891 research outputs found
Validation of FEM models describing moisture transport in heated concrete by Magnetic Resonance Imaging
Fire safety of buildings and structures is an important issue, and has a great impact on human life and economy. One of the processes negatively affecting the strength of a concrete building or structure during fire is spalling. Many examples exists in which spalling of concrete during fire has caused severe damage to structures, such as in the Mont Blanc and Channel Tunnel. Especially newly developed dense types of concrete such as HPC and SCC, have shown to be sensitive to spalling, hampering the application of these new concrete types. To reduce risks and building costs, the processes behind spalling need to be understood. Increasing our knowledge allows us to reliably predict the behaviour and take effective and cost friendly preventive measures. Moisture present in concrete is one of the reasons for spalling. When concrete is heated water will evaporate, which results in a high gas pressure inside the pores of concrete. This high gas pressure can induce spalling. To attain a better understanding of this process, a first step was taken to develop a finite element model (FEM) describing this transport of moisture in heated concrete. However, the validity of all current models (including our own) is unknown because of debatable input parameters and lack of experimental techniques to follow the transport process in situ. In cooperation with the Eindhoven University of Technology moisture transport in heated concrete can now be investigated with a home built dedicated 1D Magnetic Resonance Imaging (MRI) setup. Using the results of the MRI experiments the validity of our FEM models has been assessed for the first time. A general correspondence is observed. The FEM model described in this paper is a simplified FEM model compared to literature models. Already this simplified model shows a good correspondence with the MRI measurements
Many-body interactions and melting of colloidal crystals
We study the melting behavior of charged colloidal crystals, using a
simulation technique that combines a continuous mean-field Poisson-Boltzmann
description for the microscopic electrolyte ions with a Brownian-dynamics
simulation for the mesoscopic colloids. This technique ensures that many-body
interactions between the colloids are fully taken into account, and thus allows
us to investigate how many-body interactions affect the solid-liquid phase
behavior of charged colloids. Using the Lindemann criterion, we determine the
melting line in a phase-diagram spanned by the colloidal charge and the salt
concentration. We compare our results to predictions based on the established
description of colloidal suspensions in terms of pairwise additive Yukawa
potentials, and find good agreement at high-salt, but not at low-salt
concentration. Analyzing the effective pair-interaction between two colloids in
a crystalline environment, we demonstrate that the difference in the melting
behavior observed at low salt is due to many-body interactions
Does affirming children's autonomy and prosocial intentions help? A microtrial into intervention component effects to improve psychosocial behavior
Item does not contain fulltextPrior research has related children's prosocial behavior to overall well-being, and stimulating prosocial behavior is the aim of many social-emotional skills interventions. This study assessed if affirming children's autonomy stimulates their psychosocial behavior. We conducted a three-arm microtrial with four repeated measures to assess if a social-emotional skills intervention with an autonomy affirmation component had an additive effect on children's behavior as compared to a "regular" intervention focused exclusively on teaching social-emotional skills and a no-treatment control condition. Our sample consisted of 779 children in Grades 4-6 (Mage = 10.61, SD = 0.93). Findings from latent change modeling demonstrated that the social-emotional skills intervention with an autonomy affirmation component yielded superior effects as compared to the "regular" intervention and the no-treatment control condition on the improvement of internalizing and externalizing problem behavior in the three-month period after the intervention. The intervention with autonomy affirmation did not yield superior effects on prosociality and social skills, self-efficacy, and self-esteem or self-perceived competence. The absence of these effects may be attributed to the dosage of the interventions implemented - the affirmation of children's autonomy may require more than four sessions to sort observable effects. Overall, however, the findings of this study provide an initial suggestion that it may be beneficial to affirm children's autonomy and prosocial intentions when enhancing children's behavior.22 p
Plant- en bodemmicrobioom – belang voor gewasbescherming : Plant and soil microbiome – relevance for crop protection : 2 november, 2017, Akoesticum, Ede
Er gaat geen week voorbij, of er staat iets over micro-organismen in de krant: nieuwe infectieziektes, ziekenhuis met resistente bacteriën, de rol van darmflora op het ontstaan van obesitas in muizen. Ook de technologie om micro-organismen en hun complexe levensgemeenschappen in kaart te brengen maakt een snelle ontwikkeling door. Daarnaast zijn de technieken om grote hoeveelheden sequentiedata te verkrijgen en digitale dataopslag enorm toegenomen. Wat betekent dit voor de gewasbescherming
A 1-D modelling of streaming potential dependence on water content during drainage experiment in sand
The understanding of electrokinetics for unsaturated conditions is crucial
for numerous of geophysical data interpretation. Nevertheless, the behaviour of
the streaming potential coefficient C as a function of the water saturation Sw
is still discussed. We propose here to model both the Richards' equation for
hydrodynamics and the Poisson's equation for electrical potential for
unsaturated conditions using 1-D finite element method. The equations are first
presented and the numerical scheme is then detailed for the Poisson's equation.
