or plant part. Tissue lead concentration was determined on upper leaves, lower leaves, stems and roots. Lead accumulation in the plant positively correlated with lead exposure level. Lead concentration in the different plant parts decreased as follows: root, lower leaves, stem and upper leaves. All tobacco varieties showed similar behaviour with respect to lead treatment level and revealed the same distribution pattern of lead concentration in the different plant part. The highest values of tissue lead concentration were found in tobacco variety Pr61, while the lowest in G94-2

Implementación de un servicio de terminologías médicas en una organización privada de salud

a Codificación diagnóstica de las consultas ambulatorias y de internación, es necesaria para elaborar informes estadísticos, para mejorar el registro médico electrónico y para mejorar la calidad de la atención médica. Describiremos los avances que logramos en la definición, clasificación, organización e implementación de un Servicio de Terminología basado en Ontologías, destinado a la Codificación Asistencial.Sociedad Argentina de Informática e Investigación Operativ

AGILE Observations of the Gravitational Wave Event GW150914

We report the results of an extensive search in the AGILE data for a gamma-ray counterpart of the LIGO gravitational wave event GW150914. Currently in spinning mode, AGILE has the potential of covering with its gamma-ray instrument 80 % of the sky more than 100 times a day. It turns out that AGILE came within a minute from the event time of observing the accessible GW150914 localization region. Interestingly, the gamma-ray detector exposed about 65 % of this region during the 100 s time intervals centered at -100 s and +300 s from the event time. We determine a 2-sigma flux upper limit in the band 50 MeV - 10 GeV, $UL = 1.9 \times 10^{-8} \rm \, erg \, cm^{-2} \, s^{-1}$ obtained about 300 s after the event. The timing of this measurement is the fastest ever obtained for GW150914, and significantly constrains the electromagnetic emission of a possible high-energy counterpart. We also carried out a search for a gamma-ray precursor and delayed emission over timescales ranging from minutes to days: in particular, we obtained an optimal exposure during the interval -150 / -30 s. In all these observations, we do not detect a significant signal associated with GW150914. We do not reveal the weak transient source reported by Fermi-GBM 0.4 s after the event time. However, even though a gamma-ray counterpart of the GW150914 event was not detected, the prospects for future AGILE observations of gravitational wave sources are decidedly promising.Comment: 20 pages, 6 figures. Submitted to the Astrophysical Journal Letters on April 1, 201

AGILE detection of delayed gamma-ray emission from GRB 080514B

GRB 080514B is the first gamma ray burst (GRB), since the time of EGRET, for which individual photons of energy above several tens of MeV have been detected with a pair-conversion tracker telescope. This burst was discovered with the Italian AGILE gamma-ray satellite. The GRB was localized with a cooperation by AGILE and the interplanetary network (IPN). The gamma-ray imager (GRID) estimate of the position, obtained before the SuperAGILE-IPN localization, is found to be consistent with the burst position. The hard X-ray emission observed by SuperAGILE lasted about 7 s, while there is evidence that the emission above 30 MeV extends for a longer duration (at least ~13 s). Similar behavior was seen in the past from a few other GRBs observed with EGRET. However, the latter measurements were affected, during the brightest phases, by instrumental dead time effects, resulting in only lower limits to the burst intensity. Thanks to the small dead time of the AGILE/GRID we could assess that in the case of GRB 080514B the gamma-ray to X-ray flux ratio changes significantly between the prompt and extended emission phase.Comment: A&A letters, in pres

Prenatal tobacco smoke exposure increases hospitalizations for bronchiolitis in infants

BACKGROUND: Tobacco smoke exposure (TSE) is a worldwide health problem and it is considered a risk factor for pregnant women's and children's health, particularly for respiratory morbidity during the first year of life. Few significant birth cohort studies on the effect of prenatal TSE via passive and active maternal smoking on the development of severe bronchiolitis in early childhood have been carried out worldwide. METHODS: From November 2009 to December 2012, newborns born at ≥ 33 weeks of gestational age (wGA) were recruited in a longitudinal multi-center cohort study in Italy to investigate the effects of prenatal and postnatal TSE, among other risk factors, on bronchiolitis hospitalization and/or death during the first year of life. RESULTS: Two thousand two hundred ten newborns enrolled at birth were followed-up during their first year of life. Of these, 120 (5.4%) were hospitalized for bronchiolitis. No enrolled infants died during the study period. Prenatal passive TSE and maternal active smoking of more than 15 cigarettes/daily are associated to a significant increase of the risk of offspring children hospitalization for bronchiolitis, with an adjHR of 3.5 (CI 1.5-8.1) and of 1.7 (CI 1.1-2.6) respectively. CONCLUSIONS: These results confirm the detrimental effects of passive TSE and active heavy smoke during pregnancy for infants' respiratory health, since the exposure significantly increases the risk of hospitalization for bronchiolitis in the first year of lif

Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort

BACKGROUND: Respiratory Syncytial Virus (RSV) is one of the main causes of respiratory infections during the first year of life. Very premature infants may contract more severe diseases and 'late preterm infants' may also be more susceptible to the infection. The aim of this study is to evaluate the risk factors for hospitalization during the first year of life in children born at different gestational ages in Italy. METHODS: A cohort of 33-34 weeks gestational age (wGA) newborns matched by sex and age with two cohort of newborns born at 35-37 wGA and > 37 wGA were enrolled in this study for a three-year period (2009-2012). Hospitalization for bronchiolitis (ICD-9 code 466.1) during the first year of life was assessed through phone interview at the end of the RSV season (November-March) and at the completion of the first year of life. RESULTS: The study enrolled 2314 newborns, of which 2210 (95.5 %) had a one year follow-up and were included in the analysis; 120 (5.4 %) were hospitalized during the first year of life for bronchiolitis. Children born at 33-34 wGA had a higher hospitalization rate compared to the two other groups. The multivariate analysis carried out on the entire population associated the following factors with higher rates for bronchiolitis hospitalization: male gender; prenatal treatment with corticosteroids; prenatal exposure to maternal smoking; singleton delivery; respiratory diseases in neonatal period; surfactant therapy; lack of breastfeeding; siblings <10 years old; living in crowded conditions and/or in unhealthy households and early exposure to the epidemic RSV season. When analysis was restricted to preterms born at 33-34 wGA the following variables were associated to higher rates of bronchiolitis hospitalization: male gender, prenatal exposure to maternal smoking, neonatal surfactant therapy, having siblings <10 years old, living in crowded conditions and being exposed to epidemic season during the first three months of life. CONCLUSION: Our study identified some prenatal, perinatal and postnatal conditions proving to be relevant and independent risk factors for hospitalization for bronchiolitis during the first year of life. The combination of these factors may lead to consider palivizumab prophylaxis in Italy

Neutral pion emission from accelerated protons in the supernova remnant W44

We present the AGILE gamma-ray observations in the energy range 50 MeV - 10 GeV of the supernova remnant (SNR) W44, one of the most interesting systems for studying cosmic-ray production. W44 is an intermediate-age SNR (20, 000 years) and its ejecta expand in a dense medium as shown by a prominent radio shell, nearby molecular clouds, and bright [SII] emitting regions. We extend our gamma-ray analysis to energies substantially lower than previous measurements which could not conclusively establish the nature of the radiation. We find that gamma-ray emission matches remarkably well both the position and shape of the inner SNR shocked plasma. Furthermore, the gamma-ray spectrum shows a prominent peak near 1 GeV with a clear decrement at energies below a few hundreds of MeV as expected from neutral pion decay. Here we demonstrate that: (1) hadron-dominated models are consistent with all W44 multiwavelength constraints derived from radio, optical, X-ray, and gamma-ray observations; (2) ad hoc lepton-dominated models fail to explain simultaneously the well-constrained gamma-ray and radio spectra, and require a circumstellar density much larger than the value derived from observations; (3) the hadron energy spectrum is well described by a power-law (with index s = 3.0 \pm 0.1) and a low-energy cut-off at Ec = 6 \pm 1 GeV. Direct evidence for pion emission is then established in an SNR for the first time.Comment: accepted for publication on ApJ

Direct Evidence for Hadronic Cosmic-Ray Acceleration in the Supernova Renmant IC 443

The Supernova Remnant (SNR) IC 443 is an intermediate-age remnant well known for its radio, optical, X-ray and gamma-ray energy emissions. In this Letter we study the gamma-ray emission above 100 MeV from IC 443 as obtained by the AGILE satellite. A distinct pattern of diffuse emission in the energy range 100 MeV-3 GeV is detected across the SNR with its prominent maximum (source "A") localized in the Northeastern shell with a flux F = (47 \pm 10) 10^{-8} photons cm^{-2} s^{-1} above 100 MeV. This location is the site of the strongest shock interaction between the SNR blast wave and the dense circumstellar medium. Source "A" is not coincident with the TeV source located 0.4 degree away and associated with a dense molecular cloud complex in the SNR central region. From our observations, and from the lack of detectable diffuse TeV emission from its Northeastern rim, we demonstrate that electrons cannot be the main emitters of gamma-rays in the range 0.1-10 GeV at the site of the strongest SNR shock. The intensity, spectral characteristics, and location of the most prominent gamma-ray emission together with the absence of co-spatial detectable TeV emission are consistent only with a hadronic model of cosmic-ray acceleration in the SNR. A high-density molecular cloud (cloud "E") provides a remarkable "target" for nucleonic interactions of accelerated hadrons: our results show enhanced gamma-ray production near the molecular cloud/shocked shell interaction site. IC 443 provides the first unambiguous evidence of cosmic-ray acceleration by SNRs.Comment: 5 pages, 2 figures; accepted by ApJLetters on Jan 21, 201

Episodic Transient Gamma-Ray Emission from the Microquasar Cygnus X-1

Cygnus X-1 is the archetypal black hole (BH) binary system in our Galaxy. We report the main results of an extensive search for transient gamma-ray emission from Cygnus X-1 carried out in the energy range 100 MeV - 3 GeV by the AGILE satellite, during the period 2007 July - 2009 October. The total exposure time is about 300 days, during which the source was in the "hard" X-ray spectral state. We divided the observing intervals in 2 or 4 week periods, and searched for transient and persistent emission. We report an episode of significant transient gamma-ray emission detected on 2009, October 16 in a position compatible with Cygnus X-1 optical position. This episode, occurred during a hard spectral state of Cygnus X-1, shows that a 1-2 day time variable emission above 100 MeV can be produced during hard spectral states, having important theoretical implications for current Comptonization models for Cygnus X-1 and other microquasars. Except for this one short timescale episode, no significant gamma-ray emission was detected by AGILE. By integrating all available data we obtain a 2$\sigma$ upper limit for the total integrated flux of $F_{\gamma,U.L.} = 3 \times 10^{-8} \rm ph cm^{-2} s^{-1}$ in the energy range 100 MeV - 3 GeV. We then clearly establish the existence of a spectral cutoff in the energy range 1-100 MeV that applies to the typical hard state outside the flaring period and that confirms the historically known spectral cutoff above 1 MeV.Comment: Accepted for publication by ApJ on the 9th of Feb 2010, 5 pages, 3 figure