The Use of Growth Factors and Mesenchymal Stem Cells in Orthopaedics: In particular, their use in Fractures and Non-Unions: A Systematic Review.

AIM: The aim was to look at current evidence for treating non-unions or delayed fracture healing in regard to novel methods applying mesenchymal stem cells (MSCs) and growth factors (GF). METHODS: Pre-clinical and clinical trials focusing on the use of Mesenchymal Stem Cells and Growth Factors for fracture healing were included in this review. Published articles were identified using specific search terms in Medline, Cochrane Library, PubMed, Scopus and Web of Science. RESULTS: Of the 580 articles found, 82 met my selection criteria and were included, with 39 papers involving trials on the effects of GFs and MSCs on non-unions or bone repair. These included 11 articles on MSCs, 10 on Bone Morphogenetic Proteins, 2 on Vascular-Endothelial GF, 5 on Insulin like-GF, 4 on Transforming-GF-β, 4 on Platelet-Rich Plasma, 1 on Platelet Derived-GF and 2 on Fibroblast-GF, with the other articles included qualitatively. Overall results were positive with the addition of MSCs, Bone Morphogenetic Proteins, VEGF, IGF and TGF-β in aiding fracture healing compared to controls, with mixed results for other factors. CONCLUSION: Overall this review shows promising results regarding the use of MSCs and various Growth factors in the treatment of fractures and non-unions, as well as synergistic effects observed when combined together. However more research is indicated as these methods are still in the early stages of development

Education Par Excellence: Developing Personal Competencies and Character Through Philanthropy-based Education

This teaching note presents an innovation in accounting education called the Philanthropy Project. The Philanthropy Project emphasizes experiential learning and is designed to promote the learning of discipline-specific concepts while simultaneously addressing the social needs of the surrounding community. In the Philanthropy Project, students receive money to distribute to not-for-profit organizations (NFPs) based on a competitive proposal process they help to develop and administer. A distinguishing characteristic of this project is that it is not a simulation. Students make real decisions that have immediate consequences to certain groups of people in their own communities. They have to make difficult choices by allocating scarce resources to some agencies and saying “no” to other agencies, all with worthy causes. The philanthropy project was administered in two introductory financial accounting classes, one at University A (a regional public university) and one at University B (a comprehensive private university). At the conclusion of the project, students reported experiencing the benefits of collaboration, communication, conceptual learning, community engagement, and character development. In addition to learning typical for-profit accounting topics, students participating in the philanthropy project also learned about NFP financial statements and related economic measures. Given the specified not-for-profit context, this project could be relevant for governmental and not-for-profit accounting classes. A timeline of activities, grading rubric, and templates are provided to aid in the adoption of this project by other accounting educators

Shadows of the Planck Scale: The Changing Face of Compactification Geometry

By studying the effects of the shape moduli associated with toroidal compactifications, we demonstrate that Planck-sized extra dimensions can cast significant ``shadows'' over low-energy physics. These shadows can greatly distort our perceptions of the compactification geometry associated with large extra dimensions, and place a fundamental limit on our ability to probe the geometry of compactification simply by measuring Kaluza-Klein states. We also discuss the interpretation of compactification radii and hierarchies in the context of geometries with non-trivial shape moduli. One of the main results of this paper is that compactification geometry is effectively renormalized as a function of energy scale, with ``renormalization group equations'' describing the ``flow'' of geometric parameters such as compactification radii and shape angles as functions of energy.Comment: 7 pages, LaTeX, 2 figure

Upsilon Decay to a Pair of Bottom Squarks

We calculate the rate for $\Upsilon$ decay into a pair of bottom squarks as a function of the masses of the bottom squark and the gluino. Data from decays of the $\Upsilon$ states could provide significant new bounds on the existence and masses of these supersymmetric particles.Comment: 10 pages, latex, 2 figure

A solution to the mu problem in the presence of a heavy gluino LSP

In this paper we present a solution to the $\mu$ problem in an SO(10) supersymmetric grand unified model with gauge mediated and D-term supersymmetry breaking. A Peccei-Quinn symmetry is broken at the messenger scale $M\sim 10^{12}$ GeV and enables the generation of the $\mu$ term. The boundary conditions defined at $M$ lead to a phenomenologically acceptable version of the minimal supersymmetric standard model with novel particle phenomenology. Either the gluino or the gravitino is the lightest supersymmetric particle (LSP). If the gravitino is the LSP, then the gluino is the next-to-LSP (NLSP) with a lifetime on the order of one month or longer. In either case this heavy gluino, with mass in the range 25 - 35 GeV, can be treated as a stable particle with respect to experiments at high energy accelerators. Given the extensive phenomenological constraints we show that the model can only survive in a narrow region of parameter space resulting in a light neutral Higgs with mass $\sim 86 - 91$ GeV and $\tan\beta \sim 9 - 14$. In addition the lightest stop and neutralino have mass $\sim 100 - 122$ GeV and $\sim 50 - 72$ GeV, respectively. Thus the model will soon be tested. Finally, the invisible axion resulting from PQ symmetry breaking is a cold dark matter candidate.Comment: 30 pages, 9 figure

