Integrating Data on Ethnicity, Geography, and Conflict: The Ethnic Power Relations Dataset Family.

ArticleThis article introduces the new Family of Ethnic Power Relations (EPR) data sets, version 2014, which is the latest in a series of data sets on ethnicity that have stimulated civil war research in the past decade. The EPR Family provides data on ethnic groups’ access to state power, their settlement patterns, links to rebel organizations, transborder ethnic kin relations, and intraethnic cleavages. The new 2014 version does not only extend the data set’s temporal coverage from 2009 to 2013, but it also offers several new features, such as a new measure of regional autonomy that is independent of national-level executive power and a new data set component coding intraethnic identities and cleavages. Moreover, for the first time, detailed documentation of the EPR data is provided through the EPR Atlas. This article presents these novelties in detail and compares the EPR Family 2014 to the most relevant alternative data sets on ethnicity.Swiss National Science FoundationSwiss Agency for Development and Cooperation (SDC

Learning Latent Factor Models of Travel Data for Travel Prediction and Analysis

Abstract. We describe latent factor probability models of human travel, which we learn from data. The latent factors represent interpretable properties: travel distance cost, desirability of destinations, and affinity between locations. Individuals are clustered into distinct styles of travel. The latent factors combine in a multiplicative manner, and are learned using Maximum Likelihood. We show that our models explain the data significantly better than histogrambased methods. We also visualize the model parameters to show information about travelers and travel patterns. We show that different individuals exhibit different propensity to travel large distances. We extract the desirability of destinations on the map, which is distinct from their popularity. We show that pairs of locations have different affinities with each other, and that these affinities are partly explained by travelers ’ preference for staying within national borders and within the borders of linguistic areas. The method is demonstrated on two sources of travel data: geotags from Flickr images, and GPS tracks from Shanghai taxis.

Innate immunity: ignored for decades, but not forgotten.

The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and can bind pathogen-associated molecular patterns. PRRs also recognize self-molecules that are released after cell damage or death, known as danger-associated molecular patterns, which can be actively transported across cell membranes. The activation of PRRs leads to host defense pathways in infectious diseases, but can also contribute to tissue injury in autoimmune diseases. The identification of these pathways has provided new insight into mechanisms of vaccination and holds promise for developing better vaccines. Finally, the identification of PRRs, their ligands, and signaling pathways provides an opportunity for developing new immunotherapeutic approaches to skin conditions in which activation of the innate immune response contributes to disease pathogenesis

Hepatitis C prevalences in the psychiatric setting: Cost-effectiveness of scaling-up screening and direct-acting antiviral therapy.

Patients hospitalised because of mental illness often have risk factors for contracting HCV. Scaling-up HCV screening for all psychiatric inpatients as a case-detection strategy for viral elimination is underexplored. This study aimed to evaluate the cost-effectiveness of scaling-up HCV screening and treatment for psychiatry hospital admissions in Switzerland vs. the current standard-of-care risk-based approach, where only those with a history of substance misuse disorder are offered testing. HCV prevalence by history of substance misuse disorder was analysed in medical records from inpatient admissions to a Swiss psychiatry department. Cost-effectiveness was analysed from a healthcare provider perspective through a decision-tree screening model, using these HCV prevalence data. Model and parameter uncertainty were assessed using deterministic and probabilistic sensitivity analyses. Prevalence of HCV in psychiatry inpatients with a history of substance misuse disorder (n = 1,013) was 25.7%, compared with 3.5% among the remaining inpatients (n = 3,535). Scaling up HCV screening and treatment for all psychiatry admissions was cost-effective vs. the risk-based approach, with an incremental cost-effectiveness ratio of US$9,188 per quality-adjusted life-year gained. The incremental cost-effectiveness ratio remained cost-effective considering a HCV prevalence as low as 0.07$435,156,348, with 917 additional patients per year detected and treated at a cost of US$3,294 per person (vs. US$2,122 under risk-based screening). Scaling up HCV screening and treatment at diagnosis with all-oral, interferon-free regimens as a generalised approach for psychiatric admissions was cost-effective and could support reaching World Health Organization targets for HCV elimination by 2030. Patients hospitalised because of mental illness often have risk factors for HCV. We found that testing all psychiatry patients in hospital for HCV was cost-effective compared with testing only patients who have a history of substance misuse. Scaling up HCV testing and treatment could help to wipe out HCV

