Diagnostic significance of CK19, TG, Ki67 and galectin-3 expression for papillary thyroid carcinoma in the northeastern region of China

<p>Abstract</p> <p>Background</p> <p>To evaluate the expression and differential diagnostic significance of CK19, TG, Ki67 and galectin-3 in papillary thyroid carcinoma (PTC) (metastatic and non metastatic), follicular adenoma and nodular goiter in patients from the northeastern part of China.</p> <p>Methods</p> <p>441 PTC specimens and 151 other benign thyroid specimens (97 cases of nodular goiter, 54 cases of nonmalignant follicular adenoma) were collected. Immunohistochemistry for CK19, TG, Ki67 and galectin-3 was performed.</p> <p>Results</p> <p>CK19, TG, Ki67 and galectin-3 expression was 96.37% (425/441), 82.77% (365/441), and 40.59% (179/441), 96.82% (427/441), respectively, for the PTC group and the expression of these markers in the benign thyroid lesions group was 25.83% (39/151), 79.47% (120/151), and 37.09% (56/151), 50.99% (77/151), respectively. The expression of CK19 and galectin-3 in PTC was much higher than that in the nonmalignant group (p < 0.05). However, the expression of TG, Ki67 did not differ among these two groups (p > 0.05). The diagnostic efficiency of CK19 and galectin-3 for PTC was 96.37% (537/592) and 84.63% (501/592). CK19 and galectin-3 expression rate in PTC was higher than that in benign disease cases.</p> <p>Conclusions</p> <p>The diagnostic efficiency of CK19 for PTC was slightly better than galectin-3. The utilization of these markers combined with morphologic evaluation may be helpful in the differential diagnosis of papillary thyroid carcinoma in the northeastern region of China.</p

Lie powers of modules for groups of prime order

Let $L(V)$ be the free Lie algebra on a finite-dimensional vector space $V$ over a field $K$, with homogeneous components $L^n(V)$ for $n \geq 1$. If $G$ is a group and $V$ is a $KG$-module, the action of $G$ extends naturally to $L(V)$, and the $L^n(V)$ become finite-dimensional $KG$-modules, called the Lie powers of $V$. In the decomposition problem, the aim is to identify the isomorphism types of indecomposable $KG$-modules, with their multiplicities, in unrefinable direct decompositions of the Lie powers. This paper is concerned with the case where $G$ has prime order $p$, and $K$ has characteristic $p$. As is well known, there are $p$ indecomposables, denoted here by $J_1,\dots,J_p$, where $J_r$ has dimension $r$. A theory is developed which provides information about the overall module structure of $L(V)$ and gives a recursive method for finding the multiplicities of $J_1,\dots,J_p$ in the Lie powers $L^n(V)$. For example, the theory yields decompositions of $L(V)$ as a direct sum of modules isomorphic either to $J_1$ or to an infinite sum of the form $J_r \oplus J_{p-1} \oplus J_{p-1} \oplus \ldots$ with $r \geq 2$. Closed formulae are obtained for the multiplicities of $J_1,\dots,J_p$ in $L^n(J_p)$ and $L^n(J_{p-1})$. For $r < p-1$, the indecomposables which occur with non-zero multiplicity in $L^n(J_r)$ are identified for all sufficiently large $n$

Generalization of the Electrostatic Model for Non-Local Screening

Electrostatic model for interpreting final stae relaxation (polarization) and Auger parameter shifts/Generalization of the electrostatic model/Application of the electrostatic model for determining Si 2p surface core-level shifts at the Si(001) surface/Conclusion/References

Representações de profissionais de saúde sobre a morte e o processo de morrer

Os currículos da área de saúde deixam uma lacuna na formação teórica e prática, permitindo que a morte seja interpretada como fracasso. A pesquisa objetivou apreender as representações sociais da morte e do processo de morrer para os profissionais de saúde. Trata-se de uma pesquisa qualitativa de natureza exploratória. Foram entrevistados cinco profissionais de saúde que prestam assistência a pacientes fora de possibilidades de cura. Utilizou-se o software Alceste para apreender o conteúdo das representações sociais dos entrevistados. Da análise de conteúdo das entrevistas emergiram dois eixos distintos: o primeiro eixo agrupa classes que dizem respeito à dimensão do profissional frente à morte; o segundo eixo refere-se à dimensão subjetiva frente à morte. Os resultados ressaltam a necessidade de investir na capacitação dos alunos não somente no desenvolvimento de habilidades técnicas, mas também no desenvolvimento de habilidades interpessoais, elementos fundamentais para o cuidado humano, sobretudo diante a morte

Controlling interface anisotropy in CoFeB/MgO/HfO2 using dusting layers and magneto-ionic gating

International audienceIn this work, we present the magneto-ionic response to ionic liquid gating in Ta/CoFeB/MgO/HfO2 stacks, where heavy metal dusting layers of Ta, W, and Pt are inserted at the Ta/CoFeB and CoFeB/MgO interfaces. Dusting layers of W inserted at the Ta/CoFeB interface increase perpendicular magnetic anisotropy (PMA) by more than 50%, while no significant changes are seen for Pt. In these samples, gating cannot break the PMA seeded at the CoFeB/MgO interface, only relatively small changes in the coercivity can be induced, about 20% for Ta and Pt and 6% for W. At the CoFeB/MgO interface, a significant quenching of the magnetization is seen when W and Ta dusting layers are inserted, which remains unchanged after gating, suggesting a critical deterioration of the CoFeB. In contrast, Pt dusting layers result in an in-plane anisotropy that can be reversibly converted to PMA through magneto-ionic gating while preserving the polycrystalline structure of the MgO layer. This shows that dusting layers can be effectively used not only to engineer magnetic properties in multilayers but also to strongly modify their magneto-ionic performance