Ground exploitation using a binary phase-only optical correlator

Experimental results of an optical binary phase-only correlator using aerial imagery for ground exploitation is presented. The correlator uses magnetooptic spatial light modulators (SLMs) for dynamic operation. Input images to the correlator originate from actual aerial imagery containing aircraft and a variety of distortions. Digital image processing techniques are used on images before being input into the optical correlator to enhance the performance of the system. Filters or templates used as a database for the system are derived from models of aircraft. Rotation and scale invariance is achieved through an adaptive filtering technique in which filters are displayed sequentially against an input image. Experimental results are presented which show that the system performs well with different types of segmented images

Experimental performance of a binary phase-only optical correlator using visual and infrared imagery

Experimental results of an optical binary phase-only correlator using both visual and IR imagery are presented. The inputs to the correlator originate from actual aerial imagery containing aircraft and a variety of distortions. Filters used as a database for the system are derived from models of aircraft. Digital image processing techniques are used on images before being input into the optical correlator to enhance the performance of the system. Both noise removing and segmentation techniques are investigated. Input images to the correlator are displayed on a 128×128 magneto-optic spatial light modulator (SLM). Experimental results are presented which show that the system performs well with images which are easily segmented from the background

The triple helix: 50 years later, the outcome

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us

Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

Studies of sequence specific recognition and interaction of bis-hairpin polyamide minor groove binders with target DNA duplexes

Study of the binding of bis-MGB using DNA footprinting, native gel shift, thermal denaturation, mass spectrometry and circular dichroism. Elaboration of a method to determi

A new method for the determination of the relative affinity of a ligand against various DNA sequences by electrospray ionization mass spectrometry. Application to a polyamide minor groove binder

A new method for the determination of the relative affinity of a ligand against various dsDNA sequences is presented by using electrospray ionization time-of-flight mass spectrometry (ESI-QTOF) mass spectrometry. Thismethod does not require knowing the ligand concentration accurately. It allows determination of the relative affinity of a ligand against various dsDNA sequences for 1 : 1 complex stoichiometries in a quick manner without labeling

Etude de Complexes Non-Covalents ADN/Polymeres par Spectrometrie de Masse

Conférence du 17 au 20 Septembre 2007. Communication Orale.National audienc