Flow Path Resistance in Heterogeneous Porous Media Recast into a Graph-Theory Problem

Acknowledgment is made to the U.S. NSF (EAR-1847689) and the Donors of the American Chemical Society Petroleum Research Fund (59864-DNI9) for partial support of this research. The authors also thank Drs Matthias Willmann, Jefrey Hyman and Markus Holzner for assistance with numerical simulations and insightful discussionsPeer reviewedPublisher PD

S194-P-FADD as a marker of aggressiveness and poor prognosis in human T-cell lymphoblastic lymphoma

T-cell lymphoblastic lymphoma is a haematological disease with an urgent need for reliable prognostic biomarkers that allow therapeutic stratification and dose adjustment. The scarcity of human samples is responsible for the delayed progress in the study and the clinical management of this disease, especially compared with T-cell acute lymphoblastic leukaemia, its leukemic counterpart. In the present work, we have determined by immunohistochemistry that S194-P-FADD protein is significantly reduced in a cohort of 22 samples from human T-cell lymphoblastic lymphoma. Notably, the extent of such reduction varies significantly among samples and has revealed determinant for the outcome of the tumour. We demonstrate that Fas-associated protein with death domain (FADD) phosphorylation status affects protein stability, subcellular localization and non-apoptotic functions, specifically cell proliferation. Phosphorylated FADD would be more stable and preferentially localized to the cell nucleus; there, it would favour cell proliferation. We show that patients with higher levels of S194-P-FADD exhibit more proliferative tumours and that they present worse clinical characteristics and a significant enrichment to an oncogenic signature. This supports that FADD phosphorylation may serve as a predictor for T-cell lymphoblastic lymphoma aggressiveness and clinical status. In summary, we propose FADD phosphorylation as a new biomarker with prognostic value in T-cell lymphoblastic lymphoma

SOCS2 (suppressor of cytokine signaling 2)

Review on SOCS2 (suppressor of cytokine signaling 2), with data on DNA, on the protein encoded, and where the gene is implicated

Stability of excited states of a Bose-Einstein condensate in an anharmonic trap

We analyze the stability of non-ground nonlinear states of a Bose-Einstein condensate in the mean field limit in effectively 1D (``cigar-shape'') traps for various types of confining potentials. We find that nonlinear states become, in general, more stable when switching from a harmonic potential to an anharmonic one. We discuss the relation between this fact and the specifics of the harmonic potential which has an equidistant spectrum

New method for carbon dioxide mineralization based on phosphogypsum and aluminium-rich industrial wastes resulting in valuable carbonated by-products

A new carbon mineralization method was designed based on a sequestration agent synthesised exclusively from industrial wastes. Phosphogypsum waste from the fertiliser industry was dissolved into caustic aqueous waste from the aluminium anodising industry. The resulting precipitate consisted of katoite (Ca3Al2(OH)12, a Si-free hydrogrossular solid solution end-member of the Al-containing hydrogarnet) and thenardite (Na2SO4); the latter easily removed by rinsing with water. The carbonation performance of this katoite-rich sequestration agent was evaluated using two different methods, by bubbling in aqueous media and by weathering. Both procedures yielded high carbonation efficiencies (80% and 100%, respectively), and resulted in a solid precipitate composed primarily of calcite (CaCO3) and aluminium hydroxide (Al(OH)3). Priority attention was given to the transfer of trace elements and radionuclides of the uranium series typically present in the phosphogypsum. Results confirmed that the traces were transferred to resulting final solid carbonate at concentrations similar to those present in the raw phosphogypsum. In conclusion, these carbonated minerals would trap substantial amounts of CO2 and produce final materials with similar civil engineering uses to those proposed for current phosphogypsum wastes. This work offers new methods for jointly managing specific industrial wastes oriented to more sustainable industrial processes and controlling CO2 emissionsPeer reviewe

Fractures of the tibial plateau. Influence of the type of fracture and precision of the articular reduction on the prognosis

Se realizó un estudio retrospectivo en 43 pacientes tratados de 45 fracturas de pilón tibial entre 1990 y 1998. Según la clasificación de Rüedi y Allgöwer 6 fracturas eran tipo I (13,3%), 6 tipo II (13,3%) y 33 tipo III (73,3%). El tratamiento realizado fue manipulación e inmovilización en botín de yeso en 8 fracturas, las seis del tipo I y dos del tipo II. En las 37 fracturas restantes se realizó osteotaxis y osteosíntesis. Los resultados clínicos obtenidos fueron excelentes-buenos en 27 de las fracturas (60%), valorados por parámetros objetivos, pero solo en 16 de las fracturas (35,5%) cuando se valoraron por parámetros subjetivos. Se apreciaron mejores resultados clínicos objetivos/subjetivos cuando se consiguió una buena reducción articular y cuanto menor era el grado de desplazamiento y hundimiento de la fractura; en estos casos fue más difícil obtener una buena reducción articular. En 2 fracturas (25%) tratadas conservadoramente y en 17 (46%) tratadas quirúrgicamente se presentó al menos una complicación. Las fracturas de pilón tibial son fracturas graves, por la frecuencia de lesiones de partes blandas y de otras estructuras con que se asocian y por los resultados mediocres derivados de su tratamiento, que son peores en las fracturas tipo III y cuando no se consigue una correcta reducción articular

¿Puede considerarse diferente la calidad de la proteína y grasa de la leche de Cabra y vaca?

Peer reviewe

CloudChain: A novel distribution model for digital products based on supply chain principles

Cloud computing is a popular outsourcing solution for organizations to support the information management during the life cycle of digital information goods. However, outsourcing management with a public provider results in a lack of control over digital products, which could produce incidents such as data unavailability during service outages, violations of confidentiality and/or legal issues. This paper presents a novel distribution model of digital products inspired by lean supply chain principles called CloudChain, which has been designed to support the information management during digital product lifecycle. This model enables connected networks of customers, partners and organizations to conduct the stages of digital product lifecycle as value chains. Virtual distribution channels are created over cloud resources for applications of organizations to deliver digital products to applications of partners through a seamless information flow. A configurable packing and logistic service was developed to ensure confidentiality and privacy in the product delivery by using encrypted packs. A chain management architecture enables organizations to keep tighter control over their value chains, distribution channels and digital products. CloudChain software instances were integrated to an information management system of a space agency. In an experimental evaluation CloudChain prototype was evaluated in a private cloud where the feasibility of applying supply chain principles to the delivery of digital products in terms of efficiency, flexibility and security was revealed.This work was partially funded by the sectorial fund of research, technological development and innovation in space activities of the Mexican National Council of Science and Technology (CONACYT) and the Mexican Space Agency (AEM), project No. 262891