Then, computed streaming potentials (SPs) are compared to recently published SP
measurements carried out during drainage experiment in a sand column. We show
that the apparent measurement of DV / DP for the dipoles can provide the SP
coefficient in these conditions. Two tests have been performed using existing
models for the SP coefficient and a third one using a new relation. The results
show that existing models of unsaturated SP coefficients C(Sw) provide poor
results in terms of SP magnitude and behaviour. We demonstrate that the
unsaturated SP coefficient can be until one order of magnitude larger than
Csat, its value at saturation. We finally prove that the SP coefficient follows
a non-monotonous behaviour with respect to water saturation. Key words:
Electrical properties; Electromagnetic theory; Hydrogeophysics; Hydrology;
Permeability and porosity; electrokinetic; streaming potential; self-potential;
water content; water saturation; unsaturated condition; finite element modelin
Genotype-phenotype correlations for pancreatic cancer risk in Dutch melanoma families with pathogenic CDKN2A variants
BACKGROUND: Pathogenic variants in the CDKN2A gene are generally associated with the development of melanoma and pancreatic ductal adenocarcinoma (PDAC), but specific genotype-phenotype correlations might exist and the extent of PDAC risk is not well established for many variants. METHODS: Using the Dutch national familial melanoma database, we identified all families with a pathogenic CDKN2A variant and investigated the occurrence of PDAC within these families. We also estimated the standardised incidence ratio and lifetime PDAC risk for carriers of a highly prevalent variant in these families. RESULTS: We identified 172 families in which 649 individuals carried 15 different pathogenic variants. The most prevalent variant was the founder mutation c.225_243del (p16-Leiden, 484 proven carriers). Second most prevalent was c.67G>C (55 proven carriers). PDAC developed in 95 of 163 families (58%, including 373 of 629 proven carriers) harbouring a variant with an effect on the p16INK4a protein, whereas PDAC did not occur in the 9 families (20 proven carriers) with a variant affecting only p14ARF. In the c.67G>C families, PDAC occurred in 12 of the 251 (5%) persons at risk. The standardised incidence ratio was 19.1 (95% CI 8.3 to 33.6) and the cumulative PDAC incidence at age 75 years (lifetime risk) was 19% (95% CI 7.5% to 30.1%). CONCLUSIONS: Our results support the notion that pathogenic CDKN2A variants affecting the p16INK4a protein, including c.67G>C, are associated with increased PDAC risk and carriers of such variants should be offered pancreatic cancer surveillance. There is no clinical evidence that impairment of only the p14ARF protein leads to an increased PDAC risk
Regulation Of The Interurban Coach Services In Brazil
Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne
Electronic reminders for pathologists promote recognition of patients at risk for Lynch syndrome: cluster-randomised controlled trial
We investigated success factors for the introduction of a guideline on recognition of Lynch syndrome in patients recently diagnosed with colorectal cancer (CRC) below age 50 or a second CRC below age 70. Pathologists were asked to start microsatellite instability (MSI) testing and report to surgeons with the advice to consider genetic counselling when MSI test or family history was positive. A multicentre cluster-randomised controlled trial (ClinicalTrials.gov, number NCT00141466) was performed in 12 pathology laboratories (clusters), serving 29 community hospitals. All received an introduction to the new guideline. In the intervention group, surgeons received education and tumour test result reminders; pathologists were provided with inclusion criteria cards, an electronic patient inclusion reminder system and feedback on inclusion. Two hundred sixty-six CRC patients were eligible for recognition as at risk for Lynch syndrome. The actual recognition was 18% more successful in the intervention as compared to the control arm (77% (120 of 156) compared to 59% (65 of 110)), with an adjusted odds ratio (OR) = 2.8 (95% confidence interval (CI) 1.1–7.0). The electronic reminder system for pathologists was most strongly associated with recognition of high-risk patients, OR = 4.2 (95% CI 1.7–10.1). An electronic reminder system for pathologists appeared effective for adherence to a new complex guideline and will enhance the recognition of Lynch syndrome
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