Impact of the Deficiency of Micronutrients on Patients with HIV/Aids

Introduction: HIV-AIDS is an infectious disease that damages the immune system, putting you at risk of serious infections and certain types of cancer. Micronutrient deficiency varies widely, depending on the population and stage of the disease. It can contribute to the weakening of the immune state and the worsening of the physical condition. Objective: To identify through the collection of nutritional information the consequences produced by the lack of micronutrients in patients with HIV-AIDS. Methodology: It was carried out through bibliographic reviews, scientific articles in order to find true and proven information on the effect that micronutrient deficiency has on people with HIV/AIDS. Results: It is shown that clinical deficiencies of some nutrients occur rapidly in response to dietary deficiencies, malabsorption, or altered metabolism, while those nutrients that have reserves in the body take longer to deplete. Discussion: The acquired immunodeficiency virus that causes AIDS; is associated with weight loss due to malnutrition. There are foods that can counteract many of the symptoms of the patient with HIV/AIDS, hence the importance of their knowledge. Conclusion: Micronutrient deficiency influences the immune system, accentuating the immunodeficiency that leads to AIDS. People living with this disease should have a balanced diet with Vitamins A, B, zinc and iron to strengthen the immune system, these offer a safe and economical treatment to slow the progression of the infection. Keywords: micronutrients, HIV, AIDS. RESUMEN Introducción: El VIH-SIDA es una enfermedad infecciosa que daña el sistema inmunitario lo que pone en riesgo de contraer infecciones graves y ciertos tipos de cáncer. La deficiencia de micronutrientes varía ampliamente, según la población y el estadio de la enfermedad; puede contribuir al debilitamiento del estado inmune y al empeoramiento de la condición física.  Objetivo: Identificar mediante la recopilación de información nutricional las consecuencias que produce la falta de micronutrientes en pacientes con VIH-SIDA. Metodología: Se realizó a través de revisiones bibliográficas, artículos científicos con el fin de encontrar información verídica y comprobada del efecto que tiene la deficiencia de micronutrientes en personas con VIH/SIDA.  Resultados: Se demuestra que las deficiencias clínicas de algunos nutrientes ocurren rápidamente en respuesta a deficiencias dietéticas, malabsorción, o metabolismo alterado, mientras que aquellos nutrientes que tienen reservas en el cuerpo tardan más en agotarse. Discusión: El virus de la inmunodeficiencia adquirida causante del SIDA; está asociada con la pérdida de peso por malnutrición. Hay muchos alimentos del grupo de los micronutrientes que minimizan manifestaciones clínicas en los enfermos el síndrome de inmunodeficiencia adquirida, siendo necesario saber cuáles son. Conclusiones: La deficiencia de micronutrientes influye en el sistema inmune, acentuando la inmunodeficiencia que lleva al SIDA. Las personas que viven con esta enfermedad deben tener una dieta balanceada con Vitaminas A, B, zinc y hierro para fortalecer el sistema inmunológico, estas ofrecen un tratamiento seguro y económico para retardar la progresión de la infección. Palabras claves: micronutrientes, VHI, SIDA

In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain

Background Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients. Methods We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients. Results Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43–1.79) for all IS patients, 1.39 (1.18–1.63) for patients with SO cancer, 2.31 (1.76–3.03) for patients with haematological cancer and 3.12 (2.23–4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80–2.61), 1.97 (1.33–2.91) and 2.06 (1.64–2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure. Conclusions IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients

Implementing a privacy-enhanced attribute-based credential system for online social networks with co-ownership management

Online social network (OSN) users are exhibiting an increased privacy-protective behaviour especially since multimedia sharing has emerged as a popular activity over most OSN sites. Popular OSN applications could reveal much of the users' personal information or let it easily derived, hence favouring different types of misbehaviour. In this article the authors deal with these privacy concerns by applying fine-grained access control and co-ownership management over the shared data. This proposal defines access policy as any linear boolean formula that is collectively determined by all users being exposed in that data collection namely the co-owners. All co-owners are empowered to take part in the process of data sharing by expressing (secretly) their privacy preferences and, as a result, jointly agreeing on the access policy. Access policies are built upon the concept of secret sharing systems. A number of predicates such as gender, affiliation or postal code can define a particular privacy setting. User attributes are then used as predicate values. In addition, by the deployment of privacy-enhanced attribute-based credential technologies, users satisfying the access policy will gain access without disclosing their real identities. The authors have implemented this system as a Facebook application demonstrating its viability, and procuring reasonable performance costs

SoNeUCON_{ABC}Pro: an access control model for social networks with translucent user provenance

Proceedings of: SecureComm 2017 International Workshops, ATCS and SePrIoT, Niagara Falls, ON, Canada, October 22–25, 2017Web-Based Social Networks (WBSNs) are used by millions of people worldwide. While WBSNs provide many benefits, privacy preservation is a concern. The management of access control can help to assure data is accessed by authorized users. However, it is critical to provide sufficient flexibility so that a rich set of conditions may be imposed by users. In this paper we coin the term user provenance to refer to tracing users actions to supplement the authorisation decision when users request access. For example restricting access to a particular photograph to those which have “liked” the owners profile. However, such a tracing of actions has the potential to impact the privacy of users requesting access. To mitigate this potential privacy loss the concept of translucency is applied. This paper extends SoNeUCONABC model and presents SoNeUCONABCPro, an access control model which includes translucent user provenance. Entities and access control policies along with their enforcement procedure are formally defined. The evaluation demonstrates that the system satisfies the imposed goals and supports the feasibility of this model in different scenarios.This work was supported by the MINECO grants TIN2013-46469-R (SPINY: Security and Privacy in the Internet of You) and TIN2016-79095-C2-2-R (SMOG-DEV); by the CAM grant S2013/ICE-3095 (CIBERDINE: Cybersecurity, Data, and Risks); and by the Programa de Ayudas para la Movilidad of Carlos III University of Madrid, Spain (J. M. de Fuentes and L. Gonzalez-Manzano grants)

