Microbiological Quality Control of Probiotic Products

Microbiological quality control of probiotic products such as Imunele, Dannon, Pomogayka showed that they contain living cultures of the Lactobacillus Bifidobacterium genus in the amount of 107 CFU/ml, which corresponds to the number indicated on the label of products. It is identified that the survival rate of test-strains cultured with pasteurized products does not exceed 10%. The cell concentration of target-microorganisms was reduced by 20-45% after the interaction with living probiotic bacteria. Thus, the yogurt Activia has the most antagonistic activity

Culture stomatological health of student’s youth in Chelyabinsk

Medico-social characteristic study of 446 persons of Chelyabinsk three higher educational establishments, varying in basic stomatological status and the level of sanitary hygienic stomatological education was carried out with the help of questionnaire technique. The main part of nonmedical higher educational establishment students consults the dentist only once a year. Almost a half of them doesn’t receive necessary information about the care of oral cavity while visiting a dentist, half of respondents has already the teeth extracted. Taking into account the real teeth loss orthopedic component has a specific importance in the structure of general stomatological incidence.Изучение медико-социальной характеристики 446 представителей трёх вузов города Челябинска, различающихся по базовому стоматологическому статусу и уровню санитарно-гигиенической стоматологической грамотности, проводилось с помощью анкетного метода. Основная часть студентов немедицинских вузов обращается к стоматологу только раз в год. Почти половина не получают на приеме у стоматолога необходимую информацию о правилах ухода за полостью рта, у половины респондентов уже были удалены зубы. Учитывая реальную потерю зубов, в структуре общей стоматологической заболеваемости особую актуальность приобретает потребность студентов в ортопедическом лечении

Development of low-temperature thermochemical conversion reactors for coal power engineering

The main principles applied in developing a technology for low-temperature thermochemical conversion of brown coals to obtain fuel gas and semicoke intended for being fired in two-fuel power installations are considered on the basis of a set of experimental and calculated investigations. The obtained results are compared with the experimental data obtained using other methods and with the results of previous industrial tests. © 2013 Pleiades Publishing, Inc

Introspectiveness of Higher Education Students: Study and Development

The change in strategic guidelines in Russian education is associated with a revision of the goals of teaching and upbringing. However, the emphasis of reforms has shifted towards the formation of the required professional competences at this stage in the development of the education system of the Russian Federation. We think that it is possible to achieve the set goal of higher education through the development of the introspectiveness as a quality of the personality of students. The formation of the introspectiveness in a future specialist will have an effect on the successful mastery, expansion and transformation of social experience, as well as the internal plan of action. Thus, demonstrating the formed introspectiveness as a personality trait, the student is able to organize his educational activities independently, activities to cognize the surrounding reality and his inner world, as well as self-determine in various life situations, including the development of general cultural and professional competences. In this regard, the emphasis in the issue of developing the introspectiveness of students is made on specifying the conditions that must be created at a higher education institution for the manifestation and formation of this personality quality. The purpose of the article is to study the level of the introspectiveness of university students and develop psychological and pedagogical conditions that develop this personality quality. The leading techniques for the study of this problem were the following: Q-sort Technique; the technique for diagnostics of an individual measure of the introspectiveness degree. At the stage of the ascertaining experiment, the levels of the introspectiveness of university students were revealed. The results of the ascertaining experiment convincingly demonstrated the need to organize special work to develop the introspectiveness of students. The authors substantiated that the success of developing students’ introspectiveness is ensured by the created psychological and pedagogical conditions. A model of developing the introspectiveness as a personality quality of a future professional has been developed and tested. The results of this study create opportunities for further development of the problem in the context of the organization of lectures in the learning process for students of different courses and types of specialization. The article is intended for psychologists, tutors, education managers

