Serotonin and motherhood: From molecules to mood

Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin, in the display of maternal behaviors and reproduction-associated plasticity in the maternal brain. Serotonin is also implicated in the pathophysiology of numerous affective disorders and likely plays an important role in the pathophysiology of maternal mental illness. Therefore, the main goals of this review are to detail: 1) how the serotonin system of the female brain changes across pregnancy and postpartum; 2) the role of the central serotonergic system in maternal caregiving and maternal aggression; and 3) how the serotonin system and selective serotonin reuptake inhibitor medications (SSRIs) are involved in the treatment of maternal mental illness. Although there is much work to be done, studying the central serotonin system’s multifaceted role in the maternal brain is vital to our understanding of the processes governing matrescence and the maintenance of motherhood

Nucleon and Delta resonances in K Sigma(1385) photoproduction from nucleons

The reaction mechanisms for $K\Sigma(1385)$ photoproduction from the reaction $\gamma p \to K^+\Sigma^{0}(1385)$ in the resonance energy region are investigated in a hadronic model. Both contributions from $N$ and $\Delta$ resonances of masses around 2 GeV as given in the Review of Particle Data Group and by the quark model predictions are included. The Lagrangians for describing the decays of these resonances into $K\Sigma(1385)$ are constructed with the coupling constants determined from the decay amplitudes predicted by a quark model. Comparing the resulting total cross section for the reaction $\gamma p \to K^+\Sigma^{0}(1385)$ with the preliminary data from the Thomas Jefferson National Accelerator Facility, we find that the most important contributions are from the two-star rated resonances $\Delta(2000) F_{35}$, $\Delta(1940) D_{33}$, and $N(2080) D_{13}$, as well as the missing resonance $N\frac32^-(2095)$ predicted in the quark model. Predictions on the differential cross section and photon asymmetry in this reaction are also given.Comment: 13 pages, 6 figures, REVTeX, to appear in Phys. Rev.

On the scalar nonet in the extended Nambu Jona-Lasinio model

We discuss the lightest scalar resonances, $f_0(600)$, $\kappa(800)$, $a_0(980)$ and $f_0(980)$ in the extended Nambu Jona-Lasinio model. We find that the model parameters can be tuned, but unnaturally, to accommodate for those scalars except the $f_0(980)$. We also discuss problems encountered in the K Matrix unitarization approximation by using $N_c$ counting technique.Comment: 23 pages 3 eps figures, To appear in Nucl. Phys.

D-wave superconductivity induced by short-range antiferromagnetic correlations in the two-dimensional Kondo lattice model

The possible heavy fermion superconductivity is carefully reexamined in the two-dimensional Kondo lattice model with an antiferromagnetic Heisenberg superexchange between local magnetic moments. In order to establish an effective mean field theory in the limit of the paramagnetic heavy Fermi liquid and near the half-filling case, we find that the spinon singlet pairing from the local antiferromagnetic short-range correlations can reduce the ground state energy substantially. In the presence of the Kondo screening effect, the Cooper pairs between the conduction electrons is induced. Depending on the ratio of the Heisenberg and the Kondo exchange couplings, the resulting superconducting state is characterized by either a d-wave nodal or d-wave nodeless state, and a continuous phase transition exists between these two states. These results are related to some quasi-two dimensional heary fermion superconductors.Comment: 6 pages, 6 figure

A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes.

Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes) in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. epidermidis, a probiotic skin bacterium) can exploit glycerol fermentation to produce short-chain fatty acids (SCFAs) which have antimicrobial activities to suppress the growth of P. acnes. Unlike glycerol, sucrose is chosen here as a selective fermentation initiator (SFI) that can specifically intensify the fermentation activity of S. epidermidis, but not P. acnes. A co-culture of P. acnes and fermenting S. epidermidis in the presence of sucrose significantly led to a reduction in the growth of P. acnes. The reduction was abolished when P. acnes was co-cultured with non-fermenting S. epidermidis. Results from nuclear magnetic resonance (NMR) analysis revealed four SCFAs (acetic acid, butyric acid, lactic acid, and succinic acid) were detectable in the media of S. epidermidis sucrose fermentation. To validate the interference of S. epidermidis sucrose fermentation with P. acnes, mouse ears were injected with both P. acnes and S. epidermidis plus sucrose or phosphate buffered saline (PBS). The level of macrophage-inflammatory protein-2 (MIP-2) and the number of P. acnes in ears injected with two bacteria plus sucrose were considerably lower than those in ears injected with two bacteria plus PBS. Our results demonstrate a precision microbiome approach by using sucrose as a SFI for S. epidermidis, holding future potential as a novel modality to equilibrate dysbiotic acne

Effects of initial state fluctuations on jet energy loss

The effect of initial state fluctuations on jet energy loss in relativistic heavy-ion collisions is studied in a 2+1 dimension ideal hydrodynamic model. Within the next-to-leading order perturbative QCD description of hard scatterings, we find that a jet loses slightly more energy in the expanding quark-gluon plasma if the latter is described by the hydrodynamic evolution with fluctuating initial conditions compared to the case with smooth initial conditions. A detailed analysis indicates that this is mainly due to the positive correlation between the fluctuation in the production probability of parton jets from initial nucleon-nucleon hard collisions and the fluctuation in the medium density along the path traversed by the jet. This effect is larger in non-central than in central relativistic heavy ion collisions and also for jet energy loss that has a linear than a quadratic dependence on its path length in the medium

Similarity-Based Classification in Partially Labeled Networks

We propose a similarity-based method, using the similarity between nodes, to address the problem of classification in partially labeled networks. The basic assumption is that two nodes are more likely to be categorized into the same class if they are more similar. In this paper, we introduce ten similarity indices, including five local ones and five global ones. Empirical results on the co-purchase network of political books show that the similarity-based method can give high accurate classification even when the labeled nodes are sparse which is one of the difficulties in classification. Furthermore, we find that when the target network has many labeled nodes, the local indices can perform as good as those global indices do, while when the data is sparce the global indices perform better. Besides, the similarity-based method can to some extent overcome the unconsistency problem which is another difficulty in classification.Comment: 13 pages,3 figures,1 tabl