Early to mid-Holocene spatiotemporal vegetation changes and tsunami impact in a paradigmatic coastal transitional system (Doñana National Park, southwestern Europe)

Ministry of Economy and Competitiveness, Spanish National Park Autonomous Organism, Ministry of Natural, Rural and Marine Environment and Fundación Sénec

Relationship between the Sensory-Determined Astringency and the Flavanolic Composition of Red Wines

[EN] The relationship between the proanthocyanidin profile and the perceived astringency was assessed in 13 commercial Tempranillo red wines. The concentration and compositional information were obtained by liquid chromatography with diode array detection coupled to electrospray ionization mass spectrometry after acid-catalyzed depolymerization of wine proanthocyanidins in the presence of excess phloroglucinol. Statistical analysis of the results showed significant correlations between sensory and chemical determinations. Astringency was more affected by the subunit composition than by the total concentration or the average degree of polymerization of wine proanthocyanidins. Higher proportions of epicatechin (EC) subunits in extension positions and gallocatechin (GC) subunits in terminal positions were shown to increase astringency. On the contrary, the amount of epigallocatechin (EGC) in both extension and terminal positions was negatively correlated with the perceived astringency

Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry

Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. Objective: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Methods: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Results: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation <93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6–5.5] vs. 0.6 [0.4–1.2] µg/ml; p < 0.0001) and platelet count (median [IQR]: 208 [158–289] vs. 189 [148–245] platelets × 109/L; p = 0.0013). A pDd cut-off of 1.1 µg/ml showed specificity 72%, sensitivity 49%, positive predictive value (PPV) 4%, and negative predictive value (NPV) 99% for in-hospital VTE. A cut-off value of 4.7 µg/ml showed specificity of 95%, sensitivity of 27%, PPV of 9%, and NPV of 98%. Overall mortality was proportional to pDd value, with the lowest incidence for each pDd category depending on anticoagulation intensity: 26.3% for those with pDd >1.0 µg/ml treated with prophylactic dose (p < 0.0001), 28.8% for pDd for patients with pDd >2.0 µg/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 µg/ml and full anticoagulation (p = 0.0183). Conclusions: In hospitalized patients with COVID-19, a pDd value greater than 3.0 µg/ml can be considered to screen VTE and to consider full-dose anticoagulation. © 2021, Society of General Internal Medicine

Pharmacovigilance in children in Camagüey Province, Cuba

Purpose: Our aim was to describe the adverse drug reactions (ADRs) detected following increased education about pharmacovigilance and drug toxicity in children in Camagüey Province, Cuba. Methods: Over a period of 24 months (January 2009 to December 2010), all reports of suspected ADRs in children to the Provincial Pharmacovigilance Centre in Camagüey Province were analysed. ADRs were classified in relation to causality and severity. Results: There were 533 reports involving suspected ADRs in children in the period. Almost one third of the reports received were classified as moderate (155, 29%) or severe (10, 2%). There was one fatality in association with the use of ceftriaxone. Vaccines and antibiotics were responsible for most of the ADR reports (392, 74%) and for all ten severe ADRs. After an intensive educational package, both within the community and the Children’s Hospital, the number of reports increased from 124 in 2008 to 161 in 2009 and 372 in 2010. This was equivalent to a reporting rate of 879 and 2,031 reports per million children per year for 2009 and 2010, respectively. Conclusions: The incidence of ADRs in children Camagüey Province, Cuba, is greater than previously reported. An educational intervention about pharmacovigilance and drug toxicity in children can improve the reporting of ADRs

Cut-offs and response criteria for the Hospital Universitario la Princesa Index (HUPI) and their comparison to widely-used indices of disease activity in rheumatoid arthritis

Objective To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. Methods Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis. The areas under ROC (AUC) were compared to those of validated indexes (SDAI, CDAI, DAS28). ROC analysis was also applied to establish minimal and relevant clinical improvement for HUPI. Results The best cut-off points for HUPI are 2, 5 and 9, classifying RA activity as remission if =2, low disease activity if >2 and =5), moderate if >5 and <9 and high if =9. HUPI''s AUC to discriminate between low-moderate activity was 0.909 and between moderate-high activity 0.887. DAS28''s AUCs were 0.887 and 0.846, respectively; both indices had higher accuracy than SDAI (AUCs: 0.832 and 0.756) and CDAI (AUCs: 0.789 and 0.728). HUPI discriminates remission better than DAS28-ESR in early arthritis, but similarly to SDAI. The HUPI cut-off for minimal clinical improvement was established at 2 and for relevant clinical improvement at 4. Response criteria were established based on these cut-off values. Conclusions The cut-offs proposed for HUPI perform adequately in patients with either early or long term arthritis