Changes in glomerular filtration rate in young adults: population data

Aim of the study was to investigate glomerular filtration rate in population of 25–45 years old young people of Novosibirsk city. Material and methods. A survey of Novosibirsk typical district’s population has been carried out by the Institute of Internal and Preventive Medicine since 2013 to 2016. 1074 people (467 males and 607 females of 25–45 years old) have been included into the survey. The levels of glomerular filtration rate (GFR) were chosen according to KDIGO (2012) recommendation, such as: GFR more than 90 ml/min/1.73 cm2 – high or optimal, 60–89 ml/min/1.73 cm2 – slightly reduced, 45–59 ml/min/1.73 cm2 – moderately reduced, 30–44 ml/min/1.73 cm2 – vastly reduced, 1529 ml/min/1.73 cm2 – highly reduced, lower than 15 ml/min/1.73 cm2 – terminal renal failure. Results and discussion. Average GFR(CKD-EPI) level in all age groups was 99,9 ml/min/1.73 cm2 . Average GFR(CKD-EPI) was 104.41 ml/min/1.73 cm2 in 25–34 age group. Male average GFR(CKD-EPI) levels in appropriate age groups were reliably higher comparing to female levels. Both male and female analyzed indicators turned out to be reliably lower in older group than in the younger one. 95.1 % of male participants at the age from 25 to 34 years old had GFR ≥ 90 ml/min/1.73 cm2 , while female indicator was 76.9 %. The indicators in the age group from 35–45 years old were: for males – 86.4 %, for females – 58.3 %. Both male and female groups at the age from 35 to 45 contained people with GFR < 60.ml/min/1.73 cm2 (2 men – 0,8 %; 1 woman – 0.4 %). While GFR calculating according to MDRD and CKD-EPI formulas two dissimilar results were revealed. The advantages of CKD-EPI formulas calculating for higher GFR indicators have been evidenced

Распространенность заболеваний и патологических состояний у молодых людей до 45 лет с абдоминальным ожирением в Сибири

Aim. To study the prevalence of abdominal obesity in young people aged 25–44 years in Novosibirsk, as well as the prevalence of diseases and pathological conditions in individuals with abdominal obesity.Materials and methods. We conducted a cross-sectional, population-based study of the population of Novosibirsk aged 25–44 years. The screening examined 1,415 people, including 670 men and 745 women. For all individuals, we evaluated the presence of such conditions as abdominal obesity (AO), arterial hypertension (AH), increased body mass index (BMI), coronary heart disease (according to validated epidemiologic and functional criteria with ECG findings classified according to the Minnesota Code), diabetes mellitus (DM), reduced glomerular filtration rate (GFR), chronic bronchitis (CB), increased blood levels of total cholesterol (hypercholesterolemia) and lowdensity lipoprotein (LDL) cholesterol (hyper-LDL-cholesterolemia).Results. The prevalence of AO in the population of Novosibirsk aged 25–44 years was 42.4%: in men – 42.7%, in women – 42.1%. We found that AO had a significant direct effect on the development of AH (odds ratio (OR) = 2.550, 95% confidence interval (CI) 1.899–3.422, p = 0.0001), CB (OR = 1.830, CI 1.326–2.527, p = 0.0001), hypercholesterolemia (OR = 1.486, CI 1.193–1.851, p = 0.0001), hyper-LDL-cholesterolemia (OR = 1.527, CI 1.222–1.907, p = 0.0001) and a reverse effect on reduced GFR (OR = 0.603, CI 0.427–0.852, p = 0.004). In the male population under 45 years of age, AO had a significant direct effect on the development of AH, CB, hypercholesterolemia, and hyper-LDL-cholesterolemia. In the female population under the age of 45, AO had a significant direct effect on the development of DM, AH, CB, and hyper-LDL-cholesterolemia and a reverse effect on the reduced GFR development.Conclusion. Therefore, in the young Siberian population under 45 years of age, abdominal obesity is associated with the development of common diseases and pathological conditions. Цель – изучение распространенности абдоминального ожирения (АО) в популяции молодых людей 25– 44 лет г. Новосибирска, а также распространенности терапевтических заболеваний и патологических состояний у лиц с АО.Материалы и методы. Проведено одномоментное популяционное обследование населения 25–44 лет г. Новосибирска. На скрининге обследованы 1 415 человек, из них 670 мужчин (47,3%) и 745 женщин (52,7%). Беременные и женщины в декретном отпуске не включались в исследование. У обследуемых оценивалось наличие таких заболеваний и патологических состояний, как АО, артериальная гипертензия (АГ), повышенный индекс массы тела, ишемическая болезнь сердца (по валидизированным эпидемиологическим и функциональным критериям с расшифровкой электрокардиограммы по Миннесотскому коду), сахарный диабет (СД), сниженная скорость клубочковой фильтрации (СКФ), хронический бронхит (ХБ), повышенный уровень в крови общего ХС (гиперХСемия), повышенный уровень в крови ХС-ЛНП (гиперХС-ЛНПемия).Результаты. Распространенность АО в популяции 25–44 лет г. Новосибирска составила 42,4%, у мужчин – 42,7%, у женщин – 42,1%. Обнаружено, что в молодой популяции до 45 лет АО оказывает прямое влияние на развитие АГ (отношение шансов (ОШ) 2,550, 95%-й доверительный интервал (95%-й ДИ) 1,899–3,422, р = 0,0001), ХБ (ОШ = 1,830, 95%-й ДИ 1,326–2,527, р = 0,0001), гиперХСемии (ОШ = 1,486, 95%-й ДИ 1,193–1,851, р = 0,0001), гипер-ХС-ЛНПемии (ОШ = 1,527, 95%-й ДИ 1,222–1,907, р = 0,0001), обратное влияние на развитие сниженной СКФ (ОШ = 0,603, 95%-й ДИ 0,427–0,852, р = 0,004). В мужской популяции до 45 лет АО оказывает прямое влияние на развитие АГ, ХБ, гиперХСемии, гипер-ХС-ЛНПемии. В женской популяции до 45 лет АО оказывает прямое влияние на развитие СД, АГ, ХБ, гипер-ХС-ЛНПемии, и обратное – на развитие сниженной СКФ.Заключение. Таким образом, в популяции до 45 лет абдоминальное ожирение ассоциировано с развитием распространенных терапевтических заболеваний и патологических состояний.