Daily quantification of myoglobin forms on beef longissimus lumborum steaks over 7 days of display by near-infrared diffuse reflectance spectroscopy

Near-infrared diffuse reflectance spectroscopy (NIR-DRS) was utilized to develop an algorithm using approximately 18 wavelengths spanning 480 to 650 nm to determine oxymyoglobin (OxyMb), deoxymyoglobin (DeoxyMb), and metmyoglobin (MetMb) contents on beef longissimus lumborum muscles. Daily changes in subsurface myoglobin redox forms were evaluated for 7 d using NIR-DRS and compared with the surface color as assessed by a HunterLab MiniScan spectrophotometer as a reference modality. Both measurements revealed that MetMb increased steadily over the duration of display, showing high correlation (R2 = 0.91) between the 2 methods. Comparatively, whereas NIR-DRS revealed OxyMb to have decreased steadily over the period of display, the HunterLab MiniScan spectrophotometer indicated a much later onset of the apparent decrease of OxyMb, resulting in a moderate correlation (R2 = 0.64) between the 2 methods. No correlation was found between the 2 methods regarding the changes of DeoxyMb over the duration of display. The newly developed NIR-DRS algorithm has potential as an alternative method of color assessment in postrigor skeletal muscle.Electrical and Computer EngineeringAnimal and Food Science

Ultra High Energy Cosmic Rays from Sequestered X Bursts

Assuming that there is no GZK (Greisen-Zatsepin-Kuzmin) cut-off and that super-GZK cosmic rays correlate with AGN (Active Galactic Nuclei) at cosmological distances, it is speculated that a relic superheavy particle (X) has its lifetime enhanced by sequestration in an extra dimension. This sequestration is assumed to be partially liberated by proximity of merging supermassive black holes in an AGN, temporarily but drastically reducing the lifetime, thus stimulating an X burst. Based on sequestration of the decay products of X, a speculative explanation of the observed $\gamma/N$ ratio is proposed.Comment: 12 pages LaTe

Effect of mitochondrial inhibitor on fresh meat color

Oxygen consumption is a muscle property that influences beef color. A greater amount of oxygen consumption results in less bloom and darker meat color while lower oxygen consumption produces a more desirable, bright, cherry red color. In postmortem muscles, mitochondria are greatly involved with the process of oxygen consumption. This research investigates the addition of Rotenone as a mitochondrial inhibitor to analyze the inhibition of ATP Synthesis in the mitochondria.Lew Wentz FoundationAnimal and Food Science

Diagnosing Spin at the LHC via Vector Boson Fusion

We propose a new technique for determining the spin of new massive particles that might be discovered at the Large Hadron Collider. The method relies on pair-production of the new particles in a kinematic regime where the vector boson fusion production mechanism is enhanced. For this regime, we show that the distribution of the leading jets as a function of their relative azimuthal angle can be used to distinguish spin-0 from spin-1/2 particles. We illustrate this effect by considering the particular cases of (i) strongly-interacting, stable particles and (ii) supersymmetric particles carrying color charge. We argue that this method should be applicable in a wide range of new physics scenarios.Comment: 5 pages, 4 figure

Single gluino production in the R-parity lepton number violating MSSM at the LHC

We examine the $R_{p}$-violating signal of single gluino production associated with a charged lepton or neutrino at the large hadron collider (LHC), in the model of R-parity relaxed supersymmetric model. If the parameters in the ${\rlap/R}_p$ supersymmetric interactions are not too small, and the mass of gluino is considered in the range from several GeV (as the Lightest Supersymmetric Particle) to 800 GeV, the cross section of the single gluino production via Drell-Yan processes can be in the order of $10^2 \sim 10^3$ femto barn, and that via gluon fusion in the order of $10^{-1} \sim 10^3$ femto barn. If the gluino decay can be well detected in the CERN LHC, this process provides a prospective way to probe supersymmetry and $R_p$ violation.Comment: LaTex, 22 pages, 5 EPS file