Biomedical Co-Cr-Mo Components Produced by Direct Metal Laser Sintering

Direct Metal Laser Sintering (DMLS) is an additive manufacturing technique based on a laser power source that sinters powdered materials using a 3D CAD model. The mechanical components produced by this procedure typically show higher residual porosity and poorer mechanical properties than those obtained by traditional manufacturing techniques. In this study, samples were produced by DMLS starting from a Co-Cr-Mo powder (in the \u3b3 phase) with a composition suitable for biomedical applications. Samples were submitted to hardness measurements and structural characterization. The samples showed a hardness value remarkably higher that those commonly obtained for the same cast or wrought alloys. In fact, the HRC value measured for the samples is 47 HRC, while the usual range for CAST Co-Cr-Mo is from 25 to 35 HRC. The samples microstructure was investigated by X-ray diffraction (XRD), electron microscopy (SEM and TEM) and energy dispersive microanalysis (EDX) in order to clarify the origin of this unexpected result. The laser treatment induced a melting of the metallic Co-Cr-Mo powder, generating a phase transformation from the \u3b3 (fcc) to the e (hcp) phase. The rapid cooling of the melted powder produced the formation of e (hcp) nano-lamellae inside the \u3b3 (fcc) phase. The nano-lamellae formed an intricate network responsible for the measured hardness increase. The results suggest possible innovative applications of the DMLS technique to the production of mechanical parts in the medical and dental fields, where a high degree of personalization is required

Coinfections between persistent parasitic neglected tropical diseases and viral infections among prisoners from Sub-Saharan Africa and Latin America

© 2018 Lilian Da Silva Santos et al. In Swiss prisons, more than 70% of detained people are foreigners and over one-third originate from sub-Saharan Africa or Latin America. These two regions are endemic for various tropical diseases and viral infections, which persist after migration to nonendemic countries. Parasitic infections (schistosomiasis; strongyloidiasis) and cooccurrent viral infections (HIV, hepatitis B (HBV), and hepatitis C (HCV)) are especially of concern for clinical care but have been neglected in empirical research. These diseases often remain silent for years before causing complications, especially if they occur concomitantly. Our research aimed to study the prevalence rates and coinfections of two neglected tropical diseases, namely, Strongyloides stercoralis and Schistosoma sp. and viral infections among sub-Saharan Africans (SSA) and Latin Americans (LA) in Switzerland's largest pretrial prison. We carried out a cross-sectional prevalence study using a standardized questionnaire and serological testing. Among the 201 participants, 85.6% were SSA and 14.4% LA. We found the following prevalence ratios: 3.5% of HIV (4.1% in SSA, 0% in LA), 12.4% of chronic HBV (14.5% in SSA, 0% in LA), 2.0% of viraemic HCV (1.7% in SSA, 3.4% in LA), and 8.0% of strongyloidiasis (8.1% in SSA, 6.9% in LA). The serological prevalence of schistosomiasis among SSA was 20.3% (not endemic in Latin America). Two infections were simultaneously detected in SSA: 4.7% were coinfected with schistosomiasis and chronic HBV. Four other coinfections were detected among SSA: schistosomiasis-HIV, HIV-chronic HBV, HIV-HCV, and schistosomiasis-strongyloidiasis. To conclude, the high prevalence rates of persistent viral and parasitic infections and their potential coinfections among SSA and LA detained migrants highlight the need to implement control strategies and programs that reach people in detention centers in nonendemic countries

Integrating Data on Ethnicity, Geography, and Conflict

This article introduces the new Family of Ethnic Power Relations (EPR) data sets, version 2014, which is the latest in a series of data sets on ethnicity that have stimulated civil war research in the past decade. The EPR Family provides data on ethnic groups’ access to state power, their settlement patterns, links to rebel organizations, transborder ethnic kin relations, and intraethnic cleavages. The new 2014 version does not only extend the data set’s temporal coverage from 2009 to 2013, but it also offers several new features, such as a new measure of regional autonomy that is independent of national-level executive power and a new data set component coding intraethnic identities and cleavages. Moreover, for the first time, detailed documentation of the EPR data is provided through the EPR Atlas. This article presents these novelties in detail and compares the EPR Family 2014 to the most relevant alternative data sets on ethnicity