Concretes Made of Magnesium–Silicate Rocks

At present, there is a shortage of high-quality feedstock to produce widely used building materials—concretes. Depletion of natural resources and growing restrictions on their extraction, in connection with environmental protection, necessitate the search for an equivalent replacement for conventional raw materials. Magnesium–silicate rocks are a waste of the mining industry. We researched the possibility of using these rocks as coarse and fine aggregates in heavy concrete production. Following the requirements of the national standards, we studied the physical and mechanical characteristics of the obtained material. It was found that the strength of concrete, made of magnesium–silicate rock coarse aggregate, at the age of 28 days of hardening is within 28 MPa, while the strength of the control sample is 27.3 MPa. Replacing quartz sand with dunite sand also leads to an increase in concrete strength (~4%). Complete replacement of aggregates facilitates an increase in strength by 15–20% than the control sample. At the same time, the density of the obtained materials becomes higher. Concretes have a dense structure that affects their quality. Concrete water absorption is within 6%. The fluxing coefficient is 0.85–0.87. The application of magnesium–silicate rocks in concrete production enables the complete replacement of conventional aggregates with mining waste without reducing the quality of the obtained materials. Furthermore, the issues of environmental protection in mineral deposit development are being addressed

Detection of kidney dysfunction potential biomarkers with hypertension in the persons of 25–45 years

Aim.To assess the significance of symmetrical dimethylarginine (SDMA), uromodulin, retinol-binding protein 4 (RSB-4), transforming growth factorb1 (TGF-b1), plasminogen activator inhibitor 1 (PAI-1) as kidney dysfunction potential biomarkers persons with hypertension in persons 2545 years old. Materials and methods.The study included 147 people. Hypertension was recorded with blood pressure (BP)140/90 mm Hg, renal dysfunction with GFRCKD-EPI90 ml/min/1.73 cm2. Four groups were formed: 1 individuals with hypertension and GFR90 ml/min/1.73 cm2; 2 with hypertension and GFR90 ml/min/1.73 cm2; 3 with BP140/90 mm Hg and GFR90 ml/min/1.73 cm2; 4 with BP140/90 mm Hg and GFR90 ml/min/1.73 cm2. The groups were comparable by gender, age, and number of respondents. Creatinine, SDMA, uromodulin, RSB-4, TGF-b1, PAI-1 levels were examined in all individuals in the serum. Results.The maximum values of SDMA were determined in the 1st and 3rd groups (1.30 and 1.36 mol/l). In the 1st group, an association was found between SDMA and GFR (r=-0.324;p=0.048). In the 1st group, the minimum values of uromodulin were recorded, in the 4th group the maximum values (164.86 and 188.90 ng/ml; at the same timeр=0.921). The level of RSB-4 was the highest in the 1st group, the lowest in the 4th group (88.64 and 80.05 g/ml;p=0.011). The association of RSB-4 with SDMA in the 3rd group (r=0.400;p=0.017), the 4th group (r=0.403;p=0.018) was detected. The level of TGF-b1 was 1.5 times higher in the 1st group than in the 3rd (23.16 and 15.99 g/ml;p=0.026), the association of TGF-b1 with GFR in the 1st group had the opposite direction (r=-0.452;p=0.005). The study of similar indicators of PAI-1 did not reveal its relationship with renal dysfunction in hypertension. Conclusion.The results of the study made it possible to consider SDMA, RSB-4, TGF-b1 as potential biomarkers of renal dysfunction in hypertension in persons 2545 years old